Slashdot Mirror


Why Doctors Hate Science

theodp writes "A 2004 study found some 10 million women lacking a cervix were still getting Pap tests. Only problem is, a Pap test screens for cervical cancer — no cervix, no cancer. With this tale, Newsweek's Sharon Begley makes her case for comparative-effectiveness research (CER), which is receiving $1 billion under the stimulus bill for studies to determine which treatments, including drugs, are more medically sound and cost-effective than others for a given ailment. Physicians, Begley says, must stop treatments that are rooted more in local medical culture than in medical science, embrace practices that have been shown scientifically to be superior to others, and ignore critics who paint CER as government control of doctors' decision-making."

26 of 1,064 comments (clear)

  1. paps with no cervixes by UltimApe · · Score: 5, Funny

    I bet next they give mandatory prostate exams to women too!

    --
    "Infecting minds with my own memetic virus, one post at a time." Ultimape
  2. Evidence-based medicine by gravos · · Score: 5, Interesting

    Evidence-based medicine is not the norm in the US, but you can't necessarily blame the doctors for failing to consider it: the whole system is the problem. Consider the case of Dr. Daniel Merenstein, a family-medicine physician trained in evidence-based practice.

    In 1999 Merenstein examined a healthy 53-year-old man who showed no signs of prostate cancer. As he had been taught, Merenstein explained ... there is little evidence that early detection makes a difference in whether treatment could save your life. As a result, the patient did not get a PSA test. Unfortunately, several years later, the patient was found to have a very aggressive and incurable prostate cancer. He sued Merenstein for not ordering a PSA test, and a jury agreed--despite the lack of evidence that it would have made a difference. Most doctors in the plaintiff's state, the lawyers showed, would have ignored the debate and simply ordered the test. Although Merenstein was found not liable, the residency program that trained him in evidence-based practice was--to the tune of $1 million.

    1. Re:Evidence-based medicine by Anonymous Coward · · Score: 5, Insightful

      Data is not the plural of anecdote.

    2. Re:Evidence-based medicine by neoshmengi · · Score: 5, Informative

      I'm 53 and my physician makes a regular practice of PSA tests for men my age, actually I started having them @ 50. Also just had my first colonoscopy recently and good thing as I had one tumor removed that was pre-cancer.

      This is rule of thumb, and Dr. Merenstein should have known this.

      Actually the previous poster is right. Population based studies suggest that more harm than good is done by screening for prostate cancer.

      The evidence goes like this. Once you have an elevated PSA, you see the urologist who orders a biopsy. Biopsies and treatments for prostate cancer carry risks like bleeding and infection, urinary incontinence and impotence. Now most prostate cancers will not kill you or cause problems in your lifetime. So investigations and treatments for prostate cancer cause more harm to people than the cancer does. This makes sense in a population, but not to the guy who got a bad cancer.

      The current guidelines do not suggest PSA's in all men over fifty, but rather that you discuss the risks and benefits of screening, plus potential harm of further workup of a positive screen vs. the harm of developing prostate cancer. In practice, there is no patient who can actually understand enough of this to truly make an informed decision. Many docs haven't heard of the 'new' evidence and continue screening. The ones who do know of that evidence often ignore it because it's hard to explain, and patients will love you for finding an early cancer, even if it would never have affected them.

      As far as your colon cancer screening comment, what you describe is standard of care.

      The other thing to consider is that medicine in the US is HUGELY biased by the litiginousness of US culture. US emergency medicine guidelines, for example, are extremely aggressive and notorious for over investigating. The priority is protecting practitioners from litigation rather than appropriately treating the patient. A lot of those investigations are not recommended in socialized health care systems because they are not cost effective, nor do the benefits outweigh the disadvantages.

    3. Re:Evidence-based medicine by girlintraining · · Score: 5, Insightful

      The problem is when you introduce two separate institutions that were never really meant to interoperate. There is a perception by the general public that doctors should be like House, or Scrubs, or a dozen other TV shows out there where everyone is a genius, and the cure can be found in a 1 hour episode with just a few tests, a quick flip through a book, and some snarky commentary. It's the same with criminal investigations -- the so-called "CSI effect". Juries now want "DNA evidence" to prove someone was at a scene (or not), something that's both impractical and often unnecessary, and cases have been lost simply because the evidence was "too boring".

      The truth is doctors aren't geniuses. They sat next to you in high school. Some of them copied your answers on the math test. They are average everyday people that have been trained (hopefully well) to do a specific job. When the justice system (and the general public's expectations) meet the medical establishment, it's not pretty. Evidence is poorly understood, and when people don't understand something intellectually they fall back on their gut feelings, their emotions. As horrible as that sounds (and sometimes is), what can we really expect from Joe Average? A carefully-weighed judgment, with full knowledge and understanding of the evidence? Please.

      Here's a hard truth to swallow: All that stuff about a "jury of your peers", and being judged by people who are well versed in the law (but not necessarily the material issue at hand), doesn't work in modern society. Our method of voting and elections are horribly outdated as well, and there are dozens of systems which (at least statistically) would provide "better" results. But we as individuals want to believe we understand things well enough. We want to believe that we are righteous, and just, and overall good people. And we very well may be, but that means exactly dick in the larger equation. Just as we have specialists in medicine, technology, and elsewhere, we need a justice system, a political system, and other institutions to mirror society in it's specializations -- judges who have IT training, or medicine, etc. Politicians who make decisions about, say, telecommunications who have worked in the industry. Because society has become too complicated for us to have just judges, or just lawyers, or outdated concepts like a "jury of our peers"... Who's only qualifications were that they registered to vote in your county.

      If you want change, start by choosing the right people for the job, because contrary to popular belief in this country, not just anyone can do these things.

      --
      #fuckbeta #iamslashdot #dicemustdie
    4. Re:Evidence-based medicine by PopeRatzo · · Score: 5, Insightful

      There is a perception by the general public that doctors should be like House, or Scrubs

      Almost. The perception is that doctors should be like doctors were before a medical license became a ticket to becoming a millionaire. There was really a time when a successful doctor might have the nicest house on the block, but not also a nice house in St. Lucia and a nice house in Aspen and a nice apartment on the Gulf Coast. So now doctors fear that if we have universal health care in the US, they might have to go back to being part of the community in which they serve. The people who are going into medicine these days are doing so because there were no more spots left at Northwestern's B-school. Forget for a moment that our insurance-driven system has turned medical practitioners from independent actors into assembly-line employees. The 30%-plus profit margins that are built into every medical cost are going less and less to pay for the doctor's new Mercedes (or for their mistresses' breast implants) and more and more to the pockets of companies that have nothing to do with medicine. I actually lived in a time when almost all hospitals were non-profit, but that was back in a rosier time in our history when we had a booming economy and a 90% top income tax bracket (go figure).

      We have learned that "free market" medicine does not guarantee a healthier populace, nor does it even guarantee the best health care system.

      Of course doctors hate science. They're afraid that it might show that the product they provide is overpriced and ineffective. Then we'll end up with socialized medicine, which as we are constantly told is only one step away from gulags and a Supreme Soviet.

      --
      You are welcome on my lawn.
    5. Re:Evidence-based medicine by Fluffeh · · Score: 5, Funny

      I'm 53 and my physician makes a regular practice of PSA tests for men my age, actually I started having them @ 50. Also just had my first colonoscopy recently and good thing as I had one tumor removed that was pre-cancer.

      This is rule of thumb, and Dr. Merenstein should have known this.

      Could we please refrain from talking about a colonoscopy and using the phrase "rule of thumb" in one post?

      --
      Moved to http://soylentnews.org/. You are invited to join us too!
    6. Re:Evidence-based medicine by MR.Mic · · Score: 5, Insightful

      No, anecdote implies that the information is second-hand, can not be verified, and is therefore unreliable.
      Actual scientific data is first-hand and verifiable.

    7. Re:Evidence-based medicine by pallmall1 · · Score: 5, Insightful

      The relevant question is not how common the test is.

      You're right about that not being the relevant question. The relevant question is:

      Why is this included in an ECONOMIC STIMULUS PLAN?

      --
      3 things about computers: they're alive, they're self-aware, and they hate your guts.
    8. Re:Evidence-based medicine by twostix · · Score: 5, Informative

      To throw in a real world data point to back your claim, my healthy, active and vibrant 82 year old grandfather went in to have an operation to deal with prostate cancer, his doctor suggested that as he was in such good shape if he got rid of the cancer he could live on for quite a while longer.

      He died suddenly in the hospital from internal bleeding caused by the surgery a few hours later. Now the cancer might have gotten him eventually, but how long, five years? ten? He was 82 and healthy and happy so it was kinda pointless operating really.

      He thought so too, but let himself be talked into it by his doctor.

      Worst thing was he was completely lucid, happy and rational minutes before he died, it was very sudden and unexpected.

    9. Re:Evidence-based medicine by evanbd · · Score: 5, Insightful

      There's another problem with anecdotal evidence -- selection bias. Some anecdotes are amenable to rigorous investigation and verification; when that happens they get called case studies instead. They're very useful, but they're not the same as broad-scale survey data, even when available in large numbers. The interesting cases turn into anecdotes, the boring ones get ignored, resulting in various forms of selection bias.

      Anecdotes can tell us that something is worthy of further study. In order to conclude (for example) that PSA tests are meaningful, we need a statistically sound sample including people who both did and didn't get PSA tests. Even when the anecdotes are well researched and verified, their plural is not data.

    10. Re:Evidence-based medicine by Anonymous Coward · · Score: 5, Funny

      A second hand is involved? I'm NEVER having a colonoscopy. D:

    11. Re:Evidence-based medicine by tburkhol · · Score: 5, Insightful

      I sure as hell am not going to go through 10 years of schooling and assloads of debt just to make a wage I could have made with 4 years of school.

      M.D.s get 4 years undergrad, 4 years med school, and a few years residency. They follow the standard of practice as they learned it with starting salaries around $100k/year.

      Ph.D.s get 4 years undergrad, 5-6 years grad school, and a few years postdoc. They advance the state of art, train the physicians, and the engineers, and everyone else, with starting salaries around $60k.

      Money is not the only motivator, and if you make it the major motivator, they you're not going to attract talented, well-educated people. You're going to attract people who are motivated by money.

    12. Re:Evidence-based medicine by justthisdude · · Score: 5, Funny

      I used an anecdote once, and it was like TOTALLY reliable. Besides, I read a study in O magazine that said that 4 out of 5 statistics are completely made up.

      --
      "I love his boyish charm, but I hate his childishness" - Leela
  3. While a bit alarmist... by blahplusplus · · Score: 5, Insightful

    ... as the title of this entry suggest. Not all doctors are created equal, and lets get this straight - all human beings, no matter how educated are very fallible and human.

    I had one young doctor think I should have my moles checked out that "looked cancerous" and another doctor whom I'm also freinds with that tells me "that doctor is full of shit". I also had my GP (general practitioner) suggest I had a part of my foot cut off after a series of infections after many an ingrown nail, needless to say I rejected his suggestion and did the work on the foot myself and still have everything all intact and normal as ever.

    Just because someone suggests something who is in a position of recognized credentialed authority, does not mean it is a license to take their judgments and advice without scrutiny and a grain of salt.

    Knowing how to do this and when is the hard part, but this is something that only people who've lived long enough and have the wherewithal to gain by experience - mankind is extremely fallible. Therefore critical skepticism must be employed when decisions can have significant consequences.

    It's easy for experts to suggest something to someone else when they don't have to bear the risk and consequences of going through with it.

  4. Re:Smart move by Chonnawonga · · Score: 5, Insightful

    Even worse is the advertising that gets shoved in the faces of the doctors! There was another study recently (I'd link to it, but I'm too lazy to go search for it) that found that doctors were making a lot of choices about which drugs to prescribe based on all the advertising and free samples they're regularly bombarded with. Then there was another study that found that drug companies were spending twice as much on marketing as on research. Sadly, family physicians just don't have a whole lot of extra time to be reading up fully on every drug that hits the market. Having a way to distil research and make it more accessible to doctors could go a long way to countering that.

  5. Re:Smart move by fuzzyfuzzyfungus · · Score: 5, Insightful

    In addition, the dreaded "rationing" of healthcare is already here, brought to you by the private sector. I work, I have insurance, I pay my premiums; but the insurance company, obviously, makes more money when they deny a claim than when they pay it. A system where procedures are paid or denied based on their expected benefit, as established by actual research, would be a considerable improvement.

    In reality, "choice" in medicine is already an illusion for virtually everybody. Unless you can absorb arbitrarily high out-of-pocket expenses, or have extraordinarily generous insurance coverage, your medical choices are already circumscribed by what you can afford, or convince your insurer to pay for. Better data would, hopefully, more closely align people's options with what is actually effective, and increase overall quality.

  6. Re:Smart move by wellingj · · Score: 5, Insightful

    I see where you are coming from, but I still can't agree that people should eat food and drive cars that they can't afford. I don't to see how health care should be any different.

    I think the whole problem there stems from how health insurance morphed to health care. If you want to go see a doctor every year, pay for it. If you get run over by a truck, that's what insurance is for. Insurance is for the unforseable, not the routine. The problem is the line that has to be drawn, and it becomes a pretty grey area, so it's ended up that the insurance company is expected to pay for everything, which of course drives up the cost.

    Wondered off on a tangent there... oops.

  7. Re:Smart move by causality · · Score: 5, Insightful

    I see where you are coming from, but I still can't agree that people should eat food and drive cars that they can't afford. I don't to see how health care should be any different. I think the whole problem there stems from how health insurance morphed to health care. If you want to go see a doctor every year, pay for it. If you get run over by a truck, that's what insurance is for. Insurance is for the unforseable, not the routine. The problem is the line that has to be drawn, and it becomes a pretty grey area, so it's ended up that the insurance company is expected to pay for everything, which of course drives up the cost. Wondered off on a tangent there... oops.

    Indeed. I can't remember where I heard this, but this is an explanation I've heard: if car insurance worked like health insurance, then every time you put gas in your tank or get an oil change or replace the tires you would file a new claim.

    --
    It is a miracle that curiosity survives formal education. - Einstein
  8. Re:Random quote by rthille · · Score: 5, Interesting

    The quote I like best is: "What do you call 'Alternative Medicine' that works?" "Medicine"

    --
    Awesome furniture, accessories and cabinetry in Santa Rosa, CA: http://humanity-home.com/
  9. The system favors compliance over logic by aswang · · Score: 5, Informative

    1. Private insurance will not pay for a woman's well visit if they don't have a Pap smear. They don't care that the woman doesn't have a cervix. If you don't do it, you don't get paid, and it's just easier to do it no matter how nonsensical it is than it is to get on the phone with someone who is not medically trained and argue that, yes, you did do a well woman exam even though you didn't do a Pap smear.

    2. There is a case to be made for anal Pap smears, because HSV also causes anorectal cancer in people who participate in anal sex. Unfortunately, because it's not standard of care, private insurance won't pay for that either. (We don't even need to talk about Medicare or Medicaid because they don't pay for preventative visits.)

  10. EBM vs. the Art by Stickerboy · · Score: 5, Insightful

    If practicing medicine consisted of a video game or a board test, then yes, doctors could suspend their own judgement in favor of strict evidence-based medicine. Unfortunately, this is the Real World, and doctors frequently have to approach EBM with a healthy dose of skepticism.

    The problem with EBM is threefold: the evidence record is necessarily incomplete; many real-world patients have very little in common to patients that make it through selection criteria into randomized clinical trials (RCTs); it is very easy to skew studies in minute ways through endpoints, study design, and a thousand other ways that are difficult for busy practicing physicians to catch.

    Want some examples? A recent multicenter study (in worldwide sites) of blood pressure medications funded by the maker of Lotrel found that their combination ACE inhibitor/calcium channel antagonist (CCA) had slightly better morbidity/mortality outcomes over a given period of time than patients who were placed on a combination of the ACE inhibitor and a thiazide diuretic, with similar reductions in blood pressure. The data is fantastic, and the outcomes are probably real. But when you check closely into the outcomes criteria, one of the "bad" endpoints is "hospitalization for unstable angina" (new or worsening chest pain). One of the indications that CCAs have that diuretics do not is the treatment of angina. CCAs, through the mechanisms of its action, can prevent anginal episodes or make them better. A thiazide diuretic will not treat angina directly. Out of the room of ~20 doctors this study was being presented to, apparently I was the only one who thought of this. And since many of the patients involved in the study had prior cardiac history with ostensible angina, it made perfect sense why CCAs would perform better for these patients. But this study is not being billed as that - the study is being presented as evidence of the possible superiority of using one drug over another in the general population with high blood pressure.

    And then there's the Nexium/Prilosec fiasco. Nexium was developed by the makers of Prilosec when patent protection for Prilosec began running out. (You can buy generic Prilosec (omeprazole) over the counter.) Nexium (ESomeprazole [emphasis mine]) is filtered Prilosec - the biologically active enantiomer of Prilosec's racemic mixture. Nexium is on average six times more expensive, mg for mg, than generic omeprazole. The only study I know of (and that is certainly being quoted in wide circulation) comparing the effectiveness of the two was funded by the makers of Prilosec and Nexium, comparing healing rates of acid-reflux esophagitis with "typical" doses of Prilosec and Nexium. Nexium outperformed Prilosec in healing the worst grades of esophagitis - grades C and D. The "typical" doses used were 20 mg of Prilosec and 40 mg of Nexium. As this is the evidence out there, many doctors consider Nexium to be a "stronger" or "better" acid suppressor than Prilosec. I'll let the reader make the logical conclusions.

    And let's talk about "typical" patients and the dearth of them in the evidence record. On an inpatient service today, I saw a "typical" patient hospitalized for a hypertensive emergency. He was a type 2 diabetic (DM)(uncontrolled) who came in with a blood pressure of 180s/120s. He has diastolic congestive heart failure (CHF) from his long-term uncontrolled hypertension (HTN). He also has chronic kidney disease probably due to a combination of his smoking, his DM, and his HTN. He also has an exacerbation of his bad chronic obstructive pulmonary disease (COPD) from his smoking. Now the evidence suggests that I place him on a beta-blocker to treat his HTN and his CHF concurrently. But beta-blockers are relatively contraindicated in acute exacerbations of COPD. The evidence suggests that I place him on an ACE inhibitor to treat his DM and HTN, but that would decrease his kidney function, and he's already at the tipping point of needing dialysis so

    --
    Light a fire for a man and he'll be warm for a day. Light a man on fire and he'll be warm for the rest of his life.
    1. Re:EBM vs. the Art by Stickerboy · · Score: 5, Insightful

      >>"Real world patients do not step out of a cookie-cutter, and cookie-cutter medicine (which is what EBM zealots really are promoting) does not always equal best practices."

      >This is where you are wrong. Patients are rarely unique in any meaningful way, most get better on their own.

      Who the hell are you? I see patients on a daily basis. Most of them have underlying illnesses (or non-illnesses) that are similar to other patients. But most of them also have their own idiosyncrasies that contribute to their direction of care and treatment. They are certainly unique to the point where I have to think about what treatments the patient will derive the most benefit from. And many of the patients I see, rather than "get better on their own", are already far down the path in the other direction, the one that leads to an early exit from this life. It is my job to head them back in the right direction (assuming the patient wants to turn their health around).

      >For instance, if you come in with back pain after twisting and lifting an object, the doctor should rule out any obvious problems then send you home (maybe with a scrip for a painkiller). They shouldn't send you for an Xray because there might be something.

      I'm confused. You think doctors should rule out "obvious" problems, and yet checking an X-ray or other imaging for "obvious" back problems is out of bounds, even if their story and/or symptoms might suggest a more serious problem than muscle strain? You seem to be under the impression that 100% of patients that come in with acute low back pain "after twisting and lifting an object" have a non-serious complaint. There are plenty of serious problems to consider that could stem from a twisting and lifting injury, starting with serious lumbar disk disease.

      >If your pain does not resolve after a period of time, THEN you order an Xray.

      Even if your clinical suspicion is high that there is an underlying problem? Even if the physical exam is troubling? You're a genius! If only ERs handled chest pain complaints like you want back pain to be handled. I could certainly prove that most people with chest pain in the ER have a non-serious complaint. We could send them all home with conservative treatment, and THEN admit them if their pain doesn't resolve! Think about the cost savings! Especially from those that die without getting expensive heart caths and bypass surgery!

      >If that doesn't show anything, THEN they refer to a specialist.

      Fantastic! I would think that if the imaging indicated a diagnosis that could likely benefit from a specialist treating the problem, THEN I would send them to a specialist! But what the hell do I know? Let's send all the people with no evidence of structural back disease to the specialists for... what? Re-imaging?

      >And even if it does show a significant finding, it might be irrelevant (most people over 40 have abnormal backs).

      What curious thinking. So someone that has an abnormal health state shouldn't receive treatment, if there are sufficiently enough people in their age group that have the same problem? Interesting. By the same token, should we stop treating heart disease in everyone over 60, because older people will invariably have some degree of heart disease? I am certainly glad you won't be directing my medical care as I age.

      --
      Light a fire for a man and he'll be warm for a day. Light a man on fire and he'll be warm for the rest of his life.
  11. Re:Smart move by Estanislao+Mart�nez · · Score: 5, Insightful

    I think the whole problem there stems from how health insurance morphed to health care. If you want to go see a doctor every year, pay for it. If you get run over by a truck, that's what insurance is for. Insurance is for the unforseable, not the routine. The problem is the line that has to be drawn, and it becomes a pretty grey area, so it's ended up that the insurance company is expected to pay for everything, which of course drives up the cost.

    The problem with what you're saying is that the sort of routine care you say insurance shouldn't cover actually doesn't cost much to provide. Health care expenditures are really one of those 80/20 phenomena: the vast majority of the cost is spent on the health care of a small number of people.

    By making people pay for it out of pocket, all you do is disincentivize routine care (which is cheap to provide). You don't put a dent on the major sources of health costs, and what's worse, you prevent people from getting treated early on, while it's still relatively cheap to do so.

  12. Re:Smart move by FrankieBaby1986 · · Score: 5, Interesting

    I thought insurance companies helped pay for regular checkups and the like because it helped prevent worse illnesses that would potentially be much more costly?

    --
    ERROR: SIG NOT FOUND (A)bort, (R)etry, (F)ail?:
  13. Re:Smart move by ahabswhale · · Score: 5, Interesting

    Sorry but you are massively uninformed. There are different kinds of health insurance just like there's different kinds of auto and disability insurance. What you are talking about is a "major medical" policy that only kicks in when your costs exceed ~$2k. This is the exact kind of policy I have. Why do I have this kind of policy? Because to get a policy that starts at $0 would cost me over a $1k a month. So, these policies already exist and they are already VERY common. The fact that you and the parent poster don't know about them is utterly fucking shocking to me. Even with major medical, I still have to pay over $200 a month for health insurance just for myself (non-smoker, non-obese).

    The bottom line is that the cost of health care has skyrocketed compared to average income. It becomes less and less affordable and is becoming a greater and greater burden on the economy. In fact, the idiots that perpetuate the system we have today are driving us into socialized medicine (their worst fear) just because there will be no other way to deal with the costs. Frankly, I can't wait just so I can laugh my fucking ass off. Most doctors fucking suck anyway. Like everything else, 90% of them are worthless. Too bad you don't have time to shop around while you're in the middle of a heart attack.

    "After all, if the government was or is so efficient at providing health care then why not have them provide other things too like cars, vacations, computers, designer clothing, and everything else that people want."

    You must be fucking kidding me. It would be impossible for even the government to be less efficient than what we have today. Socialized systems in other western countries are far more efficient. We spend TWICE what England and Canada do per capita on health care.

    Seriously, you need to actually READ about this stuff before you spout your mouth off. You have no idea what you're talking about.

    --
    Are agnostics skeptical of unicorns too?