Slashdot Mirror


Addicting Mice To Light

Al writes "In an attempt to better understand how the reward system in the brain functions in people suffering from addiction, scientists at Stanford have created mice that are addicted to light. They engineered light-sensitive proteins to trigger signaling pathways in the nucleus accumbens, a part of the brain that responds to pleasurable stimuli. They then connected a fiber-optic cable to this part of the brain and delivered a blast of light whenever the mice wandered into a 'reward chamber.' In previous experiments the mice have been given drugs like cocaine or amphetamine when they enter these rooms. The light treatment works in exactly the same way but lets the researchers very precisely control timing and dose of reward administered to the brain. The approach could also provide a way to probe receptors that cannot be accessed using existing drugs."

19 of 92 comments (clear)

  1. The cure for Slashdot! by GigaHurtsMyRobot · · Score: 2, Funny

    This would get thousands of people out of their basements this summer, and some of them might even get laid!

    1. Re:The cure for Slashdot! by Stile+65 · · Score: 4, Funny

      The trick is to get women addicted to nerds.

      --
      I claim first use of "Error No. 0B" - or "No. 0B error." It'll be the new ID 10T!
    2. Re:The cure for Slashdot! by geekoid · · Score: 5, Funny

      There is a drug for that. It's called "Cash".

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    3. Re:The cure for Slashdot! by Atrox666 · · Score: 2, Funny

      Why buy? It's cheaper to rent.

  2. Morning people by geekgirlandrea · · Score: 2, Funny

    Do they bounce out of bed at the crack of dawn and show up in the office all bright and sunny with plenty of time to spare for some horrid 9 AM meeting or something? Oh, wait, that's light-addicted humans.

    1. Re:Morning people by EdZ · · Score: 2, Funny

      bounce out of bed at the crack of dawn and show up in the office all bright and sunny with plenty of time to spare for some horrid 9 AM meeting

      Ah, you're thinking of sadomasochists.

    2. Re:Morning people by geekgirlandrea · · Score: 3, Informative

      Heh. I doubt it. In my experience, BDSM events tend to be just getting started by midnight.

  3. Nucleus Accumbens by MindlessAutomata · · Score: 4, Interesting

    It should be noted that the nucleus accumbens is also involved in -expectation of reward- and not necessarily reward itself. This is a major part of addiction--the addict may be desensitized to the effects of the drug but nonetheless may seek out the drug due to EXPECTATION of "reward" and to keep away withdrawal symptoms.

    The mice associating the rooms with the effects of the drug is directly applicable to humans. Anyone who has tried to quit smoking may have had a difficult time during smoke break time because the context cues one to expect/desire their fix. Good way to kick the habit, if you're looking to do so, is not to hang out in the same spots you did your drug, not to hang out with the same people, so on and so forth. Otherwise, you'll likely fall back into your own habits.

    1. Re:Nucleus Accumbens by ZeroExistenZ · · Score: 4, Interesting

      The thing with such things is, that it is adjusted and you cannot "avoid" situations; it requires to create new associations by overriding them by entering those situations and acting differently in them, otherwise you're just avoiding and running from it.

      I've quit smoking too, after 8 years of smoking, and realized how the associations trigger the way you explained and made sure once I got comfortable with my new "identity" to face these situations and create new associations until I could transpose myself into that situation without imagening a cigarette with it. Never had the urge to smoke again.. It did some recallibration of my life, but by making some acts contious and realizing I could "override" certain less desired quirks or habits, I felt liberated to be freed from routine in that way and maximize my personal experiencing (you are missing out alot of detail when you're doing something routinely, if you change your routine, do things which are extraordinary to you, or by breaking what you are used to, more sticks and there is a much broader spectrum to hook associative information to instead of overloading and saturating a limited amount of recurrent happenings/items/impressions/... making them harder to access in your mine, plus you're contiously aware of much more in the same way you rely on routine and discard alot of information as "recurrent", when it's not outside of your limited perception.).
      Concerning my "new identity": my uncontious still struggled to adjust: I would smoke in my dreams because it was the way I had perceived myself like that for years. But the changed reality would collide and would wake me up in my dream, resulting in a lucid dream because my contious mind started wondering why there was a sigarette, trying to figure out wherever I did smoke or not).

      --
      I think we can keep recursing like this until someone returns 1
    2. Re:Nucleus Accumbens by HTH+NE1 · · Score: 3, Informative

      Just trying to help: there's no "t" in either "conscious" or "unconscious". There's also one's "conscience" which seems to want to be wrong for not being pronounced con-science. They are difficult words, easily leading to confusion. Then there's "conscientious" which does have a "t". "Consensual" is another troubling word in the group, especially with the root "consent" having its "t" change to an "s" and feeling wrong for being more like "sense" than "sent".

      I look upon all those words with suspicion when I write them, and if I didn't have Firefox's built-in spell checker I'd be consulting online dictionaries every time, so don't feel bad or upset. (It can also take me as many as four tries to spell "thorough" correctly.)

      You made other mistakes, but these are the ones you (and really everyone) should watch out for. The others are more like typos.

      --
      Oh, say does that Star-Spangled Banner entwine / The myrtle of Venus with Bacchus's vine?
  4. Now for the sharks by interkin3tic · · Score: 2, Funny

    Next step: do this with sharks
    Step after next: reverse it, such that every time a shark does a line of coke, it shoots a laser out of it's brain.

  5. All I can say by phantomfive · · Score: 4, Funny

    All I can say is the poor mice. Considering all the things the mice go through for us, all the research they help us accomplish, I think we really owe them an answer. Or a question, as the case may be.

    --
    Qxe4
  6. Re:Morning people... It COULD be worse...hehe by davidsyes · · Score: 2, Funny

    We COULD addice lice to might! We'd be in a MITEY mighty bite of trouble... itchin' for trouble and cruisin' for a bruisin'...

    --
    Previously: "Linux... Toward the Sunrise..." Now: "Linux... Toward the-- No, now, part of Every Sunrise"
  7. OT by MasterOfDisaster · · Score: 3, Funny

    I guess if Fiber-to-the-Home isn't fast enough, you've got to try Fiber-to-the-Brain.

    Stream porn straight to your visual cortex. Backup your memories with Google Hippocampus Beta. I guess mobility might be a bit of a problem, though. I wonder if it comes with one of those cool head jars?

    --
    The opinions in this post are ficticious. Any similarity to actual opinions, real or imagined, is purely coincidental.
    1. Re:OT by senorpoco · · Score: 2, Funny

      If he were selling electrons would they be from COULOMBia

  8. Lit rooms by Translation+Error · · Score: 3, Funny

    It is bright. You are likely to be attacked by a mouse.

    --
    When someone says, "Any fool can see ..." they're usually exactly right.
  9. So They've Made... by camperdave · · Score: 4, Funny

    So, what you're saying is that scientists have developed optical mice?

    --
    When our name is on the back of your car, we're behind you all the way!
  10. Re:Overengineered? by anagama · · Score: 2, Funny

    Not by themselves, at least for plants like Zhaan who'd enjoy a good photogasm from time to time.

    --
    What changed under Obama? Nothing Good
  11. Re:why light? by fractoid · · Score: 5, Funny

    Nah, I'm pretty sure that'd make it MORE funny.

    I can just see it now. Slashdot user 'clem' is reading a particularly unfunny comment. As a sneer of disdain crosses his face, something moves in the gloom behind him, dimly lit by monitor glow. With a sudden lurch, interkin3tic crosses the distance to clem's chair. Clem barely has time to look up in horror before internik3tic shouts "RAT PR0N FTW!" and punches him in the face.

    --
    Rampant carbon sequestration destroyed the Dinosaurs' tropical paradise. I'm here to help repair the damage.