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Designing DNA Circuits To Brew Tastier Beer

Al writes "Researchers at Boston University have developed a way to predict the behavior of different DNA segments and make synthetic biology a little bit more reliable. James Collins and colleagues have built libraries of component parts and a mathematical modeling system to help them predict the behavior of parts of a gene network. Like any self-respected bunch of grad students, they decided to demonstrate the approach by making beer. They engineered gene promoters to control when flocculation occurs in brewers yeast, which allowed them to finely control the flavor of the resulting beer."

15 of 135 comments (clear)

  1. Dear God! by fuzzyfuzzyfungus · · Score: 4, Funny

    Somebody must stop them... Before they produce the beverage man was not meant to brew!

    1. Re:Dear God! by Gat0r30y · · Score: 4, Funny

      Before they produce the beverage man was not meant to brew!

      Key light?

      --
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    2. Re:Dear God! by fuzzyfuzzyfungus · · Score: 5, Funny

      These are synthetic biologists, not Nephrologists...

  2. True application of science by mc1138 · · Score: 4, Insightful

    All other science to this point has solely been done as groundwork for better tasting beer.

    1. Re:True application of science by Red+Flayer · · Score: 4, Funny

      All other science to this point has solely been done as groundwork for better tasting beer.

      Yes, but only so far as better-tasting beer can help scientists get laid.

      THAT, my friend, is the true purpose of science.

      --
      "Trolls they were, but filled with the evil will of their master: a fell race..." -- J.R.R. Tolkien on Olog-hai
    2. Re:True application of science by Loadmaster · · Score: 5, Funny

      Just like when all nuclear physics came to a head when Young Albert Einstein, then a lanky youth on the island of Tazmania, split the atom finally putting bubbles in beer. So much work for such a great deed.

  3. Re:Purity by QRDeNameland · · Score: 4, Insightful

    Being that the Reinheitsgebot doesn't even mention yeast (as its existence and role in fermentation were unknown in 1516), I'd have to say "yes".

    --
    Momentarily, the need for the construction of new light will no longer exist.
  4. Backwards by Anonymous Coward · · Score: 5, Funny

    Damn fool BU geeks.
    You don't use genes to manipulate beer, you use beer to manipulate jeans.

    Kids these days....

  5. Which brings us full circle by Ungrounded+Lightning · · Score: 4, Insightful

    All other science to this point has solely been done as groundwork for better tasting beer.

    Which brings us full circle, since the development of agriculture (which led to the sedentary lifestyle, food surplus, and a leisure class with the time and resources to "do science") is believed (by some anthropologists) to have been primarily motivated by a desire to raise more grain for feeding to yeast in order to make beer (and, incidentally, bread).

    --
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  6. What's the point of applied science? by mcrbids · · Score: 4, Insightful

    Applied Science AKA "Engineering" exists to make life better. Air conditioning, blogging, better tasting beer. If not to make life just that little bit better, than for what?

    Sure, there are starving people in XYZ country, but they are starving precisely because they are NOT using engineering to make their lives better! Sure, you could donate the cost of that better-tasting beer and feed the starving kid for a few days... but then what?

    Feel free to donate to 3rd world countries (I do) but when you do, don't just throw money/food at them, donate your money towards programs that will improve their infrastructure. Things like education. (I personally sponsor to help aschool for kids in rural Haiti)

    And don't hesitate to enjoy that good-tasting franken-beer!

    --
    I have no problem with your religion until you decide it's reason to deprive others of the truth.
  7. Could be great news for those of us who homebrew by fragMasterFlash · · Score: 4, Informative

    This would be a neat trick if it allowed brewing with yeasts that produced an English flavor profile yet had the high flocculation rates associated with American ale yeasts (Wyeast 1232 is the best compromise currently produced commercially, IMHO).

  8. They could make a fortune... by Greg_D · · Score: 4, Interesting

    ... selling this technology to the cigar or wine industries.

    Because of terroir, different regions are going to have different climates and different soil content to produce different tasting or different quality products.

    But imagine being able to grow a grape in Sonoma or some cigar tobacco in Honduras and have them taste just as if they had come from France or Cuba respectively by genetically engineering a strain. Sure, some would want and have the option to keep their wines and cigars just the way they currently are. But for those who desire a taste that is currently well outside of their price range or (in the case of Cuban cigars) illegal due to embargo, this would be a boon.

    There is, for example, a stark difference between Cuban tobacco from before and after 1996. Why? They changed from using corojo tobacco to a corojo/cigarette tobacco hybrid that would withstand mold. The flavor and richness are not the same anymore. But perhaps with some genetic tweaking, they can create a strain which is resistant to the mold AND shares the same flavor characteristics as the old corojo leaf.

    So even at the top of the ladder, there is room for improvement.

    Also, I'd like to volunteer my services to test their beer.

  9. How the liquor biz really works by Animats · · Score: 5, Interesting

    The hype: Skyy Vodka

    The reality: Skyy Vodka is a marketing company. Manufacturing is outsourced. They buy bulk ethanol from a MGP Ingredients (formerly Midwest Solvents Company) plant in Pekin, IL. MGP makes ethanol for beverage and industrial purposes. They used to sell ethanol for fuel, too, but that ended in February 2009 due to financial losses; their production costs were too high for fuel use.

    The ethanol is pumped into tank cars and shipped by rail to Frank-Lin Distillers Products in San Jose, CA., which has their own railroad sidings. Frank-Lin bottles, along with Skyy Vodka, most of the low-end booze on the West Coast. They make everything from brandy to whiskey, by mixing ethanol, water, and flavoring. They make over a thousand different "brands", although they only have about a hundred different recipes.

    Frank-Lin is very automated. They have automated bottling lines that can change from one bottle and product to another without human intervention, and equally flexible packaging systems. So they can create the illusion of thousands of products, all coming from one plant.

    It's all just flavored ethanol. Deal with it.

    1. Re:How the liquor biz really works by Zalbik · · Score: 4, Insightful

      And this has to do with beer production exactly how?

      Sure the big beer producers do something very similar...fast fermenting yeast to produce ethanol, add flavor and coloring to make it taste like bubbly yellow piss.

      However, there are many many microbreweries across the US and Canada that still brew beer basically the old fashioned way. It's just unfortunate that the typical North American still prefers the crap the big breweries produce.

  10. Re:Purity by Nidi62 · · Score: 4, Informative

    The Reinheitsgebot was actually amended to allow yeast as an ingredient once it was understood the central role yeast plays in brewing.(According to a Bavarian brewer on a History channel special on beer, as well as this website:http://oldemeckbrew.com/Beer/reinheitsgebot.php)

    --
    The only thing necessary for evil to triumph is for it to be pitted against a slightly greater evil