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13,000 Volunteer To Put Personal Genomes Online

Lucas123 writes "The Personal Genome Project, which opened itself up to the public on April 25, has to date signed up 13,000 of the target 100,000 volunteers needed to create the world's first publicly accessible genome database. Volunteers will go through a battery of written tests and then offer DNA samples from which their genetic code will be derived and then published to help scientists discover links between genes and hereditary traits. While the Personal Genome Project won't publish names, just about everything else will be made public, including photos and complete medical histories. Scientists hope to some day have millions of genomes in the database."

84 of 126 comments (clear)

  1. I once put my genome online by BadAnalogyGuy · · Score: 4, Funny

    I was surfing The Hun and accidentally put some of my genome on my keyboard.

    Thank goodness for Purell and Kleenex.

    1. Re:I once put my genome online by rcamans · · Score: 2, Funny

      You know, we all thank you for your selfless efforts to personally finance the Purell and Kleenex industries. We applaud your heroic efforts, and call upon you to greater heights of achievement.

      --
      wake up and hold your nose
  2. Genome? by Norsefire · · Score: 4, Funny

    Is there a similar project for KayDE?

    1. Re:Genome? by Shikaku · · Score: 1

      You will never meet someone who has XfcY.

    2. Re:Genome? by Shikaku · · Score: 1

      Aw crap I failed, wrong chromosome. I'll take my hat and leave....

  3. bit late by LiquidCoooled · · Score: 5, Funny

    its a bit late,

    google images already says there are 286,000 pictures of gnomes already online.

    http://images.google.co.uk/images?q=garden%20gnome Results 1 - 20 of about 286,000

    --
    liqbase :: faster than paper
    1. Re:bit late by castorvx · · Score: 4, Funny

      ... Results 1 - 20 of about 286,000

      I decided to verify your research.

      Results 1 - 20 of about 298,000

      OH MY GOD THEY'RE MULTIPL-*CONNECTION LOST*

    2. Re:bit late by STFS · · Score: 2, Funny

      I decided to verify your research.

      Results 1 - 20 of about 298,000

      OH MY GOD THEY'RE MULTIPL-*CONNECTION LOST*

      I decided to verify as well and concur with your findings. 298,000 images of gnomes.

      I also found that turning off the "safe search" feature resulted in a total of 305,000 images being found.

      Can someone please tell me how I can get only those 7,000 additional images?!

      --
      You don't think enough... therefore you better not be!
    3. Re:bit late by Yadyn · · Score: 1

      Actually yes, you can use UnSafe Search. It works by performing two Google searches (one with SafeSearch on and one without) and then does the equivalent of an Oracle MINUS operation.

  4. Data Control by macbeth66 · · Score: 5, Insightful

    Just who is going to control these kinds of databases and prevent the misuse of the data? Once a condition or a hereditary pre-disposition is determined, a subject could be denied medical coverage for that condition. It may well be anonymous today, but that can not be guaranteed into the future.

    1. Re:Data Control by ilblissli · · Score: 1, Interesting

      who says you have to give them your real name? i personally just signed up to be involved in this project. i'll update my comments once i see what they require from you. if they want your full name and SS# yeah i'd probably assume it could be misused but if they just want a health history to go with your dna i don't see the harm in that.

    2. Re:Data Control by spydabyte · · Score: 3, Interesting

      Ever watch GATTACA? Think about what they coined "discrimination down to a science". Databases do not need your name to figure out majorities. If insurance companies linked a mole on the left cheekbone to a higher probability of cancer... well, maybe you'd just get the mole removed.

      Nevertheless, I'm all for the advancement of science and am interested in contributing to the project. Who knows, maybe if all the pessimists advance the project, it'll be done properly.

    3. Re:Data Control by macbeth66 · · Score: 5, Interesting

      Good point. However, if they are not asking you for information that can be used to link directly back to you, then the database is waste of time. What will stop the mis-creants from stuffing junk into the data points? What will prevent someone with a low priority condition, to submit as multiple people in an attempt to up the priority of their condition.

    4. Re:Data Control by fuzzyfuzzyfungus · · Score: 4, Insightful

      Luckily, nobody else out there would have access to your medical history and a strong financial interest in knowing what your genome contains. Definitely not an insurance company or anything. And identifying somebody with date of birth, blood type, family history, several facial photos, and a bunch of other information is certainly beyond the powers of science...

      Definitely not a problem.

    5. Re:Data Control by RDW · · Score: 5, Informative

      'It may well be anonymous today, but that can not be guaranteed into the future.'

      It's not that anonymous even today:

      'While volunteers won't have their names published with their genomic information, Church said the subjects are completely aware that anyone familiar with them can deduct from the photos and background information who they are.'

      Some early volunteers in the pilot program have gone even further than this, and explicitly linked their names to the public data.

    6. Re:Data Control by Anonymous Coward · · Score: 2, Insightful

      Just who is going to control these kinds of databases and prevent the misuse of the data?

      Isn't that the exact opposite of the point?

      That is, isn't the objective of this project to gather data from people who have given their informed consent to 'open-sourcing' their medical data, in order to free researchers from the burdens imposed by working with non-open-source data?

      Once a condition or a hereditary pre-disposition is determined, a subject could be denied medical coverage for that condition. It may well be anonymous today, but that can not be guaranteed into the future.

      This project isn't anonymous now, and doesn't claim to be! That's the point - genetic data with medical histories and photographs alongside.

      If, in the future, medical insurers decide to discriminate based on genetic tests, they won't just do it for the 13,000 people in this database; they'll require testing for every person applying for insurance. And if that happens, we can legislate against it - if we as a society want to.

    7. Re:Data Control by timeOday · · Score: 4, Insightful

      Like it or not, keeping your DNA private is just about as difficult as keeping your face private. All it takes is a hair follicle or skin cell, and you leave a trail of those everywhere you go. I'm not saying it's a good thing, but there it is.

    8. Re:Data Control by newcastlejon · · Score: 1

      I'd say "Hello, Waff", but he'd be more discrete out among the Powindah.

      --
      If God forks the Universe every time you roll a die, he'd better have a damned good memory.
    9. Re:Data Control by Autumnmist · · Score: 4, Informative

      That's why the US has GINA (Genetic Information Nondiscrimination Act (GINA) of 2008).

      Whether it'll actually work is a separate issue. One of the points of this project is that trying to keep your genetic information private is a losing battle and that it might be better/neutral to just be open about it.

      --
      --- "Many of the truths we cling to depend greatly on our own point of view." ~ Ben Kenobi, 'Return of the Jedi'
    10. Re:Data Control by gnick · · Score: 2, Insightful

      What will prevent someone with a low priority condition, to submit as multiple people in an attempt to up the priority of their condition.

      If there are only 10s of thousands of samples, it shouldn't be too tough to notice if there just happen to be a dozen people with identical genomes. That said, the techniques here are young enough that identifying sequences for anything we can seems worth-while - From heart disease to freckles. So what if a rare, 'low-priority' condition gets identified?

      --
      He's getting rather old, but he's a good mouse.
    11. Re:Data Control by astrashe · · Score: 2, Interesting

      Do they have something on the web site about this?

      My reaction when I read the story was (a) Wow, I really want to do this, and (b) what if I'm denied coverage at some point down the road because of it?

      As soon as I'm really confident that I won't get burned, I'm in.

    12. Re:Data Control by oneirophrenos · · Score: 1

      Once a condition or a hereditary pre-disposition is determined, a subject could be denied medical coverage for that condition.

      I can't believe this could even be an issue. Why don't your lawmakers make it illegal for those responsible for financing medical care to discriminate against people with illnesses?

    13. Re:Data Control by fuzzyfuzzyfungus · · Score: 2, Insightful

      To their credit, the participation page is reasonably forthright about what will be disclosed, and I'm sure that if you dig a few links deeper, you'll find more. If you really want the gory details, I'm sure that the IRB has a thick pile of documents somewhere.

      Nothing they say, though, suggests any comfort with respect to denied coverage. They can't protect you and it isn't their problem. I'm predicting that the volunteer rolls will be heavy on a) wealthy futurists/futurist-wannabes, b)young techy futurist types who still feel immortal, and c) European socialist communists who don't have to worry about it.

    14. Re:Data Control by daem0n1x · · Score: 4, Insightful

      Why don't you just scrap insurance companies and just create a public, universal health care service like the rest of the developed world? That way, they can't deny treatment.

    15. Re:Data Control by Ephemeriis · · Score: 3, Interesting

      what if I'm denied coverage at some point down the road because of it?

      It's only a matter of time.

      Modern insurance policies can deny you coverage due to a pre-existing condition. It won't be long before we're able to identify all kinds of disorders and diseases with a simple genetic screening. Then we just call having a 90% chance to develop cancer a pre-existing condition, and you're screwed.

      It is going to happen.

      --
      "Work is the curse of the drinking classes." -Oscar Wilde
    16. Re:Data Control by omris · · Score: 1

      Besides, insurance companies have become experts at denying coverage. They are: 1. legally obligated not to discriminate based on genetic information, and 2. totally unhindered by that fact. Why would they bother to start trying to use genetics when they can pay a few doctors to write letters explaining why your requested procedure isn't medically necessary? It seems to work pretty well for them.

    17. Re:Data Control by NearlyHeadless · · Score: 1

      It won't be long before we're able to identify all kinds of disorders and diseases with a simple genetic screening. Then we just call having a 90% chance to develop cancer a pre-existing condition, and you're screwed.

      There is a law against that that just went into effect.

      Also, people don't actually have that many lethal genes. There's the whole natural selection thing going on.

    18. Re:Data Control by Hal_Porter · · Score: 1

      Hmm, good point. But you accept that the genetically unclean must be prevented from occupying sensitive posts for the greater good of the race, right?

      --
      echo -e 'global _start\n _start:\n mov eax, 2\n int 80h\n jmp _start' > a.asm; nasm a.asm -f elf; ld a.o -o a;
    19. Re:Data Control by fuzzyfuzzyfungus · · Score: 2, Interesting

      "The law does not cover life insurance, disability insurance and long-term care insurance." And, if that is the website one liner, I'm guessing that there might be a few other little areas of wiggle room. You can generally find a reason.

      As for lethal genes, people don't have many that kick in before/during reproductive maturity. You then have another 30-45 years that you might like to live; but for which selective pressures have historically been a good deal weaker.

    20. Re:Data Control by rcamans · · Score: 1

      Don't worry. Slashdotters do not have to worry, as video game addiction, pron addiction, and living in yo momma's basement are not genetic defects. Are they? Oh,Ohhh

      --
      wake up and hold your nose
    21. Re:Data Control by rcamans · · Score: 1

      Hey, if slashdotters contributed, maybe they could find cures to these diseases. Oh, wait, there's that aversion to sunlight. I think I first heard of it in the H.G. Wells movie "Time Machine".

      --
      wake up and hold your nose
    22. Re:Data Control by rcamans · · Score: 1

      Recently a woman was denied an insurance payout on her husband's death (he was gunned down) because he had a pre-existing medical condition which had nothing to do with the shooting death.
      Insurance companies are in the business of screwing you.

      --
      wake up and hold your nose
    23. Re:Data Control by StikyPad · · Score: 1

      I don't think they'd pull the "chance of getting cancer card," nor would they need to with all the real genetic disorders out there. In fact, I'd wager heavily that *everyone* has a genetic disorder of some kind, even the disorder itself hasn't been identified yet. Put another way, nobody's perfect.

    24. Re:Data Control by geekdom04 · · Score: 1

      At least I'm not dropping my follicles all over the internet where anyone within a worldwide radius can get to it.

    25. Re:Data Control by Kadin2048 · · Score: 1

      I can't believe this could even be an issue. Why don't your lawmakers make it illegal for those responsible for financing medical care to discriminate against people with illnesses?

      Because at any given time, most voters either are, or think that they are, healthy; thus they're pretty receptive to arguments that eliminating pre-existing condition restrictions would raise their own costs. Basically, nobody who's healthy wants to pay for anybody else's healthcare.

      Of course, when those people get sick it's a different story. But as long as there are more people who think they're healthy than people who are sick, the 'healthy' people discriminate against the 'sick' ones.

      As the population ages, however, more people have moved from 'healthy' to 'sick' (or at least from seeing health insurance as a cost center to be minimized, to a profit center that they benefit from), and there's beginning to be a corresponding shift in attitudes with regards to insurance. Exactly how far this shift in attitudes will go and what the actual political effect of it will be, remains to be seen. I am personally quite doubtful that it will amount to much of anything beyond a tweaking of the system already in existence, but I'm admittedly hugely cynical about the political process in the U.S.

      --
      "Ladies and gentlemen, my killbot features Lotus Notes and a machine gun. It is the finest available."
    26. Re:Data Control by afaik_ianal · · Score: 1

      You can just claim it's your identical twin!

    27. Re:Data Control by Jon+Abbott · · Score: 1

      Tell that to this guy.

    28. Re:Data Control by zippthorne · · Score: 1

      You're not screwed. You just have to place the bet earlier. For instance, your parents could take out "pre-existing condition" insurance when the pregnancy is first determined, but before it's safe or practical to do a test for such conditions.

      Insurance is gambling. If information is available it will be used. You can't make things fairer by forcing one party to ignore information that all parties have access to.

      --
      Can you be Even More Awesome?!
    29. Re:Data Control by Ephemeriis · · Score: 1

      Insurance is gambling. If information is available it will be used. You can't make things fairer by forcing one party to ignore information that all parties have access to.

      That is very true.

      And, I think, that's the root of the problem most people have with the insurance companies... It is a gamble, and they're in the business to make money. It is in their best interest to deny coverage to folks wit pre-existing conditions, and to deny as many claims as they can.

      But when it comes to something as important as your health or your house, people don't want it to be treated as a game. Folks don't want to feel like they're just a mark.

      --
      "Work is the curse of the drinking classes." -Oscar Wilde
    30. Re:Data Control by kieran · · Score: 1

      Speaking as a volunteer (although I live in the UK so won't be included in the current phase), I expect my data to be (somewhat) misused. I just think the good this project will acheive is well worth the sacrifice.

      By the by, the process of "consenting" to be a member of this project involves getting a 100% pass mark on a pretty involved exam about DNA, the project and the risks involved. Apparently this is because they "take informed consent very seriously".

    31. Re:Data Control by zippthorne · · Score: 1

      Indeed. Yet, failing to think of it as a game, they end up being manipulated by people who play by different, hidden rules. For instance, folding the health care industry, fully an eighth of the us economy, into the auspices of the federal government.

      --
      Can you be Even More Awesome?!
    32. Re:Data Control by spydabyte · · Score: 1

      Sure, but we're not in Utopia. The world is run through a capitalist society. Universal Health Care won't work. It's a great goal, but like world peace: not going to happen.

    33. Re:Data Control by daem0n1x · · Score: 1

      Well, it's been happening for many decades in all the developed countries except for the USA.

      Turn off Fox News and come see the world.

  5. I for one! by Sigg3.net · · Score: 2, Funny

    Am I the only one who read: 13,000 Volunteer To Put Personal Gnomes Online ??

    Imagine an army of garden gnomes.. Well, I for one! Oh, forget it.

    1. Re:I for one! by ashtophoenix · · Score: 2, Funny

      I knew this would happen from the start of this Personal Gnome Thing.

      --
      Life is about being a Phoenix!
  6. Open Source People! by erroneus · · Score: 1

    It's quite the logical extension of the project after all! Finally we can have a REAL gnome interface!

    1. Re:Open Source People! by sakdoctor · · Score: 1

      Given enough genomes, all people are shallow.

  7. Anonymous Shnonymous by dmomo · · Score: 2, Interesting

    Putting your genetic composition online is pretty much uhm... identifying yourself.

    Given a name and an entire frickin gene sequence... I'd more quickly rely on the latter for identifying an individual.

    Who knows... maybe at some point there will be software that can generate a speculative image of a person baed on the data in genes.

  8. The genome is out there by Quiet_Desperation · · Score: 1

    Didn't the alien conspiracy already do this?

  9. Chicken or egg? by mangu · · Score: 1

    Once a condition or a hereditary pre-disposition is determined, a subject could be denied medical coverage for that condition

    Without gathering a significant number of genomes, how could anyone identify which illnesses are hereditary, much less try to find a cure?

    I'm willing to bet that in the next 30 years we will have "personal drugs" tailored to a specific genome made by a desktop machine.

    1. Re:Chicken or egg? by russotto · · Score: 1

      People, please realize this: Nearly all health problems are better prevented than fixed later. Most of the time it's way easier too. But species-appropriate food and sports are so uncool, right?

      Eat healthy, stay fit, die anyway.

  10. And your "DNA Score" is next. by moon3 · · Score: 1

    And insurance companies start to tag you according to your DNA/vulnerability score. Watch what happens when they will be able determine that you have Alzheimer's related genes in your DNA.

    1. Re:And your "DNA Score" is next. by ID000001 · · Score: 2, Insightful

      So let's get rid of insurance companies and start insuring everyone? I know I know that is like a whole other can of worm, but while this (slashdot) is a US based website, personal genome project is a world wide project, and large majority of the world doesn't have insurance or preconsidition problem. Why keep pointing this issue out when it fairly localized? I am a canadian, and I will be fairly happy if they know more about how to treat me.

    2. Re:And your "DNA Score" is next. by BoothbyTCD · · Score: 1

      What will happen is the death of private healthcare, and not a moment too soon.

      --
      snig
  11. An erudite photo caption by kopo · · Score: 1
    The article contains an image of a pile of chromosomes, and the caption reads

    The X and Y chromosomes that make up a genome.

    Believe it or not, X and Y chromosomes aren't the only ingredients...

  12. Names not needed by Captain+Spam · · Score: 3, Funny

    While the Personal Genome Project won't publish names, just about everything else will be made public [...]

    Why do we need the names? Just take the genome data and use it to concoct an unholy abomination, mocking the laws of God and man, making a soulless clone of the person in question, rousing the populace to chase you down with torches and pitchforks in an attempt to stop pure genius their pitifully small minds could never truly understand, and just ASK what his/her name is?

    --
    Demanding constant attention will only lead to attention.
  13. We alredy know.. by damn_registrars · · Score: 1

    ... the make-up of J Craig Venter's genome, as he used himself for human DNA in the first draft. It doesn't seem to have hurt him too much to have that information out.

    Although indeed if the US would at least catch up to 1960's era Europe and institute universal single-payer health care, I would be much quicker to volunteer for this. Unfortunately as others have pointed out there is abundant opportunity for our for-profit insurance companies to abuse this information to make our lives more difficult (and more expensive to boot).

    --
    Damn_registrars has no butt-hole. Damn_registrars has no use for a butt-hole.
    1. Re:We alredy know.. by damn_registrars · · Score: 1
      Good job of not reading my post. I guess that is why you posted AC, because you didn't want anything resembling a name to be associated with your paranoia and spin.

      For starters, I already stated that

      insurance companies

      Need to disappear. The idiotic for-profit megabuck healthcare system we have in the US is not ethical or sustainable. We can learn from what other countries have been doing for 50 years and implement single-payer, universal health care; and then the worries about genetic-based health care fee structure discrimination should be addressed.

      employers, HR depts

      If you employer wants to can you - or not hire you to begin with - they'll find a mechanism. Genetic testing is pretty irrelevant in that matter.

      governments

      Can you find an example of governments doing something nefarious with genetic data? I didn't think so. If you want to wear a tinfoil hat, feel free to do so; but don't try to convince us it is a normal thing to do.

      Or just google "$100 genome"

      You are free to fear it if you want. However I feel it is a good thing. This is similar to what the Archon X prize will be someday awarded for and as a scientist I think that is a very noble competition. However as a biochemist I am not aware of any technology available at this moment that makes that level of completion possible in that little time and money.

      --
      Damn_registrars has no butt-hole. Damn_registrars has no use for a butt-hole.
    2. Re:We alredy know.. by pwfffff · · Score: 1

      Sure, you're a biochemist. That's nice.

      But this guy's seen a movie about the FUTURE (and he almost spelled it right too)!

      Sooo naive.

    3. Re:We alredy know.. by damn_registrars · · Score: 1

      The first draft did not include Craig Venter's DNA

      Actually, it was partially his DNA.

      The first draft i believe was a consensus of 10 humans of varying gender and race

      The part you refer to was from the public half of the human genome project.

      Which is overlooking the fact that there was simultaneously a privately-funded (as in J Craig Venter funded) genome project that was trying to compete with the publicly funded effort and publish a draft sequence first. The private effort actually used some released portions of the public effort (the public effort was more successful at the hard-to-sequence areas), but it was primarily taken from Venter's DNA.

      (as well as his dog's)

      True, Venter's poodle is, for better or worse, the current genomic standard for Canis Familiaris

      --
      Damn_registrars has no butt-hole. Damn_registrars has no use for a butt-hole.
  14. Great film, wrong conclusions by mangu · · Score: 1

    Although I love GATTACA, that film had a faulty reasoning.

    Assuming a science so advanced people could be programmed from conception to have six fingers and become superb pianists, the same technology level would allow people to correct their genetic shortcomings. For instance, we already have Lasik to correct imperfect eyesight such as the protagonist in the film had.

    Technology works both ways, if it's so advanced it lets someone find genetic "imperfections" it can also be used to mask them.

    1. Re:Great film, wrong conclusions by kaputtfurleben · · Score: 1

      Wasn't it the case that genes could only be identified, and not controlled?

    2. Re:Great film, wrong conclusions by AnotherBlackHat · · Score: 1

      Technology works both ways, if it's so advanced it lets someone find genetic "imperfections" it can also be used to mask them.

      Necessity is the mother of invention.
      If almost no one had bad eye sight, we'd never have invented Lasik.

      If we identify and eliminate all of the "bad heart" genes, we might never figure out how to make artificial hearts.

    3. Re:Great film, wrong conclusions by malkavian · · Score: 2, Interesting

      No, I think their reasoning is perfectly sound.
      In the movie, there are those who choose not to undergo genetic modification for their child, and have it born as is.
      There's also the corporate slant; All this modification costs. How much? As much as people can afford (c.f. the US education system). The thing that then differentiates people is the extent of their modifications, and the efficacy of them. The complete set of high flying mods would cost more than most could afford. The middling mods would be aimed at the general populace, and the basic would be aimed at the 'budget' market. Probably just enough to get rid of the susceptability to cancer, heart defects etc. Nothing to add brain/muscle/lifespan.
      Seeing as there's a resource, and only so many places that'll be licensed, you really think they'll give it all away for free?

  15. James Watson had 20 bad genes by peter303 · · Score: 1

    The discoverer of the structure of DNA was the 3rd person fully sequenced. 20 of his genes appear in the bad gene database (@5000 entries). None of these have been expressed yet at his ripe old age of 80+.

    Sergey Brin is worries about finding a Parkison's gene in his genome. But he doesnt need to be overly worried.

    1. Re:James Watson had 20 bad genes by wealthychef · · Score: 1

      Genetics is still in its infancy. We don't know how or why genes are expressed!

      --
      Currently hooked on AMP
    2. Re:James Watson had 20 bad genes by JasterBobaMereel · · Score: 2, Interesting

      "The" discoverer of the structure of DNA was a group of seven people three of whom won a Nobel prize for it .. Watson, Crick, Wilkins, Stokes ,Wilson, Franklin and Gosling

      Rosalind Franklin died of Cancer before she could be nominated for the Nobel prize ...

      --
      Puteulanus fenestra mortis
    3. Re:James Watson had 20 bad genes by smegmatic · · Score: 1

      Rosalind Franklin died of Cancer before she could be nominated for the Nobel prize ...

      or, they waited until she died of cancer before they awarded the nobel prize.

  16. Facial recognition by wealthychef · · Score: 2, Interesting

    And in other news, Apple and others are mainstreaming the use of software to recognize faces, so the omission of names from the database is really a laughable gesture towards privacy. These folks are taking a risk, for sure. But hey, no risk, no rewards. I applaud them.

    --
    Currently hooked on AMP
  17. Terrible Idealism - Quit it, Hippies! by jr76 · · Score: 1

    Ok, as a person who has done DNA tests for himself and believes in the value for people working together on this, I believe this is just terrible.

    People value their privacy, and for DNA research to make progress, they need as many people involved as possible, which has not been done yet. Less than 0.0000001% of the world has had their DNA tested. So, for that to be able to be done, their privacy needs to be ensured. People, being concerned about identity theft, use of their own information for negative purposes, etc, run for the hills when being brought about DNA tests today because they believe it's the ultimate in risk for that, to do such testing.

    So, the geniuses doing this want to enhance their fears by playing right into it, by exposing everything about themselves as part of this?

    For ALL MANKIND, it is best to get into a method of keeping high security over DNA testing, revealing absolutely nothing to anyone who they don't approve of (normally specific scientists, researchers and doctors) so that we can start testing as many people as possible with every genetically-related condition on the planet, so we can find ways to prevent and eliminate them fully.

    This is about as wrong as possible, in light of that.

  18. One byte for base pair by Twillerror · · Score: 1

    TFA states they need one byte per base pair resulting in 6 gigabytes per subject.

    My guess is there is a huge sequences of duplicates so compressions could probably bring this number down quite a bit.

    Also, since a byte can store 256 distinct values would it be able to handle more then just one base pair.

    1. Re:One byte for base pair by maxwell+demon · · Score: 1

      Since there are four different bases, you need two bits to store a pair, which means you could get 4 bases into a byte without using any non-trivial compression method.
      But given that the genomes of different people are very similar, they should already save a lot of memory by storing just diffs to a "standard" genome (say, the sequence from the Humane Genome Project).

      --
      The Tao of math: The numbers you can count are not the real numbers.
  19. Plural? by bradgoodman · · Score: 1

    Isn't the plural of "volunteer", "volunteers"?

    1. Re:Plural? by maxwell+demon · · Score: 2, Informative

      Isn't the plural of "volunteer", "volunteers"?

      For the noun, yes. For the verb, no.

      --
      The Tao of math: The numbers you can count are not the real numbers.
  20. He is...the Most Interesting Man in the World by Naked+Jaybird · · Score: 1

    Scientists look at his DNA, just to admire a job well done.

  21. Question for the geneticists by Qubit · · Score: 1

    How many people must be sequenced until there is enough genetic coverage to interpolate?

    I mean, I have a certain genetic code, and I share a good deal of that genetic code with my mother and father, right? And my siblings and I have similarities as well, I assume.

    Using similar methods to those that we use for DNA testing of maternity or paternity, how many people in a given group must have their genes sequenced before you could, say, have a 50% chance of getting a match on a given bloodstain or fingernail at a crime scene (or get something close enough that a court would allow the police to go fishing for more DNA, do interviews, etc...)?

    If the answer is "all of them," then perhaps genetic sequencing is relatively innocuous to us as a whole. Individuals can make the choice to be sequenced and it can be their exercise of Free Will to do so. But if the answer is "only a small percentage," then that means that these individual actions of persons today could have far-reaching consequences for generations of people to come.

    Having control over one's own actions and own body has been an important right in many cultures; how strange it would be for us to have propelled science to a point that our personal actions could have such a devastating effect on our progeny and relatives, essentially robbing them of a piece of their personal privacy by giving up some of our own.

    --

    coding is life /* the rest is */
    1. Re:Question for the geneticists by fusellovirus · · Score: 1

      The number of people that must be sequenced to interpolate data on a disease depends on what the prevalence of that disease is in the population. A disease like xeroderma pigmentosum is quite rare and would require hundreds of thousands of genomes, while something more common like the BRCA1 gene mutation that leads to a susceptibility to some breast cancers would take 10 to 100 times fewer.

      In reality however, each individual has unique mutations that may or may not effect their susceptibility to disease or ability to live a long life, and each new genome we sequence adds to our ability to correlate genes to disease. Indeed, individual actions of persons today could have far-reaching consequences for generations of people to come, particularly for their own progeny.

      To have coverage so that 50% of criminals could be identified would require two components, a genome database and a relative database that distinguishes individuals related by blood rather than by marriage. The completeness of each database would determine the exact numbers needed. That being said I don't think I would submit my personal genome to the database with the current uncertainty of personal protection and the state of the health care industry.

  22. And a million years from now... by Snaller · · Score: 1

    ...they will come alive to mine zikspot in the torture mines the evil lord emperor Zarguf runs on the planet zzebildiz!

    --
    If Google really cared they would fix Android Chrome to reflow text, instead of discriminating
    1. Re:And a million years from now... by Nathrael · · Score: 1

      Hey, sounds cool. You should start a religion...eh, cult about that. Worked for Scientology, might work for you as well.

      --
      A good education is a bit like a STD - it makes you unsuitable for a lot of jobs and gives you a desire to spread it.
  23. How long does sequencing take nowadays? by engineerofsorts · · Score: 1

    It seems like the initial human genome sequencing took several years, ending back in 2003 or thereabouts. Just how fast is the process nowadays? I trust, if they plan to sequence DNA from tens of thousands of individuals, it must be multiple orders of magnitude faster than what the original sequencing took????

    --
    Life is tough. Life is even tougher when you're stupid.
    1. Re:How long does sequencing take nowadays? by jr76 · · Score: 1

      People are not aware that there is no complete gene sequencing available to the masses yet.

      I do believe you could get a private study to do yourself entirely, at around $200,000 if you had that much money to burn. At the rate progress is occurring, in 2-8 years full sequences will be possible for most people (at somewhat of a premium price).

      Regardless, 99% of our genes are identical, so what's done now, focusing on the 1% that fairly rapidly mutates (every~100-500yrs), is almost all of what people will find different when they do the entire genome. We'll only catch the extremely unexpected and be highly more accurate when we do the whole thing.

  24. What a hard question! by KlomDark · · Score: 1

    I've never had such conflicting diametrically-opposed thoughts then that I fully agree with the project, and think of how many great things this project has the potential to produce.

    Possibly a cure for cancer.

    Perhaps a flawless man-machine interface

    (Recursion alert) A flawless man-machine interface and the potentials for both extreme good and extreme evil. But in that case, for a certain percentage of these people, there may be generations of my descendants cursing my act. With a perfect man-machine interface, and a public copy of my DNA, bad bio-hacks could be done by nefarious individuals to me and my descendants. (But then, the "noise" induced into the DNA by each generation of reproduction that "mixes down" the individuality of the "original copy" (aka, me) would make it nearly impossible to gain any "hacking" advantage.)

    But on the other side, the knowledge we'd gain by "datamining" 0.1 Megapeople would be tremendous - it could cure cancer/aging/disease and the idea of "immortal till killed" would have to be considered.

    I must consider this...

  25. Re:who are these people? by BoothbyTCD · · Score: 1

    It doesn't bother me much, so I volunteered.

    --
    snig
  26. Oh neat, free clones! by Patch86 · · Score: 1

    I hope mine's an astronaut!