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Cells May Communicate Through Light

SilverLobe writes "The hypothesis that living cells may use photons for communications has been on the fringes of cell biology for a while. No proof positive exists, but there is some strong circumstantial evidence. Byte Size Biology reports on a simple experiment that shows how the unicellular protozoan Paramecium may use so called 'biophotons' to signal for growth and feeding. The original academic paper in PLoS ONE concludes: '... not all cellular processes are necessarily based on a molecule-receptor recognition. The non-molecular signals are most probably photons. If so, cells use more than one frequency for information transfer and mutual influence.'"

52 comments

  1. First Post ... by khoonirobo · · Score: 0, Offtopic

    well my gray cells responded at lightspeed.

  2. No proof... by Anonymous Coward · · Score: 1, Insightful

    To be fair, there is never any _proof_ in biology. Only observations of occurances and patterns. You can only disprove things in biology. Mathematics reserves the right for universal truths.

    1. Re:No proof... by SUB7IME · · Score: 2, Funny

      "Mathematics reserves the right for universal truths."

      ^

      Godel might have something to say about that.

  3. Bad science may communicate through Slashdot by SUB7IME · · Score: 4, Insightful

    FTFA: "Depending on the cuvette material and the number of cells involved, these effects were positive or negative."

    Occam's razor: These are stochastic effects.

    Seriously, he replicated these studies 4 times TOTAL. "Depending on the cuvette material and the number of cells involved, these effects were positive or negative" basically fits the definition of a null hypothesis, which I certainly won't reject on the basis of 4 trials. Call me when an outside lab replicates this in a large number of trials.

    1. Re:Bad science may communicate through Slashdot by Eukariote · · Score: 2, Informative

      Seriously, he replicated these studies 4 times TOTAL.

      You have misread the abstract and have not read the experimental-setup section of the paper, which read:

      Each experimental block consisted finally of 10 units: 2 types of material (glass or quartz) ×5 combinations of Paramecium (an inner cuvette containing 5 Paramecium within a cuvette containing 100 Paramecium, an inner cuvette with 5 Paramecium within a cuvette containing medium only or demineralised water, and an inner cuvette containing medium only or demineralised water within a cuvette containing 100 Paramecium). Twenty-eight blocks were assayed in 14 experimental sessions that were performed at different days. In each session two blocks were randomly placed on a four by five grid, where the units were optically separated from each other by a black carton.

      As might be expected, they did more than enough replication runs to get sufficiently narrow error bars to show a significant inter-cuvette communication effect that, presumably, is light-mediated.

    2. Re:Bad science may communicate through Slashdot by SUB7IME · · Score: 1

      You're discussing experiment 1. I was discussing experiment 2. Sorry for not making that clear.

  4. Maybe... by viyh · · Score: 2

    ...they were just listening to techno music during the experiments?

    --
    "I have never let my schooling interfere with my education." --Mark Twain
  5. Prove it. by jeffb+(2.718) · · Score: 4, Funny

    "Mathematics reserves the right for universal truths."

    ^

    Godel might have something to say about that.

    In the most universal sense.

  6. Evolution is smarter than you are. by JoshuaZ · · Score: 3, Insightful

    This can't be emphasized enough. Life finds incredibly clever ways of doing things. And we are only just really beginning to understand just how amazingly sophisticated life is.

    That said, this really shouldn't be that surprising. We know that many larger life forms use light to communicate. It is quick and efficient. It doesn't take time to disperse like chemical signals. And many life forms have the ability to sense light anyways so it shouldn't be that hard to evolve the use of light as a signaling mechanism.

    1. Re:Evolution is smarter than you are. by Anonymous Coward · · Score: 0

      >It doesn't take time to disperse like chemical signals

      You mean "It doesn't take a lot of time to disperse like chemical signals do" :-) {/pedantic}

    2. Re:Evolution is smarter than you are. by SUB7IME · · Score: 1

      "It is quick and efficient. It doesn't take time to disperse like chemical signals."

      Sure, propagation is quick. On the other hand, generating the light does take time and energy because it's liberated via a chemical process.

      In the end, you're simply establishing a tradeoff. With chemical signals, you have a substance that is slow to transmit, but stays around for an extended period (unless you want it to go away, then you just digest it). Light as a signal transmits rapidly, but must be regenerated constantly due to the fact that photons don't exactly linger.

      To get back on topic: the results being discussed in this article are so far from conclusive that I don't really consider this study to have added anything to the scientific corpus.

    3. Re:Evolution is smarter than you are. by Eternauta3k · · Score: 1

      You mean "It doesn't take a lot of time to disperse like chemical signals do" :-) {/pedantic}

      Some people were just compiled with -Wall -pedantic

      --
      Yeah. Would you choose a neurosurgeon who pokes around people's brains in his spare time? I wouldn't.
  7. Please don't misapply Godel's theorems by JoshuaZ · · Score: 4, Insightful

    Godel might have something to say about that.

    No, he really wouldn't. Godel's primary results are that a) we can't be sure that certain systems are self-consistent and b) there are some statements that we can't prove. That in no way alters the level of access mathematics has to universal truth. When a statement is proven from a set of axioms it does follow from those axioms and anything which satisfies those axioms will satisfy the statement. Godel's theorems have nothing to say about that. There are good arguments against the notion that mathematicians have access to universal truth. For example, we all make arithmetic mistakes comes to mind. Also, there are published papers that have incorrect results that need to be retracted. Arguments can be made in this regard, but Godel has little to do with this matter.

    1. Re:Please don't misapply Godel's theorems by JustinOpinion · · Score: 1

      Thank you!

      Too frequently on Slashdot people trot out Godel's results to dispute just about anything. Godel's theorems are surely very deep and fundamental, but that doesn't mean they can be used to call into question everything. They make very specific statements about completeness and consistency. (I see a similar pattern with people trotting out the Halting Problem in discussions of computation, when, again, it doesn't always apply.)

      The irony, of course, is that if it were true that Godel's theorem calls into question every notion of provability and truth, then you have an obvious contradiction: Godel's theorem was proven using Mathematics. If you can't trust Mathematics to give rigorous proof, then why are you trusting Godel's theorem at all?

    2. Re:Please don't misapply Godel's theorems by SUB7IME · · Score: 1

      Excuse me. I should have said "Godel might have something to say about mathematics reserving the right for *all* universal truths."

      But then again, your response would have been much less funny. Also, I know you.

    3. Re:Please don't misapply Godel's theorems by JoshuaZ · · Score: 1

      Well, if you had said that, I wouldn't have commented since I would then have been in complete agreement. Incidentally, how do I know you?

    4. Re:Please don't misapply Godel's theorems by SUB7IME · · Score: 1

      Undergrad. To be more accurate, I know people who know you. I'm not sure that we've ever met in person.

    5. Re:Please don't misapply Godel's theorems by Anonymous Coward · · Score: 0

      When a statement is proven from a set of axioms it does follow from those axioms and anything which satisfies those axioms will satisfy the statement.

      Unless the the set of axioms are not self-consistent which ties in nicely with:

      we can't be sure that certain systems are self-consistent

      By 'certain systems' you mean any system that can support very simple arithmetic.

  8. Slashdot Science and You! by opticalbiophysics · · Score: 1

    Slashdot is bringing it to the people. The unfortunate part of Slasdot's "nerd" image is that it's just preaching to the choir! "Pure" science is altruistic. The value of science is not found in how correct it is but to what effect it has on society. The value of truth has no meaning to the universe. If our lies match observations does that make them truth? Yes. PS. This particular study may be flawed but the study of light and biological communication is a fascinating story. One of many interesting examples is the work of Albrecht-Buehler from Northwestern. His group published observations of 800nm (NIR) light communication in motile fibroblasts many years ago. That's a cell with no obvious light interaction structures! Mitorchondria produce 800nm light as part of their function so there is a reason why an endothelial cell might have such a function.

    1. Re:Slashdot Science and You! by foniksonik · · Score: 1

      Are you saying those new-age hippies are correct? We do have "Auras"... that our cells are emitting light constantly at specific wavelengths... *blasphemy*

      --
      A fool throws a stone into a well and a thousand sages can not remove it.
    2. Re:Slashdot Science and You! by opticalbiophysics · · Score: 1

      New-age hippies.....mmmmmmm, delicious.

  9. Fritz-Albert Popp (almost) always said this ... by foobsr · · Score: 2, Interesting

    e.g.

    But he was never quite mainstream, and followers of his theorie(s) are rated to be in the vicinity of morons.

    CC.

    --
    TaijiQuan (Huang, 5 loosenings)
  10. International Institute of Biophysics by Eukariote · · Score: 4, Informative
    Biophotons have been a long-term research focus at the International Institute of Biophysics. Quoting from their webpage:

    Worldwide there are about 40 scientific groups working on biophotons. The biggest association is the International Institute of Biophysics (IIB) e.V., founded in 1996 in Neuss (Germany) for an interdisciplinary approach of the understanding and the investigation of living systems.

  11. Where's the evidence? by rrohbeck · · Score: 1

    Creating light (thus swamping the communication) and detecting single photons are trivial. Since they didn't do these experiments I'll have to call BS and "correlation is not causation."

    Instead I'll claim that the protozoa communicate telepathically through hyperspace, and the hyperphysical properties of the different vessels they used influenced the effectiveness of the communication.

    1. Re:Where's the evidence? by SUB7IME · · Score: 1

      Exactly. Also, I may have missed this in the paper, but why not perform the experiment with a photon-blocking device (i.e., a piece of paper or, better yet, thin lead or gold) as a control?

    2. Re:Where's the evidence? by Anonymous Coward · · Score: 0

      I'm pretty sure that's in their next grant proposal. You do know how academic science works right? You do as little as possible in a study to get enough results to acquire more money.

      If you put all the variables in one experiment, how are you supposed to make a living?

  12. I'm not convinced by hairykrishna · · Score: 3, Interesting

    If this is the case the photons should be detectable. We can design experiments sensitive to the level of a single photon so this is not too much to ask.

    --
    "Physics is to math as sex is to masturbation." -R. Feynman
    1. Re:I'm not convinced by Anonymous Coward · · Score: 0

      Oh, there is no doubt about the existence of these photons. This fact has actually been acknowledged by mainstream science. The question is if they have a function or are just some drop off from some metabolic process. Some people claim the first but this has generally be considered controversial at best.

      BTW: the photons are phase-synchronized like a laser. No kidding.

    2. Re:I'm not convinced by Anonymous Coward · · Score: 0

      {{citation needed}}
      {{COI}}
      {{NPOV}}

    3. Re:I'm not convinced by Eukariote · · Score: 2, Interesting

      If this is the case the photons should be detectable.

      Indeed. And they have been detected with sensitive photon-counting equipment and cameras. The emissions are weak and, remarkably, extend into the UV. Fritz-Albert Popp in particular has done several such experiments. For some papers, see here: http://www.lifescientists.de/ib_003e_.htm.

  13. Evolutionary rationale by oneirophrenos · · Score: 1

    Not having RTFA, I was wondering why organisms would develop such a trait. I mean, chemical messaging on the molecular level is pretty darn fast as it is. Just think of all the neurotransmitter molecules traversing the synaptic cleft to reach their receptors as I am writing or you are reading this.

    So what could be the evolutionary advantage of intercellular electromagnetic messaging?

    1. Re:Evolutionary rationale by MichaelSmith · · Score: 1

      Cells in the eye are sensitive to light. I find that to be of some use. Light sensitivity is useful in other areas. For example knowing to avoid a fire, or when to bask in the sun. Faster messaging is generally a good thing. You get faster reflexes, more bandwidth.

      Maybe your thought processes are not as reliant on chemical messaging as you think.

    2. Re:Evolutionary rationale by Thiez · · Score: 1

      > Maybe your thought processes are not as reliant on chemical messaging as you think.

      But they probably are. Since neurons have no (known) mechanism for aiming and firing beams of light (and given the amount of research done on neurons, it is rather unlikely we would have overlooked such a mechanism if it did exist), all light-based communication would be omnidirectional, which is rather useless if you want to build a cool neural network.

      Also, if such communication was used by neurons, it would be easy to measure, but so far it such communication has never been detected, so it probably doesn't exist (but I suppose if nobody has ever done such an experiment someone should do it just to make sure).

      Why would nature invent a brain that uses light to send messages when it has a perfectly good chemical messaging system already in place?

    3. Re:Evolutionary rationale by foniksonik · · Score: 2, Interesting

      Biologists recently discovered that the Komodo Lizard has poison glands, long thought to have filthy mouths full of nasty bacteria... big morphology changing poison glands - which should be un-missable. Yet they missed them for 40+ years.

      If you're not looking for something and have already discounted it's existence, you're chance of seeing it is drastically reduced.

      --
      A fool throws a stone into a well and a thousand sages can not remove it.
  14. Shielding? by meehawl · · Score: 2, Interesting

    I've read through the methods and I can't understand why either the journal editors or the referees didn't insist on replicating each experimental setup with a simple sheet of lead (or other dense material) interposed between each cuvette and sufficient to block the direct path of any putative photonic communication. Without the demonstration of an expected null result for each experiment given this setup and a photonic communication hypothesis, I can't take this paper seriously.

    --

    Da Blog
  15. Old news, again... by Corson · · Score: 0, Troll

    It is common knowledge that plants (can) communicate through UV radiation.

    1. Re:Old news, again... by Corson · · Score: 1

      Troll? Man, you should start reading science books. Most of human knowledge is not on the Net but in those "old" printed books.

    2. Re:Old news, again... by Corson · · Score: 1

      I am talking about one of the oldest experiments carried out in plants. When one plant is injured a voltage spike is measured across the leaves of a plant sitting nearby. It was determined that UV mediate this communication between plants by alternatively placing quartz and glass separators between them. As you know, UV can pass through quartz but not regular glass.

  16. need some answers by angry_joker · · Score: 2, Insightful

    Interesting idea.
    I want to omit experimental part of this work ... everyone can look in a paper and assess results themselves. Instead of this I want to mention that in my opinion paper is a little biased in direction of "bio-photons idea", and ask about two things (in paper there was not mentioned about this problems):

    + Communication needs for working simple mechanism: place where the signal is encode, reveal and point where revealed signal should be deliver, catch and interpret. Because radiation mentioned in paper is very weak, so I suppose, that one cell is able to emit only few photons. Of course photons cannot hit anywhere into neighbor cell, because this system of communication is very inefficient. Photons should hit in specific molecules into neigh. cells.
    Q. Thus, what is the mechanism of finding the direction in which photon should be send ?

    + As we know authors choose waves in UV range (I omit the reasons why they did it). And we know also that the cells are mixture of proteins, nucleic acids and so on, ... in short: mixture of many, many dipoles (not all are dipoles but many of them). As we know from basic physics any dipoles which is in non-uniform motion - radiate. To take into consideration thermal motions into cytoplasm, there is no hard to state, that molecules immersed into cytoplasm radiate in very wide spectrum of radiation.
    Q. Have any tried to compare power of bio-photons radiation with integral from (0+epsilon) to 340 nm for thermal radiation ? Maybe bio-photons radiation is neglected small or inversely ?

    Maybe answers on this two questions are essential.

  17. like in that book by davidone · · Score: 1

    brr... just like "blood music", that book from Greg Bear...

  18. Evolution should not be anthropomorphized. by iroll · · Score: 1

    This can't be emphasized enough. Evolution isn't smart. Clever solutions are the result of time and probability: millions of permutations of similar creatures until one with a slightly better permutation survives long enough to have slightly more offspring than its peers.

    If you're going to anthropomorphize evolution, call it brute-force. It's the biological equivalent of "hacking" a password by trying every permutation of letters and numbers.

    --
    Repetition does not transform a lie into the truth. - FDR
    1. Re:Evolution should not be anthropomorphized. by JoshuaZ · · Score: 2, Interesting

      Yes, anthropomorphizing it isn't a great idea. It would be more accurate to say that "many things evolve which humans would likely never have thought up on their own in any reasonable length of time." However, comparing evolution to a brute force search is extremely inaccurate. Indeed, genetic algorithms are frequently much more efficient than brute force searches. The solution space in biology isn't like a single password. A better analogy would be if there were many valid passwords each which gave slightly different degrees of access and each password was similar to passwords that gave access to similar areas. That's still a not good analogy but it is better. But genetic algorithms != brute force. The same way, evolution is not brute force at all.

    2. Re:Evolution should not be anthropomorphized. by iroll · · Score: 1

      Ah yes, the evolution of the modern analogy. What wonders will its daughters have in store for us? =)

      --
      Repetition does not transform a lie into the truth. - FDR
    3. Re:Evolution should not be anthropomorphized. by ukyoCE · · Score: 1

      This is a bit of a nitpick, but evolution is much better guided than you give it credit for.

      I didn't realize this until I started reading about artificial life, but "random mutation" has approximately nothing to do with evolution. It's all about sexual reproduction mixing genes around.

      It IS still random, but a far stretch from the terribad "tornado through a junkyard" analogy that creationists like to cite.

    4. Re:Evolution should not be anthropomorphized. by foniksonik · · Score: 1

      hmmm you've invalidated your own response with the qualifier 'search'. The parent simply said 'brute-force'. I'll restate it in my own words, possibly distorting his meaning, as "trial and error" which for most purposes is equivalent to brute-force and is likely the first example of this methodology.

      Your comment on genetic algorithms is completely off BTW as it refers to the output of evolution rather than the process. Actually the whole entirety of your argument is talking about biological processes rather than evolution.

      So I'll just discount it as a misunderstanding and move on.

      --
      A fool throws a stone into a well and a thousand sages can not remove it.
    5. Re:Evolution should not be anthropomorphized. by iroll · · Score: 1

      Yeah, I definitely wouldn't go with the tornado-through-the-junkyard analogy, but sexual reproduction is an acquired and beneficial trait, not a requirement for evolution. Gene-swapping speeds the process and increases the chance for viable improvements; however, simple asexual reproduction over millions of generations can accomplish a huge amount of change *if* there are selective pressures on the population.

      In fact, you could say the same thing about starting with a monoculture (all members of the population have same initial genetics, say, from cloning). With sexual reproduction, you'll get new genetic material spread more quickly through the population, but you still need some mutations to generate diversity, and then you need selective pressure to make a "changed" offspring more viable than its peers.

      --
      Repetition does not transform a lie into the truth. - FDR
    6. Re:Evolution should not be anthropomorphized. by iroll · · Score: 1

      Well put!

      --
      Repetition does not transform a lie into the truth. - FDR
  19. methods describe impossible geometry by goombah99 · · Score: 1

    Can some one please confirm for me the geometrically impossible conditions described in the methods section. the section on Cuvette's begins:

    Populations of Paramecia were separated from each other with cuvettes with a wall thickness of 1.5 mm. Two sizes of cuvettes were used: 2.3 mm x 2.3 mm x 40 mm, and 1.5 mm x 1.5 mm x
    45 mm.

    these are I beleive the inner and outer cuvettes. He does not state if those numbers given are the outer widths of the inner width of the cuvettes. But under either assumption they are incompatible with the wall thickness:

    to be specific: if the all thickness is 1.5mm then the inner cuvette would have to have a width at minimum of two wall thicknesses which would be 3mm. therefore the inner cell specificaiton of 1.5x 1.5 cannot be the outer width and must be the inner width. But then this is incompatible with the 2.3 mm of the outer cuvette. you can't put a 3mm wide inner cuvette into a cuvetter with an inner width of 1mm.

    The next problem is the volume in use. if you put 1mm of liquid into the cuvette that was 1.5x1.5 then it's 400 microns deep. after 48 hours this should have evaporated!

    can someone else respond to these seeming show stoppers?

    --
    Some drink at the fountain of knowledge. Others just gargle.
    1. Re:methods describe impossible geometry by goombah99 · · Score: 1

      responding to myself.

      I notice another troubling inconsistency. the experimental set up says that 1ml of medium was added to a given number of paramecium. (e.g. 100 or 25 or 5 or 0 paramecium).

      in the study organism section it says the stock culture was kept at 100 paramecium/ml

      The problem here is that a paramecium has a size of about 200 to 300 microns. which I take to translate to a volume of .3 * 0.3 *0.3 = 0.027 ml/paramecium.

      100 paramecium thus occupy 2.7 ml of solution.

      thus you can't have a stock solution of 100 paramecium per ml. Nor can you have 100 indivisuals in 1mm cuvette volume.

      Finally If I read the chart correctly the number of indivisuals increased either 3 or 6 fold. There would not be enough water in the cuvette to allow 300 or 600 individuals of volume 0.027 ml to come into existence.

      --
      Some drink at the fountain of knowledge. Others just gargle.
    2. Re:methods describe impossible geometry by Anonymous Coward · · Score: 0

      200-300 MICRONS is .2-.3 mm, not .2 to .3cm. So youÂre off by a factor of 10 in each dimension there, making for a 1000-fold overestimation of volume.

  20. Correcting an error by goombah99 · · Score: 1

    Without negating my original post questioning the cuvette geometry, I note that my statement about the volume of liquid and the numbers of individuals is highly mistaken. I mistook cubic mm of millileters which is wrong by 1000 fold. However I still think there is a svere issue with the cuvette dimensions that I'd like explained.

    --
    Some drink at the fountain of knowledge. Others just gargle.