Customer Resource Management For Non-Profits?

NoTerminal writes "My 60-person non-profit organization is looking for a tool or set of tools to keep track of our donors and contacts. A perfect solution will either replace or gracefully synchronize with Outlook's contacts module, as well as provide a powerful back-end that can handle donation tracking, grant reporting, and interaction tracking. What contact management system or customer relations management package is your non-profit using? How do you like it?"