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Doctors Baffled, Intrigued By Girl Who Doesn't Age

phyrebyrd writes "Brooke Greenberg is the size of an infant, with the mental capacity of a toddler. She turned 16 in January. Brooke hasn't aged in the conventional sense. Dr. Richard Walker of the University of South Florida College of Medicine, in Tampa, says Brooke's body is not developing as a coordinated unit, but as independent parts that are out of sync. She has never been diagnosed with any known genetic syndrome or chromosomal abnormality that would help explain why. Brooke's hair and her nails are the only two things that grow, Howard said. 'She has pajamas and outfits that are 10 or 12 years old,' he said."

29 of 599 comments (clear)

  1. I don't have anything really smart to say by cml4524 · · Score: 5, Insightful

    It just struck me reading that... it must really, REALLY suck being the first person to ever have a particular disease.

    1. Re:I don't have anything really smart to say by BrightSpark · · Score: 5, Funny

      Oh, grow up!

    2. Re:I don't have anything really smart to say by need4mospd · · Score: 5, Funny

      I bet they match the Star Wars sheets on your bed too.

    3. Re:I don't have anything really smart to say by Anonymous Coward · · Score: 5, Informative

      Wouldn't be so sure of it. From the article:

      In her first six years, Brooke went through a series of medical emergencies from which she recovered, often without explanation. She survived surgery for seven perforated stomach ulcers. She suffered a brain seizure followed by what was diagnosed as a stroke that weeks later left no apparent damage.

      At 4, she fell into a lethargy that caused her to sleep for 14 days. Then, doctors diagnosed a brain tumor, and the Greenbergs bought a casket for her.

      "We were preparing for our child to die," Howard Greenberg said. "We were saying goodbye. And, then, we got a call that there was some change; that Brooke had opened her eyes and she was fine. There was no tumor.

    4. Re:I don't have anything really smart to say by marcello_dl · · Score: 5, Insightful

      Old age is a feature, not a bug. With less turn-over it would be difficult to life as a whole to adapt to changing environment. It has drawbacks as knowledge lost by the dead individual. Advanced life forms overcome that with culture.

      Earlier simpler life forms probably lacked the aging feature, and were superseded by others who had it.

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    5. Re:I don't have anything really smart to say by Anonymous Coward · · Score: 5, Funny

      What if we have it backwards?

      What if she is the first person not to have the disease we all have and that she is aging but really really slow?

      It's like I've been saying- you kids are going _way_ too fast!

      Now, get off my lawn!

    6. Re:I don't have anything really smart to say by cabjf · · Score: 5, Informative

      That was in the article I read about her. She has had cancer and other issues that seemingly healed themselves.

    7. Re:I don't have anything really smart to say by sentientbeing · · Score: 5, Funny

      If she wants to look older she should do what every other 16 year old does:

      Learn to smoke.

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    8. Re:I don't have anything really smart to say by Anonymous Coward · · Score: 5, Funny

      So she's Wolverine?

    9. Re:I don't have anything really smart to say by Jurily · · Score: 5, Funny

      Gigantic PMS?

    10. Re:I don't have anything really smart to say by nasor · · Score: 5, Informative

      The telomeres are normal, and match up with her actual chronological age.

  2. Surgeon General's warning by Blixinator · · Score: 5, Funny

    GOVERNMENT WARNING: (1) According to the Surgeon general, women should not drink from the fountain of youth during pregnancy because of the risk of birth defects.

    --
    "The Y chromosome is genetic. The odds are very good that if you are male then your father was too." -Internet Commenter
  3. Failure to age or failure to grow? by PeterM+from+Berkeley · · Score: 5, Informative

    Reaching adulthood and then preserving the body of a 20-year-old forever is one thing. This is quite something else.

    It is not so much failure to age, as failure to grow/mature. It remains to be seen whether her abnormality will grant longer life span in practice.

  4. Re:Brooke is a deviation by MyLongNickName · · Score: 5, Insightful

    Dude. Lay off the weed.

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  5. Re:She looks retarded ... by stuntpope · · Score: 5, Informative

    Regardless of age, there are laws against sex with people with diminished mental capacity, who cannot give consent.

  6. Re:Be Careful what you wish for! by Dunbal · · Score: 5, Informative

    I wonder what the cause of diminished mental capacity might be?

          While I am not aware of the particulars of this case, as a doctor I can state that myelinization of nerve cells inside the brain is what is believed to contribute to increased cognitive ability. Babies are born with roughly the number of neurons (nerve cell) they will have for the rest of their lives, however these neurons are not fully coated in myelin. Myelin increases the efficiency and conductivity of a neuron, and is synthesized by cells surrounding the neuron. However this production takes time - a few years in the case of neurons outside the brain - which explains why babies are also clumsy. Myelinization of the brain itself takes roughly 20 years.

          I suspect that this patient isn't producing myelin, among other things, and therefore will never reach her cognitive potential.

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  7. Re:I bet it's lupus.. by darkstar949 · · Score: 5, Funny

    Except for the one time where it was lupus.

  8. the answer is in the abc article by circletimessquare · · Score: 5, Interesting

    Doctors recommended growth hormone therapy early in Brooke's life, but the treatment produced no results.

    Howard Greenberg recalled the follow-up visit to the endocrinologist. "We took her back in six months, and the doctor looked at us and said, 'Why didn't you give Brooke the growth hormones?' And I said, 'We gave Brooke the growth hormones. We gave her everything you told us to do.' And Brooke didn't put on a pound, an ounce; she didn't grow an inch."

    not that i know a damn thing about endocrinology, but i would speculate that this failed therapy suggest that, as we all have receptors for various hormones, her body has no such receptors for HGH. if someone is born genetically male, but has no male secondary characteristics, then either:
    1. his body produces no testosterone,
    2. his body produces testosterone, but his body doesn't react to it

    i would say that this girl, uh, young woman, has an incredibly rare, unique mutation: insensitivity to human growth hormone. it would explain all of her symptoms

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  9. Re:Brooke is a deviation by taucross · · Score: 5, Funny

    Man, I've been through so many drugs I've almost become a Christian.

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    "In the absence of the ability to establish the attribute of truth they tried to establish the noble attributes."
  10. Re:Brooke is a deviation by taucross · · Score: 5, Funny

    No, soldiers die because they bleed too much.

    --
    "In the absence of the ability to establish the attribute of truth they tried to establish the noble attributes."
  11. No, she is aging too by aepervius · · Score: 5, Insightful

    Some of her body part , like bone structure, are 10 years old. Thus it sounds doubtful she will reach the multi-centenarian age you cited. They tried to communicate with her , tried to teach her speaking but it failed. Anyway there is a rearrangement of the pharynx/larynx at the venerable age of 1/2 years old which is needed to be able to physically speak. Without it you can't. Maybe a doctor/biologist can chime in.

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  12. Hmm by LizardKing · · Score: 5, Funny

    She has pajamas and outfits that are 10 or 12 years old,' he said.

    That's nothing, I work in an office with some programmers who haven't changed their outfits in over twenty years.

  13. Re:Brooke is a deviation by smallfries · · Score: 5, Funny

    Mr. Taucross, what you've just said is one of the most insanely idiotic things I have ever heard. At no point in your rambling, incoherent response were you even close to anything that could be considered a rational thought. Everyone in this room is now dumber for having listened to it. I award you no points, and may God have mercy on your soul.

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  14. Another case by polymeris · · Score: 5, Interesting

    There is this girl/woman in Brazil, Maria Aldenete, who has similar syntoms. I couldn't find any info in English on her... She's 30 years old or so.

  15. Relativity by trevdak · · Score: 5, Funny

    Has anyone considered that she might just be moving very close to the speed of light?

  16. Re:She seems to grow by GauteL · · Score: 5, Insightful

    "Before the movie "50 First Dates", there was a sci-fi short story that posited this, with horrifying consequences"

    It must suck that your example of this is a crappy rom-com with Adam Sandler rather than a brilliant film like Memento.

  17. I've seen this before, sorta... by Yert · · Score: 5, Interesting

    I have an aunt who was in her third trimester when she was in a car accident, and Dolly was born soon after with no apparent damage... except she never grew up. Dolly passed away a few years ago, at the age of 33, and weighed about 80 pounds - she did grow "up", but much slower than normal - she was 20 before she weighed 40 pounds, and never spoke a single intelligible word. She never matured mentally beyond around 6 months, and was always in a crib at all the family gatherings. Thankfully, I never had to change her diaper.

    There are some differences, as Dolly did seem to physically mature, just very slowly - but the doctors didn't seem to think it was that phenomenal, just brain damage from the accident. She did have the same odd development that Megan's eyes have - the wandering eye, so to speak. (As opposed to my wandering eye, which is entirely a different sort of affliction.) :)

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  18. OK, you 'for the children' obsessives... by argStyopa · · Score: 5, Interesting

    In a couple of years, when she turns 18, would nudes of her be child porn? Eh?

    (listens for the sounds of heads exploding)

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    -Styopa