Obesity May Accelerate Brain Aging

natehoy writes "According to the US News and World Report, a recent study has shown a link between obesity and the loss of neurological tissue. The brains of elderly patients who were obese had on average 8% less tissue than their trimmer counterparts. Overweight patients had brains lighter by about 4%. This could have implications for the onset of dementia illnesses such as Alzheimer's. Just one more risk factor to add to the growing body (no pun intended) of reasons to try and stay trim."

Comments

Now I get it

[mcgrew]

Fat women have always hit on me. Now I know why -- they're stupid!

However, from TFA:

Dr. Jonathan Friedman, an associate professor of surgery and neuroscience and experimental therapeutics at the Texas A&M Health Science Center College of Medicine noted that the causal relationship here is not clear.

Another possibility is that The brains of overweight people have more receptors for the neurotransmitter serotonin than those of people of normal weight, suggesting that being overweight may be down to more than just eating habits and may have an origin in brain chemistry. Clearly, more study is warranted.

From the New Scientist article on the ssubject of big people with little brains:

In an as yet unpublished study, Thompson's team has shown that exercise, which improves cardiovascular health and blood flow, protects the very brain regions that had shrunk in the current study. "The most strenuous kind of exercise can save about the same amount of brain tissue that is lost in the obese," he says. This indicates that it is blood flow that drives brain health, not the other way round. As these areas undergo the most remodelling throughout adult life, they may be more sensitive to any changes in oxygen supply and nutrients, Thompson suggests.

But Deborah Gustafson at the University of Gothenburg in Sweden, who previously found that overweight women had less brain tissue than their leaner counterparts, questions whether obesity is driving brain atrophy or vice versa. She points out that brain atrophy in the frontal and temporal lobes, which also control eating behaviour and metabolism, could cause weight gain. "There are not enough longitudinal data available for us to know which is the chicken and which is the egg."

Re:These morally chiding "correlation" studies

[CannonballHead]

Is it any coincidence that the medical profession was once closely linked to the idea [thinkquest.org] that all illness was caused by immoral behavior?

Interestingly enough, in the Old Testament, Job's three friends made this mistake and were actually reprimanded for it. Calamity and "bad stuff" (including illness) does not, even in the Old Testament, mean judgment from God for immoral behavior.

Re:These morally chiding "correlation" studies

[b0ttle]

... the fact that the obese are often geographically concentrated in areas (like the American South) where public education is shit and poverty is high.

"American obesity rates are the highest in the world with 64% of adults being overweight or obese"
http://en.wikipedia.org/wiki/Obesity_in_the_United_States

Re:The link between carbohydrate consumption and A

[dogmatixpsych]

If I may offer my opinion as someone who researches cognitive aging and the brain, I think the link (without actually reading the article) is likely due to cerebrovascular factors. People who are overweight often have high or highly varying blood pressure. They also often have arterosclerosis and all sorts of plaque build-up in the blood vessels. Basically their cardiovascular systems in general do not work as efficiently.

The brain is very power hungry. It needs virtually uninterrupted blood flow to function well. People who have reduced blood flow (efficiency) could have lower blood perfusion in the brain. Their neurons may just be slowly starved of enough oxygen and nutrients. People who are overweight are at increased risk for developing strokes, particularly so-called "silent strokes" that might not have apparent effects at first but could over time.

I don't think it's the obesity as much as the cardiovascular issues that are associated with it. I've seen the brains of older adults who have (uncontrolled or long-term) high blood pressure and by and large, they are not pretty. Their white matter is often pretty messed up. They often have larger ventricles (more brain atrophy) and do worse on cognitive tests.

In any case, being overweight is one of the worst things you can do to your overall health. Maybe not now, but in old age overweight (particularly obese) people are going to have a lot of problems - physical and cognitive. Again, I deal not with individuals as much as with groups of people so everything I say should be taken as "on average."