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Making Babies In Space May Not Be Easy

Hugh Pickens writes "Studies of reproduction in space have previously been carried out with sea urchins, fish, amphibians and birds, but Brandon Keim writes in Wired that Japanese biologists have discovered that although mammalian fertilization may take place normally in space, as mouse embryos develop in microgravity their cells have trouble dividing and maturing. The researchers artificially fertilized mouse eggs with sperm that had been stored inside a three-dimensional clinostat, a machine that mimics weightlessness by rotating objects in such a way that the effects of gravity are spread in every direction. Some embryos were ultimately implanted in female mice and survived to a healthy birth, but at lower numbers than a regular-gravity control group. Part of the difference could be the result of performing tricky procedures on sensitive cells, but the researchers suspect they also reflect the effect of a low-gravity environment on cellular processes that evolved for Earth-specific physics. '"These results suggest for the first time that fertilization can occur normally under G environment in a mammal, but normal preimplantation embryo development might require 1G," concludes the report. "Sustaining life beyond Earth either on space stations or on other planets will require a clear understanding of how the space environment affects key phases of mammalian reproduction."'"

26 of 262 comments (clear)

  1. The beginning bit is probably tricky too by Goldberg's+Pants · · Score: 4, Funny

    Zero gravity probably makes the actual copulation bit kinda tricky too.

    1. Re:The beginning bit is probably tricky too by Anonymous Coward · · Score: 5, Funny

      cleaning up afterward might also be a bitch

    2. Re:The beginning bit is probably tricky too by Brian+Gordon · · Score: 4, Funny

      They should contact the Mile High Club to send over some representatives

    3. Re:The beginning bit is probably tricky too by RuBLed · · Score: 4, Funny

      at least no one will hear them scream...

    4. Re:The beginning bit is probably tricky too by Sumbius · · Score: 5, Funny

      Space Corp directive 34124. 'No officer with false teeth should attempt oral sex in zero gravity.'

    5. Re:The beginning bit is probably tricky too by houstonbofh · · Score: 4, Funny

      cleaning up afterward might also be a bitch

      But no worries about who sleeps in the wet spot...

    6. Re:The beginning bit is probably tricky too by Darinbob · · Score: 5, Funny

      That's what the handcuffs are for.

    7. Re:The beginning bit is probably tricky too by CarpetShark · · Score: 4, Funny

      But no worries about who sleeps in the wet spot...

      Indeed. In space, everyone sleeps in the rain.

  2. So, what I read is.. by Anonymous Coward · · Score: 5, Funny

    a) sex in space: easy
    b) consequences of sex in space: non-existant

    I am pleased.

    1. Re:So, what I read is.. by feepness · · Score: 4, Funny

      The pope won't be.

      Hey, they said "don't spill it on the ground". There's nothing about spilling it into little floating pearls.

  3. Logic fail. by Thantik · · Score: 4, Insightful
    Randomly changing the directions of gravity != no gravity. Logic fail.

    If I put an egg into a blender, I'm pretty sure it'd have a hard time forming a chicken too.

  4. childish question by RuBLed · · Score: 4, Funny

    If I put an egg into a blender, I'm pretty sure it'd have a hard time forming a chicken too.

    Why?

    1. Re:childish question by ZackSchil · · Score: 5, Funny

      Because blenders are very poor at maintaining a temperature of 102 degrees Fahrenheit and very good at turning everything inside of them into a smooth paste.

  5. Doctor, Doctor, it hurts when I do *this* by QuantumG · · Score: 5, Interesting

    So don't do that.

    Using acceleration to counteract undesirable effects of microgravity appears to be a universally ignored solution. It's like people are so amazed by how awesome zero-g is that they can't accept that working against it might be the best option.

    problem: humans lose bone mass in zero-g
    brain dead solution: we need to change humans with drugs! oh, and we'll make them exercise more too.
    problem: embryos don't develop normally in zero-g
    brain dead solution: we need to study embryonic development more, and hey, maybe we can find some drugs to fix it!
    problem: transferring cryogenic propellant in zero-g is hard
    brain dead solution: we need to learn more about fluid dynamics in zero-g!

    Back in the Gemini days they actually bothered to join a pair of spacecraft together and spin them up. The effect was about 1000th of a g, but it was a successful mission. Everyone presumed that NASA would continue this research after Apollo, with longer tethers and slower rotation, a 1g environment could be created. That didn't happen. Instead, the fixed module concept took over and "studying the effects of zero-g" became the mantra. No matter, the Japanese space program proposed a module that would allow the study of incremental gravity on mammals, everything from low gravity to three times earth gravity, or the astronauts could sleep in it. That was scrubbed.

    Meanwhile, private industry is solving the problem of propellant transfer.

    --
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    1. Re:Doctor, Doctor, it hurts when I do *this* by DerekLyons · · Score: 5, Informative

      Using acceleration to counteract undesirable effects of microgravity appears to be a universally ignored solution.

      It's not ignored - it's turned out to be devilishly difficult to arrange.
       
       

      Back in the Gemini days they actually bothered to join a pair of spacecraft together and spin them up. The effect was about 1000th of a g, but it was a successful mission. Everyone presumed that NASA would continue this research after Apollo, with longer tethers and slower rotation, a 1g environment could be created.

      Everyone who? Because everyone I know is familiar with the problems with those tethers bring with them.
       
      Its extraordinarily difficult to stop and start the rotation. Its difficult to avoid tension problems during payout, it's REALLY difficult to prevent snarls during retraction. It's extraordinarily incredibly difficult to make orbital corrections while tethered and spinning...
       
      Until someone comes up with some engineering solutions to test (and they are working on them and two tether deployment tests (both failures) have flown on the Shuttle), any experimentation is moot - kinda like sticking your finger into boiling water to see if it burns you.

  6. Re:The challenge by Runaway1956 · · Score: 4, Insightful

    "There is no reason to expect that their clinostat successfully captures the essence of the problem"

    I looked at the image of that clinostat. The researchers are probably pretty smart people, but there is just no way that a centrifuge on steroids can duplicate zero-G. The embryos have to be subjected for changing gravitational forces. Said forces may cumulatively add up to zero, in theory, but those embryos aren't experiencing theory.

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  7. Re:Where can I find results of all those experimen by stephanruby · · Score: 5, Informative

    where can I find results of all those experiments?

    You better clear out your calendar, you have a lot reading ahead of you.

  8. Re:Where can I find results of all those experimen by kestasjk · · Score: 5, Funny

    Hush, we're trying to be bitter about NASA here if you don't mind..

    --
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  9. Re:May not be easy... by Tablizer · · Score: 5, Funny

    Indeed. "According to NASA research, Tasha, we have to do this 8,000 more times before it succeeds....Honest; here's NASA's paper on it..."
       

  10. Just for the record... by IorDMUX · · Score: 5, Interesting

    ...Larry Niven predicted this years ago.

    In his Known Space universe, the true separation of space-based ("Belter") culture from Earth-based ("Flatlander") culture occurred when the Belters completed their massive 'terraforming' of the inside of an asteroid named Sanctuary as a shelter and home for pregnant Belter women. Rotating the asteroid up to 1-g, they eliminated their last unwanted ties to Earth as women no longer needed to return to the home planet for the period of gestation and birth.

    Though, if I remember correctly, Larry Niven's justification for the need was a bit different, as he reasoned that a human fetus brought to term in very low gravity would grow to a size that endangered the life of the mother... I think.

    --
    >> Standing on head makes smile of frown, but rest of face also upside down.
    1. Re:Just for the record... by DerekLyons · · Score: 4, Insightful

      Or rather Larry Niven invented a plot device to create the Belter culture... And of the hundreds of plot devices that he invented, one happened to be somewhat correct.

  11. Re:Reproduction in space by fractoid · · Score: 5, Funny

    Humans cannot withstand long term micro-gravity. Period.

    There's your problem. You're not pregnant until you STOP having periods.

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  12. Why not just send some mice up to the ISS? by michelcolman · · Score: 5, Interesting

    They carried out reproduction in space of sea urchins, fish, amphibians and birds, but no mice? If I were to study the effects of microgravity on pregnancy, I would put something similar to humans (at least a mammal) at the top of my list, instead of first trying a whole list of species that don't really resemble us. Why use centifuges to "simulate" zero G (?!) and not just send a few mice up to the ISS? OK, it might be difficult to get them to actually reproduce, maybe put them on a 1G centrifuge for the actual copulation bit and then let them float again.

  13. Re:Reproduction in space by Ephemeriis · · Score: 4, Insightful

    After about a year in space you cannot walk when you land on earth.

    This isn't necessarily a problem. Sure, if you want to walk around Earth then you're going to be in a bit of a fix... But what if you plan on spending the rest of your days in space? What if it's a one-way trip?

    If we are going to live in space we are going to have to figure out how to create gravity on whatever structure we decide to inhabit.

    I thought we'd already figured this bit out? All you have to do is spin the structure.

    I really doubt we would mutate fast enough to take advantage of weightlessness to survive.

    We don't need to.

    When's the last time you saw somebody sitting out in a snowstorm waiting to mutate and grow an insulating fur coat? Around here we just but on a coat. We're human beings, we have brains, we can make and use tools.

    That's the whole point of experiments like this one. We're not going to wait around for environmental forces to craft us into better organisms... We're going to identify the problems and fix them, just like we have for thousands of years. That's what we do.

    --
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  14. Re:May not be easy... by MyLongNickName · · Score: 4, Funny

    Tasha: "But at the rate you do it, that could take HOURS".

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  15. Re:The challenge by gtbritishskull · · Score: 5, Insightful

    People around here bash scientist a lot, when they are really reading the media. I had a teacher once who had a favorite saying that it seemed like he said at least once a class... "All models are wrong, but some are useful". The same can be said about simulations. After an experiment is performed, in which something is simulated, conclusions are supposed to be drawn. Then, further experiments are supposed to prove or disprove these conclusions. Are you suggesting that they should not have tried this experiment first (which is probably 1/10 of the cost of doing it in space)? They will probably use this experiment as justification for a grant to actually try it in space.

    Science is constrained by fiscal realities. And the honest fact is that even if we do have the experiment done completely in space, it is still being done on mice. We won't know how it affects humans until we send a girl up there to get knocked up and see what happens.