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2009 Nobel Ribosome Structures — Patented

tabascoj writes 'The announcement of this year's Nobel Prize in Chemistry is the latest reminder that fundamental components of biology are being increasingly, and aggressively, patented. A commentary, from yalepatents.org, focuses on the research and subsequent patents, held by Yale and Thomas Steitz, one of this year's laureates.'

43 of 168 comments (clear)

  1. How is this ethical? by ground.zero.612 · · Score: 3, Interesting

    Better yet, how can I patent my own DNA?

    --
    "Be prepared, son. That's my motto. Be prepared." --Joe Hallenbeck
    1. Re:How is this ethical? by matt4077 · · Score: 2, Insightful

      Maybe by investing 20 years of your life and millions of dollars to find something that will lead to a process that allows you to create antibiotics that save millions of lives. You can then patent that process and those antibiotics. For 20 years. Oh, and the royalties go to your employer who financed your research and will invest it into more research.

      Yes, it's an evil evil broken system.

    2. Re:How is this ethical? by Evil+Shabazz · · Score: 4, Insightful

      I would posit that patenting your research for commercial gain should exempt said research from Nobel Prize eligibility.. but that's just me. In Nobel's will, it's pretty clear his award was meant to encourage the advancement of mankind - not the advancement of a company's balance sheet. The two motives are pretty exclusive. Either you've done the research and are making it publicly available to all of mankind - or you are keeping it for yourself and only offering the benefits of the research to the select individuals who can afford it. If you're patenting it, your motive is profit.

      --
      Down with the career politician! SUPPORT TERM LIMITS
    3. Re:How is this ethical? by ultranova · · Score: 3, Insightful

      Maybe by investing 20 years of your life and millions of dollars to find something that will lead to a process that allows you to create antibiotics that save millions of lives. You can then patent that process and those antibiotics.

      The question here is should you be able to patent the DNA itself? You didn't design it, in fact you had nothing whatsoever to do with its existence, you merely figured out how it worked - which took 20 years and millions of dollars. Obviously that effort should be rewarded, and just as obviously you can't possibly own a (very important) part of me, this not being ancient Greece or not-so-ancient USA.

      Anyway, I don't think that Nobel prices should be given for patented work. After all, the whole point of the price is to reward improving humanity, but patents already supposedly do this.

      --

      Forget magic. Any technology distinguishable from divine power is insufficiently advanced.

    4. Re:How is this ethical? by Volante3192 · · Score: 2, Insightful

      The question here is should you be able to patent the DNA itself?

      That is not the question here, though. They've patented a method to analyze ribosomes, not the ribosomes themselves.

      Anyway, I don't think that Nobel prices should be given for patented work.

      So, if I go check out the thread on the physics prize ( http://tech.slashdot.org/story/09/10/06/1427237/Father-of-Fiber-Optics-Wins-Nobel-Prize ) I should see this argument there too?

      Anyway, everything is going to be patented now regardless. Due to how cutthroat companies are, researchers have to patent simply to defend their work from people that might eventually troll them. Maybe if the patent system actually worked, you might have a case to make there, but unfortunatly researchers have to think about their work on a legal standing these days, too.

    5. Re:How is this ethical? by santiagodraco · · Score: 2, Insightful

      It has nothing to do with motive, it has to do with effect. If it benefits mankind it qualifies. Who cares if the person profits from it at the same time? Would you begrudge someone recognition just because it profits them in some way?

      That's a sure way to cut back on advancement several tens of years or more.

    6. Re:How is this ethical? by Bazar · · Score: 2, Interesting

      No capitalism doesn't work FOR humanity's best interests, however that doesn't mean their work doesn't further the advances of humanity.

      Thinking of some of the greatest inventions of last century, the light-bulb or automobile. Both were made by great inventors, both drastically changed the world, both were made with profits in mind, and both had patents on their inventions.

      Anyone who thinks that its wrong to make money for advanced research should get a clue on how the world works.
      The same can be said for anyone who instantly assumes that all patents should be worthless.

      --
      To avoid criticism; Say nothing, Do nothing, Be nothing.
    7. Re:How is this ethical? by Canberra+Bob · · Score: 2, Insightful

      It has nothing to do with motive, it has to do with effect. If it benefits mankind it qualifies. Who cares if the person profits from it at the same time? Would you begrudge someone recognition just because it profits them in some way?

      That's a sure way to cut back on advancement several tens of years or more.

      Many on here would. It reminds me of a saying: a capitalist and a socialist are walking down the street and a man drives past in his Ferrari. The capitalist says "I hope one day I have a Ferrari like him", the socialist says "I hope one day he has to walk like me".

    8. Re:How is this ethical? by Jedi+Alec · · Score: 2, Insightful


      It has nothing to do with motive, it has to do with effect. If it benefits mankind it qualifies. Who cares if the person profits from it at the same time? Would you begrudge someone recognition just because it profits them in some way?

      That's a sure way to cut back on advancement several tens of years or more.

      Many on here would. It reminds me of a saying: a capitalist and a socialist are walking down the street and a man drives past in his Ferrari. The capitalist says "I hope one day I have a Ferrari like him", the socialist says "I hope one day he has to walk like me".

      Congratulations. You have officially been indoctrinated!

      Now, the socialist *might* argue that that same money could have been used to get all 3 of them a car instead so none of them would have to walk in the first place. But I guess US cable news doesn't go too heavy on the nuance.

      --

      People replying to my sig annoy me. That's why I change it all the time.
  2. This is sick! by Finallyjoined!!! · · Score: 2, Insightful

    I'm going to go down there & patent shit, then sue any sod that has a crap.

    What's the world coming to?

    --
    If I had an Ass, I'd call it Fanny Bottom, then I could slap my Ass; Fanny Bottom, on the Arse.
    1. Re:This is sick! by Finallyjoined!!! · · Score: 2, Insightful

      Unfortunately we won't. Too much wonga to be made by Corporations.

      --
      If I had an Ass, I'd call it Fanny Bottom, then I could slap my Ass; Fanny Bottom, on the Arse.
  3. I don't understand... by Thantik · · Score: 3, Insightful

    How can you patent something that nature already patented itself millions of years ago? Hasn't the patent run out yet?!

    1. Re:I don't understand... by buchner.johannes · · Score: 2, Informative

      ... cover not only the process for determining the structure of the molecules, but also the computation used to design new antibiotics.

      You can not patent ideas or discoveries. But you can patent applications/machines. And if you live in a weird country, algorithms.

      --
      NB: The message above might reflect my opinion right now, but not necessarily tomorrow or next year.
    2. Re:I don't understand... by wizardforce · · Score: 2, Insightful

      It takes significant R&D to determine these structures and it seems that the patent office considers the discovery of a pre-existing biological component to be deserving of protection as much as a designed system for that very reason. It's indicative that we really should get around to reforming the patent system.

      --
      Sigs are too short to say anything truly profound so read the above post instead.
    3. Re:I don't understand... by erroneus · · Score: 3, Insightful

      It takes even more to visit other planets. Should Mars become the patented intellectual property of the people running the Mars rover program?

      The significant R&D is irrelevant to the patent process. A guy inventing things at his kitchen table with coat hanger wire is more eligible for a patent than someone who discovers the workings of nature.

      We should reform the patent system.

  4. Not Very Noble by sexconker · · Score: 4, Informative

    Insert tired old joke about Nobel/Noble.

    In Nobel's own words:
    "The whole of my remaining realizable estate shall be dealt with in the following way: the capital, invested in safe securities by my executors, shall constitute a fund, the interest on which shall be annually distributed in the form of prizes to those who, during the preceding year, shall have conferred the greatest benefit to mankind."

    Seems to me someone shouldn't win for doing something that benefits their pocket books first, and mankind second.

    Angry emails to the Nobel Foundation, GO!

    Postal address: The Nobel Foundation
    P.O. Box 5232, SE-102 45 Stockholm, Sweden
    Street address: Sturegatan 14, Stockholm
    Tel. +46 (0)8 663 09 20
    Fax +46 (0)8 660 38 47
    E-mail info@nobel.se
    comments@nobelprize.org

    1. Re:Not Very Noble by dmartin · · Score: 4, Insightful

      Except that from the quote form Nobel, the benefit to pockets of the inventors does not factor into it.

      The piece of the sentence

      "The whole of my remaining realizable estate shall be dealt with in the following way: the capital, invested in safe securities by my executors, shall constitute a fund, the interest on which shall be annually distributed in the form of prizes

      states that
          i) that the prize should be distributed annually
        ii) some logistics dealing with the estate.

      So Nobel's statement is, in essence, that we should give the Nobel prize to those who, in the preceding year, shall have conferred the greatest benefit to mankind.

      In comparing two discoveries we need to compare their relative benefit to mankind; the benefit of the individual is completely and utterly irrelevant. That is, it is irrelevant if the individual (or individuals) benefited more than mankind as a whole; nor does it matter when comparing the two discoveries which group made "more" out of their discovery pre-Nobel prize. Nobel's sentiment is solely concerned with the benefit to mankind.

      To be blantent and explicit about it, pretend for a moment that "benefit" was an actual quantifiable measure. It is not, but we can still look at the logical structure of the statement. If we have two discoveries A and B with
      A: mankind benefit: 500 personal gain: 800
      B: mankind benefit: 505 personal gain: 2000
      then "B" has greater benefit to mankind of these two discoveries. The last column is completely irrelevant. (BTW, personal gain will probably always exceed mankind benefit as the scientists gain the same benefit you or I would, plus whatever recognition etc. in their field, other prizes, awards, grants, etc. The only way I could see personal gain being less is if the personal sacrafices involved were worse than all the other benefits to the individual).

      If you wish to argue that a patented discovery lessens the value to mankind as a whole, by all means go ahead. But the argument that you have presented simply does not hang together -- Nobel makes no comment (at least with the quote you have provided) about the discoverer's personal gain.

      PS. If you did want to argue about something mentioned in Nobel's statement, it is that Nobel prizes typically don't go within a year of a device conferring the greatest benefit to mankind.

    2. Re:Not Very Noble by s73v3r · · Score: 2, Insightful

      The thing is, does locking down a discovery so only one company can actually use it reduce the benefit to mankind? Many people would say yes.

  5. How by Dyinobal · · Score: 2, Funny

    How in the world do you patent something like this. I expect the people at the patent office see the patent request and are like "What the hell is this?" then a few guys pass it around and all decided they dunno what it is. So they shrug "Must be new" out comes the patent approved stamp!

    1. Re:How by matt4077 · · Score: 4, Insightful

      With less sarcasm: the ribosome is not patented. It's using the knowledge about it to create drugs using specific methods that is. Yes, it'd be great if it all were free for all, but this is arguably why the patent system was created: it's very important research, even basic research that could never be fully financed by patent royalties. It's important that some of the certainly large financial gains the drug companies made with this discovery (a lot of antibiotics target the ribosome and were discovered using the patented processes) go to the institutions that financed the risky 20-year gamble in the first place. Being in the hands of a research organization, any money will be devoted to future research.

    2. Re:How by rodarson2k · · Score: 2, Insightful

      The problem with this patent is enforement. How can they prove that you used the Steitz ribosome structure to design your new drug and not, say, the Cate structure, or the Ramashandran structure? If anything, real science would be utilizing all of the available data, comparing and contrasting bacterial and human ribosomes to determine which sites are relevant for antibiotics.

      The coordinates are publicly available, anyway, so I could run MD on the structure for 1 picosecond and i would have "my" structure, which would be an interesting legal case in its own right.

      I can't find the time to read the entire patent, but in the abstract, the "methods" they claim are used on a daily basis by groups around the world. And have been for the better part of four years.

  6. patents... by wizardforce · · Score: 3, Insightful

    New rule: you can not patent anything that you yourself did not create. No patents should be granted for any component of a naturally occuring system. Create an entirely novel system that doesn't exist in nature? Fine, have at it. On a separate note, it seems to me that with all the trouble we seem to be having with our 200+ year old patent system, that we ought to be able to devise a better system for encouraging innovation.

    --
    Sigs are too short to say anything truly profound so read the above post instead.
    1. Re:patents... by Mendokusei · · Score: 2, Informative

      That has always been the rule. A naturally occuring phenomena is what is known as a "judicial exception," and is not eligible for patent protection.

    2. Re:patents... by Random2 · · Score: 2, Funny

      New rule: you can not patent anything that you yourself did not create.

      So, does that mean I can patent my children? Maybe they'll give me a Nobel peace prize for it too.

      --
      "Our goal each year should be to increase the number of goals we set for ourselves!"
    3. Re:patents... by matt4077 · · Score: 5, Informative

      New rule: you can not comment on something you didn't even bother to read. It's processes to find or design antibiotics targeting the ribosome that were patented, not the ribosome itself. You're creating millions of ribosomes each second, and you haven't been sued yet, have you?

  7. Answers to the Article's conclussion: by rwv · · Score: 5, Interesting

    But should research so fundamental to life, such as the ribosome structure, be locked up for commercial gainâ"like Dynamite? Should a private institution, such as Yale, have the only say over how ribosomes may be developed into new biomedical technologies?

    No, research should never be locked up. The patent system should evolve to the point where laymen with appropriate field knowledge and the right tools can copy ANY patented technique.

    Yes, Yale absolutely has a right to decide what they do with their patent. If they sit on it, that's fine. There are other methods of doing what they learned to do. If the license it, that's fine too. Giving businesses the ability to benefit from their basic research is a good thing.

    If Yale accumulates a big enough patent portfolio and tampers with the free market, they should be subject to government investigations and penalties. But in the case of Yale... they'll license to patent to bring in money to fund more fundamental research to future Yale scientists can advance the state of the art even further.

    If the author really wants to attack stupid biological patents, he should investigate (correct me if I'm wrong, but I believe the biggest offender is) Monsanto.

  8. Not as evil as author claims? by Volante3192 · · Score: 5, Informative

    From the article, ...cover not only the process for determining the structure of the molecules, but also the computation used to design new antibiotics.

    Now, this might not be saying the whole story, but it doesn't sound like the ribosomes are what's being patented (which would result in ire here). Instead, it's a technique of how to find what molecules and bindings are used by the ribosomes (or something along those lines.)

    The second part, the computation, probably a little more evil, but again it's a little light on details.

    I could probably do a patent search and see exactly what the abstracts are...but I doubt I could understand them without a tl;dr and a chemistry glossary.

    Basically, there's undoubtedly something patentable within this process it's just a matter of making sure they've got the right thing patented. I don't see anyone patenting a gene or a molcule here so there's no "nature made this already" defense. Furthermore, I don't think anyone can exactly make an "obviousness" claim here; USPTO might be pretty lax about prior art, but I'd think the Nobel committee would be a bit more thorough about trying to locate prior research.

    1. Re:Not as evil as author claims? by TeethWhitener · · Score: 2, Insightful

      You're onto something. I'm a chemist, so I can understand the patents without a tl;dr. What they've patented is a method for making high-quality crystals of ribosomes for x-ray analysis and the crystals (and this is key) produced by that method. Here's an analogy. I invent a new type of generator and I patent it and its products (electricity from that generator). Nothing wrong with that. Two days later, /. runs a story with the headline 'Crazy man patents electricity.' Aaaaaand scene. But in all seriousness, I do have to take /. to task for only having this story up about the Nobel Chem prize. Kind of spoils the importance of the discovery, guys.

  9. Before you comment... by H0p313ss · · Score: 5, Informative

    ... at least read the summary carefully. They didn't patent the natural structures.

    --
    XML is a known as a key material required to create SMD: Software of Mass Destruction
  10. They should strip the Nobels.... by Anonymous Coward · · Score: 2, Insightful

    ... from anyone who patents what they won them for. The prizes should reward altruism, not greed.

    1. Re:They should strip the Nobels.... by Volante3192 · · Score: 2, Interesting

      Then strip the prize money from the award too.

      Anyway, what would stop a pharmecutical from taking the method, getting their own patent for it and suing other people who use it into oblivion? In a utopia, you might have a point, but I'd rather Yale hold these patents than Merck, Pfizer or GlaxoSmithKline.

  11. Misleading Summary by cabjf · · Score: 5, Insightful

    It's not the "fundamental components of biology" that are being patented. It's the new methods of manipulating and studying them. I don't really see the problem. Patents can be licensed and will eventually end. It costs a lot of money in R&D to do this research. Why should an organization bear this cost out of the kindness of their heart? Isn't this pretty much the point of the patent system? To promote the sharing of new and novel ideas while still protecting the inventor's/researcher's work?

    1. Re:Misleading Summary by Volante3192 · · Score: 3, Interesting

      The article is very light on details, unfortunatly. I was personally hoping for a layman's description of what the patents constituted but instead it felt I was just reading an anti-patent tirade. But what was overlooked in the article is that they didn't patent ribosomes (which it sounded like what the author was trying to imply), but they patented a method for analyzing their structure.

      The irony is this could be one of the best cases FOR having patents. Yale spends millions on research, makes a breakthrough, licences it out to Big Pharma and as a result Yale is able to get funding for more research.

      I just wish there was more detail on the patents themselves rather than someone arguing against patents in general to make a better determination on how evil, to use the local patent buzzword, these patents actually are.

  12. Re:How long by coolsnowmen · · Score: 2, Informative

    I'm betting that the Article doesn't list a lot of googleable knowledge.

    Are you looking for something like this: http://en.wikipedia.org/wiki/Term_of_patent_in_the_United_States

    For applications filed on or after June 8, 1995,[1] the patent term is 20 years from the filing date of the earliest U.S. application to which priority is claimed (excluding provisional applications).[2]

  13. Re:Patent by Volante3192 · · Score: 3, Insightful

    Except this is much more complex than just cut and paste. You can't patent, say, a person blowing air into glass for the purposes of shaping but you can patent a machine that performs the same operation.

    The problem with this blog post is the author seems more bent on proclaiming "they patented this, patents are bad, therefore this is bad" rather than saying what parts of the patents are bad. There's obviously something novel in what was accomplished here. USPTO might be ignorant to prior art, but I doubt the Nobel committees are as lax.

    Plus reading the patent abstracts don't do me much good either; I lack the necessary background to make any heads or tails of them. (Hell, I can't tell the diff between an -ane and an -ene without a cheat sheet.)

    What I can tell is they're not patenting the ribosomes or any resulting compound created, but instead some method of isolating and analyzing them. This at least opens the door for a patent and is what the patent system was designed to protect. We have a methodology now that blue chip pharmecuticals are taking advantage of hand over fist but would never have gone through the risk of actually pioneering; it makes sense to have some of that trickle down to the people that actually created the process so they can continue research and make more breakthroughs (and allow the cycle to begin anew).

  14. Re:Patent by Zordak · · Score: 2, Insightful

    Especially not the claims. Reading the claims is tantamount to reading the article. The proper ./ method for commenting on a patent is to read the title, pick a few words out of the abstract, cry about how it's obvious and how patents are killing innovation, and cite as prior art some software that was released three years after the filing date and is irrelevant.

    --

    Today's Sesame Street was brought to you by the number e.
  15. Re:license fee? by schon · · Score: 3, Funny

    On the plus side, it does give you some leverage with poorly-behaved children. :)

    "Eat your vegetables, or I won't pay your license fee, and Monsanto will come to take you away!"

  16. To Summarize by Fnord666 · · Score: 2, Insightful

    USPTO might be ignorant...

    You could have stopped right there.

    --
    'The tyrant will always find pretext for his tyranny.' - Aesop's Fables
  17. Re:It depends entirely on investment capital ... by Fnord666 · · Score: 3, Informative

    Remember: the primary valid purpose of patents is to allow the recapture of investment capital plus additional profits in proportion to the utility of the discovery.

    I disagree.

    The purpose of the patent system
    The historical purpose of the patent system was to encourage the development of new inventions, and in particular to encourage the disclosure of those new inventions. Inventors are often hesitant to reveal the details of their invention, for fear that someone else might copy it. This leads to keeping inventions secret, which impedes innovation.
    - Ius mentis

    On Thomas Jefferson
    For Jefferson the purpose of the patent office was to promulgate invention, not protect them. These two reasons are why he formulated a policy for patents that encouraged invention but maintained restrictions on what could be patented. Thus he was able to be true to his beliefs and perform the duties foisted upon him by the Patent Act of 1790.
    - www.earlyamerica.com

    --
    'The tyrant will always find pretext for his tyranny.' - Aesop's Fables
  18. Re:license fee? by futurekill · · Score: 2

    Also lends more credence to the various forms of "...meet your maker..." phrases...

    --
    The gates in my computer are AND, OR and NOT; they are not Bill.
  19. Re:Patent by ajs · · Score: 2, Insightful

    It's true. The only problems with the patent system right now are:

    * Patents in fields that advance far more quickly than physical industries are protected for the same amount of time (e.g. software)

    * Patents can be trivially modified and re-submitted in order to "renew" an existing patent (e.g. pharma industry)

    * Prior art reviews and obviousness tests are poorly done, relying mostly on court challenges after the fact to resolve such issues

    Resolve those three problems and you have a patent system that accomplishes the original goal: to foster the advancement of the sciences and useful arts.

    I've proposed solutions here before, but to re-cap:

    1) Establish a product lifecylce metric for each industry and tie patent duration to reasonable multiples of the lifecycle (e.g. 2-4 times the time it takes to design and release a new product in that industry)

    2) Enhance the review process and reject far more patents on the basis of prior art.

    3) Open the prior art review process up to the public after the first round approval.

    4) Establish fines for those who repeatedly submit applications for patents that have prior art (not just a couple of times, but as an ongoing business practice; the goal is not to hurt individuals who make mistakes).

  20. Re:license fee? by cerberusss · · Score: 2, Interesting

    "Eat your vegetables, or I won't pay your license fee, and Monsanto will come to take you away!"

    Imagine their horror when they grow up and find out that, indeed, the boogeyman from their youth does really exist :-)

    --
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