Slashdot Mirror


How Terahertz Waves Tear Apart DNA

KentuckyFC writes "Great things are expected of terahertz waves, the radiation in the electromagnetic spectrum between microwaves and the infrared. Terahertz waves pass through non-conducting materials such as clothes, paper, wood and brick and so cameras sensitive to them can peer inside envelopes, into living rooms and 'frisk' people at distance. That's not to mention the great potential they have in medical imaging. Because terahertz photons are not energetic enough to break chemical bonds or ionize electrons, it's easy to dismiss fears over their health effects. And yet the evidence is mixed: some studies have reported significant genetic damage while others, although similar, have reported none. Now a team led by Los Alamos National Labs thinks it knows why. They say that although the forces that terahertz waves exert on double-stranded DNA are tiny, in certain circumstances resonant effects can unzip the DNA strands, tearing them apart. This creates bubbles in the strands that can significantly interfere with processes such as gene expression and DNA replication. With terahertz scanners already appearing in airports and hospitals, the question that now urgently needs answering is what level of exposure is safe."

18 of 279 comments (clear)

  1. Who cares... by Anonymous Coward · · Score: 5, Funny

    Who cares if we turn into an entire country of genetically deformed freaks, at least we'll be a country of SAFE and FREE genetically deformed freaks, right? Just as envisioned by our Founding Fathers. God Bless America.

    1. Re:Who cares... by Mister+Whirly · · Score: 5, Funny

      I know what you mean. I had a friend who talked on the cell phone all the time, and then 7 years later - BAM - herpes.

      --
      "But this one goes to 11!"
  2. Shoe-Fitting Flouroscope by eldavojohn · · Score: 5, Interesting
    Reminds me of the time I was at the Science Museum in Minnesota and they had an exhibit from the Museum of Bad Science (or something like that). Anyway they had a shoe-fitting flouroscope which was a device that shoe stores bought. Basically you would put shoes on your child's feet but to see how well they fit you would jam their leg in this thing and see the bones of the toes up to the tip of the shoe and see how well it fit. See the problem yet?

    Although store clerks were frequently exposed to the radiation from the machines, the radiation was more dangerous to children who placed their feet directly into the radiation. The exposure rate is thought to have been approximately 0.005 Gy to 0.058 Gy per second. If children tried on several pairs of shoes per visit it was posited that they could be exposed to as much as 0.1 Gy to 1.16 Gy. In fact, experiments indicated that radiation could exceed 1 microGy per hour as far as 10 feet away from the machine.

    This device should be a warning (and I think it has been if you look at how cautious people are of new technologies like cell phones). Hopefully my sperm aren't being fried when I walk through a scanner in an airport--at least the parents of the 30s were using X-rays for their convenience and not the invasion of their privacy!

    --
    My work here is dung.
  3. Remember citizen by Nursie · · Score: 4, Insightful

    continuity of the state and its power structures is far more important than petty things like individual freedoms or human lives.

  4. Ethical use of panic... by h4rm0ny · · Score: 4, Interesting


    So if there's a hysterical OMGCancer panic amongst the scientific illiterate, is it ethical to take advantage of that to protect ourselves against the privacy abuses of these things at train stations and airports and on the street?

    --

    Aide-toi, le Ciel t'aidera - Jeanne D'Arc.
    1. Re:Ethical use of panic... by oldspewey · · Score: 5, Informative

      Hasn't it always been the case that you have the option to decline to use "the machine" and be hand-searched instead?

      Until this issue gets resolved, that's what I plan to do anyhow.

      --
      If libertarians are so opposed to effective government, why don't they all move to Somalia?
    2. Re:Ethical use of panic... by AioKits · · Score: 4, Interesting

      With my assorted body jewelry I find it less hassle to actually be patted down. The scanners (last time I flew it was a millimeter waves scanner) always detect something 'on me'. The last time I went through they pulled me aside and asked, "Do you have anything on your chest sir?" I thought they were asking if I had something I wanted to tell them so I said no. They had to clarify, "Do you have any foreign objects on your chest?" I have one ring in that area, but it is only 12 gauge and not big enough to be mistken for anything really. So... I was escorted to a lil clear box, patted down, and sent on my way.

      I have little to no shame, so it didn't really bother me he was patting me down. In fact he seemed to grimace at the fact he had to do it, which made it all the more enjoyable to me.

      So now I just skip any of the scanners and opt for a pat down. It slows down security, it appears to make them uncomfortable, and if I'm lucky it'll be someone attractive patting me down.

      --
      "Quote me as saying I was mis-quoted." -Groucho Marx
  5. The airport scanners are passive by Anonymous Coward · · Score: 5, Informative

    If you follow the link provided about the airport scanners you find that they are passive devices meaning they don't emit terahertz waves they only recieve the waves coming off of everything around us.
    There are some devices out there that using terahertz radiation to inspect packages much like x-ray today.

    1. Re:The airport scanners are passive by Gadgetfreak · · Score: 4, Informative

      For now. But the last paragraph of the MIT article indicates newer cameras will have their own emitters.

      --
      "No fair, you changed the outcome by measuring it!" - Professor Hubert J. Farnsworth
    2. Re:The airport scanners are passive by natehoy · · Score: 5, Informative

      The MIT article has no citations to any models coming out that use active scanning. Meanwhile, the article summary clearly implies, no, actually STATES, that they are being introduced already into airports. Which is patently false. Active scanners ARE being introduced, but they are milliwave body scanners, and these passive t-wave scanners appear to be a more effective and safer alternative.

      "With terahertz scanners already appearing in airports and hospitals, the question that now urgently needs answering is what level of exposure is safe."

      The "terahertz scanners already appearing in airports", like the cited ThruVision T5000, are passive units. There is no discussion about "what level of exposure is safe" because there is no exposure to terahertz radiation. It's detecting what your body and possessions are already emitting.

      The t-band scanners are being tested for two reasons that seem to make sense to me, at least:

      1. Their imagery can detect materials more accurately whilst simultaneously not getting as accurate a picture of the actual body. This is better scanning with better privacy.
      2. The new scanners are passive t-ray detectors as opposed to active milliwave detector.

      Better scanning, less violation of privacy, no active emitter. If true, this sounds like a trifecta to me. I'd much rather pass through one of these than a milliwave unit.

      If and when ACTIVE t-band scanners start being introduced into general airport use, I'll share your concern and be right there with you in the pat-down line.

      --
      "This post contains words, known to the State of California to cause thought. Wash brain thoroughly after reading."
    3. Re:The airport scanners are passive by Anonymous Coward · · Score: 5, Informative

      Disclaimer: I am an expert in millimeter-wave and terahertz imaging systems.

      I wanted to emphasize to everyone reading this is that the parent is exactly right. ThruVision (the only commercial terahertz imaging system currently in airports) is passive, in that it detects the blackbody radiation being emitted by your body, clothes, and other objects, and compares it to the blackbody radiation of the background. The apparent difference in radiometric temperature is what constitutes the final image. There is no emission of terahertz radiation by this system.

      On the other hand, the active microwave systems, which operate around 35 GHz (there are variations on this, of course) are essentially an active radar system. You are exposed to some non-ionizing radiation, and its reflection from your body, clothes, and other objects is received and compiled to create an image. In terms of radiation, then, the active microwave systems are irradiating you, but at a level far below your cell phone. I can give citations if you like (or refer to the SPIE conference publications by the Pacific Northwest National Lab group who pioneered the system that is currently in airports.)

      Or we can talk about privacy. The active microwave systems have far better spatial resolution than the passive terahertz systems, since they take full advantage of phase in the imaging, and have a great SNR due to transmitting their own microwave power. (the passive systems mostly use direct detectors, which are really only sensitive to the magnitude of the radiation. ThruVision's, though, uses a heterodyne receiver, and thus is quite sensitive, but since it is very narrow-band [340 GHz, +/- 5 GHz], its sensitivity is similar to a direct detector) Fancy radar algorithms give you spatial resolution far better than the diffraction-limited optics definition you are probably used to hearing about. On the other hand, the passive terahertz systems are limited by the diffraction limit, and thus their operational wavelength gives you a good idea of their spatial resolution.

      You would then say that a passive terahertz system operating at 1 THz would give you much better images than a passive system at 340 GHz, and in terms of spatial resolution you are right. However, it is commonly known that clothing transmittance drops off quickly as frequency increases from 100 to 1000 GHz (and of course even more at higher frequencies, which is why you don't see thermal IR cameras being used to detect ceramic knives under your clothes). So, somewhere between 100 and 1000 GHz is a happy medium in terms of spatial resolution AND being able to see through multiple layers of clothing.

      And yes the parent was also right that the passive terahertz systems are very bad at gathering an image of the body, since it is essentially isothermal. No radiometric temperature contrast? No image.

      One thing that everyone has missed is the amount of power needed to "unzip" DNA with terahertz frequencies. (TFS poses this question, actually. The answer is in the arxiv article.) It's actually quite high, and it is very difficult to find a source that can emit this level of power. Yes, there are terahertz lasers (at the several microwatt level), but you should be more afraid of a 10 micron CO2 laser that will punch a hole through your chest, and is also quite invisible.

  6. In most cases, airport scanners are still optional by MadCow42 · · Score: 5, Informative

    The times I've encountered the terahertz scanners at airports, they've always been optional (although they don't make it clear to you that it is). If directed to one, I've always simply asked if I must use it or if I had a choice of a "normal" metal detector. EVERY time they've allowed me to choose (and I travel a LOT). Most times they take a note of it or ask me to sign a sheet to indicate my declination - I assume so they can figure out if people object or not.

    Asking the quesiton never hurts. It also sends the message that this intrusion isn't accepted by the public. Don't surrender to these things willingly.

    --
    I used to have a sig, but I set it free and it never came back.
  7. Are you mad?!?!? by elrous0 · · Score: 4, Funny

    You would deprive us of hundreds, if not thousands, of leaked nude photos of famous celebs just to save a little DNA?!?!? Are you insane, man????

    --
    SJW: Someone who has run out of real oppression, and has to fake it.
    1. Re:Are you mad?!?!? by ragefan · · Score: 4, Funny

      You would deprive us of hundreds, if not thousands, of leaked nude photos of famous celebs just to save a little DNA?!?!? Are you insane, man????

      I'm thinking either way, there is gonna be some DNA lost.

  8. Re:Translation by commodore64_love · · Score: 4, Insightful

    >>>People don't realize it, but our bodies birth cancerous cells constantly. We usually kill them off, though.

    Yes but irritants (like tobacco smoke) create MORE cancerous cells, and therefore increase the odds you'll die of cancer. The solution is to avoid those things that encourage cancerous growth.

    --
    "I disapprove of what you say, but I will defend to the death your right to say it." - historian Evelyn Beatrice Hall
  9. Re:Doesn't worry me by Sockatume · · Score: 5, Insightful

    Actually, it's a theoretical explanation for some difficult experimental results. The issue was that some studies suggested that THz radiation would be harmful at any frequency/power range, while others pegged it as only being significant at particular resonant amplitudes or frequencies. It transpires that in the presence of thermal perturbations, you do indeed get some non-specific disruption of the base pairing, which would only be an issue if you had a long enough exposure to actually get a significant thermal perturbation and thus cause a very significant disruption. However there is also a resonant mechanism, at a particular frequency with a critical minimum amplitude, that can immediately cause a significant disruption, without the need to wait for a particularly big thermal perturbation. That's my reading, anyway.

    --
    No kidding!!! What do you say at this point?
  10. Grossly simplified, but... by Sockatume · · Score: 4, Informative

    Single-stranded DNA has its information-encoding side exposed and flops around kind of pathetically. Double-stranded DNA sticks the two information-encoding sides together so that they're hidden and inactive, and helps you wind up and store the DNA. However the double strand can "unzip" along a small part of its length to expose two single strands which can go to work.

    You can get triple-stranded DNA, but it's not traditionally been thought of as important. Normally the groove for the third strand would be occupied by proteins involved in the function and maintainence of the DNA instead. However it now seems that forming a triple strand in some regions might be important in DNA's control mechanisms too.

    --
    No kidding!!! What do you say at this point?
  11. All your mutants are belong to us --DON'T PANIC! by cosmicaug · · Score: 4, Insightful

    Wait a moment, folk! We are talking about temporary separation of already uncoiled DNA (meaning, that it's probably under the process of being expressed, anyway) under very specific conditions as predicted by a computer model.

    This is not even an empirical observation: we don't know that any of this happens in a cell free in vitro system and how significant the effect is (if any), we don't know if it happens in a cell culture in vitro system and how significant the effect is (if any) and we certainly don't know that anything like this happens in vivo.

    Even assuming that you can create these precise conditions by an airport scanner (which seems rather doubtful), you certainly would not, in any way, be facilitating mutation in any appreciable sense*. All that you would be doing, theoretically, is to subtly alter patterns of gene expression for the few seconds it would take to walk through the scanner (basically, a very subtle regulatory effect). While you certainly can facilitate the development of cancer through such a mechanism (in fact, I'd argue that dysregulation of gene expression** at some points is simply required for carcinogenesis --yes, it can be caused by mutating proteins but these mutated proteins are almost invariably going to have direct or indirect regulatory functions***), such a dysregulation of gene expression would have be the prolonged, normal state of affairs of a cell for a cancer to actually happen. For this to be happening (in a worse case scenario) for as much as a few mere seconds can hardly even be called a dysregulation in any meaningful sense and much, much less have any effect, whatsoever, on carcinogenesis.

    If, on the other hand, some government agency is monitoring you 24/7 with these scanners, then you might have reason to worry****.

    * I would speculate that there's an infinitesimal chance that DNA might be more susceptible to mutations from not being as protected as it would be when paired but you have to realize that active regions of DNA get unzipped like this all the time so this effect, if it might be real, would be a drop in the bucket and utterly swamped by the background.
    ** For purposes of this discussion, what I mean by dysregulation of gene expression is the production of various protein products at inappropriate times or in the wrong amounts (either too much or too little of a protein).
    *** Whether the function is to induce cell division or stop cell division, or to induce cell death (apoptosis) or to evade cell death (and whether it is a direct or indirect effect on the preceding --such as mechanisms sensing DNA damage, loss of contact inhibition, etc.). While other factors which may not always be strictly regulatory do exist such as invasiveness, angiogenesis, telomerase function, etc (which often will also be regulatory by involving over or under expression); these factors need to happen together with a regulatory dysfunction for an actual cancer to happen because, basically, cancer happens when a lot of different sorts of things get screwed up at the same time.
    **** About adjusting your medication dose, that is.