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Reducing One Amino Acid Could Increase Lifespan

John Bryson writes "Eating less of one amino acid might lengthen your life. There have been lots of previous studies showing that many species live long on highly restricted calories, but a lot of this benefit may be possible by only restricting one amino acid. Amino acids that have shown this have been tryptophan and methionine. A recent study, published online December 2 in Nature, a highly respected journal, may help explain some of the health benefits of restricted-calorie diets."

7 of 286 comments (clear)

  1. One simple rule by Anonymous Coward · · Score: 5, Funny

    Now I can live longer and get a flat stomach by following ONE simple rule.

  2. Re:Prolong life as a what? by Tangentc · · Score: 5, Interesting

    RTFA indeed, if you read as far as the third paragraph you'd know that it was also proven on mice, dogs, and baboons. That makes this pretty likely to apply to humans as well. Though I'm confused as to why the summary says that tryptophan also has this property, as the article doesn't even use the word. I couldn't find the original Nature article, but the linked one certainly said nothing about it.

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  3. Link to actual study by Anonymous Coward · · Score: 5, Informative

    http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08619.html for the actual study

  4. Re:No Turkey for you... by B3ryllium · · Score: 5, Funny

    Eat four pounds of chicken and gravy, and then we'll see if you stay awake. :)

    I accept the terms of your challenge.

  5. Re:Yes, but... by RAMMS+EIN · · Score: 5, Informative

    ``Ideally, if giving up Trytophan is beneficial with no negative side effects, they'd create a pill that prevents your body from digesting it.''

    Interestingly, there are actually pills that contain tryptophan. Tryptophan is an essential amino acid and is one of the precursors to serotonine. Serotonine is a neurotransmitter, and low serotonine levels are associated with such conditions as depression and anxiety disorders. So people take extra tryptophan (or, more commonly, 5-HTP, the direct precursor to serotonine) to boost serotonine levels.

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  6. Re:Yes, but... by PopeRatzo · · Score: 5, Insightful

    they might be able to design drugs or other therapies that could give the benefits of caloric restriction without cutting calories.

    I want you to think about how expensive a drug to extend life would end up being. You think world and economic leaders want to see the lifespan of all humans suddenly extended? Regardless of the research and input costs involved in developing a longevity drug, I believe it would probably end up only available to, let's say, a certain "class" of people. I mean, we wouldn't want "those people" to have longer lives, which means they become more numerous, am I right?

    Even a sudden jump of 10 years to human lifespan would cause some social disruption. 20 years or more and the ground starts to shift under our social institutions.

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  7. Oh effing great by Opportunist · · Score: 5, Funny

    So what this essentially means is that we can choose between shorter lives and not wanting longer ones.

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