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Child Receives Trachea Grown From Own Stem Cells

kkleiner writes "Doctors at the Great Ormond Street Hospital (GOSH) along with colleagues at the University College London, the Royal Free Hospital, and Careggi University Hospital in Florence have successfully transplanted a trachea into a 10 year old boy using his own stem cells. A donor trachea was taken, stripped of its cells into a collagen-like scaffold, and then infused with the boy's stem cells. The trachea was surgically placed into the boy and allowed to develop in place. Because his own cells were used, there was little to no risk of rejection. This was the first time a child had received such a stem cell augmented transplant and the first time that a complete trachea had been used."

22 of 103 comments (clear)

  1. In the immortal words of Peter Griffin... by magsol · · Score: 3, Insightful

    Why are we not funding this???

    --
    "I'd just like to emphasise that taking a million years isn't a metaphor here..." -Rich Bradshaw
    1. Re:In the immortal words of Peter Griffin... by Gordo_1 · · Score: 4, Informative

      Everyone's stance on stem cell research should be queried by the DMV and added to your driver's license, just like organ donation. Then when you need a medical procedure that has benefited from stem cell research, you get the version of the procedure that's in line with your beliefs.

      I know... but I can dream can't I?

    2. Re:In the immortal words of Peter Griffin... by Anonymous Coward · · Score: 5, Insightful

      Most of the recent advances are done using stem cells from the patient's own body... this was always legal, but too many people got caught up in fighting for embryonic stem. Maybe the restrictions against using embryonic stem cells advanced medical technology by pushing researchers and doctors to use the patient's own stem cells instead.

    3. Re:In the immortal words of Peter Griffin... by Trepidity · · Score: 4, Insightful

      We are--- the restrictions on stem-cell funding have always been on embryonic stem cells, not on research involving stem cells derived from post-fetus-stage living humans, as is the case here.

    4. Re:In the immortal words of Peter Griffin... by LordLucless · · Score: 4, Informative

      Um, you are. Or at least, you could be. The restrictions on federal funding are on embryonic stem cell research. Embryonic stem cells are interesting for their pluripotency. Adult stem cells are interesting because they don't trigger rejection. Generally, nobody has any problem with adult-stem research.

      --
      Just because you're paranoid doesn't mean there isn't an invisible demon about to eat your face
    5. Re:In the immortal words of Peter Griffin... by MobyDisk · · Score: 2, Insightful

      1) Who is "we" in your question? This was done by:

      Great Ormond Street Hospital (GOSH) along with colleagues at the University College London, the Royal Free Hospital, and Careggi University Hospital in Florence

      2) If you meant the United States, this would be government funded had it been done in that country since it deals with adult stem cells.

    6. Re:In the immortal words of Peter Griffin... by dmuir · · Score: 3, Insightful

      When people say they're against "embryonic stem cell research" everyone else just hears "stem cell research" because they're too dumb to know the difference (and that's on both sides!).

    7. Re:In the immortal words of Peter Griffin... by Anonymous Coward · · Score: 2, Insightful

      So if the parent comment is true, then we are better off due to the anti-abortion crowd. You see, if it wasn't for that there might not have been as much research into adult stem cells. Because embryonic ones are "good enough". Who cares if the patient has to take anti-rejection drugs for the rest of his life, that is just more money the pharma companies get.

    8. Re:In the immortal words of Peter Griffin... by Princeofcups · · Score: 4, Insightful

      Most of the recent advances are done using stem cells from the patient's own body... this was always legal, but too many people got caught up in fighting for embryonic stem. Maybe the restrictions against using embryonic stem cells advanced medical technology by pushing researchers and doctors to use the patient's own stem cells instead.

      Not at all. This was a natural evolution, especially due to the rejection issues. If anything, we would have had this technology sooner as more scientists would have gotten involved earlier, and we would be much further ahead.

      --
      The only thing worse than a Democrat is a Republican.
    9. Re:In the immortal words of Peter Griffin... by Lord+Kano · · Score: 4, Insightful

      I know... but I can dream can't I?

      Dream? You can't even pay attention. No one has fought against funding for research into cures using adult stem cells. No one has fought against funding for research into cures using your own stem cells. Try to pay attention.

      LK

      --
      "Hi. This is my friend, Jack Shit, and you don't know him." - Lord Kano
    10. Re:In the immortal words of Peter Griffin... by BitZtream · · Score: 2, Insightful

      Uhm ...

      His original statement is most certainly fact, more scientists where forced into doing things like this with stem cells because they couldn't use the embryonic cells they would have liked to use. This isn't something debatable, its history, its what happened.

      You can say it may have happened faster some other way, but you can't say that more people would have been working on it since the rules forced that didn't want to use this method to use it. No one that wanted to use this method stopped completely to make a point because they weren't allowed to use some other method, thats only something GPL fan boys and political nut jobs do.

      You can go ahead and try to push your own political agenda for other forms of stem cell research, thats cool and all, but the facts and history make it pretty obvious your statement doesn't really have any connection to reality.

      --
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    11. Re:In the immortal words of Peter Griffin... by HungryHobo · · Score: 4, Informative

      correction:
      Nobody who understands the difference has fought against funding for research into cures using adult stem cells.

      There's a massive ignorant crowd of fundies who still consider anything and everything to do with stem cells to be bad.

  2. "Minor" correction by oldhack · · Score: 2, Insightful

    The headline would be correct if we can synthesize the collagen molding and do away with the need for donor organ.

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    Fuck systemd. Fuck Redhat. Fuck Soylent, too. Wait, scratch the last one.
  3. let me just say by martas · · Score: 4, Insightful

    holy crap.

    good job, guys.

  4. Re:Cancer? by Kjella · · Score: 4, Insightful

    There's always some people who need surgery NOW and whether they get cancer in 2-5-10-20 years or not it's still a win. I'm all for medical testing and not rushing out unsafe procedures, but the reactions I see are mostly knee-jerk "it's STEM cells, omg you can't" not based on real research. In fact, they don't want the research done in the first place. Of course it's highly experimental medically, so was heart transplants. The first guy survived two weeks, but today we average 15 years. Research can prove or disprove (ok, don't get all philosophical on me) whether it helps medically, but it won't matter because most of the resistance is due to the fanatic anti-abortion crowd which equate embryonic stem cells with unborn babies. And if it's not embryonic, they'll pretend there's no difference because only blind rage will do.

    --
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  5. Stem Cell Hucksters Spam, Email Servers Crash by WidgetGuy · · Score: 2, Funny

    ...adjusting "penis enlargement" spam filter to let emails with "stem cells" in the subject or body through...

    You're never too rich, too thin or too well-hung.

    --
    One "Aw, Shit!" is worth 100 "Ata boys!"
  6. Re:Cancer? by ThomConspicuous · · Score: 3, Informative

    I have my son's stem cells in a bank. He's alive and healthy at 1.5 yrs old. Still, it's good to know that we have them.
    They came from his cord blood. I'm pretty sure that can be considered embryonic, but I'm not a doctor or scientist. Just a happy parent.

  7. Combo Breaker by sick_em · · Score: 3, Interesting

    Wait a second, stem cells that regenerate but will probably give you cancer, and nanoparticles that eat cancer for breakfast ...if my math works out correctly regeration + cancer - cancer = regeneration (or at least non-rejectable organ transfers). Can anyone say ultra combo?

  8. Re:Cancer? by TooMuchToDo · · Score: 2, Insightful
    Was it expensive to have it saved?

    /not a parent....yet

  9. 3-D printing + Stem Cells by HighOrbit · · Score: 3, Interesting

    Instead of using a donor and then stripping cells to get the collogen scaffold, next they should do 3-D printing of collogen into any shape they want. "Grown" organs in the future will not be grown, they will be built layer-by-layer.

  10. Re:Cancer? by ThomConspicuous · · Score: 2, Interesting

    It was about $2k initially w/ 12 mths interest free plans. Not super cheap but we felt it was worth it.
    We used Cord Blood Registry at www.cordblood.com
    It's $125/yr renewal but there are referral incentives.

  11. Re:Cancer? by Will47 · · Score: 3, Insightful

    Stop this BS guy... Come on, you speak of anti-abortion activists. Right, ANTI-ABORTION activists... It is not the use of stem cells they are fighting, and if you read their papers where they speak about stem cells, there is a context for it, and you know it as well... You can disagree with them as much as you want, but here, you are just distorting the truth (sure, it is an easy way to demonize and discredit them). BTW, they are sure happy with alternative paths making embryonic (and abortionist) stem cell research unneeded or useless.... It's just one of their best weapon and their best argument with indecisive people.