Slashdot Mirror


The Future of the Most Important Human Brain

mattnyc99 writes "About a year ago, we watched live as neuroanatomist Jacopo Annese sliced the brain of Memento-style patient Henry Molaison (aka H.M.) into 2,401 pieces. Since even before then, writer Luke Dittrich — whose grandfather happened to be the surgeon to accidentally slice open the H.M. skull in the first place — has been tracking Annese and a new revolution in brain science. From the article in Esquire: 'If Korbinian Brodmann created the mind's Rand McNally, Jacopo Annese is creating its Google Maps. ... With his Brain Observatory, Annese is setting out to create not the world's largest but the world's most useful collection of brains. ... For the first time, we'll be able to meaningfully and easily compare large numbers of brains, perhaps finally understanding why one brain might be less empathetic or better at calculus or likelier to develop Alzheimer's than another. The Brain Observatory promises to revolutionize our understanding of how these three-pound hunks of tissue inside our skulls do what they do, which means, of course, that it promises to revolutionize our understanding of ourselves.'"

18 of 252 comments (clear)

  1. An odd approach... by Rival · · Score: 3, Interesting

    While I have no wish to demean their efforts, this approach still seems somewhat brutal to me. I'm no neurologist, but isn't this still a rather macro-level view of things, with the cutting process still causing damage to the fine structures they want to study?

    It seems likely to me that future scientists will look back at this in not too long with stifled laugher and perhaps a little shock at the approach.

    1. Re:An odd approach... by Raenex · · Score: 3, Insightful

      There are lots of ways to image and study the brain. This is just one more. Sure, in a hypothetical future they might be able to scan it down to the finest detail, but for now we do what we can.

    2. Re:An odd approach... by fuzzyfuzzyfungus · · Score: 5, Insightful

      It almost certainly is disrupting fine structures or details of network connections that future neurologists might want to study; but I suspect that this is one of those situations where they don't really have a choice.

      The brain is extremely complex, and nondestructive imaging methods are either expensive, low-resolution, or both. Good old slice-n-stain, with a dash of modern robotics, is cheap and high resolution.

      Since we know so little about how brains actually work, it isn't a bad idea to just build a giant dataset, using an economic and high-resolution technique, and hope that that dataset allows future researchers to pinpoint more closely what they should actually be looking for.

      Given that the supply of brains donated to science, while not huge, can be reasonably expected to continue into the indefinite future, starting with destructive; but quick, reverse engineering steps, and then gradually progressing down to finer, more focused ones, seems pretty sensible.

      A lot of the brains thus sliced will, it is true, be destroyed as far as the researchers of the future are concerned; but slicing them may be the only way to get the researchers of the future to a position of sufficient knowledge.

    3. Re:An odd approach... by TapeCutter · · Score: 4, Funny

      Or as Douglas Adams put it - "If you try and take a cat apart to see how it works, the first thing you have on your hands is a non-working cat."

      --
      And did you exchange a walk on part in the war for a lead role in a cage? - Pink Floyd.
    4. Re:An odd approach... by interkin3tic · · Score: 5, Informative

      but isn't this still a rather macro-level view of things, with the cutting process still causing damage to the fine structures they want to study?

      No, the cryostat is designed to preserve things down to the subcellular level. Had they just cut it up with a scalpel, yeah, that would not preserve much. Fixing it with, say, paraformaldehyde, then freezing it and sectioning it, the sections do okay if you're skilled at it. You can see down to the neuron level.

      It seems likely to me that future scientists will look back at this in not too long with stifled laugher and perhaps a little shock at the approach.

      I personally am always astounded at what past scientists were able to accomplish with the tools at hand. Ramon Y Cajal, the "father of neuroscience" had primitive microscopes and a method of staining cells that sounds exhausting, but described the brain in astonishing detail. I personally doubt I could have accomplished what he did with the tools we have now. Unless future scientists are idiots, they'll likely realize that these are the best tools we have now.

    5. Re:An odd approach... by sznupi · · Score: 3, Funny

      As opposed to working cat before? What's that?

      (/me looks around...yup, the beast sleeps; on the coffer this time)

      --
      One that hath name thou can not otter
    6. Re:An odd approach... by CrimsonAvenger · · Score: 3, Informative

      She said the weapons they used on the soldiers at the time also helped to crank up the barbarism, with soldiers often loading chains, nails, and anything else they could find into cannons when they ran out of shells.

      This is not so likely to be historically correct as one might suppose. Fact is, what they fired out of cannons back then wasn't loose powder and shot, but a single bag containing powder and a cannonball. In other words, if you don't have any cannonballs (not shells), then you've got no powder to shoot nails and chains.

      Sure we already knew about anesthesia, but good luck finding any in a muddy field hospital in the middle of TN with a battle going on.

      Ether was used more than you might suppose in the Civil War. At least by the Union, who could afford to make the stuff and had the wherewithal to deliver it in quantity to their armies.

      Troops and doctors on both sides simply didn't realize it was gonna be such a hideous war, believing it would be a "gentlemen's conflict" like the revolutionary war.

      Anyone who believed in 1861 that the Revolutionary War was a "gentlemen's conflict" was so deluded about history that he can be excused for thinking that the Civil War was going to be one. Alas, history doesn't agree about the nature of the Revolutionary War.

      Note, for reference, that the people who tended to think in terms of "gentelmen's war" were mostly Southern aristocrats. Most of the soldiers on both sides weren't able to kid themselves that standing on a battlefield with 30,000+ other people trying to kill you was going to be a friendly sort of affair.

      a muddy field hospital in the middle of TN with a battle going on

      Oddly enough, I had a great-great-grandfather in just such a situation. Battle of Franklin, in fact.

      --

      "I do not agree with what you say, but I will defend to the death your right to say it"
  2. Clearly this is a front organization by Anonymous Coward · · Score: 3, Funny

    Clearly this a front organization--for zombies!

  3. Re:This is simply misguided -- don't we know bette by h4rr4r · · Score: 3, Insightful

    No, someone's intelligence or outlook on the world is a combination of upbringing, willpower and education. Anyone could be as intelligent and knowledgeable as they wanted to be, if they wanted to be.

    How young are you?
    This is one of the most naive things I have ever heard. Some folks are never going to be rocket surgeons.That might not be ok with the current everyone is a genius and everyone gets a trophy crowd but it is the truth.

  4. Re:This is simply misguided -- don't we know bette by LoudMusic · · Score: 5, Insightful

    This is so unbelievably unintelligent that if it weren't so long I might think it was a joke.

    I often resort to extreme examples when explaining the ability for variations to people who deny variations exist. So with that in mind, an extreme example of a different kind of brain would be the autistic mind. Clearly it is different. It has little to nothing to do with the way the person was raised or educated over time. It is how their brain was created. If a brain can be created to that extreme of difference why not changed in more subtle ways that allow enhanced mathematical capabilities or greater empathy.

    Just because you can't see it doesn't mean it doesn't happen or exist.

    The whole point of science and these studies is to figure these things out. To learn about the things we can't see but effect our daily lives.

    --
    No sig for you. YOU GET NO SIG!
  5. Re:This is simply misguided -- don't we know bette by jelizondo · · Score: 5, Insightful

    Sorry to disagree with you, but clearly the physical properties of the brain matter.

    Which physical properties? Well, we need to find out.

    Think about it for a while. All my life I would have given a leg and an arm to learn to play any musical instrument (went to schools for years) and could never get beyond the really easy stuff; a seven year-old child could out-play me every time. But I have a gift for analisys and abstraction, thus I'm good at writing software.

    You say upbringing, education and will-power. Well I had all three: mom was a music director who wrote music and poetry, I went to very good music schools and I yearned to be able to play music; I simply don't have the right "hardware".

    Try running Deep Blue's software in your bog standard PC, see how far it gets.

    --
    Be very, very careful what you put into that head, because you will never, ever get it out. - Cardinal Wolsey
  6. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 3, Informative

    Affect

  7. Re:This is simply misguided -- don't we know bette by Naturalis+Philosopho · · Score: 3, Insightful

    I was going to mod you troll, but I'll give you the benefit of the doubt that you really do believe that all brains are created equal- but in that case, and by your own argument, you must not be very motivated or lack the discipline to learn the truth of the matter. I wonder what could account for that?

  8. Re:This is simply misguided -- don't we know bette by Bruce+Perens · · Score: 3, Informative

    This illness for which H.M. is studied is one with gross pathology that should be very visible with the method used. The study of Einstein's brain did the most important thing that a scientific experiment can do: it falsified a hypothesis. Nobody really knew that Einstein did not have gross pathology until they looked. This is not to say that the person who kept Einstein's brain in a jar on his desk for his whole life had any right to do that, but preserving the brain for the imaging tools of a later generation was a good idea.

  9. It is being done for the heart by npuzzle · · Score: 3, Interesting

    The same applies to the dissection of other organs as well. For instance, any dissection of the heart is inherently biased towards the cutting planes defined by the dissector (source). The true arrangement of muscle fibers in the left ventricle of the heart (more precisely the existence of sheet structure) is still a subject of hot debate because of this. Obviously, one might think that by now, we should be able to just pick an organ and throw it into the best relevant imaging scanner (CT, MRI, PET, etc.). The truth is, there is still anatomical information that even state-of-the-art medical imaging modalities cannot reliably reveal.

    As an example, consider DT-MRI that measures the diffusion of water molecules along the tissue fibers in an organ. The discretization in the data is such that only the local average orientation of the diffusion of water is known at any given location. To obtain more useful anatomical information, the full fiber pathway in a region needs to be reconstructed, a task called fiber tractography. Different computational methods based on different anatomical assumptions lead to results that are often contradictory (as is the case in the heart models described in the article cited above) and since there is no ground truth (remember that the dissection is biased), we currently hit a dead-end.

    Hopefully, as more dissections (like this one) are performed and the data is made available publicly, we will eventually be able to faithfully reconcile pieces of what we observe in medical conditions, in medical scanners, and on the dissection table.

  10. Re:This is simply misguided -- don't we know bette by cptdondo · · Score: 5, Insightful

    Anyone with that aspiration can teach themselves what they need to, go to school or get training, and do it. Especially for that type of discipline(physics/math) where prerequisite knowledge is more important than original thinking.

    You're not serious, are you?

    You mean I can train myself to have perfect pitch, like some musicians? Or to have perfect color sense, like artists? Or a deep understanding of multiple dimensions?

    That's like saying that we can all play basketball like Wilt Chamberlain, or ride a bike like Lance Armstrong.

    Each brain is drastically different, each is capable of different things. No amount of training will make my daughter an engineer like her brother in spite of her nearly perfect math skills. No amount of training will give my son the empathy to deal with animals like his sister has.

    Brains are as different as our bodies, and no amount of training will let me run a marathon; my body won't allow it. For some, no amount of training will let them keep up with me on a bicycle.

    No amount of training will let most people keep up with me in my field of intellectual expertise; I have great vision in that one area, and I'm a total doofus in others.

    Yeah, I can learn to flip burgers. But that won't let me compete with an accomplished chef, who has talent and vision.

  11. Still... by denzacar · · Score: 3, Insightful

    I can't escape a feeling that what they are doing is akin to slicing apples and then taking high grain black and white photos of those slices - in order to find out how they taste.

    --
    Mit der Dummheit kämpfen Götter selbst vergebens
  12. Re:This is simply misguided -- don't we know bette by jelizondo · · Score: 4, Funny

    The Funny English Language

    No wonder the English language is so very difficult to learn.
    I sometimes wonder how we manage to communicate at all!
    We'll begin with a box and the plural is boxes.
    But the plural of ox should be oxen, not oxes.

    The one fowl is a goose but two are called geese
    , Yet the plural of moose should never be meese.
    You may found a lone mouse or a whole set of mice,
    Yet the plural of house is houses not hice.

    If the plural of man is always called men,
    Why shouldn't the plural of pan be called pen?

    If I speak of a foot and you show me your feet,
    And I give you a boot, would a pair be called beet?
    If one is a tooth and a whole set are teeth, Why should not the plural of booth be called beeth?

    Then one may be that and three would be those,
    Yet hat in the plural wouldn't be hose.
    And the plural of cat is cats and not cose.

    We speak of a brother and also of brethren,
    But though we say Mother, we never say Methren,

    Then the masculine pronouns are he, his and him,
    But imagine the feminine she, shis and shim, So English, I fancy you will all agree,
    Is the funniest language you ever did see.

    Why can’t people from all over the world speak English?

    --
    Be very, very careful what you put into that head, because you will never, ever get it out. - Cardinal Wolsey