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Dolly the Sheep Alive Again

SpeZek writes "Dolly the sheep has been reborn. Four clones have been made by the scientist behind the original research. The quads, which have been nicknamed 'the Dollies,' are exact genetic copies of their predecessor, who was put down seven years ago. The latest experiments were partly carried out to check if improvements to the technique cut the risk of problems in and out of the womb. Named after country and western singer Dolly Parton, Dolly was created from a cell taken from a mammary gland. The rest of the sample of tissue has lain in a freezer since, until it was defrosted to make the Dollies."

52 of 233 comments (clear)

  1. Just in time for christmas .... by tomhudson · · Score: 5, Funny
    Bahhhh, Humbug.

    Pass the mint jelly :-)

    1. Re:Just in time for christmas .... by NotQuiteReal · · Score: 4, Funny

      ...freezer... until it was defrosted...

      I don't know, it is never as good after that. But still, with enough jelly...

      --
      This issue is a bit more complicated than you think.
  2. Dolly Parton by Dan+East · · Score: 2, Interesting

    Okay, is my mind totally in the gutter, or is there a significance to the mammary gland / Dolly Parton link?

    --
    Better known as 318230.
    1. Re:Dolly Parton by Microlith · · Score: 4, Informative
    2. Re:Dolly Parton by CaptainPatent · · Score: 5, Funny

      Glad we could keep you abreast of the situation.

      --
      Well, back to rejecting software patent applications.
    3. Re:Dolly Parton by Xeno+man · · Score: 5, Funny

      A few billion Barbie dolls would disagree.

    4. Re:Dolly Parton by grcumb · · Score: 2

      Okay, is my mind totally in the gutter, or is there a significance to the mammary gland / Dolly Parton link?

      Well, if it helps, the meadow where they graze is called the Valley of the Dolls....

      (If you were a New Zealander, the mere mention of sheep would have been enough....)

      --
      Crumb's Corollary: Never bring a knife to a bun fight.
    5. Re:Dolly Parton by MacGyver2210 · · Score: 4, Funny

      Well this news is simply TITillating!

      --
      If the only way you can accept an assertion is by faith, then you are conceding that it can't be taken on its own merits
    6. Re:Dolly Parton by Mistlefoot · · Score: 5, Funny

      Are we only going to here that nice pair of jokes or are people going to keep milking this one?

    7. Re:Dolly Parton by CaptainPatent · · Score: 5, Funny

      Don't be such a boob.

      --
      Well, back to rejecting software patent applications.
    8. Re:Dolly Parton by Qzukk · · Score: 5, Funny

      Are we only going to here that nice pair of jokes

      You could say this thread is a bust.

      --
      If I have been able to see further than others, it is because I bought a pair of binoculars.
    9. Re:Dolly Parton by jrumney · · Score: 2

      Or rather, was known for them, before the days of augmentive surgery. Nowdays they would probably be rather average by Hollywood standards.

    10. Re:Dolly Parton by Ihmhi · · Score: 4, Funny

      The whole thing went tits up!

    11. Re:Dolly Parton by mcgrew · · Score: 2

      Ewe must be knew here.

  3. Dolly is the new teacup? by Anonymous Coward · · Score: 4, Interesting

    I'm curious to know if Dolly will be the new teacup (used to test rendering algorithms) or Lenna (for image processing).

    Will we be cloning the same sheep over and over again as a common reference?

  4. Re:Awesome. by TheKidWho · · Score: 2

    Well, it's not as if they created her out of some sort of vacuum. They're just manipulating the machines that nature has already provided.

  5. REINCARNATION DOES NOT WORK THAT WAY! by straponego · · Score: 3, Funny

    GOOD NIGHT!

  6. Not alive again by Culture20 · · Score: 3, Insightful

    Stupid journalists and movie makers keep thinking cloning something makes a true copy. These are genetic progeny; Dolly's sisters, not Dolly.

    1. Re:Not alive again by afidel · · Score: 2, Insightful

      No, they are being cloned from the same sample that Dolly was cloned from. Since the DNA won't be exactly the same as the cell that was used to create Dolly I would say sisters is the most appropriate, unless they used DNA polymerase on the original cell and these are being created from that same cell's mass copied DNA in which case they are simply identical clones of the Dolly line =)

      --
      There are 4 boxes to use in the defense of liberty: soap, ballot, jury, ammo. Use in that order. Starting now.
    2. Re:Not alive again by Atmanman · · Score: 5, Insightful

      Its clear they aren't sisters, daughters or twins. Maybe we need a new word for what they are. Oh wait, we do... they're called CLONES.

  7. Should have named them by initialE · · Score: 2

    Duncan Idaho...

    --
    Starbucks, Harbuckle of Breath.
    1. Re:Should have named them by beefncheese · · Score: 2

      Looks like the beginning of the golden pa-a-a-a-a-th.

  8. Re:I wonder how the pet resurrection is going by tomhudson · · Score: 4, Insightful

    This makes me wonder how many people are cloning their pets and bringing them back.

    I'm not sure I could do that myself. I miss some of mine, but would it be appropriate to bring them back, or should I just get another?

    Don't know. But I think about it.

    There are so many that need homes right now ... I know that I miss my first Newfie and my St. Bernard, but I also know that when my current Newfie and mutt pass on, there will always be other large dogs that need a home ...

    -- Barbie

  9. now we know the identity of by QuantumBeep · · Score: 2

    Now we know the identity of the Lost Cylon.

  10. For years by Colourspace · · Score: 3, Insightful

    They've been doing this for years in Medicine. Just ask Henrietta Lacks.

  11. A major "con" of cloning falls apart by Myji+Humoz · · Score: 5, Interesting

    From the article, the original Dolly was put down after about 6 years due to all kinds of medical conditions (infections, arthritis, etc). However, these four sheep are 3.5 years old, and are apparently in perfect health. A major argument against the use of cloned animals in animal husbandry (either cloning particularly tasty animals or using clones to breed) is that cloned animals end up in constant agony due to their origin.

    Since these cloned animals appear just as comfortable and pain free as your "run of the mill" farm animal, it seems as if cloned animals can be just as humane to farm as normal animals. In fact, since the meat yield from each animal is much higher (by definition of selective cloning as the pinnacle of selective breeding), I would argue that using more cloned animals would reduce the ecological impact of the meat industry.

    Ye average American Joe might not want to eat cloned meat, but clones are already breeding like mad to produce more productive offspring. Perhaps this new longitudinal study will give more insights on the ethics and health impacts of cloned meat.

    --
    Signatures are the new names.
    1. Re:A major "con" of cloning falls apart by Anonymous Coward · · Score: 5, Insightful

      And by breeding hundreds, thousands or even tens of thousands of Dollys, you make a population that will collapse much faster when that virus or bacteria mutation comes along that has a liking for the Dolly host.

    2. Re:A major "con" of cloning falls apart by bogaboga · · Score: 2

      I wouldn't mind eating beef from a cloned animal if I were to be informed accordingly. Matters become rather complicated when it comes to burgers and other processed meats where I understand such meats might be made of more than 100 animals. Scary!

    3. Re:A major "con" of cloning falls apart by daemonc · · Score: 2

      I had never heard that argument, but even if it were true it would still be absurd. Compared to the horribly unsanitary conditions that exist on most factory farms, and the painful end in store for them at the slaughter house, I'd think a little arthritis would be the least of the animals' worries.

      But all that aside, this is still not the "major con" to cloning. The big one that comes to mind is the susceptibility to disease due to lack of genetic diversity. All it takes is one mutation in some common disease, and not only is your herd / crop wiped out, but so is everyone's who bought the same clones.

      --
      All that we see or seem is but a dream within a dream.
    4. Re:A major "con" of cloning falls apart by Myji+Humoz · · Score: 4, Interesting

      The article says that: "Animal welfare campaigners say that cloned animals and their surrogate mothers still suffer immensely."

      The immune system argument is indeed the primary flaw of mass cloning, but our understanding of the role of genetics in forming an immune system is weak at best. However, we do know that immune systems aren't deterministic; genetic makeup X + environment Y doesn't always yield protection Z. As you said, the unsanitary conditions in factory farms induce tremendous suffering in the animals, but it also leads to a serious suppression of natural immune function. They are pretty much saturated in antibiotics from birth to slaughter to suppress infections; their natural immune system are essentially useless in those conditions. I'm purely speculating here, but what if a particular animal or animal line had an immune system that retained most of its function under terrible conditions? What if a particular animal displayed tremendous variability in initial antibody seeding?

      It's tempting to think of animals as computer systems, where a single computer virus can easy take over identical systems with nearly identical ease. However, the immune system just doesn't work like that. To use a crude and somewhat misleading example, factory farms are like networks of computers running Windows XP with no service patch, no firewall, and no built in antivirus. However, every 4 hours, a godlike remote antivirus scan is run, and purges each system. If a virus or a bacterial strain is powerful enough to kill a line of Dollies, it's most likely strong enough to kill a line of sheep on the constant verge of death. Throw in antibiotic overuse, and it seems unlikely that there's a statistically significant risk increase between a factory full of Dollies and a factory full of randoms.

      --
      Signatures are the new names.
  12. Re:I wonder how the pet resurrection is going by Arancaytar · · Score: 2

    What is the difference between getting a new pet and getting a new pet that shares your old pet's DNA?

    (Aside from the high risk of the clone having genetic defects and dying young.)

  13. Piracy by Degro · · Score: 4, Interesting

    So how long until the first genetic piracy article on Slashdot?

    1. Re:Piracy by igreaterthanu · · Score: 2
      T+4years

      From a quick Google search, there are probably earlier examples.

      --
      I dream of a nation where a man is not judged by his skin color but by an number assigned by a credit rating agency.
    2. Re:Piracy by SheeEttin · · Score: 4, Informative

      It's been and gone. Haven't you heard of Monsanto?

  14. Re:I wonder how the pet resurrection is going by rubycodez · · Score: 5, Funny

    I would think after 3 or 4 incarnations you'd not feel so guilty about putting a bullet in one after it shits on the carpet

  15. Obligatory Dune Reference by fl_litig8r · · Score: 3, Funny

    Dolly Idaho.

  16. So it is written. by fuzzyfuzzyfungus · · Score: 3, Funny

    Abduhl Al-Hazred, in his Necronomicon wrote:

    "That is not dead which can eternal lie,
    And with strange aeons even death may die."

  17. Re:Human Cloning by jack2000 · · Score: 2

    There's a gene literally one gene in particular that determines how well your body copes with extreme long running sessions.
    Those with one expression of it keep on jogging while the ones with a slightly different collapse. The ones with the first gene are also better suited to prolonged exertions of force.
    The geneticists who actually breathe drink and live the human genome every day know of many genes that combined properly will give you the ultimate soldier.
    It doesn't stop there, you can have faster thinking scientists, people needing less sleep the posibilities are endless. It boggles the mind why we as a society are crippling our scientific pursuits, and for what? For nothing!

  18. Four sheep at once by hessian · · Score: 4, Funny

    Now that is a Texas-size sexual fantasy!

  19. Reagan by Tablizer · · Score: 5, Funny

    The GOP is hoping to clone Ronald Reagan before the 2012 election, being that they are short real candidates.

  20. Re:I wonder how the pet resurrection is going by icebike · · Score: 3, Informative

    There is no bond. Its a new individual. Its all in your head. The animal won't know or care.
    One thing you can be assured of is that it will have a different personality (anamality?). You will probably be disillusioned.

    --
    Sig Battery depleted. Reverting to safe mode.
  21. Re:I wonder how the pet resurrection is going by Dan+East · · Score: 5, Insightful

    Too much of the development is dependent upon protein activation times and whole bunch of other stuff I know nothing about, for the cloned animal to be exactly like the original. For example, in the case of cats, the color is not directly determined by the DNA. The cat CC was the first cloned pet, and it did not look like its genetic donor. I imagine behavior is even more finicky, as it is affected by experiences and other such nebulous factors.

    --
    Better known as 318230.
  22. Re:I wonder how the pet resurrection is going by amRadioHed · · Score: 3, Funny

    Exactly. When my dear kitty passes on I'm sure she'll want me to give another shelter cat the same chance at a happy life that she had.

    Plus, why would I disturb her from her eternal nap? Surely that's any cat's idea of heaven.

    --
    We hope your rules and wisdom choke you / Now we are one in everlasting peace
  23. Re:Awesome. by Anonymous Coward · · Score: 2

    They said only god could create life, well, then Dolly is irrefutable prove that there is no god.

    Or that they were wrong about only God being able to create life.

  24. Not Exact Copies by pbizannes · · Score: 2

    Unless they used eggs from the same host animal as before, they are unlikely to be genetically identical since the mitochondrial DNA will be different.

    The mitochondrial DNA problem is one reason why embryonic stem cells produced via cloning are still rejected by the animal in which it is implanted.

  25. Re:I wonder how the pet resurrection is going by Anonymous Coward · · Score: 2, Interesting

    (I'm not the same AC)

    I think it's presumptive to assert that clones will have a different personality. I imagine that's quite possible, especially for those who adopted pets which were already mature (thus their personality was fully formed beforehand). However, I've had several cats from birth (because we had taken in the mother), and other cats and dogs right from weaning. Those animals developed their personalities under our care, and I suspect there would be a better than even chance that their clones' personalities would at least be very similar to original. I base that on the idea that whatever part of cat (or dog) personality is determined by genetics should be identical (barring cloning errors), and that the environment in which they would develop would be quite similar.

    That said, I'd probably rather just take in strays/rescues, particularly given the likely ridiculous costs of pet cloning.

    - T

  26. And in a freak lab accident... by ToastedSpider · · Score: 2

    The result was a Dolly Llama

  27. Re:Awesome. by Custard+Horse · · Score: 3, Funny

    I wonder if they have a hive mind - could this be the first Beowool cluster?

  28. Re:Awesome. by VolciMaster · · Score: 2

    I wonder if they have a hive mind - could this be the first Beowool cluster?

    If the sheep have a hive mind, wouldn't it be a Bee-O-Wool cluster?

  29. Re:I wonder how the pet resurrection is going by dylsexia · · Score: 2

    I'm reminded of an old vet friend telling us about the "$4.95 budgie cure". When some tearful kid would come in holding a stone cold bird, the vet would quietly nip out the back door to the k-mart next door and buy another bargin budgie, and give it to the overjoyed child saying "Polly's cured!" and present the knowing parents with a bill for $4.95. If the child ever noticed the feather coloration or size was a bit off, then the vet would simply say "Oh, that's just a side effect of the medication".

    So now you're telling me that the cloned cat CC did not really look like its genetic donor because of "protein activation times"? The cloning process that was used didn't cost $4.95, by any chance, did it?

  30. Time to rewrite the nursery rhymes. by Remus+Shepherd · · Score: 3, Funny

    Mary had a little lamb, its fleece was slightly grey,
    It didn't have a father, just some borrowed DNA.
    It sort of had a mother, though the ovum was on loan,
    It was not so much a lambkin, as a little lamby clone.

    And soon it had a fellow clone, and soon it had some more,
    They followed her to school one day, all cramming through the door.
    It made the children laugh and sing, the teachers found it droll,
    There were too many lamby clones, for Mary to control.

    No other could control the sheep; their programs didn't vary,
    So the scientists resolved it all by simply cloning Mary.
    But now they feel quite sheepish, those scientists unwary,
    One problem solved! But what to do, with Mary, Mary, Mary...

    -- by Anonymous (it's not mine; the writer's name is forgotten.)

    --
    Genocide Man -- Life is funny. Death is funnier. Mass murder can be hilarious.
  31. (Breast != MammaryGlands); by Zero__Kelvin · · Score: 2

    Thanks for the social lesson. On a related note, people quote Sarah Palin a lot because she is funnier than, well - almost anyone with a clue. Now, allow me to return the favor: Scientist use the term mammary gland instead of breast, because not all breasts have mammary glands, and the two words, while related, are not synonymous.

    --
    Guns don't kill people; Physics kills people! - John Lithgow as Dick Solomon on Third Rock From The Sun