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Scientists Create Programmable Bacteria

wilmavanwyk writes "In research that further bridges the biological and digital world, scientists at the University of California, San Francisco have created bacteria that can be programmed like a computer. Researchers built 'logic gates' – the building blocks of a circuit – out of genes and put them into E. coli bacteria strains. The logic gates mimic digital processing and form the basis of computational communication between cells, according to synthetic biologist Christopher A. Voigt."

19 of 117 comments (clear)

  1. Can't resist urge to make bad pun.., by antifoidulus · · Score: 3, Insightful

    But how will they be able to find "bugs" in their program when the program is all bugs? Thank you, thank you, I'll be here all week, try the fish, the bacteria in it all programmed in Sea.... Oh I did it again!

    I apologize profusely for whatever pain the above might have caused.

    1. Re:Can't resist urge to make bad pun.., by MichaelSmith · · Score: 2

      But how will they be able to find "bugs" in their program when the program is all bugs?

      It works for me!

    2. Re:Can't resist urge to make bad pun.., by Metabolife · · Score: 4, Funny

      "Today marks a milestone for the computer science and pharmaceutical industries. Partnering with one of the software industry giants, Roche Pharmaceuticals today unveiled the future of fighting rapidly mutating semi-lifeforms. Thanks to Norton Antivirus, no human body will ever be unprotected again!"

      Please note that losing the ability to run or perform other activities quickly is a known and acceptable side-effect.

    3. Re:Can't resist urge to make bad pun.., by xMrFishx · · Score: 2

      This will give a new meaning to "My computer has died". Also. What do you call a virus used to kill bacteria computing? "OMG I have an antivirus! Help it's killing my pc".

  2. That leads to a joke by Chrisq · · Score: 4, Funny

    What do the University of California E-coli research team and Microsoft have in common?

    They are both full of shit programmers

  3. Killer app by Anonymous Coward · · Score: 5, Funny

    Finally we're gonna see a decent implementation of Conway's Game of Life!

  4. Antibiotics? by MichaelSmith · · Score: 3, Interesting

    Say you could tailor a bacteria to attack or compete with a bacteria which you needed to control. As the target mutates your attack vector could be reprogrammed accordingly.

    Or how about extending the idea to build a programmable immune system? If the patients immune system has crashed you just feed in tailored bugs to keep infection under control.

  5. Tinfoil Hat by Aldenissin · · Score: 3, Interesting

    No matter how tight I wear my tinfoil hat, unless it is actually a full body suit and electrified on the outside, I think this will obsolete it. Imagine, cells turn cancerous if your black, gay, white, short, don't have any certain genetic or set of genetic markers. If you leave a certain atmospheric pressure, like come down off your mountain prison it reacts to a change in your body. If you pass or leave a magnetic field (or it accidentally loses power) you're a goner. I could go on and on.

      While I can also think of the wonders this could allow, I think more of what could easily go wrong. When you have American scientists laughing because they gave the Russian's leukemia on accident with an early vaccine test, this doesn't make me feel any better.

    --
    Like a city whose walls are broken down is a man who lacks self-control.
    1. Re:Tinfoil Hat by Anonymous Coward · · Score: 2, Insightful

      Take a deep breath.

      People have been poisoning each other with both chemicals and bacteria for thousands of years; what you describe is no different.

      Even the race thing. Each race is statistically more or less resistant to a given disease than others. Think smallpox in the Americas. And if you can't find a suitable genetic marker, just distribute your poison at a suitable gathering.

      Police state devices can already be created with electronics.

      As for these things taking over the world, they'd be out-competed by their wild cousins (the ones that aren't expending energy on computations that are of no direct use to them).

  6. Re:Yes but... by PRMan · · Score: 2

    Yes. And they have a virus that runs Windows...

    --
    Peter predicted that you would "deliberately forget" creation 2000 years ago...
  7. Viruses? by maakri · · Score: 2

    So, they'll still be prone to bacteriophage viruses right?

  8. Has to be the worst layman analogy, ever. by pinkushun · · Score: 2

    “At some point, Microsoft Word had to have been converted to 1s and Os. It's the same way with cells," Voigt said. "What we've done here is created a fundamental language to show that they can work in bacteria. We still have a lot fewer circuits that you could use in computers."

    *chuckles*

  9. Trek becomes Reality by Anonymous Coward · · Score: 5, Funny

    In the TNG episode "The Chase", it's discovered that aliens seeded the oceans of various planets with life and placed part of a computer program into the DNA distributed on each planet. When the various races (humans, vulvans, cardassians, etc) put the code together a billion years later they find an ancient race has left us a holographic message of goodwill and peace.

    We Must do this! Except we change the message to play "Never gonna give you up", Rick Astley built right into the DNA of all living beings forevermore. Just waiting to be found in a billion years. Most epic troll ever.

    1. Re:Trek becomes Reality by Stooshie · · Score: 2

      WTF? Vulvans? Wow! I assume they must be all female and use cloning as there means of reproduction.

      I for one welcome our new Vulvan overlords!

      --
      America, Home of the Brave. ... .and the Squaw.
  10. Programmable E. coli by MindKata · · Score: 2

    Great I can program up projectile vomiting over my boss's desk, to get a few days off work as sick leave and then get the Programmable E. coli to stop 2 minutes after I leave the office. :)

    --
    There are 10 kinds of people in the world... those who understand binary and those who don't.
  11. Re:Yes but... by Barny · · Score: 2

    Bacteria? Hell in my day we were lucky to have an atom!

    Get off my lawn!

    --
    ...
    /me sighs
  12. possible original source by anonymousNR · · Score: 3, Informative

    Robust multicellular computing using genetically encoded NOR gates and chemical ‘wires’
    I am not a Biologist. Can some one verify if this is the original paper?

    --
    -- It is the mark of an educated mind to be able to entertain a thought without accepting it. -- Aristotle
    1. Re:possible original source by gilleain · · Score: 2

      Robust multicellular computing using genetically encoded NOR gates and chemical ‘wires’ I am not a Biologist. Can some one verify if this is the original paper?

      It certainly looks like it. One interesting feature that was left out of the /. summary is that the 'wires' in the circuit are quorum sensing molecules - or signalling molecules that are sent and received by all the bacteria in a group. Except that the abstract refers to 'orthogonal' quorum sensing receivers and producers, so I guess each colony make one compound and senses another? Interesting stuff.

  13. Re:Yes but... by Ihmhi · · Score: 5, Funny

    Does it run Linux?

    Yes, but as a side effect it causes open sores.