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Engineer Designs His Own Heart Valve Implant

nametaken writes "In 2000, Tal Golesworthy, a British engineer, was told that he suffers from Marfan syndrome, a disorder of the connective tissue that often causes rupturing of the aorta. The only solution then available was the pairing of a mechanical valve and a highly risky blood thinner. To an engineer like Golesworthy, that just wasn't good enough. So he constructed his own implant that does the job better than the existing solution--and became the first patient to try it."

31 of 151 comments (clear)

  1. Inventor CV by Saija · · Score: 4, Informative
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  2. Link to Original Article by PatPending · · Score: 4, Informative

    Fuck POPSCI, here's the link to the original article (Warning: graphic photographs)

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    1. Re:Link to Original Article by noidentity · · Score: 3, Informative
      Highlights:

      'It seemed to me to be pretty obvious that you could scan the heart structure, model it with a CAD routine, then use RP [rapid prototyping] to create a former on which to manufacture a device,' explained Golesworthy. 'In a sense, conceptually, it was very simple to do. Actually engineering that was significantly more complex.'

      Golesworthy believes that projects such as this demonstrate that the interface between engineers and the rest of the world isn't functioning in the way it should. 'When it does function, huge advances can be made in a very short time period, on very little money,' he said. 'We have changed the world for people with aortic dilation and we have done it on a fraction of the cost.'

      In May 2004, Golesworthy became the first recipient of his own invention after undergoing surgery at the Royal Brompton Hospital. Since then, 23 patients have successfully had the implant fitted and another seven are hoping to undergo the procedure. According to Golesworthy, the technique will soon replace the Bentall procedure and could be used to treat other heart conditions.

      Wrapping the aorta with artificial material isn't a new idea. More than 20 years ago, US surgeon Francis Robicsek attempted to fashion an external, hand-tailored support for the aorta. The proposal was made before the widespread use of CAD, MRI and RP. Materials such as polypropylene, nylon and knitted Dacron were proposed, with Dacron being the most popular. However, attempting to accurately recreate the shape of the aorta using material cut during surgery proved extremely difficult and the technique never caught on. Instead, off-the-shelf composite valve conduits were offered as a more realistic solution. 'Technology has allowed us to revisit the idea,' said Golesworthy. 'The aorta is such an extraordinary shape that you can't possibly do it by a "taking a yoghurt pot I prepared earlier'. The only way was to bring scanning, CAD and RP together.'

    2. Re:Link to Original Article by Anonymous Coward · · Score: 4, Funny

      (Warning: graphic photographs)

      I sure hope so; all these ascii photographs around the webs have been driving me nuts.

    3. Re:Link to Original Article by guruevi · · Score: 3, Insightful

      Communications. The people that design your meds and implants are doctors and PhD's. They actually have very little understanding of solving problems in the real world. I work in the field as a support staff but actually graduated in industrial electronics. I recently had to explain 3 PhD's from the EE department how to interface a 10MHz optical signal with a coax cable - they were going to rework the whole link, I recommended they buy a media converter.

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    4. Re:Link to Original Article by Thelasko · · Score: 3, Insightful

      Golesworthy believes that projects such as this demonstrate that the interface between engineers and the rest of the world isn't functioning in the way it should.

      On the contrary, I feel that the interface between doctors and the rest of the world isn't functioning in the way it should. Much of engineering is focused on customer needs, where as doctor's tend to have an attitude of superiority that breaks down communication. The field of biomedical engineering aims to fix that.

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  3. Anyone can do it by Lord_of_the_nerf · · Score: 5, Funny

    I knew a conceptual artist who tried the same thing.

    I miss him.

  4. Re:Karma Beating.. by yoblin · · Score: 5, Funny

    Yeah, it's nice when you can really put your heart into something.

  5. yay for engineers! by prakslash · · Score: 5, Funny

    As an engineer by training, I find this to be very cool.

    I myself suffer from a physical... ahem.. shortcoming.
    So, just like this engineer, I designed and constructed a solution using a banana and some duct tape.
    My wife loves it!
    After reading this article, I am thinking I will go ahead and publicize my invention.
    Another yay for engineers!

  6. More medical engineers by Mahonrimoriancumer · · Score: 3, Interesting

    Stories like this make me proud of my alma mater, Colorado School of Mines, for having a bio-medical engineering minor for mechanical engineers. We need more engineers working in medicine.

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  7. By any chance was this guys actual name... by Coraon · · Score: 3, Funny

    Tony Stark? Because if so I want to talk to him now about building a few other upgrades for me.

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  8. Like God said by elashish14 · · Score: 3, Funny

    Do it yourself ;-)

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  9. Not really the whole story... by demonlapin · · Score: 4, Interesting

    There's no need - and hasn't been for a long time, at least 15-20 years - to put in a mechanical valve just for aortic valve disease. There are cadaveric (organ-donor) valves and porcine (pig-heart) valves available. They don't last as long as the mechanical ones, but they don't need anticoagulation. Given that he had Marfan syndrome, however, it's quite likely that the problem was a valve-and-aortic-root problem, just like the Bentall procedure I did the anesthesia for today, which does better with a mechanical valve. His solution is impressive: no quibbles on that here. Imaging a heart to get dimensions is hideously difficult. Getting a 3D model of the aorta is some fine engineering in itself.

    However, he has mostly transferred the problem downstream - the root of the aorta is the most elastic part of a very elastic vessel, and transmitting the higher pressure downstream (which his aorta-corset will do) will lead to increased ballooning of the segment closest to the heart. The hard part is to make sure that that segment can handle it for the remainder of his expected lifespan.

    1. Re:Not really the whole story... by demonlapin · · Score: 3, Funny

      Reminds me of the greatest Pratchett quote ever:

      "Give a man a fire and he's warm for the day, but set fire to him and he's warm for the rest of his life."

    2. Re:Not really the whole story... by guruevi · · Score: 3, Interesting

      Yes, they have really nice sales representations when a lot of data is collected, processed and interpolated (which can be done almost on the fly these days). In the field it doesn't work that well, there are still quite some artifacts and issues where doctors will miss things because they weren't visible. It works good enough to see big things like growths or major defects but I wouldn't trust it to make a precise valve replacement.

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    3. Re:Not really the whole story... by Kilrah_il · · Score: 3, Informative

      When you transplant an organ, it is connected to blood vessels and thus is exposed to the immune system. When you put in biologic valves, no blood vessels are connected and there is no immune rejection. We do not understand completely why they are not rejected, because obviously they do get some blood, since they aren't ischemic, but I believe it has to do with the lack of good blood supply.
      BTW, as far as I know Porcine valves also do not need immunosuppresion, same as corneal implants.

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    4. Re:Not really the whole story... by kabloom · · Score: 3, Informative

      The life expectancy of someone with Marfan syndrome was 32 +/- 16 years in 1972, and is now 41 +/- 18 years (all you need to see from that link is the abstract). If I could guess that the increase has to do with improved treatment technology (rather than improved management strategies), then someone getting surgery for Marfan syndrome is probably in their 20s or 30s, because they're unlikely to live too much longer than their late 30's or early 40's without surgery.

  10. Re:Hardcore... by PopeRatzo · · Score: 3, Insightful

    Implanting a heart valve of your own design into your own chest would only be made sweeter if it had been fabricated on your own 3D printer.

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  11. What BS by Jack9 · · Score: 4, Interesting

    I have had 3 aortic valves implanted throughout my lifetime. Starting at the age of 2. I've also survived a Konno procedure and aortic stem reformation the last time around.

    First of all, Warfarin is pretty fucking safe. If I take an extra 5mg pill once a week, nothing happens. Out of all the thinners, it's not exactly aspirin mild, but it's not horrendously dangerous. Like all drugs, bodies react differently and while I'm ridiculously allergic to tetracycline, I'm middle of the road for reactions to warfarin (over 30 years of it). It's always shock and awe so a news story can give infotainment. Within my lifetime thinners have gained a lot of traction (due to aging boomers). Look up replacements for warfarin. It's big money and the idea that I'll be on warfarin for the rest of my life is unrealistic. Yes I'll be on something, but that's par for a mechanical valve.

    The prosthetic design he came up with, is for his specific problem, weak aortic tissue which involves the stem. As mentioned in the article, a prosthetic aorta isn't a new idea. I'm not exactly sure it's any better an idea than it used to be, nor is anyone else, with a sample size of 30ish. The meat of the story is how the prosthetic is customized. Scan, 3d model, manufacture, affordably. That is pretty radical, from the perspective of current internal medicine. This whole thing sounds like a medical device ad. What I'm more interested in, aortic valves and thinners, they demonize or don't talk about at all. Pity.

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  12. Re:Engineering seems slow in this area by demonlapin · · Score: 4, Informative

    Living tissue (like a vein) is the most infection-resistant substrate. Infection is a major worry when using artificial graft material, because there isn't and won't be any blood supply to the graft. Synthetic grafts would be grossly inferior to venous grafts, which themselves are poor substitutes for arterial grafts (but there are remarkably few redundant arteries, so the question is generally moot).

  13. Lucky he wasn't a by Compaqt · · Score: 3, Funny

    software engineer!

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  14. A new heart valve and a set of 12" brass balls! by Chas · · Score: 4, Interesting

    Okay, I'm a big fan of good engineering and all, but you gotta have some SERIOUSLY heavy-metal nards to be the first guy on the table for your own device for something like this!

    Talk about putting your money where your mouth is!

    Kudos and major man points!

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  15. Re:Well, how does it work? by robbak · · Score: 3, Informative

    From reading the theengineer.co.uk article, it seems that it is a precisely created wrapping around the outside of the bulging aorta, supporting it. The 'breakthrough' is using medical imaging and 3D printing to make a model of his aorta, so the wrapping can be made accurately before the operation. Previous attempts where the aorta had to be measured and the support created during the operation had been tried unsuccessfully.

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  16. Physics by Roger+W+Moore · · Score: 4, Interesting

    the root of the aorta is the most elastic part of a very elastic vessel, and transmitting the higher pressure downstream (which his aorta-corset will do)

    I'm not a medic but I am a physicist and what you say does not make sense from a physics point of view. If you take a bulge in a pipe containing a flowing liquid and squeeze it back down to the diameter of the rest of the pipe you do not increase the pressure lower down. In fact, if anything, you will reduce it because the narrower pipe will have a larger pressure drop along it due to viscous flow.

    This is not the same as squeezing a closed, static system, like a balloon where squeezing it at one point reduces the volume considerable which does increase the pressure causing the unrestricted part to bulge. Yes, technically there is a volume change by restricting the aorta but surely this is only a small fraction of the total circulatory system and even then wouldn't this just cause the body to eventually reduce the amount of blood in circulation by that amount?

    So unless, I have over simplified something (not taking account of the pulsed flow for example), I don't see from a purely physics perspective how it would make the pressure lower down any higher and so make the situation worse. There may be medical reasons for for increased concern but not the pressure reason you state above.

    1. Re:Physics by demonlapin · · Score: 3, Informative

      The aorta is more like a balloon, less like a pipe. The graft is not very large, maybe 5-6 cm in length. In effect, you have moved the beginning of the aorta downstream a few cm. The aorta is supposed to expand with each beat and absorb the blood squeezed out by the heart, then shrink back down to size during diastole. This graft means that the first part of the aorta can't do that, and so the next part will have to. Soon, it too may need a jacket...

  17. Nothing to see here... move^W read along by vlueboy · · Score: 4, Informative

    It's a perineum gangrene (pubic area) acording to the internet. Grangrenes are painful rotting of living tissue and require amputation lest you get infected from the necrotic tissue; I suppose its picture has lots of black tissue where you expect skin colors, pus, gore, lots of rotting and hanging skin, and unkempt pubic hairs, and badly decayed sexual organs; male and female.

    We see tons of hearts on TV, and they're beating --not rotting-- while being operating on, unhealthy as they may be at the moment. No, there's no need to see a picture of your proposed comparison to sober up. But thanks for letting us inspect how bad things can get.

  18. The attitude here saddens me by 2Bits · · Score: 4, Insightful

    Just a few comments, and all the negative comments already: big deal, there is nothing new here.

    You know what, when I hear news like that, it really gives me more confidence in technical people (engineers, scientists, geeks, etc). The guy got a heart problem, he got the skills (with the help of doctors and others, probably) to design the best solution for himself, and in the meantime, for other people too. And guess what, he even got the ball to install it on himself first. And it seems to work just fine. What can be more cool, more geeky, more nerdy than that? Sure, it's only "a small sample of 30ish", as someone said here. So what? Even if this solution only applies to one person, it is still a fucking cool solution.

    For me, I'd like to hear news like that everyday, that's news for nerds, stuff that matters. If I had kids, I would tell them this, and other similar stories, as bed-time stories everyday.

    1. Re:The attitude here saddens me by pbhj · · Score: 3, Interesting

      Roald Dahl apparently co-invented a shunt that was fitted to his daughter to drain a fluid build up.

      http://en.wikipedia.org/wiki/Wade-Dahl-Till_valve

      Perhaps that can be bedtime story for tonight. (I heard about it on a BBC Radio4 programme during the recent Roald Dahl season).

  19. Re:Um... by Another,+completely · · Score: 3, Insightful

    But in 2004, they couldn't have had this bit:

    Since then, 23 patients have successfully had the implant fitted and another seven are hoping to undergo the procedure.

    and without that it's just lucky.

  20. Re:Um... by realityimpaired · · Score: 3, Informative

    In May 2004, we wouldn't have known if the procedure was actually successful. The fact that they tried a new technique isn't news. That he's still alive 7 years later is news.

  21. Re:doctors protect doctors by malloc · · Score: 3, Insightful

    This is an anomaly. The medical community(doctors in particular) doesn't cotton to these sorts of antics from outsiders. Just wait to this becomes more widely known amongst the Doctor fraternity. It will become like mid-wifery - a fringe practice prone to potentially costing your baby its life.

    To clarify, you mean how many Obstetricians consider mid-wifery "a fringe practice prone to potentially costing your baby its life", despite the overwhelming evidence to the contrary?[1]

    [1] See Google, really

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