Researchers Show How Cellular Complexity Can Evolve
ananyo writes with an excerpt from a Nature news release: "By bringing long-dead proteins back to life, researchers have worked out the process by which evolution added a component to a cellular machine. ... In a paper published in Nature, researchers recreated an 'ancestral' version of a cellular machine called the V-ATPase proton pump, which channels protons across membranes and is vital for keeping cell compartments at the right acidity. Part of this machine is a ring of six proteins that threads through the membrane. Animals and most other eukaryotes have a ring composed of two types of protein component; fungi are alone in having a ring with three. The researchers used computational methods to work backwards and find the most likely sequences of these proteins hundreds of millions of years ago. The team inserted the DNA into yeast and found that just two mutations can turn the simple 2-protein ring into the more complex 3-protein ring."
So this is not about cell phone networks?
I see even classic Slashdot is now pretty much unusable on dial up anymore.
inb4 anyone mentions Creationism. But seriously, this is incredibly fascinating and I'm looking forward to how this knowledge can/will be applied.
inb4 creationist jokes
From the article:
"The work, published online in Nature, reveals the pathway by which the two-component ancestral protein (let’s call the components A and B) became a three-component one. The gene encoding protein A duplicated, and two identical copies of the gene started making proteins A1 and A2. Then, A1 and A2 started to accumulate mutations so that they could no longer substitute for each other in the ring."
"In this case, the more complex version doesn’t seem to work better or have any other obvious advantage compared with the simpler one; it is more likely that A1 and A2 proteins were just corrupted by random mutation. (The yeast didn’t seem worse off when they were stripped of their own three-protein ring and instead used one built of two ancestral proteins.) “What’s surprising to me is the idea that greater complexity doesn’t require acquisition of new functions. It can come from partial degeneration of the ancestor,” Thornton says."
The research was published in PLoS Biology, not in Nature.
Second link points to wrong paper, Nature paper is here. http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10724.html
Verizon sneaks in a new charge, they see who complains. If no one they leave it, if people do they remove or reduce it.
This process is repeated as often as possible.
Cellular complexity is the result
"The researchers used computational methods to work backwards and find the most likely sequences of these proteins hundreds of millions of years ago."
So why are we just hearing about it now?
Pat Robertson: "Science perverting resurrection is an abomination, and God's wrath will strike us most likely in the form of a random earthquake or hurricane or tornado sometime within the 12 months."
I'd add the /sarcasm tag just to show I'm just making fun of him, but I actually think my prediction of what will show up on YouTube from him next is pretty accurate.
I8-D
The V-ATPase generally has more than 6 proteins that cross the membrane. Depending on the species, it is usually more around 10-12 individual subunits that work together to form a ring for useful transport.
From a biochemical perspective, it is also worthwhile to point out that the enzyme is powered by ATP hydrolysis - hence the name V-ATPase. It is a motor, and ATP is the fuel. Without ATP you get no useful work.
Damn_registrars has no butt-hole. Damn_registrars has no use for a butt-hole.
Here is the Nature Article mentioned in the summary - the link in the summary goes to a PLoS Biology article.
It was just published online today, I don't see any other copies available yet. However, the primary author of the paper is supported by an NIH grant, so the paper should be released in its entirety as a non-paywalled article fairly soon to comply with the NIH funding rules.
Damn_registrars has no butt-hole. Damn_registrars has no use for a butt-hole.
This is just an example why you can't really 'argue' with a creationist. Anything you come up with, they can make a magic-fairy-dust argument that it's because God wanted it that way. It isn't science.
"Scientists" don't always follow science either. With respect to religion the pro- and anti- camps have both let personal biases interfere with the scientific process. For example leading scientists of the day dismissed the big bang theory because it "smelled like creationism". These eminent scientists were biased because the big bang theory was introduced by catholic priest.
"Monsignor Georges Henri Joseph Édouard Lemaître ( lemaitre.ogg (helpinfo) 17 July 1894 – 20 June 1966) was a Belgian priest, astronomer and professor of physics at the Catholic University of Louvain. He was the first person to propose the theory of the expansion of the Universe, widely misattributed to Edwin Hubble. He was also the first to derive what is now known as the Hubble's law and made the first estimation of what is now called the Hubble constant which he published in 1927, two years before Hubble's article. Lemaître also proposed what became known as the Big Bang theory of the origin of the Universe, which he called his 'hypothesis of the primeval atom'."
http://en.wikipedia.org/wiki/Georges_Lemaitre.
in b4 6000 year's
"researchers have worked out the process by which evolution added a component to a cellular machine"
No, they did not.
I do not believe in karma. "Funny"=-6. Do good and forbid evil. Yours, Oft-Offtopic Flamebaiting Troll.
Let me get this straight...
1)We start with a system which has a valid, functioning two-protein arrangement, and a valid, functioning three-protein arrangement. Therefore, even according to the creationists, the three-protein design is not irreducibly complex, and its "design," even according to them, proves nothing for creationism. We should have started with the two-protein ring and worked out how it was created from a one-protein design. THAT would throw them for a loop. No pun intended.
2)We engineer an "ancestral" protein using our human intelligence. All we can derive is a working protein which has only components of the two shared proteins we have - there's no way to presume that this is in any way ancestral to what we see today, because portions of the genome which have changed may have changed in only one fork, and portions which are ancestral may have been removed from, or changed in, both modern genomes.
This is akin to looking at the latest Linux mainline kernel, and the latest Android kernel, and deriving an actual copy of Linux 2.2.0. If someone can tell me how this can be done, I'm all ears, because it would eliminate the need for source control and diffs and make my job much easier. In reality, all we've done is engineered a third, artificial, sequence which has the desired functionality. Is it ancestral? No, we just made it up, and have no idea if it reflects a previous version of the genes any more than we can recreate Linux 2.2.0 without anything but two forks of the newest kernel version.
3) To make this hypothetical protein, we use a custom-built lab, and computational methods.
4) We determine which "ancestral" (hypothetical) sequences are valid by only selecting for those which work, by intelligently determining which work and which don't.
5) We define a pathway by which this ancestral genome could have forked into what we see, and work out a way to make that happen.
6) We then engineer the mutations to make our predicted path to mutation happen, from our intelligent study of genetics.
7) We observe no evolutionary advantage from the new, mutation-engineered protein over the engineered hypothetical ancestral protein. Therefore, were it to arise in the wild, it would not have been actively preserved by natural selection, yet the real three-protein ring has been preserved. If the two-protein system evolved in fungi to the three-protein system, then at some point there were two-protein fungi and three-protein fungi. There are no two-protein fungi any longer, which means that the three-protein ring produced an evolutionary advantage, which preserved its hosts while the two-protein-ring-containing fungi were all eliminated. This should be a red flag that there's a problem with our hypothetical ancestral reconstruction.
So basically, we created an artificial system, call it ancestral, and work out a way to engineer it to become the system which we see today. We use intelligent design (by humans) to disprove intelligent design (by a god).
Guys, I'm all for disproving these wackos, but if we're going to do it we're going to have to do better than setting up a house of straw which someone who doesn't even agree with them can knock down with five minutes of thought. This is really just making us all look stupid. The fact that Nature would publish it and say it is evidence against the creationists, in any medium, and stand by its claims just makes me a bit sad for the kinds of straws we'll grasp at to try and shut these guys up. Aren't we supposed to be the ones with the critical thinking and rationality?
the camps are split by 4 words
In The Beginning ? (GOD|BANG)
You can't say that SOMEONE didn't create everything since you can't prove that a Supreme Someone does not exist.
AIG and ICR are 2 sites that gather the details of things that should make Macro-Evolutionists go Oh Really?? (simple stuff that is not simple and problems with dating and the order of fossils are 2 examples)
did you know that there are Fossils with BioMatter included??
also the non-wackadoodle Creationists attribute The Great Flood with making most of the fossils.
Any person using FTFY or editing my postings agrees to a US$50.00 charge
Evolution does not *necessarily* imply an increase in complexity.
If complexity is expensive and is not providing an advantage to the organism, the mechanism in question may mutate "back" to a state that an ancestor of that organism already expressed/had. But you're still "evolving" because you're better able to compete *now*.
With the first link, the chain is forged.
This is a great (and very short) essay by Asimov on that very subject:
http://chem.tufts.edu/AnswersInScience/RelativityofWrong.htm
http://en.wikipedia.org/wiki/The_Relativity_of_Wrong
With the first link, the chain is forged.
"The result, they say, is a challenge to proponents of intelligent design who maintain that complex biological systems can only have been created by a divine force."
Oh, come on! You aren't even trying to be honest at this point! No one who can access the Internet has any excuse to give such a sloppy definition of Intelligent Design.
OK, say it with me: "Irreducible Complexity." Do you understand the words coming out of my keyboard? Apparently not! The term is IC, not just C. Even though some evolutionists deny that any complex system is irreducibly complex, that is not justification for distorting the ID position.
Taking stuff apart since 1969 (TM)
Well, that sounds like a reuse pattern to me rather than evolution.
by adding addition ring, system doesn't become Irreducible Complex. Many people do not understand meaning of IC. And experiment shows nothing new. One more ring! So what? I can show human with two heads, Fruit fly with four wings...