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Early Exposure To Germs Has Lasting Benefits

ananyo writes "Exposure to germs in childhood is thought to help strengthen the immune system and protect children from developing allergies and asthma, but the pathways by which this occurs have been unclear. Now, researchers have identified a mechanism in mice that may explain the role of exposure to microbes in the development of asthma and ulcerative colitis, a common form of inflammatory bowel disease. The researchers show that in mice, exposure to microbes in early life can reduce the body's inventory of invariant natural killer T (iNKT) cells, which help to fight infection but can also turn on the body, causing a range of disorders such as asthma or inflammatory bowel disease (abstract). The study supports the 'hygiene hypothesis,' which contends that such auto-immune diseases are more common in the developed world where the prevalence of antibiotics and antibacterials reduce children's exposure to microbes."

6 of 136 comments (clear)

  1. Of course it is by ravenspear · · Score: 5, Insightful

    Humanity (or human like creatures) survived for several hundred thousand years without modern medicine. If the body was not capable of developing defenses to disease we wouldn't still be here.

    1. Re:Of course it is by Anonymous Coward · · Score: 5, Insightful

      On the other hand, the average life span of human being was around 30 years in those early days at best. It is modern medicine and general quality of life that extends that to 70+ years.

  2. Re:Sorry by JoeMerchant · · Score: 4, Insightful

    Finding this hard to swallow personally. I was born with pneumonia and had chronic infections early in life. In my 20s I am still plagued by allergies, asthma and generally poor health despite generally good habits as far as diet, exercise, and hygiene. I cringe when I think about what kind of state I'd be in if I didn't.

    The theory goes that it's too late for sloppy hygiene to help you much, now, but if you ate more dirt as a kid, you'd be healthier.

    Most of my anecdotal observations in life tend tend to agree: life in a bubble isn't good for you, even if you never leave it.

  3. Re:Sorry by MaxEmerika · · Score: 5, Insightful

    Getting sick isn't the point. In fact, it might be exposure to relatively harmless microbes that helps stave off auto-immune disorders. The problem is that antibacterials/antimicrobials kill everything, not just the bugs that pose a threat.

  4. Re:This explains it by Bruce+Perens · · Score: 4, Insightful

    Actually, what kills 1 out of 2 kids every generation makes you stronger. That's how evolution works. But it doesn't mean we want it.

  5. Re:Glad this is finally being proven. by SpeZek · · Score: 4, Insightful

    Only a few select sources of food are overly-infected with nasty things, specifically beef supplies (which are just horrible for you in general)

    Most other things are completely safe eaten raw. That includes milk

    I hate to break it to you, but milk and beef comes from the same filthy animal.