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Treating Depression With Electrodes Inside the Brain

cowtamer writes "CNN has a writeup on a method of treating depression with implanted electrodes. If this works, we may be seeing a lot more of this type of technology in the future. '[The patients] were lightly sedated when the holes were drilled and the electrodes implanted, but they were awake to describe what they experienced. Several patients reported profound changes just minutes after the stimulator was turned on. One said the room suddenly seemed brighter and colors were more intense. Another described heightened feelings of connectedness and a disappearance of the void.' While I haven't looked into any of the academic literature on this, it seems that yet another Larry Niven Prediction has come true!"

40 of 237 comments (clear)

  1. Well, it's not ECT! by Auroch · · Score: 3, Insightful

    It'll be interesting when people start getting this surgery as a performance enhancing drug.

    Though, I worry about the "drive by" hackings.

    --
    Quartz Extreme and Core Image. Are there any other real reasons to spend all that money on generic hardware?
    1. Re:Well, it's not ECT! by SomePgmr · · Score: 3, Informative

      There's an excellent TED talk about this.

      I believe this is it... my apologies if someone already brought it up.

      http://www.youtube.com/watch?v=oEZrAGdZ1i8

  2. A great band-aid solution by thatkid_2002 · · Score: 5, Funny

    I need electrodes for depression like I need several holes drilled in my head.

    1. Re:A great band-aid solution by 2.7182 · · Score: 2

      This is great. I'll be able avoid ECT.

    2. Re:A great band-aid solution by cdrudge · · Score: 2, Insightful

      A band-aid solution? After that comment, I'll presume that you aren't a depression sufferer of 40 years and multiple failed suicide attempts.

    3. Re:A great band-aid solution by Anonymous Coward · · Score: 4, Funny

      A band-aid solution? After that comment, I'll presume that you aren't a depression sufferer of 40 years and multiple failed suicide attempts.

      Well, let's be honest. It would only take one successful attempt and you wouldn't have 40 years of depression.

    4. Re:A great band-aid solution by gl4ss · · Score: 2

      well, the description is that supposedly it's like being on shrooms 24/7 only enjoying the positive benefits.

      so.. really. why the fuck not? seems much like better solution than getting your brains scrambled with a stick.

      --
      world was created 5 seconds before this post as it is.
    5. Re:A great band-aid solution by Mr2cents · · Score: 2

      And lack of asperin causes headaches? Of course not, that doesn't justify your point. Depression can be caused by all sorts of factors. Throwing it all on one big pile and claiming that depression will go away with affection is a gross, naive oversimplification.

      --
      "It's too bad that stupidity isn't painful." - Anton LaVey
    6. Re:A great band-aid solution by nbritton · · Score: 4, Insightful

      A band-aid solution? After that comment, I'll presume that you aren't a depression sufferer of 40 years and multiple failed suicide attempts.

      Well, let's be honest. It would only take one successful attempt and you wouldn't have 40 years of depression.

      As someone afflicted with bipolar disorder, I got a nice chuckle out of that comment. It's true, suicide is very easy if you don't care about having an open casket or being in pain before you pass. I don't think anyone ever actually wants to die though, in my experience it's a means to an end. Going through these turbulent states is literally hellish torture; one resorts to suicide as a way to end that. I'd hazard to guess that I have PTSD just from that torture, and the act of trying to kill yourself is just as traumatizing. Gabbing a shank into your vain so you can bleed out to end the torture is not something most people will ever experience or relate with. I cried for hours because I thought I was never going to see my family or friends again, and the burden I would cause them in the aftermath; the pain was too much to bare though. In retrospect, I'm thankful that the nurse made rounds sooner than expected, because Lithium was able to calm the storm a few days after that. I had not been on Lithium prior to that, I have to say it's a truly remarkable drug... err.. element.

    7. Re:A great band-aid solution by NFN_NLN · · Score: 4, Informative

      A band-aid solution? After that comment, I'll presume that you aren't a depression sufferer of 40 years and multiple failed suicide attempts.

      Well, let's be honest. It would only take one successful attempt and you wouldn't have 40 years of depression.

      As someone afflicted with bipolar disorder, I got a nice chuckle out of that comment. It's true, suicide is very easy if you don't care about having an open casket or being in pain before you pass. Going through these turbulent states is literally hellish torture; one resorts to suicide as a way to end that.

      1) Watch the BBC documentary: How to Kill a Human Being (2008)
        a. There are many sources of the same information but they actually did a nice job
      2) Go to a welding supply shop and rent a pressurized gas cylinder with argon or nitrogen (inert gas)
      3) Go to a welding supply shop and buy a regulator (this will drop the pressure down to a usable level)

      You'll feel better just knowing the option exists and you're not trapped here...

      Just like computers everything has glitches; including the human body. When it comes to breathing the human body only panics when there is a build up of CO2 NOT when there is a lack of O2. If you can eliminate the CO2 and the O2 (which will convert to CO2) then the body won't panic. Breathing inert gas you'll just get tired and euphoric. Instead of pain you'll actually feel high! Eventually the lack of O2 will cause you to pass out. Everything starts to shut down. Before the brain shuts down you'll start convulsing as a last attempt to clear whatever is blocking the oxygen. When that doesn't work your brain will die.

      Remember people: Don't kill yourself with helium... it is a limited resource :)

      Posted non-AC so I don't get filtered out.

    8. Re:A great band-aid solution by ColdWetDog · · Score: 2

      Unfortunately those natural substances have serious side effects.

      And sticking things directly in your brain doesn't?

      Whatcouldpossiblygowrong?

      --
      Faster! Faster! Faster would be better!
    9. Re:A great band-aid solution by causality · · Score: 2

      Unfortunately those natural substances have serious side effects.

      Yeah like persecution by the state for the "crime" of altering your consciousness in unauthorized ways.

      As though your consciousness were theirs to regulate. I can understand why they regulate the roads with traffic laws -- they used tax money to build those roads and continue using tax money to maintain them. Makes sense and you can clearly see why they would have a claim there. But the inner sanctum of your consciousness?

      Just because idiots who like to screw with things they haven't taken the time to understand might hurt themselves?

      --
      It is a miracle that curiosity survives formal education. - Einstein
    10. Re:A great band-aid solution by __aaltlg1547 · · Score: 2

      There may be reason to believe that depression can be stopped without drugs in some cases, but the drugs have the distinction of having been scientifically demonstrated to be effective whereas attempts to help those with persistent depression by cognitive methods alone do not have strong evidence nor a generally accepted treatment regime.

    11. Re:A great band-aid solution by crakbone · · Score: 2

      I'm starting to think it may be a bad idea having you as a friend.

    12. Re:A great band-aid solution by sjames · · Score: 2

      The drugs do seem to work in many cases, though not as well as advertised. The current models meant to explain their action simply do not fit reality. Followup efficacy studies raise a lot of questions, particularly if the blinding in the original studies was effective. That is, the side effects are a dead givaway compared to sugar pill.

      Naturally the manufacturers would like the SSRIs to be something you take for the rest of your life, but there is some suggestion that they are best used as an adjunct to cognitive therapy and then tapered after a while.

      Really though, the upshot is that the Dalai Lama isn't necessarily wrong and isn't confusing cause and effect.

    13. Re:A great band-aid solution by brouiller · · Score: 2

      Naturally the manufacturers would like the SSRIs to be something you take for the rest of your life, but there is some suggestion that they are best used as an adjunct to cognitive therapy and then tapered after a while.

      Would you mind giving a citation for this statement? I'm sincerely interested because this sounds exactly like the situation my friend is in.

      --
      In life you hoped to do what you could but mostly you did what you were told and that was the end of it.
  3. Re:Sci Fi has done this... by dak664 · · Score: 3, Informative
  4. Sounds nice. by Av8rjoker · · Score: 2

    I'd love to try this. Unfortunately I'm an American and don't have health insurance. I'm sure the VA (my only "provider") probably won't get it for a long time.

    1. Re:Sounds nice. by PolygamousRanchKid+ · · Score: 4, Funny

      Who needs health insurance? You need:

      • A car battery
      • Two ice picks
      • Jumper cables
      • A Black & Decker
      • A bottle of Jack Daniels as anesthetic

      Home cures are best.

      --
      Schroedinger's Brexit: The UK is both in and out of the EU at the same time!
    2. Re:Sounds nice. by tomhath · · Score: 3, Informative

      No no, ice picks and hammers are used for lobotomies

    3. Re:Sounds nice. by Av8rjoker · · Score: 3, Insightful

      That's great that you have a wonderful job that provides affordable insurance. I can't afford insurance and even if I could, the inseurance available to me won't cover my pre-existing conditions. By the way, I'm a tax payer too.

  5. "Sorry, I was powered down." by Anonymous Coward · · Score: 5, Funny

    The new all-purpose excuse.

    In addition to people crossing the street while yakking in their phones, college kids texting while walking, and crazed bicyclists weaving through city traffic while sipping Red Bull, we might have to start dodging people standing on the sidewalk saying, "Charging.... charging... charging...."

  6. It's been done. by jtownatpunk.net · · Score: 5, Funny

    I can't be the only person who remembers Stimpy's Happy Helmet.

  7. Mixed feelings by Anonymous Coward · · Score: 5, Insightful

    On the one hand, I have long suffered from depression that resists all treatment. Some days, it is literally a fight to want to live just for that day, and the only thing that keeps me from suicide is the knowledge that my friends (the few I have) and family (who have mostly rejected me altogether at this point) would blame themselves. I don't think many people understand just how devastating Depression can be -- it can literally take away everything you value in life. The worst part is the blame: the attitude that, if you just "wanted" to be different, you would be. If this treatment could actually cure my depression, I would have to "go for it".

    On the other hand, I remember reading Terminal Man by Michael Chrichton, in which a similar technique was used to treat Temporal Lobe Epilepsy. The subject grew addicted to the stimulation from the computer, and literally turned into a homicidal maniac.

    1. Re:Mixed feelings by timeOday · · Score: 2

      This is your (real) life. Don't even give a moment's thought to some sci-fi author's brainfart. That's just fiction.

  8. *Facepalms* by lightknight · · Score: 4, Interesting

    Me thinks they are missing the point.

    Aside from genetic tendencies, depression is typically a form of feedback from your environment not being 'right' for you. And I am not talking about ecosystems here.

    So, while it is a scientific triumph (huzzah!) to find a temporary way to get around depression by sticking a wire in your brain, it's not one we should readily consider. Instead, we should focus on a more permanent solution, that of removing people from environments that would necessitate putting an electrode in their brains.

    On a separate note, I am surprised at the number of psychs / etc. who prescribe pills in preference to telling their patients that they need to quit their job / move somewhere else. Sometimes the solution isn't a bunch of SSRIs, it's moving to another state (across country), or quitting an abusive job.

    --
    I am John Hurt.
  9. Sounds like a psychedelic experience by Brian+Feldman · · Score: 4, Interesting

    Yet without any of the customary safety we come to expect by using natural compounds! Where can I sign up to have my head drilled into rather than trusting the wisdom of the ancients?!

    --
    Brian Fundakowski Feldman
    1. Re:Sounds like a psychedelic experience by Burpmaster · · Score: 2

      Yet without any of the customary safety we come to expect by using natural compounds! Where can I sign up to have my head drilled into rather than trusting the wisdom of the ancients?!

      Linkified that for you.

  10. There's more than one kind of despression by Kupfernigk · · Score: 5, Informative
    There is rational depression (i.e. caused by obvious external circumstances) and depression with no rational cause. Among well known sufferers from the latter are Stephen Fry, Dr. Samuel Johnson and Winston Churchill. It has recently been argued that the reason this kind of depression does not get removed by natural selection is that it has protective value for the community; depressives seem to be good at thinking about the negatives and so are more likely to predict threats and outcomes (Churchill being an obvious case.)

    As an obvious example, Roosevelt took Stalin more or less at face value whereas Churchill was (quite rightly) deeply suspicious of him.

    If you take a non-rational depressive and move him or her to another job on the far side of the country, you will now have a rational depressive feeling even worse off because everything is new and unfamiliar. That is likely actually to increase suicide risk.

    --
    From scarped cliff or quarried stone she cries "A thousand types are gone, I care for nothing, no not one."
  11. I'm quite happy with my solution... by Aphrika · · Score: 3, Interesting

    ...going for a walk. A good walk works wonders and is a little less extreme than electrodes in the brain. That said, my depression was a side effect of a long term illness and the walking may have had other health benefits that improved my mindset.

    That said, walking might not be a great idea if you'd lost your job, sold your car, etc. etc...

    1. Re:I'm quite happy with my solution... by FrootLoops · · Score: 4, Informative

      It's important to note that the patients discussed had severe depression which resisted other forms of treatment:

      She tried a variety of treatments, including talk therapy and psychiatric medicines, but nothing worked.

      St. Jude is hoping to win Food and Drug Administration approval for commercial use of DBS for treatment-resistant depression.

      The summary and title could be taken to imply (incorrectly) that this treatment is aimed at depressed people in general. It's still brain surgery, you need an implanted battery, and it doesn't work on all patients.

  12. Effects by nurb432 · · Score: 3, Funny

    One said the room suddenly seemed brighter and colors were more intense. Another described heightened feelings of connectedness and a disappearance of the void

    LSD is cheaper, and you don't need any extra holes in your head.

    --
    ---- Booth was a patriot ----
  13. Niven's euphoria/depression concept oversimplified by gestalt_n_pepper · · Score: 3, Interesting

    Like many of the more readable writers, certain concepts were simplified. The "droud" in Niven's books stimulated pleasure centers. Doing this is different than relieving depression. Admittedly, the brains wiring isn't following such neat little concepts, but conceptually, relieving depression so you can feel normal is very different than seeking pleasure for its own sake.

    --
    Please do not read this sig. Thank you.
  14. Extra Perception? by axlr8or · · Score: 2

    And now you can imagine. You'll be tuning in radio stations just by thinking about it. Solar storms will either make you feel like crap or really wake you up. Insurance companies will increase your rates because your now far more likely to be struck by lightning. You won't need a wireless presence indicator anymore, your friends will just ask you to home in on one. When the TSA scans you, the agents will call you a skull bomber. But, on the bright side, my hopes the wold will become a simile for 'Johnny Mnemonic' are closer.

  15. Re:Translations of experiences...? by LongearedBat · · Score: 2

    Poor attempts at humour aside...

    This is very interesting. A good friend of mine left her loving husband and two children, to then commit suicide. That sort of deep unhappiness affects more than just the clinically depressed. It can affect all their family and friends in drastic ways.

    If there's a way to make life liveable, then good. Hope more advancements are made.

  16. New treatment for resistant depression..that works by DaneM · · Score: 5, Informative

    I'd probably write this in a private message, but since you've (understandably) posted as anonymous, and since others might benefit from this information, I'll post it openly. Private messages are welcome, should someone wish to contact me.

    Before I continue, though, I have to ask something: I hope that those who read this will respect just how debilitatingly painful clinical depression (i.e. based on bad brain chemistry) is, and also how sensitive a topic it is, both to those who have it, and to those who don't understand it, and treat depressed people like garbage as a result. Truly, I can't imagine a more excruciating torture than having one's own brain be in constant, unbearable pain (in severe cases like mine, it goes beyond depression, into an intangible agony of the mind; and also manifests as severe, measurable physical symptoms). I honestly can't bring myself to wish such torment on any person or creature--no matter how evil. It can and does literally drive people insane, and in the face of this, I have a knowledgeable respect for those who decide that it's simply not worth living through any more such torture; those who haven't been tormented in such an ungodly way (yes, I do mean to imply theological conflict) can't even begin to understand the topic of depressive suicide, so I encourage you not to comment on it; simple kindness would be much more believable and meaningful. (I'm writing now about a possible solution, so please wait on such thoughts if you're having them.) I ask that any replies to this be respectful and not flippant/humorous. Thanks.

    I've recently found an unconventional treatment that has helped my severe depression (featuring suicidal ideation), after having thought (for good reason) that nothing was going to work. First, so that you can better determine if this is something worth looking into, I'll give you an abbreviated list of things I've tried, without success. In almost every case, the medicines and treatments worked after about a month of use, then stopped working, then made my depression worse than it otherwise would have been. Notably, I also suffer from anxiety, physical pain (muscles, joints, skin), and ADD (among others). The most sensible diagnosis I've gotten is fibromyalgia, and it's reached a disabling state. (Of course, fibromyalgia is largely used as a diagnosis that really means "we have no idea what's causing all this.") Here's a list of failures, and example name brands (what DOES work is below them):

    Tri-cyclic anti-depressants (Amitriptyline/Tryptomer)
    SSRIs (Prozac)
    Benzodiazepines (Xanax) (for anxiety)
    (Atypical) antipsychotics (Abilify) (in conjunction with other meds, to enhance them)
    Anticonvulsants (Lamotrigine/Lamictal) (for enhancing effects, as above)
    Lithium (used to treat [type 2] bipolar disorder and mood swings)
    SNRIs (Cymbalta)
    NRIs (Strattera) (for ADD, and as an enhancer)
    NDRIs (Bupropion/Wellbutrin) (for ADD, and as an antidepressant, and as an enhancer)
    Amphetamines (Adderal; this was exceptionally bad, especially in conjunction with Wellbutrin; it caused a psychotic panic attack) (for ADD and chronic fatigue)
    Azapirones (Buspirone) (for anxiety)
    Electro-convulsive therapy (A.K.A. ECT)

    The treatment that I finally discovered, and convinced my doctor to do some research on (i.e. look up as much info as possible) involves increasing the amount of glutamate in the brain--which is now thought to be a more "direct" influence on depression than seratonin, etc.--at least in the "tough" cases. This was discovered as a result of some doctors noticing the use of the street drug, Ketamine, for self-treatment of depression. (Ketamine has some serious/dangerous side effects, of course.) During trials, it was discovered that Ketamine (pain reliever), as well as Riluzole (used to treat Lou Gehrig's disease) and Scopolamine (for motion sickness and surgical nausea) were extremely effective in treating those with severe, "tough" cases of depression. Of the three, Scopolamine (as a transdermal

  17. Re:Well, it's not Black! by flyneye · · Score: 2, Insightful

    Defining the problem is a first step.
    You are correct in your fist posit. It is not race.
    It is a subculture matter, and I see no skinheads or Nazis standing around our thread so we can assume its not a race matter.
    Hate comes from fear and we can see from the above post that the A.C. fears both gangsta culture and liberal culture.
    Who can dispell the fear?
    If fear comes from ignorace, enlighten him.
    Find his sources, ask for citations to his fears.
    Reframe the problem in a more realistic light.
    Darkness is dispelled by light.

    --
    *Repent!Quit Your Job!Slack Off!The World Ends Tomorrow and You May Die!
  18. Re:Depression is normal by Soporific · · Score: 2

    I think maybe OP was trying to say that humanity isn't supposed to go about life the way it does now. i.e., under a fluorescent light 40+ hours a week, then in front of a TV for another 20+, etc., and that may be the source of depression.

    ~S

  19. Re:Depression is normal by Zontar+The+Mindless · · Score: 4, Interesting

    Maybe I took the bit about the "happy robots" other than in the spirit in which it was intended. Sometimes it's difficult for me to be completely objective about such matters, since the subject hits rather close to home, even when I'm not in one of my less happy phases.

    It's also come to my notice recently that there seems to be an endless supply of online jerks who seem to think that depressives are that way by choice, or that they're just trying to look emo-hip.

    Regarding the emo thing: I tend to take the emo scene with a large grain of salt. I appreciate that there are others with problems similar to mine, and many of them have it worse than I've ever had. But I don't need to see it glorified, and I don't need to broadcast to the world that it should feel sorry for me.

    What I think helped to empower me was coming to the realisation that, while I can't always control how I feel, I can try to control what I do about it. And that feeling sorry for myself or expecting others to feel sorry for me negates that control.

    --
    Il n'y a pas de Planet B.
  20. Damn euphemisms by ChrisMaple · · Score: 2

    Die! DIE! The word is die . Not pass, like a test or a motorcar. Not "in a better place". Not "with the angels." Not "sleeps with the fish." Stop avoiding the issue. When someone stops living, he dies.

    --
    Contribute to civilization: ari.aynrand.org/donate