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Researchers Identify Genetic Systems Disrupted In Autistic Brain

hessian sends this excerpt from Medical Xpress "Autism has a strong genetic basis, but so far efforts to identify the responsible genes have had mixed results. The reason for this is that autism is influenced by many different genes, and different genes are involved in different individuals, making it hard to find the common genetic ground between patients. Now, research conducted at the Hebrew University of Jerusalem has shown that despite this fact, the different genes involved in autism tend to be involved in specific processes in the brain. This can explain, on the one hand, similarities in the behavioral symptoms of different autistics, but also the large spectrum of behaviors observed in different autistic individuals."

167 comments

  1. Firmware defective by SpaceLifeForm · · Score: 0

    It will be difficult to work around the bugs.

    --
    You are being MICROattacked, from various angles, in a SOFT manner.
    1. Re:Firmware defective by triffid_98 · · Score: 2

      In some cases I'd consider them bugs, in other cases they're arguably features. Who knows what the world would look like today if Nikola Tesla had been born normal.

    2. Re:Firmware defective by w.hamra1987 · · Score: 2

      Indeed. Once you get used to it, you find it hard to believe that the rest of the world can't think like you. For the autistic (the high functioning ones), they find their minds highly logical, and can't understand how that is a "weird" thing. As far as I'm concerned it's an advantage one ought to be proud of.

      --
      my sig pwns your sig
    3. Re:Firmware defective by mcgrew · · Score: 1

      Unless you believe in creationism, there are no "bugs" in an organism (just real bugs like fleas and bacteria). A bug is when you write a program and it doesn't behave like the programmer wanted it to behave.

      If you are a creationist, how do you know that God didn't deliberately design some infants with autism?

    4. Re:Firmware defective by networkBoy · · Score: 5, Interesting

      My son is a high functioning Autism spectrum disorder child. He is 7 and has his feelings hurt quite genuinely and easily.
      That is the hard part about being a parent of a child with this issue. His mom and I long ago decided it is not a disability, and not to treat it as such. You are very correct that he has an extremely ordered mindset, very logical and very strongly identified concept of right and wrong. The kicker is that his labels of right and wrong are very accurate, not just with the niavite of a 7 year old. The hardest part is helping him understand that the world is distinctively unfair. That right and wrong, while ideal logical statements often have substantial color to them that makes right wrong and wrong right enough to really make it difficult to just say "That's not right". One of his current passions (they seem to run in very deep streaks) is martial arts. The high focus / high structure seems to really work well for him.

      I think he has a future that will be bright, as long as I can help steer his course in life towards something that resonates with him.

      Since it sounds like you have experience in this environment, have you any sage advice for a parent that wants to do the right thing for his child?

      -nB

      --
      whois gawk date unzip strip find touch finger mount join nice man top fsck grep eject more yes exit umount sleep dump
    5. Re:Firmware defective by chill · · Score: 0, Troll

      Please tell me you take a dump BEFORE going to sleep...

      (and "sudo make me a sandwich" needs to be in there close to the end).

      --
      Learning HOW to think is more important than learning WHAT to think.
    6. Re:Firmware defective by elgeeko.com · · Score: 5, Interesting

      One of my closest friends is a high functioning Autistic. He's a wonderful human being and I cherish our friendship. He does have a high degree of social interaction problems and he was in his mid thirties before we could go out in public without him having an episode or creating a scene (he doesn't like people touching him or making eye contact).

      I met him when we were in middle school and he was often a target of bullying. As we moved into high school the bullying started to become worse, but there were several of us who befriended him and it soon became known that to mess with him was to mess with us.

      Today he lives on his own and has married a woman very similar to himself, he still can't manage his own finances and he does require some watching but he holds down a very nice job as a data analyst (his mind was made for abstract numbers) and lives a mostly normal life. The older he gets the better his social skills become, although he is definitely different.

      Ironically I don't think there's a darn thing wrong with him, he's perfect just the way he is. Yes, he's different, but in so many wonderful ways.

      You're right, your son is not disabled and you're doing the right thing by not treating him like he is. He might be different, but that doesn't mean he's disabled, it just means he's different.

    7. Re:Firmware defective by Anonymous Coward · · Score: 0

      I think we are witnessing evolution in progress, but whatever....

    8. Re:Firmware defective by netsavior · · Score: 5, Interesting

      Since it sounds like you have experience in this environment, have you any sage advice for a parent that wants to do the right thing for his child?

      I am autistic and I grew up in special needs classes and went on to college and now work in a marginally social insurance analysis software development role for a big company. I have a wife, a bunch of kids, a full life.
      The big piece of advice is: let him follow his passions, and they will change often, there really is no fighting it, and hey like me he might even end up using it for a nicely compensated occupation.

      My second is, try to do your best to teach him how and why to lie. Anybody can say things that aren't true, but the little social lies everyone tells every day were the hardest thing I ever had to overcome. You described a highly black and white world, and largely I had the same thing. I had no idea why you would pretend to not to be disgusted by religious people, or why you wouldn't say things like "no thanks I don't eat food served by people who have dirty shirts and nervous fingernail habits." There is a very blurry line between tact and deceit and that took me a lot of bullying and a lot of painful trial and error to figure out, it is not typically intuative for an autistic person, because largely we would prefer to know the real reasons behind things, but non-autistic people prefer to be lied to in social situations.

      Most of the lies I tell people in a social context are straight out of movie scripts, because I can never figure out how to word it correctly on my own. People seldom notice, and when they do they think I am making an "in" joke with them. It is a win-win.

    9. Re:Firmware defective by w.hamra1987 · · Score: 3, Insightful

      It seems like you have the right idea of how to deal with him.

      You are right, it's not a disability. The most important thing to consider, is getting him ready for the world outside. His interaction with society will never be as normal and easy as with the majority of people, but with proper training, and education, he can act like it is. People with autism lack empathy, and don't understand human emotions properly. It confuses them, and can put them in awkward positions as they rack their brain trying to guess what a non-autistic person would have done in similar circumstances. And this is the part to be focused on. Teaching them standard social behaviour. Autistic people love rules, love routine, and teaching them proper responses to common questions, proper behaviour to common incidents, will certainly make them much happier in life. If they dont know how to respond to something, they'll try and remember taught rules, then try to remember past experiences, maybe something they've seen in a movie, or read from a story, or happened with another family member.

      For example, if one day, your son got married, and his wife bought him a bouquet of flowers. You shouldn't expect him to be as delighted as most men would be. But with proper training, he'll understand the gesture, he'll understand what she means by them, and will display the delight she's expecting, even though in reality, he really doesn't care about flowers at all. Eventually, he'll be capable of understanding most social interactions, understand expected responses, and cope with society, hiding his syndrome from everyone except those close to him.

      All it takes is the basic understanding of what he has, and what *others* are like, and why he should try and cope.

      Hope this helps you.

      --
      my sig pwns your sig
    10. Re:Firmware defective by Anonymous Coward · · Score: 4, Informative

      People with autism lack empathy, and don't understand human emotions properly. It confuses them, and can put them in awkward positions as they rack their brain trying to guess what a non-autistic person would have done in similar circumstances.

      Just wanted to mention, non-autistic people have the same lack of empathy toward autistic. And you'll also find a lot of empathy among those on the spectrum. (Seems to be especially strong among females on the spectrum, from what I've seen.) A lack of understanding of how that empathy is portrayed by autistics has resulted in a strong believe that there is a lack of empathy.

    11. Re:Firmware defective by MarkRose · · Score: 1

      I used to have extremely black & white thinking, and was often accused of having it (as derision). The high functioning autistic mind will often attempt to enforce rules of logic where there is none to tame and make sense of an illogical world. It wasn't until I started learning about various forms of philosophy that my mind expanded to see the shades of grey. A simple example is democracy: on the one hand, it promises fairness by giving everyone equal say; but on the other, the majority has tyranny over the minority. Some will say fairness is everyone having equal amounts; others will say fairness is only having and keeping all of what you earn. I still deeply detest the discordance of life, but it is what it is: an inescapable game. The rules are what they are, and they change, so accept and adapt to the rules and play it to win.

      --
      Be relentless!
    12. Re:Firmware defective by Anonymous Coward · · Score: 0

      As someone born with Autism - I agree with what you have written and find it refreshing to hear of a parent with an Autistic child that actually understands what to do. I'm sure your son will turn out amazingly talented as long as you keep up as you are, don't drug him and don't let those bastard teachers place him in remedial special ed classes just for being different.

    13. Re:Firmware defective by Internetuser1248 · · Score: 2

      I would like to add a note here on behalf of those Autistic people who are not high functioning, as many of them are unable to post on internet sites. I have worked with many of them and it is a really serious disability. High functioning autistic people are able to live fairly normal lives and can be fascinating people to know, at the other end of the spectrum though it can be pretty hard.

    14. Re:Firmware defective by Guppy · · Score: 1

      Just wanted to mention, non-autistic people have the same lack of empathy toward autistic. And you'll also find a lot of empathy among those on the spectrum. (Seems to be especially strong among females on the spectrum, from what I've seen.) A lack of understanding of how that empathy is portrayed by autistics has resulted in a strong believe that there is a lack of empathy.

      This makes perfect sense, if you accept that the core essence of empathy is being able to create a "model of mind" for another being, and then look (back at yourself, out at the world) as that "model" would see/feel.

      To be able to do this when faced with the Alien is not easy.

    15. Re:Firmware defective by Taco+Cowboy · · Score: 1

      After reading the description of your friend, I realize that I'm a lot like him - sans the protection racket that he got, that is.

      Since I was a kid - heck, since I was a little baby - I always know that the world is totally fucked up because they just can't see what I see and they just can't think what I think

      Yes, I had a really bad time adjusting, but adjusting I did - and still do

      While my IQ is way over 200, my EQ is still lower than a kindergaten toddler.

      And to that dad of that special boy, to you, I will say "Congratulation !" for you do treasure what's inside your boy.

      --
      Muchas Gracias, Señor Edward Snowden !
    16. Re:Firmware defective by Anonymous Coward · · Score: 0

      Get your kid a computer and a BASIC interpreter stat! A logically ordered mind should pick up programming really easily, and learning how to program early in life will be a huge leg up for him, even if he decides not to go into the tech industry - it allows you to think more clearly about processes instead of results, which is going to come in handy as he grows up and social interactions start becoming more complex. Teach him a basic API for interacting with girls, for example.

    17. Re:Firmware defective by KevBoxBender · · Score: 1

      My son is a high functioning Autism spectrum disorder child. He is 7 and has his feelings hurt quite genuinely and easily. That is the hard part about being a parent of a child with this issue. His mom and I long ago decided it is not a disability, and not to treat it as such. You are very correct that he has an extremely ordered mindset, very logical and very strongly identified concept of right and wrong. The kicker is that his labels of right and wrong are very accurate, not just with the niavite of a 7 year old. The hardest part is helping him understand that the world is distinctively unfair. That right and wrong, while ideal logical statements often have substantial color to them that makes right wrong and wrong right enough to really make it difficult to just say "That's not right". One of his current passions (they seem to run in very deep streaks) is martial arts. The high focus / high structure seems to really work well for him.

      I think he has a future that will be bright, as long as I can help steer his course in life towards something that resonates with him.

      Since it sounds like you have experience in this environment, have you any sage advice for a parent that wants to do the right thing for his child?

      -nB

      I'm a "high-functioning autistic". I was diagnosed when I was 41 years old. Had a really crazy first 30 years or so. I was (literally) raised in an abandoned building
      and was beaten by both parents. I was beaten by my classmates from the age of 8 to the age of 16, about 3 times per week. I was sexually molested in front
      of teachers on school grounds, and was suspended for "causing trouble". I was forced to enlist in the Navy when I was 20, under threat of death, with a
      gun in my face. I was set on fire, had urine saved up and thrown in my face while sleeping, etc.

      Now I'm not saying "oh poor me". I'm just saying, I truly understand what it's like to be autistic in America.
      But you know what?

      I can also say the following:
      * Became certified as a technician class amateur radio operator at 14.
      * Became a 2nd Class Commercial (Tv/Radio broadcasting engineer) at 16.
      * Managed 80 men (they didn't like me- but that was their problem) and 2 nuclear reactors at 24.
      * Started a dot.com DURING the dot.com crash, that has earned me over 2 million profit.
      * Have worked in IT for 20 years in networking and systems, and am now a Principal Systems Engineer
      * Married/Been with my wife for 15 years now.
      * Raised my step-daughter for the same period of time.

      And I didn't even KNOW I was autistic until I was 41, which was 9 years ago.

      I've known a number of auties, other than myself as well, that are pretty happy and successful. It can certainly be done,
      if the disability aspects aren't completely overwhelming.

      But yes, a little help can go a long ways. There are work-arounds for most things that autistic people must face, but obviously not everything.
      For example bright light and almost any sound is very difficult for me. I have no sense of direction at all. I really have problems
      with authority figures. And of course, even after 15 years, my primary relationship (my wife) will never cease to be "interesting".
      Of course you don't have to be autistic to understand that!
      I could fill a book with advice (but I'm sick of all those books on autism out there!), but you might consider the following:

      1) Read up on "Observer perspective", try to practice it yourself, and help your son with that.

      2) If your son has issues with reciprocity, then study that subject yourself, and help him see reciprocity from a logical perspective.

      3) If your son has issue with "empathy", then study compassion and share things about compassion with your son. I myself don't
      have that much empathy, as the circuits don't seem to be there so much, but I've understood and practiced compassion since I
      was 6. If you practice compassi

    18. Re:Firmware defective by Anonymous Coward · · Score: 0

      fuck! some good ideas! I should start doing that! I have a hard time masking my disgust at things. They are, at least, rather consensually regarded as disgusting (standing water growing smelly on the kitchen counter, for example), but I've had a hard time telling people tactfully that they're grossing me out. A few white lies would be so much better. Hmmm. that also explains a lot of the strange stories I hear from people that don't quite add up.

    19. Re:Firmware defective by cthulhu11 · · Score: 1

      My son has the 299.00 diagnosis, and he so far shows no signs of concern for the feelings of anyone. He finds it funny when I wince or say OUCH as he kicks me in the face or nads.

    20. Re:Firmware defective by tolkienfan · · Score: 1

      Dyjkstra: It is practically impossible to teach good programming to students that have had a prior exposure to BASIC: as potential programmers they are mentally mutilated beyond hope of regeneration.

    21. Re:Firmware defective by Anonymous Coward · · Score: 0

      That's just rationalizing bullshit.

    22. Re:Firmware defective by doston · · Score: 1

      My son has the 299.00 diagnosis, and he so far shows no signs of concern for the feelings of anyone. He finds it funny when I wince or say OUCH as he kicks me in the face or nads.

      I've never known a little boy who doesn't laugh when he kicks me and I say ouch. All my nephews, all my cousins...all thought it was hilarious. Don't assign to a disease something that's fairly normal in young boys. I don't doubt the diagnosis, but that particular example seems normal in my world. Ever heard "little boys are cruel". It's true.

  2. Hear That Wakefield, You Murdering Piece Of Trash by MightyMartian · · Score: 4, Interesting

    Hear that Andrew Wakefield, you murdering piece of trash! Real researchers are finding real causes for autism, and not making them up and compromising the health of tens of thousands of people to make a buck.

    May you roast in hell, and in the meantime come down with some particular noisome and noxious kind of cancer that makes you smell like rotting flesh and cause unceasing and unbelievable agony.

    --
    The world's burning. Moped Jesus spotted on I50. Details at 11.
  3. Re:Hear That Wakefield, You Murdering Piece Of Tra by Sarten-X · · Score: 3, Funny

    No, no, no.... See, the vaccines contain chemicals like dihydrogen monoxide that travel through the bloodstream up to the brain, where they interact with the homeopathic echoes of infancy still resonating in the neurons. These deadly chemicals then alter the genes to cause further infant behavior, as has been observed here. Since the child now has to fight against these infant tendencies, development is slowed in what we call "autism".

    Totally makes sense, I swear...

    --
    You do not have a moral or legal right to do absolutely anything you want.
  4. Something to ponder by Terwin · · Score: 4, Interesting

    Considering that low levels of autism-like symptoms seem to be prevalent in engineering disciplines, is this something that could be used to turn your dreamy/artistic/social child into more of a nerd/engineer type?

    Also, I wonder what sort of reaction there would be if instead of autism, this paper was dealing with a potential to detect/fix some more politically sensitive group such as the GLBT community

    1. Re:Something to ponder by jimbolauski · · Score: 1

      Considering that low levels of autism-like symptoms seem to be prevalent in engineering disciplines, is this something that could be used to turn your dreamy/artistic/social child into more of a nerd/engineer type?

      Also, I wonder what sort of reaction there would be if instead of autism, this paper was dealing with a potential to detect/fix some more politically sensitive group such as the GLBT community

      People with severe gayness can still function in the world, autism not so much, some can not even talk, they simply communicate through pointing and grunting.

      --
      Knowledge = Power
      P= W/t
      t=Money
      Money = Work/Knowledge so the less you know the more you make
    2. Re:Something to ponder by MozeeToby · · Score: 2

      So your saying that instead of the research being about a disability that millions of parents fear and hundreds of thousands of children are diagnosed with, the research would be about who someone is sexually attracted to? I'd call it a waste of money, but not much beyond that; I don't understand why researching the normal ranges of human sexuality would be interesting. It would be like spending hundreds of millions of dollars to identify what genes cause red hair.

      Besides, I think you'd find the ultra-conservative "homosexuality is a choice" crowd more upset with the research than the liberal "homosexuality is innate" crowd, given that they identified genetic, not environmental factors that affect the rate of autism.

    3. Re:Something to ponder by w.hamra1987 · · Score: 1

      ... and hacking your electronics into oblivion when provoked.

      --
      my sig pwns your sig
    4. Re:Something to ponder by Sprinkels · · Score: 1

      In what way is their 'social retardedness' their own fault? Does it matter they have Aspergers or not? What's the difference of a person having Aspergers and a person showing the symptoms of Aspergers? How can you tell the difference?

    5. Re:Something to ponder by kubernet3s · · Score: 1

      I believe the parent is alluding to the fact that there are members of the autistic community who campaign for its classification as a condition, rather than a pathology. I actually support several implications of this claim, but my views are not important: what is important is that no one should go shooting off their mouth about how they should "cure" someone who has no wish to be cured. Not that I object to the aims of this study, it's just something to keep in mind while we look for ways to prevent this "horrible disease."

    6. Re:Something to ponder by Anonymous Coward · · Score: 1, Insightful

      I believe the parent is alluding to the fact that there are members of the autistic community who campaign for its classification as a condition, rather than a pathology. I actually support several implications of this claim, but my views are not important: what is important is that no one should go shooting off their mouth about how they should "cure" someone who has no wish to be cured.

      Not that I object to the aims of this study, it's just something to keep in mind while we look for ways to prevent this "horrible disease."

      My daughter is autistic and to any parent that thinks it's special and thinks it's what makes their kid, their kid, "fuck you!". Seriously, I'd cure it in a second, just like most people would make their teenage daughter magically "un-pregnant" if they could wave a wand and make it like it had never happened.

    7. Re:Something to ponder by mjwx · · Score: 5, Interesting

      Considering that low levels of autism-like symptoms seem to be prevalent in engineering disciplines, is this something that could be used to turn your dreamy/artistic/social child into more of a nerd/engineer type?

      Oh fuck off.

      Being an engineer/nerd does not make you autistic.

      Fuck off

      Sorry, but that makes me feel better, I'm not posting as AC and the troll mods be dammed, I'm both a network engineer and diagnosed as having aspergers, on the very mild end of the autistic spectrum of disorders. Most people who post this have no fucking idea what it means to have an autistic disorder. I'm good at my job but talking to people, even people I know well is difficult. Yep, I can interrogate a thousand databases, connect VPN's the world over, figure out connectivity problems from a few clues but fucked if I can make small talk. This would also explain why I'm attracted to women who cant speak English properly (read: Asian) because they have more patience for my broken speech.

      So I can do complex maths in my head but going to a restaurant makes me scared, when I go to a fast food joint like McD's or Nando's I order the same fucking thing every time, why? Because I fucking practised how to say it. I hate talking to strangers and that's not because I hate strangers, I've got nothing against people I don't know but it's hard for me to talk to them. It takes a great deal of effort to talk to people and I'm considered a success case because I can hold down a fucking client facing job. I can talk to people, but I'd rather not because of the fear factor, it takes a good amount of will power to start conversations with suppliers and clients even though when it's over I don't understand what made it hard in the first place. I can do it, but as I said I'd rather use other means of communication like email.

      I know the GP meant no harm but I'm a little bit incensed over the notion that you can just "turn" and autistic person into an engineer because it doesn't work like that.

      --
      Calling someone a "hater" only means you can not rationally rebut their argument.
    8. Re:Something to ponder by Medievalist · · Score: 1

      I wonder what sort of reaction there would be if instead of autism, this paper was dealing with a potential to detect/fix some more politically sensitive group such as the GLBT community

      People with severe gayness can still function in the world, autism not so much, some can not even talk, they simply communicate through pointing and grunting.

      OK, but if you can point and grunt, you fit the profile of the typical GUI user, right?

    9. Re:Something to ponder by MozeeToby · · Score: 2

      Have you ever met someone with real, severe autism. Not "I'm so quirky and antisocial, I think I has aspergers" but the debilitating flavor that basically means they will never be able to live on their own, never be able to form any but the most rudimentary relationships (and even then only with those dedicated to their care), and never be able to have real back and forth communication with another human being?

      Perhaps there are sections of the Autism spectrum disorder that are just part of the normal human variation, but there are certainly sections of that are serious and life destroying disabilities that any parent in the world would treat in a heartbeat.

    10. Re:Something to ponder by Anonymous Coward · · Score: 0

      Really, this is the way you're going to go with this?

      Autism might be a crippling disorder, but it makes people who they are so let's keep it going?

      If you start saying you "prevent person X from becoming person X by removing this genetic trait before birth", how are you any different than pro-life folks who believe the fetus is a person at conception and that abortion "kills person X before birth"?

      Unless you're pro-choice and/or believe the fetus/unborn isn't a person. In which case, alright there's no cognitive dissonance.

    11. Re:Something to ponder by tepples · · Score: 1

      So what hope is there for people who have been professionally diagnosed with Asperger-type high-functioning autism to improve relationships with (for example) their employers despite their disability?

    12. Re:Something to ponder by sandytaru · · Score: 3, Interesting

      A friend of mine has a son with this level of autism. He is 15 years old, cannot speak, and can only communicate via words typed on a laptop. She cried when he "said" his first words at the age of 11 after months of type therapy, which was "want ice cream" ... cried not only in happiness, because due to the expense of his care, she did not have any ice cream to give him as a reward. High functioning autism may be quirky, but low functioning autism is devastating AND horrifically expensive to deal with.

      --
      Occasionally living proof of the Ballmer peak.
    13. Re:Something to ponder by rock_climbing_guy · · Score: 0

      Thanks for sharing your story.

      You said something about Asian women. Personally, I believe that they are the most beautiful women in the world.

      A while back, I hatched a plan to attend graduate school in Hawaii because there are so many Asian women living there.

      Unfortunately, that didn't turn out well for me because not only are Asian women there by and large native-born Americans who grew up speaking English, but the local people there have insular social attitudes in general.

      A friend of mine suggested to me that a foreign-born Asian girlfriend/wife might be more suitable for me for the reasons you described.

      I actually met my (Asian) wife the year after I moved away from Hawaii.

      Thanks for giving a great response to the OP and sharing your story with us.

      --
      Wh47 d1d j00 541, 31337 15n't t3h r0xor5 ne m0r3???
    14. Re:Something to ponder by mjwx · · Score: 1

      Besides, I think you'd find the ultra-conservative "homosexuality is a choice" crowd more upset with the research than the liberal "homosexuality is innate" crowd.

      Ultra-conservatives may be different where you come from, but in my country they're spilt between the camps of "homosexuality is ungodly and needs to be burned out" and "homosexuality is a disease that needs to be cured". To them saying it's a choice is like admitting it's normal, like the choice between chocolate or strawberry.

      BTW, nothing against gays mind you.

      --
      Calling someone a "hater" only means you can not rationally rebut their argument.
    15. Re:Something to ponder by Reverand+Dave · · Score: 0

      Because they refuse to accept that the problem and the solution lies with them instead and not a "disease." I'm not talking about real aspergers, just the socially inept douche nozzles that try to hide behind a self diagnosis of it.

      --
      I got here through a series of tubes
    16. Re:Something to ponder by jimbolauski · · Score: 1

      Because they refuse to accept that the problem and the solution lies with them instead and not a "disease." I'm not talking about real aspergers, just the socially inept douche nozzles that try to hide behind a self diagnosis of it.

      So a person who is socially awkward but does not have aspergers, self diagnoses themselves so they don't feel as bad about their ineptitude, how awful. Looks like the douche nozzle is pointing back at you.

      --
      Knowledge = Power
      P= W/t
      t=Money
      Money = Work/Knowledge so the less you know the more you make
    17. Re:Something to ponder by jimbolauski · · Score: 1

      So your saying that instead of the research being about a disability that millions of parents fear and hundreds of thousands of children are diagnosed with, the research would be about who someone is sexually attracted to? I'd call it a waste of money, but not much beyond that; I don't understand why researching the normal ranges of human sexuality would be interesting.

      Do you find porn interesting?

      --
      Knowledge = Power
      P= W/t
      t=Money
      Money = Work/Knowledge so the less you know the more you make
    18. Re:Something to ponder by Guignol · · Score: 1

      Yep, I have two out of three (there should have been four) kids with autistic "features"
      This is hell
      In fact I gave up and knowingly turned away to alcohol, waiting for some other kind of (less) painful death

    19. Re:Something to ponder by jimbolauski · · Score: 1

      Besides, I think you'd find the ultra-conservative "homosexuality is a choice" crowd more upset with the research than the liberal "homosexuality is innate" crowd.

      Ultra-conservatives may be different where you come from, but in my country they're spilt between the camps of "homosexuality is ungodly and needs to be burned out" and "homosexuality is a disease that needs to be cured". To them saying it's a choice is like admitting it's normal, like the choice between chocolate or strawberry. BTW, nothing against gays mind you.

      You forgot the more prevalent third group, they don't give a shit what you do just stay out of their wallet.

      --
      Knowledge = Power
      P= W/t
      t=Money
      Money = Work/Knowledge so the less you know the more you make
    20. Re:Something to ponder by Reverand+Dave · · Score: 1

      Not so much so they don't have to feel bad, but just to absolve themselves of the responsibility of improving themselves. I never said anything about feeling bad. I was talking about personal responsibility.

      --
      I got here through a series of tubes
    21. Re:Something to ponder by interkin3tic · · Score: 1

      Also, I wonder what sort of reaction there would be if instead of autism, this paper was dealing with a potential to detect/fix some more politically sensitive group such as the GLBT community

      Not sure how that matters. We couldn't do anything about the genes. Gene therapy never really got off the ground. We can't reprogram DNA. Even if we could in the next few years, we STILL probably couldn't do anything about autism. The structure of the brain isn't completely plastic, it's likely that the disease will maintain itself even absent the genetics that made it autistic in the first place.

      So would a "politically sensitive" community like GLB get upset if someone looked into the genetic causes? Maybe, until someone explained to them that no one was trying to "fix" them. If they're sensitive, it's undoubtedly due to discrimination, hatred, and misguided religious attempts to "cure" them with abuse.

      (and not for nothing, but transgendered individuals, the "t" in that acronym you just used, they do fix that with surgery.)

    22. Re:Something to ponder by BenoitRen · · Score: 2

      I think you underestimate the problem that self-diagnosis is. There are so many people who claim to have Asperger's Syndrome today that 1) the numbers seem worse than they're already are and 2) those who claim to have it are often not taken seriously.

    23. Re:Something to ponder by Anonymous Coward · · Score: 0

      As a programmer, and a father of a child who is diagnosed (by an actual neurologist) on the spectrum (mild to moderate), I think I have some experience in this area. First off, there's a lot of people that display "Autistic tendencies". Just like out of all the sensory issues, everyone usually has at least one. For this reason it's not like other diseases where if you display some tendencies you can self-diagnose. It's quite a process to determine whether someone is on the spectrum or not. Personally I display quite a few tendencies that are on the spectrum, but I don't call myself autistic. I call myself an introvert who does better with bits than with people :)

      Regarding the other parent's sentiments, in our case what it took was acceptance from us to let our daughter know that she was different, but that's ok. We were lucky enough to get a diagnosis early, and were very opposed to medications (even though they were pushed at us a lot). In the end after years of behavior, speech, and occupational therapies we have learned that most of the struggle wasn't in our daughter, but in us. It was our job as her parent to learn things that were her triggers, and deal with them. The hard part is learning which thing you as a parent should deal with, and which things she needs to learn to deal with.

      A good example of this is scheduling. Most people advocate a rigorous schedule for children on the spectrum. While this does seem to help the child cope with things some, it really seems to prove to worsen things in the end. We specifically give her notice whenever something is going to change, and reassure her that it will be ok after the change. For her to cope, she needs as much information as we can give her without setting the boundaries ourselves. After four years of this, we can easily say "let's go shopping today," and she's ok with that. When she was on a schedule, any deviation was a nightmare followed by a breakdown.

      As far as the question of would I change her? I fought myself with that question for years. I think it depends on the individual situation for each person on the spectrum. The question has to be, does the child feel that they should be changed, or will changing the child improve their life overall. I think that's a very personal question to all of us. Personally, I wouldn't change her for anything. She has struggles sometimes, but who doesn't? Again, every situation is different.

    24. Re:Something to ponder by geekoid · · Score: 1, Insightful

      Yes, social skill and analysis skill are different. Your point?

      "ust "turn" and autistic person into an engineer because it doesn't work like that."
      How do you know?
      I mean, no one else does, so , please, clue me in n your discovery. I assume you will be in next years Nobel list.

      And you post reads like some who has assburgers instead of aspergers.

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    25. Re:Something to ponder by geekoid · · Score: 1

      No, he seems to be asking what would people be saying if this research detected the homosexuality was a genetic expression. ONe that could potentially be changed.

      It's a good question. He isn't saying where any money should be spent.

      You're being overly touchy.

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    26. Re:Something to ponder by triffid_98 · · Score: 2

      High functioning autism may be quirky, but low functioning autism is devastating AND horrifically expensive to deal with.

      Which makes it unconscionable to me that private insurance tries so hard not to cover it. Oh in my state it is technically mandated, but since the therapists are all out of network you're paying at least 50% out of pocket, assuming you've already met your yearly deductible and they can't exclude you due to 'lifetime coverage limits'.

    27. Re:Something to ponder by Anonymous Coward · · Score: 0

      It sounds like you're describing social anxiety more than any kind of autism, or maybe a very mild form that I share. My situation was fixable; Yours may be as well.

      I had difficulties similar to yours, and failed to go to college due to my inability to deal with anyone other than a very few close friends, but medication (60mg Celexa daily) fixed me a decade ago, and I've been completely fine since.

      I now have conversations with random people wherever I go, and can't help but be outgoing. It just plain feels good to be around people, rather than draining me like it used to whenever I had to laboriously simulate normal human interaction.

      Don't just live with the limitations your brain hands you when there may be chemical patches for the underlying problem available.

    28. Re:Something to ponder by mcneely.mike · · Score: 1

      Mod points, please!

      --
      soylentnews.org Go there to enjoy the people!
    29. Re:Something to ponder by Anonymous Coward · · Score: 0

      What you're trying to say, is that an engineer slept with your wife?

    30. Re:Something to ponder by spiffmastercow · · Score: 1

      I'm in a similar situation.. I have a lot of social anxiety and can't read people, but my son is actually autistic (according to two sets of tests administered by autism specialists; we're in the process of getting him in to see an actual MD to get the official diagnosis), and there's a difference between autism and shy/awkwardness. My son only recently started greeting people, whereas he used to say hello/goodbye only to inanimate objects. When we take him to the park, he doesn't want to play on the jungle gym because he'd rather stare at the wood chips. Luckily he's not a stickler for schedules, though.

      I was wondering, what type of therapy did you get for your daughter? ABA therapy isn't covered by insurance in my state, and I'm curious as to the outcome for children who only get speech or occupational therapy.

    31. Re:Something to ponder by Anonymous Coward · · Score: 0

      "talking to people, even people I know well is difficult. ... fucked if I can make small talk."
       
      Step one: Try to avoid joining any conversation with the words "Oh fuck off.
       
      Small steps, one at a time...

    32. Re:Something to ponder by MarkRose · · Score: 1

      He's describing Asperger's, not social anxiety. Chemicals won't fix/ameliorate Asperger's, though they may relieve some symptoms (such as depression).

      Social skills and awareness are something just about anyone with Asperger's can learn, but it takes years/decades of practice and embarrassment to build up scripts of "normal" behaviour and responses for common situations. Most people innately know what another person is feeling, what their perspective is, what's acceptable, etc. To an aspie, figuring out what's on another person's mind and pick up on social queues is like a playing a hard game of Sudoku while simultaneously trying to carry on a conversation. It can be done, but it's mentally exhausting.

      I wish it were as simple as taking a pill to suddenly "get" people. I've tried many. I've learned to make small talk for a few minutes, and I deal with people throughout the day, but on the weekends, I can't wait to be alone. It's not that I'm avoiding people, it's just that I'm mentally drained from dealing with them. I wish I had more capacity to maintain relationships! But if I push it I get burnt out and depressed. Accepting that helped tremendously.

      I am, however, glad Celexa has helped you. Out of curiosity, after dealing with people all day, do you feel refreshed/recharged? Or simply not overwhelmed?

      --
      Be relentless!
    33. Re:Something to ponder by MarkRose · · Score: 1

      I agree completely. Having Asperger's is no excuse for not taking personal responsibility. Victimitis is disgusting. Asperger's is a mental disorder. Victimitis is a social disease. The two are orthogonal.

      --
      Be relentless!
    34. Re:Something to ponder by MarkRose · · Score: 3, Informative

      Considering that 1 in 88 have a form of autism, I think a lot of people underestimate how common it is.

      I think the real problem is those who use it as an excuse for a lack of effort and for not taking personal responsibility, stigmatizing the syndrome, not the syndrome's prevalence.

      --
      Be relentless!
    35. Re:Something to ponder by Anonymous Coward · · Score: 0

      A really curious thought I just had: Is it possible that asian cultures had a high tendancy for asperger's/autism and adjusted their cultures accordingly? That would seem to fit well with highly regimented social interactions like are common, especially in china/japan?

    36. Re:Something to ponder by Anonymous Coward · · Score: 0

      Hey, thanks for sharing. Your story sounds a lot like me. I've never been diagnosed with Asperger's, but I have always been asocial, and I'm considered a genius amongst my coworkers--mostly engineers, and at least three genuine geniuses.

      In recent years, I've started to figure out the social scene, but it would kill most of my friends to know that I'm mostly faking interest. I love them, but I still hate interacting with them socially; it hurts me to say that. A smile and a friendly comment every so often go a long way.

      --Engineer not sure if he's an aspie

    37. Re:Something to ponder by Anonymous Coward · · Score: 0

      I smell research project.

    38. Re:Something to ponder by The+Wooden+Badger · · Score: 1

      I wonder if some of this is that there are so many therapies that are not well researched. My sister-in-law has multiple kids with ASD from mild/middle of the road Aspergers Syndrome to full blown can't speak Autism. She is one of the "vaccine caused" types and goes for all kinds of kooky therapies that I can completely understand not being covered. The therapies that are most researched and tested are ones she doesn't want, but are understandably covered therapies in her insurance. She would rather pay 100% out of pocket for stuff that she is convinced will help her kids, but won't use stuff her insurance will cover.

      In our case, we have a son who is so mild a case of Aspergers Syndrome that it almost isn't worth mentioning. The amount of anecdotal support for a genetic link to ASD is so ubiquitous in our families that it is amazing she still hangs on to the vaccine "link".

      --
      Heroscape, it's like legos combined with anachronistic wargames.
    39. Re:Something to ponder by lsatenstein · · Score: 1

      Would a stutterer be suffering from aspergers, or is it the converse, a person with aspergers would likely also stutter?

      --
      Leslie Satenstein Montreal Quebec Canada
    40. Re:Something to ponder by badkarmadayaccount · · Score: 1

      Modafinil + social contact. Try it. I didn't need stimulants to overclock my cognition, but I'm much more prone to overclocking my brain as an instinct, it may not be so for you. In time, you will develop cognitive capacity to handle socialization and start to integrate it with the brain centers neurotypicals use. Therapy helps handling the lack of logic in the outside world making existence less draining, freeing resources otherwise locked up. Get a good shrink - your relationship with him/her borders on/is a special kind of intimacy - there are no bad shrinks (ok, not so, but that's beyond the point), there are bad client/shrink relationships.

      --
      I know tobacco is bad for you, so I smoke weed with crack.
  5. Re:Hear That Wakefield, You Murdering Piece Of Tra by Anonymous Coward · · Score: 2, Funny

    It is true that, if there were no dihydrogen monoxide in the brain, the child would not exhibit autism.

  6. Nonsense by Anonymous Coward · · Score: 0, Troll

    Autism is not genetic, it is acquired due to vaccination. Please keep your hands off the precious bodily fluids!

    1. Re:Nonsense by Sprinkels · · Score: 4, Funny

      +---------+
      | Sarcasm |
      +----+----+
           |
           |

  7. But can they CURE it? by Anonymous Coward · · Score: 0

    [NT]

    1. Re:But can they CURE it? by Anonymous Coward · · Score: 0

      You don't cure getting hit by a bus, you try and recover from it as much as you can.

  8. Re: No No No.... by TWX · · Score: 4, Funny

    ...the article is dealing with a gene for Autism Spectrum Disorder, not Tourette Syndrome.

    You're in the wrong discussion!

    (Inspired by a Monty Python skit about an argument... "Oh, this is abuse!")

    --
    Do not look into laser with remaining eye.
  9. Re:Hear That Wakefield, You Murdering Piece Of Tra by Anonymous Coward · · Score: 2, Informative

    There is malice, then there is malice that causes the death of hundreds.

    While I am personnaly againts the death penality, that guy is guilty beyond any shadows of a doubt. The facts are as follows:

    1- He wanted to sell a "vaccine alternative"
    2- He decided the best way to do that was if people were afraid of vaccines.
    3- Profit

    That was his plan, and because of it hundreds of kids are now dead.

    I wish him the worst

  10. Re:Hear That Wakefield, You Murdering Piece Of Tra by Gideon+Wells · · Score: 1

    You know it is also scientific fact that all people with mental disorders, terrorists and pedophiles have dihydrogen monoxide in their bodies. Surely we must think of the children's mental and physical healthy while punishing terrorists. Ban the stuff!

    --
    by Anonymous Coward: I, for one, welcome the shift from car analogies to pizza analogies. um.. overlords?
  11. Re:Hear That Wakefield, You Murdering Piece Of Tra by Anonymous Coward · · Score: 0

    But the media are also to blame for thoroughly scapegoating him - he wasn't alone, but from all the coverage, you definitely get the impression that he was...

  12. Why highlight this paper? by Anonymous Coward · · Score: 0

    While the effort put into the analysis in this paper is admirable, it sort of fades into the background of the glut of "we took existing data sets and made a network -- here's the picture" sort of systems biology papers that are being cranked out right now. I'm just wondering, of all the rigorous and higher-impactautism genetics research being done right now, why did this one in particular warrant a slashdot blurb? This certainly isn't the first (or even most compelling) research to uncover convergent biological processes in the autistic brain.

    1. Re:Why highlight this paper? by Jeng · · Score: 1

      Step one, someone has to submit the story.

      Did you submit those stories?

      --
      Don't know something? Look it up. Still don't know? Then ask.
  13. How long before the next name change? by uigrad_2000 · · Score: 1

    The first attempt to make the syndrome seem not-so-bad was the labeling of "simple". When you called someone "simple", others knew what you meant, but it was clear you were sympathetic to their state. That changed dramatically over the course of a decade or two, as "simple" took extremely negative connotations.

    The next derivation of the term was "dumb". By calling someone this, you avoided the idea of "low intelligence" all together. In fact, you were saying they were quite smart, but just weak with verbal skills. I suppose this is closest to how we use "Asberger Syndrome" today. Of course, time did not honor this PC term well, and it quickly came to mean the exact opposite.

    Next was "slow". Unfortunately this term didn't sound scientific enough, so a new term, "retarded" was quickly invented to take its place. Sure, those with Latin language background knew what it meant, but to the general public, it was a new term. So, it was the accepted term for quite a while, but like all those before it, its time was limited. PSA's are shown on TV today to completely end the use of this term that was once promoted by the medical community.

    Autism is now usually argued as something separate from all those terms above, however the lack of medical diagnosis of retardation has caused significant confusion among parents today. Although it is more narrowly defined by the medical community than previous terms, I predict that it, like all the others, will eventually became used as a taunt, and suddenly be regarded as a slur.

    I don't know if this progression is necessarily a bad thing. Medical diagnoses are getting better, and the fact that we keep changing terms to keep everyone happy shows sensitivity that previous generations may not have had.

    But, the down side is that the term is used for just about everything. The current conditions labeled as Autism covers far too much for studies such as the one in this headline to ever be successful. There is almost no chance that a single cause of autism would ever cover more than about 5% of the cases.

    --
    Free unix account: freeshell.org
    1. Re:How long before the next name change? by Anonymous Coward · · Score: 0

      You forgot about Dr. Mencia's term, "dee-de-dee".

    2. Re:How long before the next name change? by spiffmastercow · · Score: 1

      Well, they've shown a strong convergence in the symptoms that we're calling "autism" that are distinct, though are often found along with mental retardation. Autism often occurs alongside mental retardation, but not always, and an autistic person may have an overall IQ between vegetable and super genius. It's a specific deficit in communication and social intelligence, as opposed to a general intelligence classification.

    3. Re:How long before the next name change? by AnonyMouseCowWard · · Score: 0

      I was going to mod people but instead found this post, and it's... incensing, to say the least.

      There's a good reason why autism or Asperger's are dissociated from being "slow", "retarded", etc. Let me clue you in: it's not the same fucking thing.

      Have you actually talked to "highly-functioning" autistic people? It has nothing to do with being slow. It's not their brain power that's in question. It just happens that there are things that they can't do, and although there are common themes between them, autistic people are very different from each other as well.

      Now, I will agree that some autistic people have trouble learning, and might never fit in a normal classroom or be able to work in a social environment, but that's not because they're stupid. It's not about their intelligence, even if from an external point of view it might look very similar. For that matter, how do you call lightly autistic (aka, Asperger's syndrome) people that can function in society, but just happen to not like fur, eat sandwiches by the corners, hate phones and can't catch a ball? They have "limitations", but they're not stupid. I call "being stupid" the person that says "sir, you moved the x from the left to the right side of the equation but you made a mistake, you copied the + into a - sign!" stupid.

    4. Re:How long before the next name change? by uigrad_2000 · · Score: 1

      Now, I will agree that some autistic people ...

      The whole point I was making is that the term is now used too broadly, and you seem to be confirming this. The term "autism", when I first heard it, was narrowly defined. The current HFA classification of autism was all that was originally covered by the original use of "autism", but already the term has been broadened to cover far more than that. It will continue to change meaning, even if the medical community would prefer that it doesn't. Eventually (and regrettably), it will (in common usage) mean any kind of stupidity. For example, just last week, I heard a woman say "I was being autistic the other day and left my purse at home..."

      Broad terms are dangerous to use, because you end up grouping people with others that they don't deserve being grouped with. That's clearly what set you off. Not all the broad terms I listed in my first post are equivalent, but, they do have something in common. They were all created as ways to refer to people with disabilities in a way that would not be demeaning. In turn, they've all changed to mean something much different than they originally meant. If you disagree with that statement, please explain.

      I will stand by my point that the term "autism" will continue to morph. People already use it in derogatory ways. I have no doubt that 30 years from now, it will be rare for a patient to be diagnosed with "autism", because it will have negative connotations. At that time we can have this same discussion again. You can say that "xxxxx (term of the future) is a specific term for ___ ty ___ ___, and is completely different than people who are just plain autistic."

      --
      Free unix account: freeshell.org
  14. Re:Hear That Wakefield, You Murdering Piece Of Tra by networkBoy · · Score: 1

    Well played sir, well played.
    -nB

    --
    whois gawk date unzip strip find touch finger mount join nice man top fsck grep eject more yes exit umount sleep dump
  15. A check on the social facade by tepples · · Score: 2

    In some cases I'd consider [autism symptoms] bugs, in other cases they're arguably features.

    Someone on a board I hang out on told me that Asperger syndrome exists as a check on the social facade to prevent it from diverging too far from honesty. Consider this article about how extroverts answer personality surveys.

  16. Re:Hear That Wakefield, You Murdering Piece Of Tra by networkBoy · · Score: 1

    For what it's worth, if you have a friend or family member say they don't want to vaccinate their kids remind them of the following math:

    If you count *all* children with autism where anybody made any claim that it was the fault of a vaccine...
    And you count all children that have a medical reason for the vaccine hurting them (egg allergy, severe adverse reaction, etc.)...
    And you count *all* children that were made very ill (beyond the normal fever, but not bad enough to be in the above category)...

    If you take all those kids in one pool, and count them against the number of children that died young every year from the diseases vaccines prevent, you will find that even accepting the pseudoscience as truth, it is *still* better to vaccinate your kids from a numbers game. I forget the exact numbers, but IIRC it was like 3:1 deaths to everything else as a ratio.
    I converted one of my family members with this argument. True they were still reluctant, but laying out the numbers you can't counter that, especially when you count the pseudoscience numbers in favor of the pseudoscience, and the vaccines still win.

    I'd love to see Randal do an XKCD chart on this...
    -nB

    --
    whois gawk date unzip strip find touch finger mount join nice man top fsck grep eject more yes exit umount sleep dump
  17. Imperfection entered humankind through Adam by tepples · · Score: 0

    If you are a creationist, how do you know that God didn't deliberately design some infants with autism?

    Everything that God created in the six creative ages was "very good", without disability, according to Genesis 1. Imperfection entered humankind through Adam.

    1. Re:Imperfection entered humankind through Adam by Captain+Splendid · · Score: 0

      Imperfection entered humankind through Eve.

      FTFY. Cocks don't cause problems, vaginas do.

      --
      Linux, you magnificent bastard, I read the fucking manual!
    2. Re:Imperfection entered humankind through Adam by mcgrew · · Score: 1

      That's true, but who are you or I to say that autism is a flaw or disability at all? I'd be willing to bet that Thor (inventor of the hammer) and prometheus (tamer of fire) were high functioning autistics.

      And I don't know what version of the bible you're reading, but "without disability" isn't in the King James version. Are you reading that (very bad) edition that says "do not lie" rather than "thou shalt not bear false witness against thy neighbor" (do not SLANDER)?

      Oh, and imperfection isn't what the bible says Adam and Eve brought about, it was SIN.

    3. Re:Imperfection entered humankind through Adam by tepples · · Score: 1

      And I don't know what version of the bible you're reading

      New World Translation, similar methodology to the English Standard Version.

      but "without disability" isn't in the King James version.

      It was a paraphrase; hence the lack of quote marks. I was expressing my own understanding of what it means when God, the very personification of perfection, calls something "very good". But the KJV does mention "without blemish" several times. Would not low-functioning autism be considered a "blemish" on man?

      Are you reading that (very bad) edition that says "do not lie"

      My Bible has "You must not testify falsely as a witness against your fellowman." (Exodus 20:16) Among these translations of the same verse, are you referring to the "GOD'S WORD(R) Translation"?

      Oh, and imperfection isn't what the bible says Adam and Eve brought about, it was SIN.

      Same diff. Sin led to a population bottleneck in AM 1656, and this population bottleneck led to an even more thorough corruption of the genome.

    4. Re:Imperfection entered humankind through Adam by ozduo · · Score: 1

      Don't you mean Eve. She was the first to be devious and women have been following her example ever since.

      --
      I got to the chocolate box before you, that's why the hard ones have teeth marks.
    5. Re:Imperfection entered humankind through Adam by Chris+Burke · · Score: 1

      It was a paraphrase; hence the lack of quote marks. I was expressing my own understanding of what it means when God, the very personification of perfection, calls something "very good". But the KJV does mention "without blemish" several times. Would not low-functioning autism be considered a "blemish" on man?

      Let's not go projecting our human notions of what's "good" and what's a "blemish" are on God, okay? It just smacks of hubris.

      BTW, this is still true if we replace God with "nature".

      --

      The enemies of Democracy are
    6. Re:Imperfection entered humankind through Adam by mcgrew · · Score: 1

      are you referring to the "GOD'S WORD(R) Translation"?

      Yes, after reading that one I decided to stick to good ol' King James. I can't trust a bible that's under copyright protection. No man should have a monopoly on God's word.

  18. Well, on the plus side by Anonymous Coward · · Score: 0

    It makes them excellent drivers XD

  19. The command line by tepples · · Score: 1

    some [people with low-functioning autism] can not even talk, they simply communicate through pointing and grunting.

    So in other words, neurotypicality is like the command line and low-functioning autism is like a GUI. Or what do I misunderstand?

  20. Re:Hear That Wakefield, You Murdering Piece Of Tra by Anonymous Coward · · Score: 0

    May he die of something that would have otherwise been treatable if he had gotten a vaccine.

  21. Extreme News Flash! by spads · · Score: 2

    "Autism has a strong genetic basis, but so far efforts to identify the responsible genes have had mixed results. The reason for this is that autism is influenced by many different genes, and different genes are involved in different individuals, making it hard to find the common genetic ground between patients."

    Perhaps, alternately to considering a more complex/obfuscated genetic basis, we should again consider a NON-genetic basis?

    How about the experiment everyone conveniently chooses to forget, the occurrence of autism in only one genetic twin (sharing identical genes, gestation environments, etc.).

    --
    Bukowski said it. I believe it. That settles it.
    1. Re:Extreme News Flash! by geekoid · · Score: 1

      A) Identical twins does not mean 100% identical genes
      B) Identical Genes don'e mean identical expression.

      I notice how conveniently you choose to ignore the fact that you don't really know anything about genes or genetic twin.
      .

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    2. Re:Extreme News Flash! by shiftless · · Score: 1

      How about it? Clearly their genes were not actually identical (do you think our sequencing abilities today are perfect?), OR there is more complexity in the genetic mechanics than you and every other short sighted scientist knows or believes (not just likely--TRUE.)

      I am autistic (Central Auditory Processing Disorder, with autism), and I am quite certain in my case it's inherited.

    3. Re:Extreme News Flash! by spads · · Score: 1

      Oh, we're talking about random MUTATIONS (ie. some other basis of non-identical genetic twin genes?) able to counteract this (purported) complex genetically coded condition IN ALL OF ITS MAJOR ATTRIBUTES???

      Oh, and, to my knowledge, identical gestation environments theoretically equates to identical expression, NO, or do all of these (purportedly multiple) genes involved in this expression, simultaneously (in concert) decide whether to express themsleves or not?

      If the preceding is not essentially the case with genetically identical twins, how is it that they even end up resembling each other consistently in the vast majority of the cases? Is it just that we can dispense with (the law of) genetic resemblance for this one special case?

      --
      Bukowski said it. I believe it. That settles it.
    4. Re:Extreme News Flash! by spads · · Score: 1

      Or consider this - the genes they were looking at had nothing in the world to do with it. Problem solved! ;)

      On what basis do you believe it/yours to be inherited?

      I do not feel that I could definitively know the cause of this complex condition, but I feel some affinity with it (and aversion to its contemporary medical analysis). My favorite thing that I read was the (initially (in the US) lionized and ultimately demonized) Bruno Bettelheim's Empty Fortress. He was an early one to point out the genetic twins point, something which has somewhat amazingly been able to be glossed over by all the test-tube monkeys. Basically, I am concerned that, perhaps the primary political entity, parents, have been able to dismiss this, a virtual Emperor's New Clothes type scenario/campaign. Extreme as it sounds, I myself would not dismiss this out of hand. Finally, I am not at all about assigning any kind of blame, just getting to the truth of the matter.

      --
      Bukowski said it. I believe it. That settles it.
    5. Re:Extreme News Flash! by DpEpsilon · · Score: 1

      I call auto-immune damage to the genes.

    6. Re:Extreme News Flash! by Sparky+McGruff · · Score: 1

      There are multiple genetic factors that are strongly linked to Autism. That's not really a huge debate in the field. None of the factors are absolute: they don't guarantee the occurrence of autism, instead, they are associated with increased risk.

      This isn't a novelty in the psychiatric genetics world. The same holds true for schizophrenia, depression and other mood disorders, and most other brain disorders for that matter. It is likely that this has to do with an interaction between disease genes and environmental factors, other genetic factors, or with stochastic (random) processes.

      It's not that different than most other complex diseases. For example, you may carry a risk allele for heart disease. If you follow the right diet, and have a blissful, stress-free life, you might be in luck. But, if you're carrying a second risk allele (whoops!), or down a few too many Big Macs... that risk allele will bite you in the ass. For that matter, even if you do take care of yourself, that risk allele may still bite you in the ass. It's an odds game, and each risk factor makes the odds that much worse.

      As for your "experiment that everyone conveniently chooses to forget"-- there's an extensive literature of twins with Autism. It also shows that there is a strong genetic component, but it's not absolute. The concordance of Autism in twins is extremely high -- but not absolute. However, even identical twins have significant differences -- yes, even genetically. And, even though they may share the same womb, they may have siginficant differences in fetal nutrition (depending on how the placenta is located), and they may be subject to different gestational stresses or birth trauma.

      In other words -- nobody's conveniently forgetting anything.

    7. Re:Extreme News Flash! by UnknowingFool · · Score: 1
      Random mutations happen all the time. Most of the time they are not beneficial or harmful

      Oh, and, to my knowledge, identical gestation environments theoretically equates to identical expression, NO, or do all of these (purportedly multiple) genes involved in this expression, simultaneously (in concert) decide whether to express themsleves or not?

      Your knowledge is faulty. Look up de novo mutation.

      If the preceding is not essentially the case with genetically identical twins, how is it that they even end up resembling each other consistently in the vast majority of the cases? Is it just that we can dispense with (the law of) genetic resemblance for this one special case?

      There is a difference between inheritance and genetics. They are not always equal. If identical twins grew up in the same household, wouldn't that rule out environment?

      --
      Well, there's spam egg sausage and spam, that's not got much spam in it.
    8. Re:Extreme News Flash! by UnknowingFool · · Score: 1

      On what basis do you believe it/yours to be inherited?

      Genetic does not always mean inherited. This is the crux of your lack of understanding.

      --
      Well, there's spam egg sausage and spam, that's not got much spam in it.
  22. Re:Hear That Wakefield, You Murdering Piece Of Tra by MightyMartian · · Score: 1

    Wakefield was the scam artists. Yes, lawyers, TV show hosts, celebrities and a whole host of incredibly fucking stupid people helped him, but at the end of the day it was his scam.

    --
    The world's burning. Moped Jesus spotted on I50. Details at 11.
  23. Re:Hear That Wakefield, You Murdering Piece Of Tra by mcgrew · · Score: 2

    What does that link go to, goatse? I can think of no other reason to use bit.ly at slashdot. This ain't twitter. I'm not clicking any damned links that I don't know where they lead to.

    Be glad I'm not moderating today, shortened URLs in comments get an automatic "troll" from me, simply because there's no rational reason except trolling to use one.

  24. Re: No No No.... by mcneely.mike · · Score: 1

    You're in the wrong discussion!

    No he isn't!

    (Further inspired by a Monty Python skit about an argument... "Oh, this is abuse!")

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    soylentnews.org Go there to enjoy the people!
  25. No, fuck YOU by shiftless · · Score: 1, Interesting

    My daughter is autistic and to any parent that thinks it's special and thinks it's what makes their kid, their kid, "fuck you!"

    This condition IS a huge part of what makes me special, bro. I will make billions of dollars in my lifetime thanks to this condition. Yes it has given me challenges, but you know what, I have benefited from learning to overcome them.

    Your ignorance and stupidity is disgusting and revolting. Look in the mirror. Animals like you are driven by your fear, not facts and reason. You are so busy stampeding towards a "cure" for "autism" (who can say with certainty what the fuck autism even IS, anyway?) to fix your OWN problems (YOUR daughter and HER condition), that you would gladly, willingly, happily, ignorantly run right over and fuck over others like me in the process.

    If it were up to stupid assholes like yourself, people like me would be identified at 3 years old as "autistic", then immediately put on prescription meds to "cure" us. Whole generations of minds would be fucked over and ruined thanks to the ignorance and just plain inability to think of normal simpletons with their average intelligence and average stupidity.

    So as a person who is autistic, and fucking proud of it....let me the one to say: No, Anonymous Asshole.....Fuck YOU.

    1. Re:No, fuck YOU by Tharkkun · · Score: 0

      My daughter is autistic and to any parent that thinks it's special and thinks it's what makes their kid, their kid, "fuck you!"

      This condition IS a huge part of what makes me special, bro. I will make billions of dollars in my lifetime thanks to this condition. Yes it has given me challenges, but you know what, I have benefited from learning to overcome them.

      Your ignorance and stupidity is disgusting and revolting. Look in the mirror. Animals like you are driven by your fear, not facts and reason. You are so busy stampeding towards a "cure" for "autism" (who can say with certainty what the fuck autism even IS, anyway?) to fix your OWN problems (YOUR daughter and HER condition), that you would gladly, willingly, happily, ignorantly run right over and fuck over others like me in the process.

      If it were up to stupid assholes like yourself, people like me would be identified at 3 years old as "autistic", then immediately put on prescription meds to "cure" us. Whole generations of minds would be fucked over and ruined thanks to the ignorance and just plain inability to think of normal simpletons with their average intelligence and average stupidity.

      So as a person who is autistic, and fucking proud of it....let me the one to say: No, Anonymous Asshole.....Fuck YOU.

      You obviously have a very mild case of autism. In fact you're probably not even counted in the numbers based on what you describe yourself as. When you meet a 3 year old who suddenly stops talking and hasn't spoken a word in over 2 years come back to us and say it's a quirk that doesn't need to be resolved. Just because you have a quirky social disorder than many of us here doesn't mean Autism shouldn't be cured.

    2. Re:No, fuck YOU by geekoid · · Score: 3, Insightful

      You're not going to make a billion dollars, slow the fuck down.

      Also, genius, it's a spectrum disorder. Ranging from people who might have it, or are just using it as an excuse to be a dick, like you, to people who can not funtion.

      You falsely link intelligent with autism. IF someone made it so you were comfortable around people, you would still be just as smart as you atr. Not nearly as smart as you think you are, but that's the case now, so no change.

      Parents of Kids that rock back in forth all day, drool on themselves and can't communicate would probably love to cure the disorder.

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    3. Re:No, fuck YOU by mcneely.mike · · Score: 1

      Wish i had mod points... modding you up with a nod and a thanks.

      --
      soylentnews.org Go there to enjoy the people!
    4. Re:No, fuck YOU by Anonymous Coward · · Score: 0

      You wont make a dime. You'll die as another cubicle slave like your other wankas.

  26. Re:Hear That Wakefield, You Murdering Piece Of Tra by mcneely.mike · · Score: 0

    And then you remember that out of every 66 boys born today, one of them will become affected by some form of autism....

    so those of you who are pregnant or have a wife/girlfriend/family member who is pregnant, ONE OUT OF SIXTY-SIX! If you like those odds, go for it and take no precautions, do the vaccinations. I for one would love to do it over, would love to have skipped the vaccines at least for a few more years. But to watch your 'normal' child who just learned to say 'butterfly' revert downwards and now his biggest recognizable word is 'Mum', you've got to think back to 'what could i have done'. maybe if we had put off the vaccines for a couple years....

    Not saying it IS the vaccines, but as a father of an autistic boy, i sometimes think.
    Those who are about to have a child... 1 in 66. 1 in 66. 1 in 66. Do you like the odds? Do you punk?

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  27. Good by geekoid · · Score: 2

    Keep moving forward.

    Now if they can only find a genetic link in why so many people on /. have Assburgers~

    reference:
    http://www.cracked.com/blog/6-real-diseases-that-have-somehow-become-trendy/

    --
    The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
  28. Re:Hear That Wakefield, You Murdering Piece Of Tra by Rasperin · · Score: 1

    3:1 seems rather high, I'd like to see the true facts, I couldn't figure it being higher than 500:1 and that's just a guess. The reason I say this is that any kid that is afflicted by an effect of vaccines hits national media, get's huge coverage, etc and that only seems to happen once or twice a year. Hep C (a vaccine given to kids) afflicts millions of Americans and thousands die daily from it. Then we have cervical cancer vaccine for girls, the standard vaccines, etc etc etc.

    --
    WTF Slashdot, why do I have to login 50 times to post?
  29. Re:Hear That Wakefield, You Murdering Piece Of Tra by compro01 · · Score: 1

    1- He wanted to sell a "vaccine alternative"
    2- He decided the best way to do that was if people were afraid of vaccines.
    3- Profit

    Not quite correct. He didn't want to sell a vaccine alternative, he wanted to sell an alternative vaccine. He had a stake in a company that made a measles vaccine and wanted to defame the MMR vaccine in favor of that.

    Obviously, things did not go according to plan.

    --
    upon the advice of my lawyer, i have no sig at this time
  30. The irony of the first steps into modern eugenics by __aasehi2499 · · Score: 1

    Being done by Jews. After the pseudo-science perpetrated on their ancestors by the Nazis.

  31. Like congenital deafness by Anonymous Coward · · Score: 0

    There are also members of the deaf community who get P.O.d when doctors suggest that congenital deafness in an infant or child is a pathology to be treated. E.g. with cochlear implants.

    That means exactly boo when it comes to deciding whether cures should be developed for congenital deafness and the same applies to developing cures or treatments for high functioning autistics (as Aspergers is now classed per the new DSM). And someone who actually has Aspergers would be less likely to buy in to the moral relativism behind such claims than an Evangelical. Sadly, lying to ourself is the last kind of lying we give up.

  32. Re:Hear That Wakefield, You Murdering Piece Of Tra by MightyMartian · · Score: 2

    It isn't the vaccines, and not vaccinating puts not only your own child at risk, but other children as well as herd immunity breaks down.

    This has been dealt it. Wakefield was a fraud, and if things worked as they ought to, he'd be rotting in prison. There was no link between MMR and autism. Never was. Never ever ever ever was. You might as well not feed your child milk, because guess what, I'm sure you could make some correlation between milk and autism.

    Let it be repeated into your dull, stupid, worthless brain. Correlation does not imply causation.

    But I'm all for you denying your child vaccinations. By the same token I think it should be against the law for you to put them in public school, in any publicly funded daycare, that they should have to wear full environmental suits when around other children until all the parents of those children have signed a waiver.

    --
    The world's burning. Moped Jesus spotted on I50. Details at 11.
  33. He's not heavy by Anonymous Coward · · Score: 0

    He's my brother! the grad student who did this research that is. Kudos bro!

    (I apologize for the lack of real content here, I'm just so excited for my brother)

    1. Re:He's not heavy by Anonymous Coward · · Score: 0

      Your bro is an idiot, there is no such thing as a genetic epidemic

  34. Re:Hear That Wakefield, You Murdering Piece Of Tra by Eli+Gottlieb · · Score: 1

    Should be fixable with a quick sonic screwdrivering, then.

  35. Troll? by jbwolfe · · Score: 1

    Your sense of humor is apparently misunderstood under appreciated. Not everyone with mod points know what to do with them.

    --
    Have you ever noticed that anybody driving slower than you is an idiot, and anyone going faster than you is a maniac?
    1. Re:Troll? by jbwolfe · · Score: 1

      Oh, BTW. I usually dump after I wake in the morning rather than before going to sleep. To each his own...

      --
      Have you ever noticed that anybody driving slower than you is an idiot, and anyone going faster than you is a maniac?
    2. Re:Troll? by networkBoy · · Score: 2

      I think they thought he was trolling me rather than responding to my sig.
      Also: "sudo make me a sandwich" exceeds the character limit or it would have been in there.
      -nB

      --
      whois gawk date unzip strip find touch finger mount join nice man top fsck grep eject more yes exit umount sleep dump
  36. Re:Hear That Wakefield, You Murdering Piece Of Tra by networkBoy · · Score: 1

    Like I said I don't remember the exact numbers, but I remember thinking the same thing. 3 kids would have died (without vaccines) for every one that got sick (with them).
    Now herd immunity will skew those numbers given that the majority of the population is vaccinated, but it is still crazy numbers.
    -nB

    --
    whois gawk date unzip strip find touch finger mount join nice man top fsck grep eject more yes exit umount sleep dump
  37. Re:Hear That Wakefield, You Murdering Piece Of Tra by networkBoy · · Score: 2

    Are you woken up at 4:30 a.m. because your autistic child won't go back to sleep?

    Or kept up till midnight for the same reason, or end up giving up and sleeping on the floor next to him? yes.

    Do you have to spend $6.00 on a gluten free loaf of bread?

    no, because I don't have those allergies in my family.

    Does it hurt when you remember what your son WAS like and wonder if he will ever be 'normal'?

    not so much, I am happy I have a son that is high functioning (which it sounds like may not be your case, so you have my sympathies).

    etc.

    Look, all of us have issues, I've not walked in your shoes, just like you've not walked in mine (high function Autism and factor IX hemophilia), I'll agree that the post you were responding to was worded badly, and aggressively, but I must agree with him that the vaccinations were highly unlikely to have been causative. I'm going to guess this happened around the time he got the MMR shot series? This developmentally also happens to be the time when the brain makes lots of changes, one of which is manifesting symptoms of the miswiring we are discussing here.
    -nB

    --
    whois gawk date unzip strip find touch finger mount join nice man top fsck grep eject more yes exit umount sleep dump
  38. Re:Hear That Wakefield, You Murdering Piece Of Tra by Chris+Burke · · Score: 2

    Not saying it IS the vaccines, but as a father of an autistic boy, i sometimes think.

    Right. No offense, because I understand the emotional feeling of lacking control, but what you could have done is increased your child's chance of contracting a potentially dangerous disease with no effect whatsoever on their autism condition.

    Autism is a developmental disorder. It happens over time, as the brain develops. A child who at first seems normal but then takes a turn, regressing, is perfectly normal progression of the disease. It is impossible for the changes to have occurred between when they first received vaccines and when you first noticed symptoms.

    You say "if you like those odds" as if vaccines have anything to do with the odds. Those odds exist independent of vaccination, so liking the odds should have nothing to do with the decision to vaccinate. If you like the odds of your child getting sick with a preventable disease for the completely illusory feeling of having done something about autism, then by all means, skip vaccinations.

    This desire to blame something tangible, to try to find something we could have done differently, is an emotional reaction and not a sound basis for medical advice. It's perfectly understandable, but understanding it is exactly why we shouldn't listen to it. I'm sorry about your kid, but there's nothing you could have done and not getting vaccines would have only been for the worse.

    --

    The enemies of Democracy are
  39. Re:Hear That Wakefield, You Murdering Piece Of Tra by mcneely.mike · · Score: 0

    As in my post, i am NOT saying it IS the vaccines, just that as a parent of an autistic child, you punish yourself sometimes and wonder if, maybe, it COULD have been that (there is mercury in some vaccines which has been linked to a cause of autism).
    The old 'woulda, coulda, shoulda'. Maybe if.... maybe if only.... what if....

    If you were to have a child become severely disabled right before your eyes because of some other reason, you would grab at straws too.
    I appreciate what you are saying and ESPECIALLY the way you said it: intelligently and like an adult. But yes, i still punish myself and wonder... maybe if the vaccine had, as you said, NOT been given at the age where the brain IS making a lot of changes...... wonder, wonder, wonder, punish, punish, punish.

    And yes, lol, i know ALL about the sleeping on the floor in front of his door so he can't get out to wake everyone else up: i certainly can feel THAT pain and sympathize. Also, the gluten free diet IS helping make him a little more 'normal'. Best thing we ever did for him, expensive as it is.
    Thank you for expressing yourself in an adult manner!
    Mike.

    --
    soylentnews.org Go there to enjoy the people!
  40. My theory... prions by Panaflex · · Score: 0

    We have information from the EPA which concludes that the turning-point for the autism boom started in 1988.

    This coincides with the decade when many vaccines distributed were newly manufactured from human fetal tissue rather than chicken, pig and other cell lines. For some diseases there is no other option - the varicella virus will only grow in human tissue. Considering what we know about Kuru, BSE, Creutzfeldt-Jakob and other same-species prion diseases it isn't a big surprise that problems can occur along these lines.

    So perhaps some of the vaccines contain DNA/RNA/Prion type impurities which are interfering with the neural stem-cells during development. Or perhaps other types of prions are being propagated through human milk, formula, medical equipment or other vectors. Prions are not destroyed during pasteurization and they can have long-lasting latencies. Most labs won't deal with prions as they are highly resistant to sterilization.

    --
    I said no... but I missed and it came out yes.
  41. Study does not point to a particular bug in brain by mrclevesque · · Score: 1
    Conclusion of study:

    "The results of this study point toward contribution of minor and major perturbations in the two sub-networks of neuronal genes to ASD risk"

    Notice genes *contribute* not cause, and they contribute to risk of ASD, not to ASD

  42. Re:Hear That Wakefield, You Murdering Piece Of Tra by mcneely.mike · · Score: 0

    This desire to blame something tangible, to try to find something we could have done differently, is an emotional reaction and not a sound basis for medical advice. It's perfectly understandable, but understanding it is exactly why we shouldn't listen to it. I'm sorry about your kid, but there's nothing you could have done and not getting vaccines would have only been for the worse.

    Some people would say the same about a belief in a God, that it is a need to blame something, an emotional reaction and not a sound basis for running your life, but a lot of people still believe.
    As long as my son can no longer say 'butterfly' i will still kick myself and wonder (but no i dont believe in a higher power). I love my son, but when it is 4:30 a.m. you wonder and wish and wonder and wish. Lacking control is one thing... losing your son and sanity is another.

    --
    soylentnews.org Go there to enjoy the people!
  43. Re:Hear That Wakefield, You Murdering Piece Of Tra by Chris+Burke · · Score: 1

    Like I said, I understand that -- as much as I can, not being you and not going through it, of course.

    But to compare to something less emotional, I also understand why people think they're safer in a car they are driving versus a plane someone else is piloting. It makes perfect psychological sense why someone would be convinced airplanes are death traps and they are much better in a car. However advising people not to fly in airplanes because they'll be safer driving across the country in a car does not make sense. That is factually wrong. It's bad advice. A national movement of people promoting this viewpoint would be bad for public safety.

    This is why despite respecting your feelings, when you say "if you like 1 in 66 odds of autism (implied: as a consequence of vaccines, much lower or no odds for the non-vaccinated) then go ahead " then it's no longer just feelings but bad, dangerous FUD and it must be countered before it becomes a public health risk (more than it already has).

    But back to your feelings, maybe there's something you can help me understand which I never have before: Why does it seem like so much of the late-night wondering and second-guessing is focused around vaccines? Why is this quest for a reason for this to have happened -- perfectly understandable -- focused like a laser on something that there is essentially no chance is actually responsible because it goes against everything that is understood about the disease? That had the only thing actually implicating it as the cause shown to be an outright fraud?

    I ask because I imagine that if I were in your shoes, I would want to find the reason, but I would want to find the real reason. I would want to find the real reason because if you find the real reason you could perhaps find real help. Or at least understand what happened, that it was indeed something I did, or if it was always out of my control and simply fate. So I'd like to think that I might have suspected vaccines, but once every piece of evidence showed that this isn't it, I'd have moved on to something else that might be right. Like, say, the science in this article.

    Why isn't this so? I honestly don't get it.

    --

    The enemies of Democracy are
  44. Re: No No No.... by TWX · · Score: 1

    No he isn't!

    Yes he is!

    (Even further inspired by a Monty Python skit about an argument... "Oh, this is abuse!")

    --
    Do not look into laser with remaining eye.
  45. Re:Hear That Wakefield, You Murdering Piece Of Tra by mcneely.mike · · Score: 0

    I'm not saying i believe it is the vaccines... just that you second guess EVERYTHING. Maybe if...
    i'm just saying you kick yourself ANYWAYS. It's probably like the people who don't believe in God, but don't take the lords name in vain just in case. Maybe if we had delayed giving him the vaccine. Maybe if i'd had different parents. Maybe if i hadn't eaten so many beets. Maybe....
    And the one in 66 isn't due to vaccine causitive belief... 1 in 66 boys is a FACT! 1 in 66 boys born, 1 in 100 children (the autism rate in girls is much lower, and they don't know why yet). I was just stating a fact. But if you are the one in 66, it's like the machine gun bullet found you out of the 66 people heading over the wall. Why me? What if i'd gone over the wall a little slower?... what if i'd dodged left?... what if i hadn't eaten those beets the night before...
    Just saying you grab at straws... BUT, you also head for facts, which is why we have him on the gluten free diet. He used to regurgitate his food until he smelled like bile all the time, his clothes, his hair, his breath, HIM! His behaviours were also wild and his pain threshold was extremely high: he'd hurt himself and we wouldn't know until we saw the bruise or cut (gluten acts like an opioid in his gut is the way it was explained to us). We grabbed at the straw that was the gluten free diet and it worked. Grabbing at that straw that is the vaccine long past is something you just do. You kick yourself and wonder.

    Sometimes straws are all you have. That and booze. :-)

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  46. News Flash: Identical twins are not identical. by mhotchin · · Score: 1

    You should look up 'X chromosome Mosaicism'. In female mammals, each cell deactivates one of the two X chromosomes. It basically happens randomly, so *any* female mammal is a mix of cells with about half having an active *maternal* X chromosome, and the others having an active paternal X chromosome.

    Identical twins will have different patterns of X chromosome activation. This can be a completely visible difference, such as in tortiseshell or calico cats

    So, if any of the AD genes are on the X chromosome, they can be expressed *very* differently in otherwise identical twins.
    http://www.vivo.colostate.edu/hbooks/genetics/medgen/chromo/mosaics.html

    That's just the one mechanism I know of off the top of my head that can cause differences in twins, no doubt there are others. Once you get into environmental causes, I'm sure that does nothing but expand the possibilities.

  47. You missed the point--as expected by shiftless · · Score: 1

    You're not going to make a billion dollars, slow the fuck down.

    Says who? Who are you again?

    Also, genius, it's a spectrum disorder. Ranging from people who might have it, or are just using it as an excuse to be a dick, like you, to people who can not funtion.

    .....and your point is?

    You falsely link intelligent with autism.

    Intelligence*

    You have no clue what reasoning I've taken to come to my conclusion, because I haven't explained it to you ..... nor do I feel any obligation to.

    Not nearly as smart as you think you are, but that's the case now, so no change.

    You just love saying that, don't you? I wonder why you feel so driven to insult me?

    IF someone made it so you were comfortable around people, you would still be just as smart as you atr.

    are*

    What makes you ASSume "being uncomfortable around people" is my definition of "autistic"? That's a simplistic definition invented by a simpleton.

    Parents of Kids that rock back in forth all day, drool on themselves and can't communicate would probably love to cure the disorder.

    Sure. And I bet parents of kids who "don't listen", who forget things they're told verbally, who have strange habits like skipping up and down the house excitedly and flapping their hands, who are willful and impulsive, etc, would love to cure their kids of this "disorder" as well.

    Which is why I'm well and fucking glad mine weren't able to.

  48. NTs unable to teach; TV trying to kill us by tepples · · Score: 1

    Autistic people love rules, love routine, and teaching them proper responses to common questions, proper behaviour to common incidents, will certainly make them much happier in life.

    I agree. The problem that I've found as an Aspie, however, is that a lot of neurotypical people don't know how to express these rules, and especially the principles underlying them, in a language that I understand.

    If they dont know how to respond to something, they'll try and remember taught rules, then try to remember past experiences

    And without taught rules, sometimes they'll overgeneralize from past experiences, or they'll undergeneralize and end up in trouble again.

    maybe something they've seen in a movie

    Hence the CSI Effect and other unsafe cases of confusion that results from misapplying storytelling tropes to real life.

    1. Re:NTs unable to teach; TV trying to kill us by Jedi+Alec · · Score: 1

      I agree. The problem that I've found as an Aspie, however, is that a lot of neurotypical people don't know how to express these rules, and especially the principles underlying them, in a language that I understand.

      One of my favorite examples has always been when 2 people who know each other but aren't close friends cross one another in the street. The "unwritten code of conduct" as I've come to call it dictates that it is polite to inquire about the well-being of the other individual(in some languages the greeting even contains this part by default), but at the same time one should not go too far into detail when answering the same question. Finding the proper balance on how long to keep talking and what about is incredibly difficult for many folks with autism to judge. The only way to really learn is to go out there and mess up time and time again, but to do it around people who are willing and honest enough to correct without being an asshole about it.

      --

      People replying to my sig annoy me. That's why I change it all the time.
    2. Re:NTs unable to teach; TV trying to kill us by Anonymous Coward · · Score: 0

      I agree. The problem that I've found as an Aspie, however, is that a lot of neurotypical people don't know how to express these rules, and especially the principles underlying them, in a language that I understand.

      One of my favorite examples has always been when 2 people who know each other but aren't close friends cross one another in the street. The "unwritten code of conduct" as I've come to call it dictates that it is polite to inquire about the well-being of the other individual(in some languages the greeting even contains this part by default), but at the same time one should not go too far into detail when answering the same question. Finding the proper balance on how long to keep talking and what about is incredibly difficult for many folks with autism to judge. The only way to really learn is to go out there and mess up time and time again, but to do it around people who are willing and honest enough to correct without being an asshole about it.

      May I suggest a late night learning scenario? Have said Aspie wander around a city park after dark and interact with its kindly denizens; they tend to be honest sort and it's tough to be an asshole with your dick in somebody's mouth or ass.

  49. Re:Hear That Wakefield, You Murdering Piece Of Tra by Anonymous Coward · · Score: 0

    More like forget about it in two minutes and never think of it or you again.

  50. KJV is under perpetual copyright by tepples · · Score: 1

    I can't trust a bible that's under copyright protection.

    Three works of authorship are subject to perpetual copyright-like rights in Great Britain and Northern Ireland. One of the three is the King James Version of the Bible.

    No man should have a monopoly on God's word.

    Which is why the Watch Tower Society puts its literal New World Translation online and distributes printed copies at no charge.

    1. Re:KJV is under perpetual copyright by mcgrew · · Score: 1

      Three works of authorship are subject to perpetual copyright-like rights in Great Britain and Northern Ireland.

      Interesting, where can I learn more? But it's public domain everywhere else.

      Which is why the Watch Tower Society puts its literal New World Translation online and distributes printed copies at no charge.

      Isn't that the Jehova's Witnesses? I don't trust them, either.

    2. Re:KJV is under perpetual copyright by tepples · · Score: 1

      Three works of authorship are subject to perpetual copyright-like rights in Great Britain and Northern Ireland.

      Interesting, where can I learn more?

      Learn about it from one advocate of KJV-onlyism or from Wikipedia. (The other two works with perpetual copyright-like rights in the UK are the Book of Common Prayer and Peter Pan.)

      the Watch Tower Society puts its literal New World Translation online and distributes printed copies at no charge

      Isn't that the Jehova's Witnesses? I don't trust them, either.

      Why not, might I ask?

    3. Re:KJV is under perpetual copyright by mcgrew · · Score: 1

      Why not, might I ask?

      Because I've spoken to quite a few of them in my time (I've been stuck on this rock for sixty years) and every single one seemed crazy. Plus, I don't like door to door salesmen.

      They do have quite a few views I agree with, like not liking Christmas trees and Easter Bunnies.

      Thanks for those links, that was informative. I found this linked from the wikipedia article you cited especially interesting, and makes me like the KJV that much more.

  51. Re:Hear That Wakefield, You Murdering Piece Of Tra by T+Murphy · · Score: 1

    Wakefield never wanted people to not get vaccinated (he just wanted people to buy his company's vaccines, he tried to scare people off of the competitor's one). It is people like McCarthy who actually advocated not getting vaccinated, so please put the blame squarely where it belongs. Wakefield was a greedy moron but the blood isn't on his hands.

  52. Re:Hear That Wakefield, You Murdering Piece Of Tra by tolkienfan · · Score: 1

    It's not your fault.
    Really.

  53. Re:Hear That Wakefield, You Murdering Piece Of Tra by tolkienfan · · Score: 1

    Dude, in all seriousness, get some counselling.
    It can really help.
    You need it.

  54. TR vs. NU by tepples · · Score: 1

    I've spoken to quite a few of [Jehovah's Witnesses] and every single one seemed crazy.

    In the first century, Jesus seemed crazy.

    Plus, I don't like door to door salesmen.

    JWs base their "house to house" ministry on Acts 5:42, if I remember correctly. JWs aren't obligated to preach that way, as I understand it; it's just one thing they can do in addition to sharing the gospel with friends and family.

    [A list of verses omitted from most modern translations of the Greek Scriptures] makes me like the KJV that much more.

    The Greek Scriptures in the Luther Bible, KJV, and NKJV are based on TR, as opposed to the NU (Nestle-Aland and United Bible Societies) text based on the oldest manuscripts, which underlies NIV, NWT, and most other twentieth-century translations. TR-type texts include back-translations from Latin into Greek of some verses that do not appear in the original manuscripts of the New Testament. NKJV is based on TR, but editions of NKJV published by Thomas Nelson include footnotes as to which verses are omitted in NU, for the benefit of those who believe that these extra verses are not inspired and did not exist in the first century.

  55. Re:Hear That Wakefield, You Murdering Piece Of Tra by networkBoy · · Score: 1

    It is focused on vaccines because there is an amazing correlation between the MMR vaccine and Autism onset. The correlation is strong enough that there have been multiple studies to see if there was also causation. There is not.
    The brain goes through some crazy changes at 18 to 30 months, the MMR vaccine is targeted for 24 months. Since in many cases Autism onset appears to be rapid, and there is a high probability of recently (within 6 months) of having gotten shots, naturally people seize on that. I even grappled with that, the scientific part of me said it was not the cause, but the parental protection part of me, yeah, that crossed my mind. I'd be lying if I said otherwise.
    -nB

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  56. Re:Hear That Wakefield, You Murdering Piece Of Tra by networkBoy · · Score: 1

    Seconded tolkein fan.
    I've had a shrink for a while. It does help, and there is no shame in it. (Not to say I don't enjoy a drink now and then).
    Don't let this become your demon.
    And, you can always contact me for some moral support :)
    -nB

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  57. Re:Hear That Wakefield, You Murdering Piece Of Tra by mcneely.mike · · Score: 0

    Ha, can't afford a shrink... if i could, i'd have a real shiny computer setup, dual screen, ba-boom!

    And you really should take a dump before sleep. The rest, i like! I like! loool! :-)

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    soylentnews.org Go there to enjoy the people!
  58. Re:Hear That Wakefield, You Murdering Piece Of Tra by networkBoy · · Score: 1

    Most basic health care plans will provide one for free, they will be a LCSW (Licensed Clinical Social Worker), not a psychiatrist; kind of like seeing a Nurse Practitioner rather than an MD. If you don't have health care, there are still support services out there. It really will help, I promise. Having someone to talk to other than us anon dicks here on /. really works well. They can help you place stuff in perspective and place your priorities where they need to be (as opposed to where you honestly think they should be). They will help you with tools to work with your son, how to step back when the frustration gets to be too much, but in a way that does not make him worse.

    Know that you are not alone in this. There are plenty of us here with autism, or like me and you, parents of autistic children. Find a local support group, talk to people. We recently lost my wife's grandmother, who lived with us for several years, that was particularly hard for my son, and by extension for us. If it weren't for the support out there I don't know how I would have dealt with it.

    Come to think of it, talk to your child's care provider... they may be able to hook you up with someone.
    -nB

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