Slashdot Mirror


MIT Study: Prolonged Low-level Radiation Exposure Poses Little Risk

JSBiff sends this quote from MITnews: "A new study from MIT scientists suggests that the guidelines governments use to determine when to evacuate people following a nuclear accident may be too conservative. The study (abstract), led by Bevin Engelward and Jacquelyn Yanch and published in the journal Environmental Health Perspectives, found that when mice were exposed to radiation doses about 400 times greater than background levels for five weeks, no DNA damage could be detected. Current U.S. regulations require that residents of any area that reaches radiation levels eight times higher than background should be evacuated. However, the financial and emotional cost of such relocation may not be worthwhile, the researchers say."

23 of 142 comments (clear)

  1. 5 weeks = long term? by AmiMoJo · · Score: 3, Insightful

    The article says low levels of exposure for five weeks resulted in no DNA damage. Five weeks is nothing, people living in contaminated areas will be there for years, and once radioactive material gets inside them it will be there for the rest of their lives. That is where the biggest danger is, long term internal exposure to material absorbed by the body into the organs.

    --
    const int one = 65536; (Silvermoon, Texture.cs)
    SJW, n: "Someone I don't like, and by the way I'm a fuckwit" - AC
    1. Re:5 weeks = long term? by Rising+Ape · · Score: 5, Interesting

      The interesting thing to note (if this study is correct) is that they observed a difference between an acute dose and a chronic one. Our radiation health data is mostly based on acute doses - the Hiroshima and Nagasaki bombings, mainly. The low dose risk estimates are basically based on that, extrapolated downwards linearly.

      If acute dosing behaves differently to chronic, that model wouldn't be appropriate.

    2. Re:5 weeks = long term? by demonbug · · Score: 4, Interesting

      The interesting thing to note (if this study is correct) is that they observed a difference between an acute dose and a chronic one. Our radiation health data is mostly based on acute doses - the Hiroshima and Nagasaki bombings, mainly. The low dose risk estimates are basically based on that, extrapolated downwards linearly.

      If acute dosing behaves differently to chronic, that model wouldn't be appropriate.

      Hiroshima and Nagasaki radiation victims are some of the few human models that have been studied, but the DOE (and probably other government agencies around the world) did extensive testing on the effects of radiation at various doses using animal models. In one large-scale study I know of they used two exposure groups of beagles, one using the radioactive isotopes the bomb victims were exposed to in order to establish a baseline model correlation (human effects vs. effects observed in laboratory animals) and the other group exposed to isotopes expected to result from nuclear accidents and the new generation hydrogen bombs (different fallout characteristics than the original atomic bombs). Quite a bit of research was done on this, especially during the 1960s and 1970s. They also experimented with direct gamma exposure at various levels; rumor has it (I've never seen published results on the experiments) that there was a sweet spot in the gamma ray exposure scenario that actually lead to significantly longer lifespan than the control group, with many theories as to the cause.

    3. Re:5 weeks = long term? by CrimsonAvenger · · Score: 3, Informative

      The article says low levels of exposure for five weeks resulted in no DNA damage. Five weeks is nothing, people living in contaminated areas will be there for years, and once radioactive material gets inside them it will be there for the rest of their lives.

      They also said 400x normal, rather than 8x normal.

      --

      "I do not agree with what you say, but I will defend to the death your right to say it"
    4. Re:5 weeks = long term? by hbar+squared · · Score: 5, Informative

      once radioactive material gets inside them it will be there for the rest of their lives.

      Wrong. Many radioactive isotopes aren't absorbed by the body and are flushed out rapidly, and some of the most damaging particles (alpha emitters in particular) are at their worst when airborne, only staying 'in' your body for the length of a breath. There are some isotopes that are absorbed easily (namely Iodine), but they are the minority. There is not a single "Radiation", there are a staggering number of different radioactive elements, and for each one, the chemistry matters far more than the half-life.

    5. Re:5 weeks = long term? by geekoid · · Score: 4, Informative

      Maybe you, and the mods, might want to familiarize yourself with lab mice. They are precisely breed.
      We know pretty much everything about them. For example, you can get mice that will get a specific cancer at 2 months, and it happens every time. 'only' 99.9% guarantee, but I have never seen one in a control not get cancer at the expected time

      SO, for this test, 5 weeks is fine. But with ALL STUDIES, one isn't enough. DO several, control different variables, move to different species.

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    6. Re:5 weeks = long term? by Rising+Ape · · Score: 3, Interesting

      That's a very difficult kind of test to do though, because making sure that radiation dose is the *only* difference between groups is virtually impossible. Even the abstract of that paper says that "Further studies will be important to better assess the role of tobacco and other occupational exposures in our risk estimates.". At least this mouse study allows for a proper controlled trial, and the Hiroshima data, while not perfect, is much less prone to such factors than your linked one.

      Also, reading the part that says "Among 31 specific types of malignancies studied, a significant association was found for lung cancer (ERR/Sv 1.86, 90% CI 0.49, 3.63; 1457 deaths)" rather reminded me of this.

    7. Re:5 weeks = long term? by skids · · Score: 3, Interesting

      One has to take care in this case to distinguish between the bio-retention of chemically pure compounds, and what happens in the real world, which is radioactive compounds embedded in small clumps with other material that makes them stick around, e.g. in the lungs. Especially if they get pulled through a cigarette or car engine on their way there.

    8. Re:5 weeks = long term? by Xyrus · · Score: 3, Informative

      Spoken like someone who knows nothing about radioactive materials and how they interact biologically.

      Few radioactive elements stay in the body permanently. Most of them like Cs137 and I131 cycle through the body in days to couple of months. Plutonium is one of the few that has a biological half life of significant length, and it is one of the lesser radioactive isotopes. The most likely isotope you'd encounter after a nuclear accident that has a long biological half-life is Strontium-90.

      The effective half-life of an isotope is measured by taking into account the physical half-life of the isotope and the biological half-life of an isotope. Thus, an element like Strontium 90 has an effective half-life of about 18 years while plutonium has an effective half-life of about 50 years (due to their propensity for gather in bone). Cesium has an effective half-life of about 70 days, and iodine has an effective half-life of about 7.6 days.

      With that in mind, chronic long term exposure can only occur if they are taking in enough radioactive materials to replace those that are expelled from the body. To accumulate, you'd need to be taking in more.

      --
      ~X~
    9. Re:5 weeks = long term? by Diamonddavej · · Score: 3, Insightful

      Interesting. But while there were very many experiments carried out in the 1960-70s, the radiation doses applied were generally much higher then the background levels we are interested in now. People are worried over a few extra MiliSieverts a year.

      Scientists in the 1960-70s were were not able to observe subtle cellular effects, typical defence and repair mechanisms, that operate at and just above background levels of radiation (20 mSv). They were mostly crude LD50 and cancer frequency tests. Very few experiments investigated doses 0.1 Gy (about 100 mSv & 0.8% increase in human cancer risk). And the few experiments that did involve low doses gave confused results because of poor statistical certainty (some even suggested Radiation Hormesis, as you alluded to).

      That's why these resent experiments are so important and interesting, they're finally investigating how organisms cope with low level radiation, and indeed they suggest the risks are grossly overestimated.

      Crump, K. S. et al. 2012. A Meta-Analysis of Evidence for Hormesis in Animal Radiation Carcinogenesis, Including a Discussion of Potential Pitfalls in Statistical Analyses to Detect Hormesis. Journal of Toxicology and Environmental Health, Part B 15, 210–231.
      Tubiana, M., Feinendegen, L. E., Yang, C. & Kaminski, J. M., 2009. The Linear No-Threshold Relationship Is Inconsistent with Radiation Biologic and Experimental Data. Radiology, 251, 13 –22.

  2. Re:As opposed to... by YodasEvilTwin · · Score: 5, Insightful

    Funny, but "no detectable DNA damage" is not the same as "no DNA damage or other side effects". This study would need to be much longer term and need to look for more than obvious DNA damage for me to trust it, personally. It was only 5 weeks!

  3. Re:Why Should I Trust This Study by godrik · · Score: 3, Insightful

    Probably you should not trust that one study. Currently, that is the only study that lead to this conclusion. Public safety regulation should not be lowered based on a single study.

    Once the result has been succesfully reproduced in multiple independent labs, then the question will be different.

  4. Re:Magical DNA damage testing? by istartedi · · Score: 5, Informative

    If you follow the links to the abstract, it actually explains what they measured. Apparently, certain types of DNA damage leave easily measured chemical signatures. They also dosed them with the same radiation total over a short period of time and observed damage.

    This is akin to turning your thermostat up 10 degrees for a few weeks as opposed to heating your house up to 500 degrees for a minute.

    I'm not saying I want to invest in cheap Fukushima real estate. I'm just saying that maybe this science isn't as junky as some Slashdotters think.

    --
    For all intensive purposes, "whom" is no longer a word. That begs the question, "who cares"?
  5. Re:As opposed to... by ozmanjusri · · Score: 3, Insightful

    This study would need to be much longer term and need to look for more than obvious DNA damage for me to trust it,

    This study will never be trustworthy.

    The danger to civilians from a nuclear accident is unlikely to come from background dose. That's more likely to be the exposure mode for workers and people very close to the incident.

    found that when mice were exposed to radiation doses about 400 times greater than background levels for five weeks, no DNA damage could be detected.

    No surprises there, but they didn't test what would happen when the mice ingested radioactive particulates, or when their entire food chain or water table was contaminated. Those are the real dangers from nuclear accidents.

    --
    "I've got more toys than Teruhisa Kitahara."
  6. Background level by Relic+of+the+Future · · Score: 4, Informative
    Seems a bunch of people really don't understand the scale of how low "background level" really is, how quickly levels can drop as the worst isotopes rapidly decay, or how the body repairs over time. That last one is maybe okay; we really haven't put a lot of study into anything beyond immediate exposures, so no one has a good understanding of that; or, I should say, HAD. And to see so many first reactions to this new science being "I refuse to believe it!"? Very disappointing. It's amazing how much disbelief a purportedly "scientific" group can conjure when scary radiation is mentioned.

    Btw, 100x background for 5 weeks is still less than the maximum year-long dose. Check the should-now-be-iconic xkcd radiation chart.

    --
    Those who fail to understand communication protocols, are doomed to repeat them over port 80.
  7. Re:It's alright by SuperKendall · · Score: 4, Funny

    Uh, is this a penis enlargement joke? Because I don't think radiation does that.

    It does if radiation excites you sexually.

    --
    "There is more worth loving than we have strength to love." - Brian Jay Stanley
  8. Re:As opposed to... by Anonymous Coward · · Score: 5, Informative

    Are you talking about chemical poisoning, or magical evil pixie dust. 125I decays emitting low-energy gamma radiation (the type that gets adsorbed adversely by living things). Eating this will have no different an affect than living right under it, as an object like a person, or mouse, is not a relevant shield for gamma radiation.

    Now, if we were talking about inhaling dusted alpha emitters, then you'd have a point. However, those are either heavy metals, oxidize and drop out of the air, or decay rapidly to long-term emitters. The dust will be much more poisonous than dangerous as a radioisotope.

    Damnit, I fed the troll.

  9. I'm fine with that, moron. by SuperKendall · · Score: 4, Insightful

    There's nothing I detest more than some douche who has spent some time
    at a university telling us all "we have nothing to fear".

    Oddly, there's nothing I detest more than some idiot who is terribly afraid of something long after it's been proven to be safe.

    I'd happily live in an area with 200x the level of background radiation (hey, my AT&T reception couldn't get any worse). The best benefit is that I can be sure compete morons like yourself will not be neighbors.

    They said that about DDT.

    Um, yeah...because DDT is safe. And millions have been killed from malaria that could have been saved without idiots like yourself "protecting" them.

    Moron.

    --
    "There is more worth loving than we have strength to love." - Brian Jay Stanley
  10. Re:As opposed to... by ozmanjusri · · Score: 3, Informative
    A recently published study in the Journal of Environmental Radioactivity confirms that the radioactive fallout from the Fukushima nuclear disaster reached Europe (Lithuania), and included plutonium. Likewise strontium (89 and 90) levels were elevated globally.

    The amounts were tiny, but randomly sized/distributed particulates are notoriously hard to measure and map.

    --
    "I've got more toys than Teruhisa Kitahara."
  11. Re:As opposed to... by spike+hay · · Score: 3, Interesting

    Do you live near a freeway? That doubles the rate of atherosclerosis. Air pollution kills hundreds of thousands a year in the US, and also causes other significant morbidity like asthma in children. Way more dangerous that a measly radiation dose. Yet, I don't see people wanting to evacuate from around coal plants and freeways.

    --
    If you don't understand any of my sayings, come to me in private and I shall take you in my German mouth.
  12. Re:As opposed to... by budgenator · · Score: 3, Informative

    Funny, but "no detectable DNA damage" is not the same as "no DNA damage or other side effects". This study would need to be much longer term and need to look for more than obvious DNA damage for me to trust it, personally. It was only 5 weeks!

    Not that much longer, a mouse goes from infancy to maturity in about 6 to 10 weeks, a year can get you a generation or two. A mouse can have 5 - 10 litters in a year and their lifespan is 9 to 12 months; 5 weeks for a mouse is like 20 years for a human.

    --
    Apocalypse Cancelled, Sorry, No Ticket Refunds
  13. Re:As opposed to... by Diamonddavej · · Score: 3, Informative

    Sophisticated molecular and genetic analyses were not available in 1950s - 70s when many experiments investigating the effects of radiation on plants and animals took place; most were crude LD50 and cancer frequency tests conducted at moderate to very high doses, few were conducted at low doses (0.1 Gy) where cells could potentially repair the damage caused. This has all changed in the last ~20 years.

    Sophisticated laboratory techniques now detect and observe the defence & repair mechanisms that operate in cells and whole organisms at low doses (100 mSv, ~0.8% increased risk of cancer in humans). For example, healthy people's cells repair all radiation induced DNA Double Strand Breaks (DSBs) within 24-hours after a CAT scan, indicating little or no additional risk of cancer. It is clear from resent experiments that living organisms are not passive accumulators of radiation damage but they actively combat and repair the damage done. After all, life involved with radiation and 3.5-3.8 billion years ago radiation levels were many times greater then now, it was necessary to evolve sophisticated error correction mechanisms. Indeed, it is likely that radiation is far less harmful or harmless below a certain threshold, possibly ~ 20 mSv year.

    Crump, K. S. et al. 2012. A Meta-Analysis of Evidence for Hormesis in Animal Radiation Carcinogenesis, Including a Discussion of Potential Pitfalls in Statistical Analyses to Detect Hormesis. Journal of Toxicology and Environmental Health, Part B 15, 210–231.
    Neumaier, T. et al. 2012. Evidence for Formation of DNA Repair Centers and Dose-Response Nonlinearity in Human Cells. PNAS 109, 443–448.
    Löbrich, M. et al., 2005. In vivo formation and repair of DNA double-strand breaks after computed tomography examinations. Proceedings of the National Academy of Sciences of the United States of America 102, 8984 –8989
    Tubiana, M., Feinendegen, L. E., Yang, C. & Kaminski, J. M., 2009. The Linear No-Threshold Relationship Is Inconsistent with Radiation Biologic and Experimental Data. Radiology 251, 13–22. (Paper available without subscription).

  14. Re:As opposed to... by BlackPignouf · · Score: 3, Insightful

    5 weeks for a mouse is like 20 years for a human.

    Maybe, but 5 weeks for mouse's DNA is like 5 weeks for human's DNA.

    It's like the birds and rodents living happily in Chernobyl.
    Who cares if you get a cancer after 15 years of radiation if your average life expectancy is 10 years?