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Coffee Consumption Strongly Linked To Preventing Alzheimer's

An anonymous reader writes "Those cups of coffee that you drink every day to keep alert appear to have an extra perk — especially if you're an older adult. A recent study monitoring the memory and thinking processes of people older than 65 found that all those with higher blood caffeine levels avoided the onset of Alzheimer's disease in the two-to-four years of study follow-up. Moreover, coffee appeared to be the major or only source of caffeine for these individuals."

46 of 205 comments (clear)

  1. So, I suspect that a good strong cup of tea ... by Jerry · · Score: 2, Interesting

    will work just as well?

    If so, why am I so forgetful? I drink two or three cups of tea a day.

    --

    Running with Linux for over 20 years!

    1. Re:So, I suspect that a good strong cup of tea ... by betterunixthanunix · · Score: 3, Informative

      If I remember correctly, tea will only achieve half the concentration of caffeine that coffee will. Of course, tea has many other benefits, such as protection against cancer, and neuroprotective effects (even some protection against lead poisoning). You should, however, keep in mind that tea can be dangerous in too large a quantity; tea plants absorb quite a bit of Florine from the soil, and lower-quality, older tea leaves can have very high concentrations (these are what you get with Lipton etc.). Japanese teas tend to have less Florine because of the low Florine levels in Japanese soil, and white tea has lower concentrations because the leaves are so young.

      --
      Palm trees and 8
    2. Re:So, I suspect that a good strong cup of tea ... by NEDHead · · Score: 5, Funny

      And the Japanese tea has this cool glow-in-the-dark ambiance...

    3. Re:So, I suspect that a good strong cup of tea ... by m00sh · · Score: 5, Interesting
      No, tea won't work.

      Most recently, they reported that caffeine interacts with a yet unidentified component of coffee to boost blood levels of a critical growth factor that seems to fight off the Alzheimer’s disease process.

    4. Re:So, I suspect that a good strong cup of tea ... by gestalt_n_pepper · · Score: 2

      I imagine tea plants absorb quite a bit of fluorine too.

      Unless they loose it somewhere. :)

      Yes, I am a spelling Nazi. Get over it.

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      Please do not read this sig. Thank you.
    5. Re:So, I suspect that a good strong cup of tea ... by betterunixthanunix · · Score: 4, Interesting

      You know, it is not all that hard to test for the presence of radioisotopes. Take a Geiger counter to your local tea shop and scan the Japanese teas if you are really concerned...

      --
      Palm trees and 8
    6. Re:So, I suspect that a good strong cup of tea ... by Norwell+Bob · · Score: 4, Funny

      Then, as a spelling Nazi, I assume you didn't actually mean "Unless they lose it somewhere.

    7. Re:So, I suspect that a good strong cup of tea ... by Anonymous Coward · · Score: 3, Informative

      However, given the amount of caffeine in even the darkest chocolate, you would need to eat so much of it that you would likely die from diabetes long before you had to worry about Alzeheimers. TFA talks about people who drink 3 cups of coffee per day, which would equate to around 300-350mg of caffeine, which would be around a 1/3 to 1/2 a pound of very dark chocolate.

      You'd probably die of Theobromine poisoning far before the onset of diabetes. The darker the chocolate, the more cacao, the less sugar.

    8. Re:So, I suspect that a good strong cup of tea ... by Billy+the+Mountain · · Score: 2

      Yeah, and while you are at it, scan the brazil nuts and bananas. (two foods with the most radioactivity where the radioactivity occurs naturally)

      --
      That was the turning point of my life--I went from negative zero to positive zero.
    9. Re:So, I suspect that a good strong cup of tea ... by TheLink · · Score: 2

      The article says other sources of caffeine had no effect.

      I bet if people drink lots of Coca Cola everyday the odds of them getting Alzheimer's go way down. The higher the dose the stronger the effect.

      Even reduces the odds of dying of cancer.

      --
    10. Re:So, I suspect that a good strong cup of tea ... by Anonymous Coward · · Score: 5, Informative

      The article says other sources of caffeine had no effect. So it's probably not the caffeine but some other coffee component. (Or maybe just the hot water.) Personally I'd rather eat dark chocolate than drink coffee (ick).

      Yes, this is perhaps the important quote from the article:

      Since 2006, USF’s Dr. Cao and Dr. Arendash have published several studies investigating the effects of caffeine/coffee administered to Alzheimer’s mice. Most recently, they reported that caffeine interacts with a yet unidentified component of coffee to boost blood levels of a critical growth factor that seems to fight off the Alzheimer’s disease process.

      The interaction between the caffeine and the coffee component appears to produce something that is highly beneficial. Maybe it can be identified and synthesized and patented and sold in pill form. On the other hand, coffee is so cheap that it could be the generic version for those of us who don't mind drinking it.

      Load up on SBUX stock! Doctors will be prescribing three cups a day and insurance will be paying for it!

    11. Re:So, I suspect that a good strong cup of tea ... by fuzzyfuzzyfungus · · Score: 3, Funny

      On the plus side, if the caffeine is the causative agent, supplementation would be pretty easy.

      The one positive side effect of the (otherwise dreadful) fad for leaching perfectly good caffeine out of wholesome caffeinated goods is that it creates a supply of the relatively pure stuff that can be added to things deprived by nature of their rightful share...

    12. Re:So, I suspect that a good strong cup of tea ... by treeves · · Score: 3, Funny

      Well, as a *spelling* Nazi, his expertise is limited to detecting misspelled words, not misused words. He apparently doesn't have the combined spelling/grammar or spelling/usage Nazi certification.

      --
      ...the future crusty old bastards are already drinking the Kool-Aid.
    13. Re:So, I suspect that a good strong cup of tea ... by DaveAtFraud · · Score: 4, Interesting

      From TFA:

      Since 2006, USF’s Dr. Cao and Dr. Arendash have published several studies investigating the effects of caffeine/coffee administered to Alzheimer’s mice. Most recently, they reported that caffeine interacts with a yet unidentified component of coffee to boost blood levels of a critical growth factor that seems to fight off the Alzheimer’s disease process.

      Cheers,
      Dave

      --
      They that can give up essential liberty to obtain a little temporary safety deserve neither safety nor liberty.
      Ben
    14. Re:So, I suspect that a good strong cup of tea ... by gestalt_n_pepper · · Score: 2

      The :) after the sentence was supposed to alert you to the fact that the misspelling was an intentional joke. Sorry. I'll try and be less subtle next time.

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    15. Re:So, I suspect that a good strong cup of tea ... by arth1 · · Score: 4, Insightful

      Honestly, as long as the point comes across you shouldn't really care.

      But it didn't come across. I was about to google "florine" to find out what I had missed when I saw the GN's post. Because I'm not a phonetic reader, it never occurred to me that florine might be fluorine.

      The devil is in the details. Being imprecise not only sends someone on a wild goose chase, but also means no distinction between fluorine, fluorene and fluoride, all of which are quite different things. And it's not fluorine that's thought to be a problem, but fluoride compounds, specifically hydrogen fluoride. It's as wrong as saying oxygen when you mean ozone.

    16. Re:So, I suspect that a good strong cup of tea ... by icebrain · · Score: 5, Insightful

      What's that whooshing sound?

      (Ok, I'll explain it... drinking lots of Coke every day does increase cholesterol and lead to obesity and such... and increasing your chances of dying early before Alzheimer's kicks in. So yes, the odds of dying from Alzheimer's go down, because you're much more likely do die earlier from something else.)

      --
      The meek may inherit the earth, but the strong shall take the stars.
    17. Re:So, I suspect that a good strong cup of tea ... by mcgrew · · Score: 4, Funny

      Dew knot truss yore spill checker!

    18. Re:So, I suspect that a good strong cup of tea ... by flyingsquid · · Score: 3, Insightful

      On the plus side, if the caffeine is the causative agent, supplementation would be pretty easy.

      Possibly, but perhaps caffeine doesn't have anything to do with it. I think the phrase "correlation does not equal causation" is something of a cliche, but it's a cliche for a good reason. We know that there's an association, but because this isn't an experiment with a control and a treatment, we don't know why that association exists.

      For an example of how this logic can break down, consider a recent study of coffee (again) that found that nurses drinking lots of coffee suffered lower rates of depression. So coffee has antidepressant effects, right? Well, that's one possible explanation. Here's another possible explanation: symptoms of depression include anxiety and trouble sleeping. So if you're anxious and can't sleep at night, the last thing on earth you want is 4-5 cups of coffee a day making you wired, twitchy, and wakeful. So yes, one reading is "coffee drinking reduces depression" but an equally plausible reading of the data is "depression reduces coffee drinking." The only way to tease it apart is with an experiment: take a population, give half of them coffee, give half of them decaf (to control for placebo effect), and see whether the incidence of depression varies between the two. So what's the answer? Nobody knows.

      Likewise, we have to look at the possibility that decreased coffee consumption is caused by Alzheimer's. If coffee is part of your morning ritual and social functioning, then as you become less functional, you might forget to make that morning cup and have trouble interacting with people at the coffee shop. So perhaps Alzheimer's causes people to drink less coffee. The only way to figure it out is to take a population and give half of them coffee, and half of them decaf, and see how they do.

    19. Re:So, I suspect that a good strong cup of tea ... by gvaness · · Score: 4, Funny

      God yes, I remember that stuff. My Mom had a huge bar of it in the freezer for baking and told me I wouldn't like it, and not to eat it. Ten year old me thought he was so smart to figure out that Mom was just pulling one over on him to keep all the chocolate for herself. After all, how the hell could they make chocolate that I wouldn't like? Then I snuck a big chunk of it and could only think it had been a trap the whole time.

    20. Re:So, I suspect that a good strong cup of tea ... by TheLink · · Score: 2

      It's not sarcasm though. It's a claim that's backed by many scientific and medical studies.

      A reason why some people don't get it is they don't fully realize they will eventually die. They "know" it, but they don't really know it all the way.

      One problem is if they make decisions as if they would live forever. So you have these people putting up with options that they don't like, to live longer, then they get cancer. And they're so surprised... If it's not in your genes to live in good health till 90 (check your blood relatives) and die of pneumonia or something, you are likely to get something nasty when you prolong your life past your "best by date"- dementia, cancer, go blind. It's fine to do so you have a good reason to want to try to prolong your life (live to see your favourite great grandchildren grow up). But it has to be better than "I don't want to die", because you will die.

      Even many scientists/researchers make a similar mistake. For instance when they calculate the economic cost of smoking to society. It is true more smokers die of something expensive earlier in their life.
      But if you don't smoke and so live longer past your retirement age, don't contribute significantly to society (economically or otherwise), and still end up going for one or more expensive treatments in hospitals before eventually dying, you're a greater cost to society than the average smoker that dies early after their retirement- especially if the smoker is also paying very high tobacco taxes (in some countries the taxes are very high). FWIW I'm a nonsmoker.

      Same for many of those game theory and "antigambling" stuff. Often their assumption is that the participants aren't going to die. Whereas if they took that into account, some (not all!) of the things people do start to make more sense. For example if you are uneducated, very poor, with no great connections and your goal is to be as rich as a big lottery winner, working much harder isn't that much more likely to do it, than buying a lottery ticket, when taking into account the personal cost of working harder and that you will eventually die. Social mobility in many countries isn't very high.

      Research into prolonging quality life is good, but always remember you will die eventually.

      And be thankful for that! If it were impossible for you to die, what will you do by yourself for eternity when the last stars in the universe finally burn out? If people really had immortal imperfect souls, they would end up in a hell one way or another, if they weren't "fixed" somehow.

      --
  2. Excellent... by fuzzyfuzzyfungus · · Score: 2

    Truly, drugs are nature's hugs.(and parasitic filarial nematodes are nature's psycho abusive stepparents...)

  3. Spice by Megane · · Score: 5, Funny

    It is by caffeine alone I set my mind in motion. It is by the beans of Java the thoughts acquire speed, the hands acquire shaking, the shaking becomes a warning. It is by caffeine alone I set my mind in motion.

    --
    #naabhaprzrag, #sverubfr-000, #agi-fcbafberq, negvpyr[pynff*=' negvpyr-ary-'] { qvfcynl: abar !vzcbegnag; }
    1. Re:Spice by chinton · · Score: 2

      This (para)phrase is the best thing to come from Lynch's Dune.

    2. Re:Spice by PCM2 · · Score: 2

      Yeah, except as I recall, the quote his joke references doesn't come from Frank Herbert's Dune. Only the movie.

      --
      Breakfast served all day!
  4. Small Sample? by Anonymous Coward · · Score: 4, Insightful

    124 people in the study is pathetic. Why wouldn't they get a bigger sample size for a study like this? Not like it should be difficult. Apparently a study published in the New England Journal of Medicine included over 400,000 older adults in similar study.

    1. Re:Small Sample? by leuk_he · · Score: 2

      Agreed, but it can be even worse. The study does not give a cause reason that this happens. It just show 2 factors that correspond. Some other factors might even cause this. e.g. some of the people with Alzheimer do not drink coffee because their health is too bad for if, or the medicins they use do not allow coffee. Or the shakes coffe gives them causes them not to drink coffee. I do not know.

      Without a cause reason this makes great headlines, but is only a very tiny to do with resolving the disease.

      AND EVEN besides this points, the science might by very valid. It describes very well how they came to the conclusions. But the major conclusions should be that there must be investigations with bigger test groups and that the root cause must be found in futher investigations. But that conclusions make bad headlines in the press.

    2. Re:Small Sample? by jpate · · Score: 4, Insightful

      Yeah! There's no way that trained scientists would be able to calculate reliable a difference is given a certain sample size with an observed variance! That's just wayyyy too hard. The only way to do real science is to get 400,000 data points for every comparison; it's the only way to be sure.

      In all seriousness, huge sample sizes are only important if we are comparing several variables, where a large sample size can give us good estimates for rare combinations of events, and/or small effects, where a large sample size allows us to achieve small confidence intervals over the relevant comparisons. It's quite possible for a sample size of 124 to yield a significant difference for one effect if the effect is of at least moderate size.

    3. Re:Small Sample? by Rich0 · · Score: 2

      However, significance is only accurate if you propose a hypothesis BEFORE you collect data, or you account for the number of hypotheses that you COULD have tested when you started hunting for correlations.

      If you ask 100 people for a list of everything they do and eat and everything wrong with them, and find a correlation, I don't care what test you claim you've done, it isn't going to truly be significant.

      If you want to determine if caffeine prevents lung cancer, survey 100 people and just ask about caffeine intake and lung cancer, then MAYBE I might believe claims you've made. However, I will only do so if you didn't just survey 100 people the week before about orange juice and heart disease without publishing the negative result.

      The problem with most hypothesis testing is that people rarely account for all of their negative results. This is why clinical trials are one of the most unreliable forms of data in science (the problem is that nobody has a better alternative, though some reforms like advance registrations of trials might help).

    4. Re:Small Sample? by jpate · · Score: 2

      However, significance is only accurate if you propose a hypothesis BEFORE you collect data, or you account for the number of hypotheses that you COULD have tested when you started hunting for correlations.

      Wagenmakers et al (2011) make a similar but slightly different point. The important thing is to distinguish between exploratory studies and confirmatory studies. In an exploratory study, hypotheses are based on correlations found after gathering data, while in a confirmatory study, the examined hypotheses are planned in advance. Both are important. Without confirmatory studies, exactly your point criticism applies, but, without exploratory studies, non-intuitive insights are difficult to come by.

      This is why replications of previous studies, with new data, are so important. Research is messy enough that the first examination of a hypothesis is at least partly exploratory, and it's up to the next five research papers to replicate the original instantiation of the hypothesis on the way to exploring the next elaboration of it.

  5. Re:Anecdotal Evidence by betterunixthanunix · · Score: 2

    Nothing is guaranteed in life; if I tell you that drinking coffee reduces your chance of getting Alzheimer's by 90%, that does not mean that you will definitely not get Alzheimer's if you drink coffee. This is not math, where a single counterexample is sufficient.

    --
    Palm trees and 8
  6. Re:Anecdotal Evidence by gestalt_n_pepper · · Score: 3, Insightful

    Or necessarily false either. Had she not been drinking coffee, the onset might have started a decade earlier.

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  7. what did you say? by ILongForDarkness · · Score: 3, Funny

    Who are you, why are you here?

  8. Re:Correction Factors? by PPH · · Score: 2

    People who drink coffee might be doing it at work, which keeps you alert and prevents dementia.

    Depends on where one works. At some companies, dementia seems to be a prerequisite for employment.

    --
    Have gnu, will travel.
  9. Re:Anecdotal Evidence by avandesande · · Score: 2

    She made it to her eighties? My grandfather died of Alzheimer at a much younger age which means I am at risk. If I can keep it at bay until I am eighty I will be quite pleased!

    --
    love is just extroverted narcissism
  10. Re:Correlation or causation? by 0123456 · · Score: 3, Funny

    Maybe people with Alzheimer's forget where they left their coffee and never drink it.

  11. Obligatory... by tool462 · · Score: 4, Funny

    ... SMBC ;)
    Had you for a second there, didn't I?

    It's not that caffeine prevents Alzheimer's, caffeine dilates time itself. We live a lifetime of productive bliss in only a few moments. Why else do non-coffee drinkers never appear to age? In what feels like 60 years for us, only a short time passes for them. They look younger because they are younger. But, they also live long enough to get Alzheimer's, Parkinson's, cancer. In a twist of irony our lives are shorter but our years are longer. We looked to the internet for the Singularity, but we should have looked inside. The Singularity is us.

  12. Re:Coffee Miracle by Khyber · · Score: 2

    Bypass blood/brain barrier and just inject coffee directly to brain!

    --
    Still waiting on Serviscope_minor to wake up to fucking reality and realize that Jessica Price isn't going to fuck him.
  13. Re:Some issues by avandesande · · Score: 2

    FTFA

    "“We found that 100 percent of the MCI patients with plasma caffeine levels above the critical level experienced no conversion to Alzheimer’s disease during the two-to-four year follow-up period,” said study co-author Dr. Gary Arendash."

    100% is a extremely strong correlation....

    --
    love is just extroverted narcissism
  14. Re:I doubt this is a good study by Daniel+Dvorkin · · Score: 2

    And my grandfather recently died at the age of 103, after a lifetime of smoking, drinking, getting hardly any exercise, and eating crappy food. None of which means that these are recommended practices for extending your lifespan. The plural of "anecdote" is not "data."

    --
    The correlation between ignorance of statistics and using "correlation is not causation" as an argument is close to 1.
  15. Re:Yeah, yeah. by slimjim8094 · · Score: 2

    What are the giant list of negative effects, exactly? The wiki doesn't seem to show more than a few Aside from the high blood pressure stuff (which kicks in with more than the study's amount of coffee), everything else is either benign or a reason people drink it in the first place (it keeps you awake)

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  16. Re:Yeah, yeah. by slimjim8094 · · Score: 2

    Interesting. The brain is quite powerful, specifically with regards to psychosomatic issues. As a kid, I used to love kettle popcorn, but I ate too much of it and it ... well, let's just say that it was sharp on the other side and I was in agony for a few days. Since then, even the thought of kettle corn makes me quite nauseous. I tried to eat some a few weeks later and it made me so sick I couldn't leave the house. I'd throw up if I tried to stand.

    It was all in my head, of course. The intensely bad experience spoiled it for me, and my brain made my body react very strongly to it. There wasn't anything about the popcorn that had changed. Even though I know now that it's all in my head, I still can't eat the stuff.

    Perhaps that's what happened to you? It explains the Red Bull situation.

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  17. Re:Correlation or causation? by canajin56 · · Score: 5, Informative

    They didn't do a random test, say "oh hey look coffee did something lets make wild conclusions". They worked from mice studies, the most recent in 2006, then specifically did a human test by taking people with minor cognitive impairment (which often progresses into Alzheimer's), they tested them for their blood caffeine levels, and looked for further cognitive decline. What they found was that in mice with Alzheimer's, coffee prevented further mental decline. And, in those mice, there was a specific and identifiable immune response connected with this effect. What they also found was that decaff coffee produced neither the protective effect, nor the correlated immune response. And caffeine alone or from other sources did not have this effect, either. This new 4 year study took patients and looked at their blood caffeine levels, and found that those who drink a lot of coffee had the SAME identifiable immune response as the mice did, and that this immune response is also strongly correlated with protecting from further mental decline in humans.

    So, if you weren't paying attention, this isn't a correlation study, that isn't "conclusion section speculation". There's an identifiable response, they know this identifiable response doesn't occur with decaff, or with non-coffee caffeine sources, so they conclude it is some combination of caffeine with some unknown agent in coffee. But the actual response is identified. The correlation is not between coffee and Alzheimer's per se, but between Alzheimer's and this specific immune response that is almost certainly triggered by coffee, because although it's hard to do a controlled experiment with people, it's not hard to do with mice! And they did. Six years ago.

    At any rate, what they don't know is what other chemical is causing this, how this response is protecting against cognitive decline, and if having smaller amounts of coffee will have a lesser effect, or be just plain ineffective. (Some people have quoted 3 cups of coffee per day, but TFA says 3 cups of coffee shortly before being tested, which would indicate a lot more than 3 cups per day total)

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  18. Re:emoticon Nazi by gestalt_n_pepper · · Score: 3, Funny

    A thousand pardons ;)

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  19. Most people have never had good coffee. by bdwoolman · · Score: 2

    Roasted coffee starts to get stale after about a week. And is at its peak about 24 hours after roasting. Only a very few coffee houses consistently serve freshly roasted specialty coffee. (Places that serve Counter Culture coffee do a pretty good job.) Vacuum packing roasted coffee does not prevent the deterioration (It helps a bit, but then the coffee stales almost immediately after exposure to air.) Nor does freezing help either.

    The darker roasts served up by the mass market coffee houses are actually eschewed by real coffee geeks, who prefer to roast their own and to a lighter degree. And, in any case, the dark roasted beans at these joints are usually stale anyway. Dude. Once you have tasted, say, a freshly roasted Yirgacheffe from Ethiopia, or a great Kenyan AA you will not say "ick". And here is another fact. Green coffee lasts for two years. And is roughly half the price per pound as roasted coffee. Which is why I roast my own coffee in a home roasting appliance. (I use a Nesco). I make about a third of a pound at a time, It is wonderful. Rarely in life is cheaper better. But in this case it is true (Except for the energy involved in roasting of course.) The fact is that coffee, like bread, is just better when it is fresh. A lot better.

    With care coffee can be roasted on the stove top in a black cast iron pan. It smokes a lot so you should have a venting hood. There are tons of on-line instructions. To get my beans I go to Sweet Maria's or to Burman Coffee traders. But there are many places to get green beans. Equipment is available from these places I mentioned as well.

    --
    "No fear. No envy. No meanness." Liam Clancy
  20. Re:Anecdotal Evidence by mcgrew · · Score: 2

    Yeah, well, my great uncle started smoking at age 12 and quit at age 82, and lived another decade. But I wouldn't suggest that his longevity disproves the fact that smoking is bad for you.

    Were it not for the coffee, your granny might well have shown symptoms earlier and been dead by now.