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Scientists Keep Rabbits Alive With Oxygen Microparticle Injections

ananyo writes "Rabbits with blocked windpipes have been kept alive for up to 15 minutes without a single breath, after researchers injected oxygen-filled microparticles into the animals' blood. Oxygenating the blood by bypassing the lungs in this way could save the lives of people with impaired breathing or obstructed airways (abstract). In the past, doctors have tried to treat low levels of oxygen in the blood, or hypoxaemia, and related conditions such as cyanosis, by injecting free oxygen gas directly into the bloodstream. But oxygen injected in this way can accumulate into larger bubbles and form potentially lethal blockages."

61 of 274 comments (clear)

  1. One step closer by alexbgreat · · Score: 5, Funny

    And with this...we're one step closer to the zombie apocalypse.

    1. Re:One step closer by Garridan · · Score: 5, Insightful

      Yeah... something tells me that "kept alive" means "killed" in this study.

    2. Re:One step closer by interkin3tic · · Score: 4, Insightful

      You mean we're one step closer to the futurama head jars. Or gills for people maybe?

      On a more serious note, probably also a step closer to easier surgeries like lung transplants. Maybe a step toward treating cystic fibrosis.

      But zombies, absolutely not. There's nothing contagious here, and I thought zombies breathe. I mean, if they weren't using their lungs and windpipes, how are they always moaning... always moaning... day and night, keeping me awake... realizing that it's inevitable...

    3. Re:One step closer by viperidaenz · · Score: 4, Insightful

      They don't use their lungs for breathing though. Shots to the chest do little to stop a zombie, you need a head shot.

    4. Re:One step closer by agm · · Score: 5, Insightful

      "Yeah... something tells me that "kept alive" means "killed" in this study."

      It's a rabbit. If sacraficing a creature so stupid to not even be self aware can save hundreds or thousands of human lives, so be it. Science is cruel, but well worthwhile.

      How do you know they're not self aware, and if you don't know 100% that they're not is it worth the risk?

    5. Re:One step closer by tibit · · Score: 3, Interesting

      Said a bozo who doesn't realize that a human skin color goes from all black to all white in 100 generations.

      --
      A successful API design takes a mixture of software design and pedagogy.
    6. Re:One step closer by tbird81 · · Score: 2, Insightful

      It's a fucking rabbit.

    7. Re:One step closer by mug+funky · · Score: 4, Interesting

      there's no action that you can perform in this world without directly causing death to many creatures.

      a vegan just draws the line a little lower than everyone else.

      in nature, all is expendable. better get used to it.

    8. Re:One step closer by Thiez · · Score: 5, Interesting

      Because it will *hurt*. You still need to breathe out to get rid of carbon dioxide. It is not lack of oxygen, but build-up of CO2 that makes you feel like you need to breathe. Don't breathe out long enough and you'll find the pH of your blood going down, which is not very healthy. I imagine having these oxygen injections without breathing will feel a lot like asphyxiation, except that instead of passing out in 3 or 4 minutes, the experience will last 15 minutes.

      Also, as mentioned in the article, these microparticles don't magically disappear so you can't keep adding them indefinitely.

    9. Re:One step closer by L4t3r4lu5 · · Score: 3, Funny

      Jesus, they could have let him finish off first.

      One last hooray, if you will.

      --
      Finally had enough. Come see us over at https://soylentnews.org/
    10. Re:One step closer by azalin · · Score: 2

      As far as rabbits are concerned, 15 minutes should be plenty.

    11. Re:One step closer by azalin · · Score: 4, Insightful

      It might also be a way to increase "shelf life" of organ transplants. It won't allow long term storage, but even a few extra hours might help a lot.

    12. Re:One step closer by Hillgiant · · Score: 2

      "Just" a rabbit?

      Follow. But. Follow only if ye be men of valour, for the entrance to this cave is guarded by a creature so foul, so cruel that no man yet has fought with it and lived. Bones of full fifty men lie strewn about its lair. So, brave knights, if you do doubt your courage or your strength, come no further, for death awaits you all with nasty, big, pointy teeth!

      --
      -
    13. Re:One step closer by Anonymous Coward · · Score: 2, Insightful

      Are insects animals? Because vegans eat them. There is no way to avoid it. Dust mites and other microscopic critters are in any food you choose to eat.

      The only way to avoid taking animal lives in this world is to give up your own life.

  2. Lots of applications by Grayhand · · Score: 4, Interesting

    I can see this as a major help in organ transplants like lung and heart. Also there's a potential for cystic fibrosis since it bypasses the lungs.

    1. Re:Lots of applications by demonlapin · · Score: 2, Informative

      No, it's not useful for those. You already have an established airway for those. And in CF, the lungs aren't often the killer, these days.

    2. Re:Lots of applications by demonlapin · · Score: 3, Informative

      No. The volume requirements alone will rapidly render this useless. To supply an adult human, you would need 300-600 mL of infused volume per minute. Given that an adult has a blood volume of roughly 5 L, you can imagine that you're going to run into problems pretty quickly.

    3. Re:Lots of applications by MightyYar · · Score: 3, Insightful

      But you might target the brain?

      --
      W..w..W - Willy Waterloo washes Warren Wiggins who is washing Waldo Woo.
    4. Re:Lots of applications by interkin3tic · · Score: 4, Interesting

      To supply an adult human, you would need 300-600 mL of infused volume per minute. Given that an adult has a blood volume of roughly 5 L, you can imagine that you're going to run into problems pretty quickly.

      I don't see why. They inject the microparticles directly into the blood, and this rapid infuser at least can move 1000 mls of fluid per minute.

      The mircoparticles themselves sound like they could be made fairly rapidly:

      The microcapsules are easy and cheap to make, says Kheir. They effectively self-assemble when the lipid components are exposed to intense sound waves in an oxygen environment — a process known as sonication.

      The article notes that this would probably not be something you would do for long term though, and that there are already techniques to oxygenate blood externally then pump it back in, used during surgery.

    5. Re:Lots of applications by tibit · · Score: 3, Insightful

      Established airway for a lung transplant? Huh? Sure you can use an external heart-lung machine, but the problem is always with hemolysis and clotting. Deleting the "lung-" part from the "heart-lung" machine would certainly help with both.

      --
      A successful API design takes a mixture of software design and pedagogy.
    6. Re:Lots of applications by BeanThere · · Score: 2

      Clearly, lungs are impossible.

  3. Beats current techniques by niftydude · · Score: 2

    This sure is better than having someone perform an emergency tracheotomy with a steak knife on you.

    --
    You can never know everything, and part of what you do know will always be wrong. Perhaps even the most important part.
    1. Re:Beats current techniques by demonlapin · · Score: 5, Informative

      The experimental solutions contained 50-90 mL of O2 per deciliter - to sustain an adult human, you need about 300 mL O2 per minute. At least 300 mL of IV fluid and as much as 600 mL per minute is going to have to go through one hell of an IV. I doubt you could achieve such infusion rates without specialized equipment (e.g., 8.5 French rapid infusion catheter + Level One pump) or multiple intraosseous needles.

      Furthermore, this is temporizing just like any other O2 delivery method. Oxygen is essential for life, but eventually you have to clear the CO2, or it's pointless. As a bridge to a secure airway or crash on to cardiopulmonary bypass? Sure, it's not a bad idea, except that the only thing that matters in that kind of life-or-death situation is how long it takes to get it in the room. By the time you get this stuff out of the refrigerator in pharmacy and run it to the OR, ER, or ICU, you could have gotten a surgeon there to do the cricothyrotomy or even a proper tracheostomy.

    2. Re:Beats current techniques by Auroch · · Score: 5, Insightful

      The experimental solutions contained 50-90 mL of O2 per deciliter - to sustain an adult human, you need about 300 mL O2 per minute. At least 300 mL of IV fluid and as much as 600 mL per minute is going to have to go through one hell of an IV. I doubt you could achieve such infusion rates without specialized equipment (e.g., 8.5 French rapid infusion catheter + Level One pump) or multiple intraosseous needles. Furthermore, this is temporizing just like any other O2 delivery method. Oxygen is essential for life, but eventually you have to clear the CO2, or it's pointless. As a bridge to a secure airway or crash on to cardiopulmonary bypass? Sure, it's not a bad idea, except that the only thing that matters in that kind of life-or-death situation is how long it takes to get it in the room. By the time you get this stuff out of the refrigerator in pharmacy and run it to the OR, ER, or ICU, you could have gotten a surgeon there to do the cricothyrotomy or even a proper tracheostomy.

      That's all technically true. I think the question you AREN'T asking is the most important one - what if you're not trying to sustain a human, but simply lengthen the amount of time before cell death? If I recall my first aid training (and I do), even an extra 10 minutes can be the difference between brain damage and 100% recovery.

      --
      Quartz Extreme and Core Image. Are there any other real reasons to spend all that money on generic hardware?
    3. Re:Beats current techniques by MrMista_B · · Score: 3, Interesting

      Hell, not to mention organ donation. If you have a severe enough head trauma such that the person is /undeniably/ dead, something like this could save a lot of organs, and by extension, a lot of other lives.

    4. Re:Beats current techniques by EdIII · · Score: 2

      If there is one thing that religious people have taught me in this life, it's that there is no such thing as "undeniably" dead.

      They can deny, deny, deny, and then deny some more.

      More likely this will lead to more vegetable gardens being carefully maintained. That's their decision really and I hope I am never faced with it.

    5. Re:Beats current techniques by ThePeices · · Score: 2

      "..., but simply lengthen the amount of time before cell death? "

      This would be awesome for meat. You could have the tissue alive right until you chuck it on the grill.

      mmmm, tender meat.

    6. Re:Beats current techniques by Idarubicin · · Score: 4, Insightful

      You could have the tissue alive right until you chuck it on the grill. mmmm, tender meat.

      Well, no, actually.

      The tenderest beef has been dead for days or even weeks. As the cells within a cut of beef die, they release enzymes that slowly digest connective tissue (mostly collagen). "Live" steaks would contain intact, live cells that wouldn't have a chance to release any digestive enzymes before being cooked.

      --
      ~Idarubicin
    7. Re:Beats current techniques by ed1park · · Score: 2
  4. So what? by Digital+Vomit · · Score: 5, Funny

    Scientists Keep Rabbits Alive With Oxygen Microparticle Injections

    So what? I have a pet rabbit that I can keep alive with regular oxygen particles.

    And I don't even have to inject them or anything. They just go into the holes in his face.

    --
    Modern copyright is theft of culture from everyone and it retards the progress of the useful arts and sciences.
  5. Obviously not... by Narrowband · · Score: 3, Insightful

    ...they were experimenting with Rabbits.

  6. they forgot something by v1 · · Score: 5, Interesting

    CO2 must also be removed. that's probably what ultimately killed the rabbits.

    Besides overloading the red blood cells with CO2 and preventing the removal from the cells, it also screws up the PH of the blood really quick. I assume that with this process it could get bad enough to lead to shock.

    Now what would be really cool would be if they could come up with a sold-state exchanger for CO2 to O2. Something like a fuel cell in reverse - create a chemical exchange from an electrical power. Implant that into a body and it could run on batteries instead of breathing. But I don't think that technology in that form currently exists. They have "rebreathers" but those are huge space-suit-size affairs and operate on a far more involved process.

    But I bet someone's working on it right now. Probably several someones.

    --
    I work for the Department of Redundancy Department.
    1. Re:they forgot something by demonlapin · · Score: 5, Informative

      You can't turn CO2 + H2O into O2 + C(H2O) efficiently unless you're a plant, and you'd have to get the CO2 out of solution quickly (easy) and get more O2 back into solution quickly (hard).

      Rebreathers just scrub CO2 from the atmosphere and lock it up as a carbonate. They need not be particularly large, though - the CO2 scrubber on the GE (Datex-Ohmeda) ADU Carestation is about the same size as a pint glass. The rest of the system is the bulky part, and in most situations could actually be done without.

    2. Re:they forgot something by RivenAleem · · Score: 4, Funny

      Can't they just shake them to get the dissolved CO2 out? Works for a bottle of coke. What if they gave the rabbit a Mentos?

  7. This will change the Tour de France forever by Teresita · · Score: 5, Funny

    But will Lance Armstrong submit to a blood test for oxygen microparticles?

    1. Re:This will change the Tour de France forever by phantomfive · · Score: 3, Insightful

      He submitted to a blood test for everything else

      --
      "First they came for the slanderers and i said nothing."
  8. Re:How many rabbits were sacrificed? by BrianH · · Score: 5, Insightful

    Probably less than 1/10000th the number of rabbits that were sacrificed for dinner plates last night alone.

    --

    There is nothing so pathetic as seeing a beautiful young theory roughed up by a tough gang of facts.
  9. Re:How many rabbits were sacrificed? by bmo · · Score: 3, Interesting

    >Yes, I'm pretty conflicted about animal experimentation myself

    When it comes to life saving medicine, I'm not conflicted one bit.

    Thumper or...

    Me.

    I vote me.

    --
    BMO

  10. Re:Science... by Ironhandx · · Score: 5, Interesting

    Thats something sci-fi pulled out of the US Air Force books actually. Also Canadian Air Force books. It was originally thought up as a concept in canada to combat the massive g-forces the avro arrow could generate. It turned out it wasn't needed. Its been tested extensively by the US since(and there was some testing done in canada as well) but never used for any regular procedures afaik. It has also seen some testing for under water purposes, deep diving(Similar problems to massive g-forces and ridiculous altitudes)

    I've actually tried it myself at a marine research facility. Its extremely fucked and you can choke to death while being fully oxygenated(if you're a wuss, essentially). Also excess fluid left in the lungs can cause infections etc to set in.

    Doing something dangerous enough to have a paramedic crew standing next to you when you start it is a bit of a head trip too.

    Once you're in there tho... its not even slightly comfortable. It feels like your chest is being heavily pressed on and you have this constant drowning feeling that takes a bit to get over. Overall, I'd say thats probably the main reason it hasn't been used much. On paper the whole deal is fantastic. In reality, not so much.

  11. Lame by lessthan · · Score: 3, Interesting

    Why, why, why are these stories always "save peoples lives" angled? How cool would it be to dive with this stuff running in your veins? I bet the liquid is incompressible too. I wonder what the ratio of volume of the liquid versus how much oxygen contained within it is.

    --
    Space Shuttle was a program that strapped humans to an explosion and tried to stab through the sky with fire and math
    1. Re:Lame by Orgasmatron · · Score: 3, Informative

      Well, liquids aren't compressible in general, so I suspect that is already covered.

      The problem with diving isn't the blood, it is the lungs, and later (when you resurface) the difference in solubility of various gasses in your tissues under different pressures.

      The amount of, for example, nitrogen that can dissolve into your blood (again, for example) depends on the pressure. As the pressure goes up, more can dissolve. As the pressure goes down, less can dissolve, which means that when you surface, nitrogen dissolved in your body can suddenly reappear as a gas bubble which requires many times the volume that it took while dissolved. In a joint, or long muscle or fat, this can be painful. In an important artery or in your heart or other important organ (most of them), this can be fatal.

      --
      See that "Preview" button?
  12. Re:The Matrix by EdIII · · Score: 4, Insightful

    You forgot about that huge contraption that he had to pull out of his face....

  13. Yawn. ECMO, anybody? by SlowGenius · · Score: 2

    Nothing new/useful to see here. Move along, move along. Feel free to Google "ECMO" as you're heading out the door....

    --
    Listen to what I say, not what I mean...
  14. Re:So instead of just pumping it in, by davydagger · · Score: 2

    the internal combustion/electric engine "hybrid" was perfected in ww2 in submarines.

    They then figured out it could also work for cars 60 years later, and called it a breakthrough in technology.

  15. Cruel experiment by exploder · · Score: 3, Insightful

    Yeah, about the CO2 thing...you know that visceral panic you feel when you can't breathe? It's not triggered by lack of oxygen, but rather by excess CO2. I'm sure dying from asphyxiation is unpleasant enough, but having the experience dragged out to fifteen minutes (or more, once the methods are improved) must be horrific.

    --
    Yo dawg, I heard you like the Ackermann function, so OH GOD OH GOD OH GOD
  16. Re:How many rabbits were sacrificed? by kevmitch · · Score: 5, Insightful

    This seems to be the consensus among slashdotters given the consistent downmodding of people who even remotely question, let alone challenge, the ethics of animal experimentation. However, no one seems to address the rational justification for elevating humans to a higher level of worth. I'm not saying that experimentation is outright wrong, but the ethical assessments like these should never be automatic.

  17. Re:Am I the only one NOT OK with this? by Anonymous Coward · · Score: 2, Insightful

    Well, sorry Mrs. Smith. There might have been a technique that couuld have saved your boy; but we couldn't kill the rabbit. Would you like to pet the rabbit? So there's Mrs. Smith at her son's funeral petting the rabbit, and that makes up for it.

  18. Nobody tell the State Department by Majik+Sheff · · Score: 4, Interesting

    You think waterboarding is torture? Wait until some goon figures out how to use this technique to allow them to keep their victim alive as they experience their own suffocation. Over. and. Over.

    --
    Women are like electronics: you don't know how damaged they are until you try to turn them on.
  19. Re:Science... by cheekyjohnson · · Score: 2

    I wonder how many PETA vegans who develop fibrosis in the lungs will turn down any potential treatment to keep them alive developed from this.

    If someone somehow found a cure for cancer by sacrificing a million human babies, and no more babies would need to be killed afterwards in order to treat people, would you refuse the treatment? That would be pointless. The ones who died are already dead, and refusing the treatment will not bring them back.

    --
    Filthy, filthy copyrapists!
  20. Obviously so... by RawsonDR · · Score: 5, Funny

    Yes, the rabbits were the subject of the experiment. The mice were being choked to pass the time. It's just what these researchers do.

  21. Re:How many rabbits were sacrificed? by bmo · · Score: 3, Insightful

    >I don't believe it's possible to give a convincing argument for choosing you over a member of something else's species.

    You are drowning.
    Thumper is drowning.

    Who am I to save. Hmm.... let me think about it.

    Oh wait, I shouldn't think about it because I should pick you over Thumper. Because only people with absolute lack of empathy would pick Thumper.

    Sorry if this annoys you.

    --
    BMO

  22. Re:So instead of just pumping it in, by Jeremi · · Score: 2

    They then figured out it could also work for cars 60 years later, and called it a breakthrough in technology.

    To be fair, the cost, size, weight, and safety standards are a little more stringent in the private passenger car market. I suspect the breakthroughs involved meeting those requirements.

    --


    I don't care if it's 90,000 hectares. That lake was not my doing.
  23. Oh god by SmallFurryCreature · · Score: 5, Interesting

    You see no problem with pumping a human being full of a non-blood liqued at a rapid rate?

    The human in question would either explode OR the blood will become ever more diluted until all you got is the new liqued which isn't blood. And you need blood to survive, even if you are not a vampire.

    The article makes this pretty damn clear, it is not for surgery, it is for emergencies. There already exist perfectly fine methods for putting oxygen into blood, they are used routinely during surgery. But they are bulky and slow, so they can't be used on the scene of an accident or in an emergency room.

    This method is for keeping a patient alive until surgeons can save him. It is to stretch the window between incident and surgery to give emergency services more time. You would be suprised how advanced medicine is in saving people and how hard it is to get that advanced care available fast enough to work in an accident that could happen anywhere EVEN outside a hospital! Amazing I know but people do insist on getting accidents more then a minute away from a emergency room.

    If it could be allowed legally, it might become possible for ambulance crew to give patients a shot of this stuff and make sure their brain has oxygen enough to survive until proper life support systems can take over.

    But you CANNOT just pump a human being full of non-blood and expect them to survive.

    --

    MMO Quests are like orgasms:

    You may solo them, I prefer them in a group.

    1. Re:Oh god by tibit · · Score: 3, Interesting

      The only real problem I see is lack of clotting: that liquid will leak like crazy from any broken vessel...

      --
      A successful API design takes a mixture of software design and pedagogy.
  24. A lot of /. readers are emotionally stunted young by SmallFurryCreature · · Score: 3, Insightful

    A lot of /. readers are emotionally stunted young men, I wouldn't expect most of them to have any morals beyond their own immediate instinctive needs. It is not how things work.

    A decision as to how to live and die only comes when dead becomes a reality. Like people who decide to stop treatment of a fatal disease because they want to live the remainder of their live with some dignity rather then have a tiny hope with misery of dangerous medication. But you cannot judge this, until you have faced death.

    In some games and lots of movies and books, this is explored, from sophies choice, to Lawrence Oates self-sacrifice. What would YOU do? The current zombie game "The walking dead" gives you such choices, who do you save? There is a site that shows all the choices people made in the first episode. Of course, such a game is not real. But I wonder if the choices made are influenced by the players history. Will a person from a civil war, a parent, someone who lost someone dear, a young man, a woman who had an abortion for convenience, etc etc, make different choices NOT for gameplay reasons but because the choice fits with their world view?

    Hard research because there is a LOT of prejudice at work in just the previous sentence. Not just the abortion one, even presuming a young man is a different type then the rest says a LOT. Not sure what it says, it is just a lot.

    But when you are young you tend to think in "Me, me me" terms. It is as you experience more (and that happens as you age) that you develop a more rounded view of life. Including perhaps one day, the choice as to how the end of your life should be. But statements as "It is better to die a free man then to live as a slave" are only truly understood by people who had to make the choice. Do you take every option to survive or do you say "no, this line, I will not cross". Ultimately, if you are faced with such a choice, it defines you. Just not for very long. But often moral choices such as that come down to, "could I live with myself if I did this?". For some the answer will be yes, for some the answer will be no.

    But I wouldn't expect to find a many non- "me me me" responses on a site aimed at emotionally stunted young men. Or one aimed at young women either for that matter. And that is good. No reason for the young to think about how they are going to die, clutching at every straw, taking your own life or refusing to extend it at all costs. That is something for the old and terminally ill, let the rest believe they are going to live forever and that hanging on as long as possible is the only thing that matters.

    --

    MMO Quests are like orgasms:

    You may solo them, I prefer them in a group.

  25. Re:Science... by wonkey_monkey · · Score: 2

    you have this constant drowning feeling that takes a bit to get over.

    I nominate this for understatement of the year.

    --
    systemd is Roko's Basilisk.
  26. Re:Human dignity by cheekyjohnson · · Score: 3, Insightful

    So you are saying that it is okay to use human babies as fertilizer for your lawn and skin them to make lamp shades?

    No, I was saying that I think it's pointless to refuse a treatment because of the methods used to develop it that are no longer in use. The scenario I described was a one-time thing, and the perpetrator would be punished, but the treatment would remain available. I suppose you could refuse the treatment, but I just think it's meaningless.

    And yes, for some this includes making use of research obained through immoral means.

    What a meaningless sacrifice.

    That you do, says a lot about you.

    That I have a different opinion than you?

    For most, "everyone else is doing it" is thankfully not good enough or we all be living in a world like Somalia and other hell holes where individual morals have disappeared.

    Individual morals likely never disappear as long as you're human. I don't see where anyone mentioned the fact that everyone else is doing it, either.

    The daily proof is that we don't eat our dead.

    I thought that was unhealthy, anyway? And who is "we"? I'm sure there are some cultures that do.

    I predict you will be shunned.

    Eating human sounds rather unappetizing to me, so I'll pass on that. But I find it amusing that a few sentences prior to this you mentioned "everyone else is doing it," and here you basically say, "no one else is doing it!"

    Amazing as it may appear to you, some people would indeed refuse such a treatment.

    I never said that they couldn't. I just said I thought it was meaningless.

    It is what makes them human.

    And people who don't are... goblins or something? No True Human would go through with the treatment! Statements such as these always amuse me. They attempt to state as a fact what a human being should act like, and anyone that doesn't follow their made-up rules must be some sort of alien in disguise as a human.

    That you can't means you are an animal.

    All humans are animals, and I believe you'd be hard-pressed to find a human being that doesn't have any morals whatsoever. Them having different morals than you doesn't mean that they don't have any at all.

    --
    Filthy, filthy copyrapists!
  27. Re:How many rabbits were sacrificed? by cheekyjohnson · · Score: 3, Insightful

    We called them eugenicists.

    What? I don't believe that has anything to do with what I said.

    --
    Filthy, filthy copyrapists!
  28. Re:Choking Mice by SuricouRaven · · Score: 4, Informative

    Standard procedure for killing test animals is nitrogen. Animal in chamber, nitrogen in chamber, oxygen out of chamber, animal dead. It's painless, and it doesn't cause any damage that might obscure important features.

  29. Re:How many rabbits were sacrificed? by cheekyjohnson · · Score: 2

    And you've gone down this road mentally, thought about it, and wrote down that you're not sure if certain humans should be allowed to live versus another species or whether humans are worth sticking up for at all.

    It depends on the situation. Deciding whether or not to save a member of another species you love over a human has nothing to do with eugenicists.

    I didn't say anything about whether humans are worth sticking up for at all or not. That's a subjective matter.

    Don't message me back.

    Then don't reply to me in a place where I have the ability to reply to your comments.

    --
    Filthy, filthy copyrapists!
  30. Perfect timing by snsh · · Score: 2

    This is just in time for the Olympics. Let's see how well Phelps can keep up with microparticle enhanced bubble-head mariners.