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Scientists Keep Rabbits Alive With Oxygen Microparticle Injections
ananyo writes "Rabbits with blocked windpipes have been kept alive for up to 15 minutes without a single breath, after researchers injected oxygen-filled microparticles into the animals' blood. Oxygenating the blood by bypassing the lungs in this way could save the lives of people with impaired breathing or obstructed airways (abstract). In the past, doctors have tried to treat low levels of oxygen in the blood, or hypoxaemia, and related conditions such as cyanosis, by injecting free oxygen gas directly into the bloodstream. But oxygen injected in this way can accumulate into larger bubbles and form potentially lethal blockages."
And with this...we're one step closer to the zombie apocalypse.
So what? I have a pet rabbit that I can keep alive with regular oxygen particles.
And I don't even have to inject them or anything. They just go into the holes in his face.
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CO2 must also be removed. that's probably what ultimately killed the rabbits.
Besides overloading the red blood cells with CO2 and preventing the removal from the cells, it also screws up the PH of the blood really quick. I assume that with this process it could get bad enough to lead to shock.
Now what would be really cool would be if they could come up with a sold-state exchanger for CO2 to O2. Something like a fuel cell in reverse - create a chemical exchange from an electrical power. Implant that into a body and it could run on batteries instead of breathing. But I don't think that technology in that form currently exists. They have "rebreathers" but those are huge space-suit-size affairs and operate on a far more involved process.
But I bet someone's working on it right now. Probably several someones.
I work for the Department of Redundancy Department.
The experimental solutions contained 50-90 mL of O2 per deciliter - to sustain an adult human, you need about 300 mL O2 per minute. At least 300 mL of IV fluid and as much as 600 mL per minute is going to have to go through one hell of an IV. I doubt you could achieve such infusion rates without specialized equipment (e.g., 8.5 French rapid infusion catheter + Level One pump) or multiple intraosseous needles.
Furthermore, this is temporizing just like any other O2 delivery method. Oxygen is essential for life, but eventually you have to clear the CO2, or it's pointless. As a bridge to a secure airway or crash on to cardiopulmonary bypass? Sure, it's not a bad idea, except that the only thing that matters in that kind of life-or-death situation is how long it takes to get it in the room. By the time you get this stuff out of the refrigerator in pharmacy and run it to the OR, ER, or ICU, you could have gotten a surgeon there to do the cricothyrotomy or even a proper tracheostomy.
But will Lance Armstrong submit to a blood test for oxygen microparticles?
Probably less than 1/10000th the number of rabbits that were sacrificed for dinner plates last night alone.
There is nothing so pathetic as seeing a beautiful young theory roughed up by a tough gang of facts.
The experimental solutions contained 50-90 mL of O2 per deciliter - to sustain an adult human, you need about 300 mL O2 per minute. At least 300 mL of IV fluid and as much as 600 mL per minute is going to have to go through one hell of an IV. I doubt you could achieve such infusion rates without specialized equipment (e.g., 8.5 French rapid infusion catheter + Level One pump) or multiple intraosseous needles. Furthermore, this is temporizing just like any other O2 delivery method. Oxygen is essential for life, but eventually you have to clear the CO2, or it's pointless. As a bridge to a secure airway or crash on to cardiopulmonary bypass? Sure, it's not a bad idea, except that the only thing that matters in that kind of life-or-death situation is how long it takes to get it in the room. By the time you get this stuff out of the refrigerator in pharmacy and run it to the OR, ER, or ICU, you could have gotten a surgeon there to do the cricothyrotomy or even a proper tracheostomy.
That's all technically true. I think the question you AREN'T asking is the most important one - what if you're not trying to sustain a human, but simply lengthen the amount of time before cell death? If I recall my first aid training (and I do), even an extra 10 minutes can be the difference between brain damage and 100% recovery.
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Thats something sci-fi pulled out of the US Air Force books actually. Also Canadian Air Force books. It was originally thought up as a concept in canada to combat the massive g-forces the avro arrow could generate. It turned out it wasn't needed. Its been tested extensively by the US since(and there was some testing done in canada as well) but never used for any regular procedures afaik. It has also seen some testing for under water purposes, deep diving(Similar problems to massive g-forces and ridiculous altitudes)
I've actually tried it myself at a marine research facility. Its extremely fucked and you can choke to death while being fully oxygenated(if you're a wuss, essentially). Also excess fluid left in the lungs can cause infections etc to set in.
Doing something dangerous enough to have a paramedic crew standing next to you when you start it is a bit of a head trip too.
Once you're in there tho... its not even slightly comfortable. It feels like your chest is being heavily pressed on and you have this constant drowning feeling that takes a bit to get over. Overall, I'd say thats probably the main reason it hasn't been used much. On paper the whole deal is fantastic. In reality, not so much.
This seems to be the consensus among slashdotters given the consistent downmodding of people who even remotely question, let alone challenge, the ethics of animal experimentation. However, no one seems to address the rational justification for elevating humans to a higher level of worth. I'm not saying that experimentation is outright wrong, but the ethical assessments like these should never be automatic.
Yes, the rabbits were the subject of the experiment. The mice were being choked to pass the time. It's just what these researchers do.
You see no problem with pumping a human being full of a non-blood liqued at a rapid rate?
The human in question would either explode OR the blood will become ever more diluted until all you got is the new liqued which isn't blood. And you need blood to survive, even if you are not a vampire.
The article makes this pretty damn clear, it is not for surgery, it is for emergencies. There already exist perfectly fine methods for putting oxygen into blood, they are used routinely during surgery. But they are bulky and slow, so they can't be used on the scene of an accident or in an emergency room.
This method is for keeping a patient alive until surgeons can save him. It is to stretch the window between incident and surgery to give emergency services more time. You would be suprised how advanced medicine is in saving people and how hard it is to get that advanced care available fast enough to work in an accident that could happen anywhere EVEN outside a hospital! Amazing I know but people do insist on getting accidents more then a minute away from a emergency room.
If it could be allowed legally, it might become possible for ambulance crew to give patients a shot of this stuff and make sure their brain has oxygen enough to survive until proper life support systems can take over.
But you CANNOT just pump a human being full of non-blood and expect them to survive.
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