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Australian Scientists Discover Potential Aids Cure
smi.james.th writes "Several sites report that Australian researcher David Harrich and his team have potentially discovered a way to stop HIV becoming AIDS and ultimately cure the disease. From the article: 'What we've actually done is taken a normal virus protein that the virus needs to grow, and we've changed this protein, so that instead of assisting the virus, it actually impedes virus replication and does it quite strongly.' This could potentially hail one of modern medicine's greatest victories."
This would be a gene therapy treatment- using viral vector to express a mutant protein in your cells. Last year, the European Medicines Agency approved a gene therapy treatment for the first time (no approvals in the US currently). Glybera is indicated for lipoprotein lipase deficiency, a rare disorder that affects fatty acid metabolism. Glybera uses a viral vector to deliver a working copy of the LPL gene to cells; this proposed AIDS treatment would deliver a nonworking copy of TAT to infected cells in a similar fashion. I bring up Glybera for comparison purposes because it is expected to cost over 1 million dollars a patient for a course of treatment. Eventually, gene therapy may become such a routine way of creating treatments that costs will be very low. That is not the present situation.
"FDA staff reviewers expressed concern about the number of patients who were left out of the study because they died."
Just starting animal trials. Too early to know if it's really going to work.
The preliminary results of the animal trials are startlingly good, and in an interview the chief researcher said he believes the approval cycle will be short (ie: less than 5 years) because of the probability that this therapy will pass safety trials etc. We'll have to wait and see of course.
Do it yourself, because no one else will do it yourself. [beta blockade 10-17 Feb]
1. They aren't allowed to advertise prescription medicine.
2. They aren't allowed to offer payola to doctors for using their drugs. Both the doctor and the company get busted if they get caught.
You've just described the developed world... except for the USA and New Zealand.
Everyone else has strong limitations on direct-to-consumer-advertising, or an outright ban.
3. Generics are readily available. Instead of buying Panadol (Tylanol) I can get Brand X paracetamol/codeine which is the same recipe but 1/4 the price. The same is true for most prescription drugs.
As it turns out, generics aren't necessarily equivalent to the original perscription drug.
Since it's late, you get the first article I found on Google
It's a fair representation of the other articles I've read on the subject.
The TLDR version is that generics don't always make the same amount of drug available to the patient
and even if they do, the drug may not be released in the same fashion, leading to early or late peaks of the drug.
[Fuck Beta]
o0t!
Protip: Medicines with the same Product License Number are the same. The number has to be printed on the packaging. If you compare various over-the-counter painkillers, for example, you will find that the cheap own-brand ones, the branded ones, the fast actions ones, the long lasting ones and the premium max strength ones all have the same Product License Number and are in fact exactly the same.
const int one = 65536; (Silvermoon, Texture.cs)
SJW, n: "Someone I don't like, and by the way I'm a fuckwit" - AC