Drug Testing In Mice May Be a Waste of Time, Researchers Warn

An anonymous reader writes "A group of researchers including Dr. H. Shaw Warren of Mass. General Hospital and Stanford genomics researcher Ronald W. Davis have published a paper challenging the effectiveness of the 'mouse model' as a basis for medical research, based on a decade-long study involving 39 doctors and scientists across the country. In clinical studies of sepsis (a severe inflammatory disorder caused by the immune system's abnormal response to a pathogen), trauma, and burns, the researchers found that certain drugs triggered completely different genetic responses in mice compared with humans. The Warren-Davis paper was rejected by both Science and Nature before its acceptance by the Proceedings of the National Academy of Science, perhaps suggesting the degree to which the 'mouse model' has become entrenched within the medical research community. Ninety five percent of the laboratory animals used in research are mice or rats. Mice in particular are ideal subjects for research: they are cheap to obtain and house, easy to handle, and share at least 80 percent of their genes with humans (by some reckoning, closer to 99 percent). Over the past twenty five years, powerful methods of genetically engineering mice by 'knocking out' individual genes have become widely adopted, so that use of mice for drug testing prior to human clinical trials has become standard procedure."

Comments

Of course it is

[h4rr4r]

A mouse can't even roll a joint, much less handle a lighter. Nor do they make syringes that small.

Why was anyone suspecting their mice of using drugs in the first place?

Rejection

[Anonymous Coward]

>> The Warren-Davis paper was rejected by both Science and Nature before its acceptance by the Proceedings of the National Academy of Science, perhaps suggesting the degree to which the 'mouse model' has become entrenched within the medical research community.

Or maybe it was rejected because it isn't a good paper? Just a thought.

Re:Rejection

[Silas is back]

Science's and Nature's rejection rates are very high, there are just this many articles they can publish every week, 15 to 20 for Nature. Almost every paper gets rejected on the first draft, good ones are encouraged to resubmit after revisions. It can take a few years to get your paper into one of these journals, that's what makes the papers of highest quality -- not to be confused with "certainly true", even high quality research can turn out to be wrong.

The leftovers get resubmitted to lower-ranked journals; that's what you usually do if you want to submit something, you aim for a high ranked journal and hope to get in, if not you revise and resubmit or submit to another journal.

How many

[canadiannomad]

I often wonder how many drugs we reject long before human trials because some researcher used the wrong animal to test.

Also an obligatory SMBC comic