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Tooth Cavities May Protect Against Cancer

Hugh Pickens DOT Com writes "John Gever reports at MedPage Today on a new study conducted by researchers from the University of Buffalo, which found that people with more cavities in their teeth are 32 percent less likely to suffer from head and neck cancers. 'To our knowledge, the present study suggests, for the first time, an independent association between dental caries and head and neck squamous cell carcinoma.' The researchers proposed a mechanism for the apparent protective effect: that cariogenic, lactic acid-producing bacteria prompt cell-mediated Th1 immune responses that suppress tumor formation. The team examined records of patients older than 21 seen in the university's dental and maxillofacial prosthetics department from 1999 to 2007, identifying 399 who were newly diagnosed with head and neck squamous cell carcinoma. Assuming that the association between caries and reduced cancer risk is real, the team suggests that one could regard the cariogenic bacteria as beneficial overall, with caries 'a form of collateral damage.' Therefore an appropriate strategy could be to target that effect specifically without aggressively targeting the bacteria. 'Antimicrobial treatment, vaccination, or gene therapy against cariogenic bacteria may lead to more harm than good in the long run.'"

5 of 149 comments (clear)

  1. The bacterial excretions by dutchwhizzman · · Score: 4, Informative

    The research suggests that the excretions of the bacteria and the bodies reaction to that are the cause -> effect mapping. However, your suggestion that toothpaste may have unknown carcinogenic properties could be just as valid.

    --
    I was promised a flying car. Where is my flying car?
    1. Re:The bacterial excretions by Anonymous Coward · · Score: 5, Informative

      Raising PH level means less acidic. Acid excreted by these bacteria would decrease PH, not raising it.
      PH less than 7 is acidic while PH greater than 7 is alkaline.

    2. Re:The bacterial excretions by lightknight · · Score: 4, Informative

      The X-Ray dose is trivial...especially the digital versions, which use, I believe, six times less radiation than a normal non-digital version.

      http://www.physics.isu.edu/radinf/dental.htm

      2 or 3 mrem is the reported dose for a dentist X-Ray.

      http://www.nrc.gov/about-nrc/radiation/around-us/doses-daily-lives.html

      On average, Americans receive a radiation dose of about 0.62 rem (620 millirem) each year.
         

      --
      I am John Hurt.
  2. Whoa, slow down there! by mark_reh · · Score: 5, Informative

    "Once fluoride is incorporated into the teeth of children, the problem of dental infection by decay-causing bacteria is solved, because the pH required to cause decay in teeth that have fluoride included is never achieved by the bacteria."

    It doesn't work that way. I am a dentist and can guarantee you that even fluoride treated teeth and teeth with systemic fluoride incorporation can and do get cavities. I drill and fill them all day every day. Fluoride is only one factor in keeping teeth healthy. You still have to brush, floss, maintain a healthy diet, etc.

    1. Re:Whoa, slow down there! by mark_reh · · Score: 3, Informative

      There are a million possible explanations. Everyone is different. Caries is a function of personal habits, exposure to fluoride, both systemic and topical, your immune system, the anatomy of your teeth, diet, etc. There is no way to explain specifically why one person gets more cavities than another.

      I hear patients tell me that they've never had problems with their teeth until they started going to the dentist. People seem to think that if there is nothing causing pain there is nothing wrong. That could not be further from the truth. I have extracted hundreds of teeth from people with mountain-dew mouth and meth mouth who have multiple teeth rotted down to the gum line. I always ask if any of those teeth ever hurt and frequently they tell me that those teeth never caused any discomfort at all. I don't know why, but it happens a lot. If lack of pain is the only measure of your own oral health I have two things to say to you: 1) go see a dentist anyway. 2) I wish you continued luck.

      People say "Why should I go to the dentist- my teeth don't hurt. Every time I go there they want to take x-rays and drill holes in my teeth, and even pull some of them out, even though there is nothing wrong with them. I think it's just a racket to separate me from my money." So they don't go to the dentist and their conspiracy theory becomes a self-fulfilling prophecy. When they go to a dentist once every ten years they end up getting drilled and filled (if they are lucky) or worse.

      Pay attention because I'm going to drop some knowledge on you: the lack of pain is NOT a reliable indicator of oral health, just as it is NOT a reliable indicator of health in general. Anyone who knows about the long term effects of high blood pressure or diabetes knows that both are seriously unhealthy conditions - ask someone with high blood pressure or diabetes if their illnesses cause them any pain.