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Experiment Shows Caffeine Boosts Long Term Memory

An anonymous reader writes "A team of researchers at Johns Hopkins has published results demonstrating that caffeine seems to boost long-term memory. In a double-blind study, participants were shown a series of images soon after taking either a caffeine pill or a placebo; 24 hours later they were tested on a similar, but not identical, series of images. Those who took the caffeine pill were more likely to correctly classify images as being different, identical, or similar to those seen the previous day; researchers refer to this as a 'pattern separation' test. The beneficial effect of caffeine on the long-term memory of honey bees was covered by Slashdot earlier."

33 of 123 comments (clear)

  1. "I WILL have a third cup!" by rmdingler · · Score: 4, Interesting
    It is always welcome news when something you already engage in is reported to have benefits.

    Like the health benefits of a couple of alcoholic drinks, there will undoubtedly follow a recommended modest dose, beyond which the diminishing returns corollary overtakes any health benefits.

    --
    Happiness in intelligent people is the rarest thing I know.

    Ernest Hemingway

    1. Re:"I WILL have a third cup!" by Kongming · · Score: 2

      Certainly; with a high enough dose, the subject would die.

      That aside, the finding is interesting. Based on the summary, I thought that it might just be helping the subjects get closer to the ideal level of psychological arousal for what is probably a simple, routine, and possibly slightly boring task. However, the article states that the subjects were given the pills after having been shown the images, not before, in order to control for that possibility.

      There is still one alternative explanation that I can see to a direct chemical effect of caffeine. For the subjects given caffeine after doing the first task in the experimental setting, an association was formed between the setting and getting caffeine. When the subjects returned to do a similar task in the experimental setting again, they received a slight boost in psychological arousal in anticipation of receiving the caffeine. (This kind of effect is commonly seen with many drugs, although I don't know if 200mg of caffeine would induce the effect with a single exposure.) The increased arousal during the follow-up task could explain the increased performance. If they wanted to control for it, one way would be to administer the follow-up task in a different environment than the one in which they did the first task, thereby reducing the impact of any associations with the original setting.

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      (no sig)
    2. Re:"I WILL have a third cup!" by interkin3tic · · Score: 2

      Also keep in mind that as a nearly universal rule, nothing has completely good effects, and many effects on the brain are subtle. It's unlikely that there aren't long term effects of caffeine that you wouldn't like. Unknown long term negative effects aren't a reason anyone should stop drinking coffee of course, just saying lets not be shocked if researchers find out it, say, decreases your IQ in your senior years or something. It appears to DECREASE your chances of getting alzheimers, which is good, but it's clearly having some permanent effects on the brain. It can't be all beneficial.

    3. Re:"I WILL have a third cup!" by hawkinspeter · · Score: 3, Funny

      I don't know how I remembered your Folger's reference as I don't think they showed it in the UK when I was a kid in the 70s. Must be the blood content in my caffeine stream.

      --
      You're a temporary arrangement of matter sliding towards oblivion in a cold, uncaring universe
  2. Coffeine by war4peace · · Score: 4, Funny

    As a heavy caffeine user, I confirm that... hmm... erm... what was I saying?

    --
    ...gis sdrawkcab (usually not responding to ACs; don't bother posting as AC)
    1. Re:Coffeine by daem0n1x · · Score: 2

      You shouldn't season you coffee with pot.

    2. Re:Coffeine by hawkinspeter · · Score: 3, Informative

      You left out the obvious "wine".

      --
      You're a temporary arrangement of matter sliding towards oblivion in a cold, uncaring universe
    3. Re:Coffeine by phoenix_rizzen · · Score: 2

      Come back tomorrow and you'll remember!

    4. Re:Coffeine by lxs · · Score: 2

      Thanks. I was about to swallow a landmine.

  3. Re:Real article behind paywall by Lazere · · Score: 2

    I'm not seeing a paywall. Perhaps you haven't had your caffeine yet?

  4. The Secret by h00manist · · Score: 5, Funny

    so *that's* the secret.

    Yup, that's the secret. Feed coffee to your computer and you won't need backups any more.

    --
    Build your own energy sources from scratch. http://otherpower.com/
  5. 24 hours is long term? by rodrigoandrade · · Score: 4, Funny

    What, we're hiring scientists with severe ADHD now???

    1. Re:24 hours is long term? by Sockatume · · Score: 3, Informative

      Yes, the long-term memory system is used for everything older than a few minutes. They're different functional units of the brain. Maybe if you had a longer attention span you could've looked up what "long-term memory" means and figured that out for yourself? Maybe learned something?

      --
      No kidding!!! What do you say at this point?
    2. Re:24 hours is long term? by rodrigoandrade · · Score: 5, Funny

      What are you talking about again?

  6. Re:Real article behind paywall by Anonymous Coward · · Score: 5, Informative

    So the article costs $32 to read. It begs the question, what are they hiding?

    Most likely nothing. Yes, they could have submitted it to an open-access journal, but when you've a shot at getting something into Nature Neuroscience then most authors will go for it because, bottom line and right or wrong, it's what Universities and Institutions often look at when deciding who to hire and who to fire.

    Besides, if you wanted to hide something why would you hide it behind a paywall which a large proprotion of research insititutes probably have access to? You're basically advertising your secrets to anyone who is knowledgeable in the field and has a research job.

  7. Raktajino by Anonymous Coward · · Score: 3, Funny

    Raktajino helps me remember Trek trivia.

  8. Re:The detrimental effects for sleep thwart it for by i+kan+reed · · Score: 2

    Considering the demographics on slashdot, I'm going to take a shot in the dark: caffeine and other stimulants have been noted to have uncommon side-effects in ADHD diagnosed population. Could that be you?

  9. Re:Real article behind paywall by oodaloop · · Score: 3, Funny

    I'll take it with cream and sugar, thanks for asking.

    --
    Tic-Tac-Toe, Global Thermonuclear War, and relationships all have the same winning move.
  10. Re:unable to rermember genuine history events by Anonymous Coward · · Score: 2, Funny

    our hardwired religious abuse fairytail history & heritage will have to do?

    Ever notice the similarities between evangelical Christians and evangelical athiests? Neither drawer's knives are very sharp (and as Pratchett says, they may even be spoons).

  11. Memorizing vs Recollection by baffled · · Score: 5, Interesting

    The experiment used caffeine during memorization. Does caffeine have any relative effect on recollection?

    1. Re:Memorizing vs Recollection by TAiNiUM · · Score: 3, Informative

      No, it does not help recollection. It helps to form and store the information.

      ie, drink cafeine when you study to store the information. Drinking caffeine during the test won't increase recollection though it will help focus.

  12. Re:do be a do bee by Sponge+Bath · · Score: 4, Funny

    In other news, caffeinated bees boost long term cardio health for humans running in fear.

  13. Parts of the brain by tomhath · · Score: 5, Funny

    The memory center in the human brain is the hippocampus, a seahorse-shaped area in the medial temporal lobe of the brain.

    Then why don't they call it the seahorsecampus? These guys make everything so difficult.

    1. Re:Parts of the brain by rollingcalf · · Score: 2

      >Then why don't they call it the seahorsecampus? These guys make everything so difficult.

      Hippocampus is derived from the Greek words hippos (horse) and kampos (sea monster).

      --
      ---------
      There is inferior bacteria on the interior of your posterior.
  14. My wife proposes the theory that it ... by PseudoCoder · · Score: 2

    destroyed my short term memory. I can't even remember where I put my cup.

    --
    "Now, I doubt any of you would prefer a rolled up newspaper as a weapon against a dictator or a criminal intruder."
  15. Same old... by ccanucs · · Score: 3, Informative

    Coffee's bad for you ....

    Coffee's good for you ....

    Coffee's bad for you ....

    Coffee's good for you ....

    Same old.... (as far as I recall :-) )

  16. Re:The detrimental effects for sleep thwart it for by Anonymous Coward · · Score: 2, Informative

    Seeing as how I was diagnosed with ADHD as a kid, I can certainly say that Caffeine and many other stimulants tend to work bass-ackwards on me by putting me to sleep.

    For those interested, look up how/what Ritalin is and what it was approved for, which isn't ADHD

  17. Memorization, or attention to detail? by LeDopore · · Score: 5, Informative

    I have a PhD in sensory neuroscience from UC Berkeley. It could be the effect mentioned in TFA is sensory, not memorization.

    Caffeine is known to increase acetylcholine release. Acetylcholine makes your brain pay more attention to here-and-now details than to its internal model of what's going on.

    I'm also dubious about the idea that any one, simple chemical can ever make you smarter in any general way without adverse consequences. Evolution has a lot of time to scope out all simple neurochemical effects, so beware studies that suggest they've found a "smart pill". Sure, it's possible to take a drug to make you better at one specific task to the detriment of some others, but the idea that there is any simple cognitive enhancing substance would imply either "evolution couldn't mimic the effect of this substance on the brain" or "cognitive enhancement isn't an evolutionary good move". Neither seems very likely.

    --
    Expected time to finish is 1 hour and 60 minutes.
    1. Re:Memorization, or attention to detail? by jeffb+(2.718) · · Score: 4, Insightful

      Evolution has a lot of time to scope out all simple neurochemical effects, so beware studies that suggest they've found a "smart pill". Sure, it's possible to take a drug to make you better at one specific task to the detriment of some others, but the idea that there is any simple cognitive enhancing substance would imply either "evolution couldn't mimic the effect of this substance on the brain" or "cognitive enhancement isn't an evolutionary good move". Neither seems very likely.

      I'm not seeing the evidence for strong forces selecting for better cognitive performance. It seems like there are a lot of evolutionary niches where brain-power loses out to other specializations.

      Suppose there's a substance that improves overall cognitive processing, but at a metabolic cost that requires 30% more caloric intake? Or suppose it interferes with efficient storage of fat? Either of those would be a deleterious trait in pre-modern populations.

      Suppose it improves cognitive processing, but reduces fertility by 50%? Again, it would be bred out rapidly.

      Many of the constraints that guided our evolutionary history no longer apply. I don't expect a miracle pill, either, but saying "if cognitive enhancers existed we'd already have evolved to produce them" seems kind of disingenuous.

    2. Re:Memorization, or attention to detail? by Thomas+Miconi · · Score: 2

      Did you miss the "post-study" bit in the title and abstract? Caffeine was delivered after stimulus presentation, excluding a purely sensory effect.

      I guess you could do with a cup of coffee! ;)

    3. Re:Memorization, or attention to detail? by jeffb+(2.718) · · Score: 2

      To be fair, the summary got it exactly backward:

      In a double-blind study, participants were shown a series of images soon after taking either a caffeine pill or a placebo;

  18. Re:The detrimental effects for sleep thwart it for by NewWorldDan · · Score: 2

    Sleep? Nah. But caffeine is also one of the leading causes of diarrhea. So I'm off the stuff. Too bad, a cup of coffee or tea was a nice way to start the day.

  19. Re:do be a do bee by Sockatume · · Score: 2

    That's a popular little trivia fact that unfortunately isn't supported by the evidence. http://www.sciencedirect.com/science/article/pii/S0278691502000960

    --
    No kidding!!! What do you say at this point?