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20% of Neanderthal Genome Survives In Humans

vinces99 writes "A substantial fraction of the Neanderthal genome persists in modern human populations. A new analysis (abstract) of 665 people from Europe and East Asia shows that more than 20 percent of the Neanderthal genome survives in the DNA of this contemporary group, whose genetic information is part of the 1,000 Genomes Project." Another study published today (abstract) finds that Neanderthal genes are present in some parts of our genome that we've found to be important. Some of the genes influence fertility and skin pigment, and others actually increase our susceptibility to diseases like diabetes and lupus. The researchers are now taking these known genetic markers and seeing if they correlate with any other health conditions.

40 of 202 comments (clear)

  1. Yes but by oldhack · · Score: 4, Funny

    You replicate those genes by 3d printing, and offer them for bitcoins, and that's how you end up on slashdot.

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  2. As someone who works in tech support... by FuzzNugget · · Score: 4, Funny

    I'm surprised it's not higher.

    1. Re:As someone who works in tech support... by dreamchaser · · Score: 2

      I'm surprised it's not higher.

      I agree based on my neighbor Kevin. He looks exactly like reconstructions of Neanderthals.

    2. Re:As someone who works in tech support... by rolfwind · · Score: 3, Interesting

      But who says Neanderthals were dumber though? They managed to survive the cold climate for much longer than we have (which takes considerable more resources and planning than surviving tropic temperatures), and my knowledge is rudimentary, but from what I seen in documentaries, them dying off/merging may simply have been a matter of a warming earth. They were more barrel chested and not able to withstand the warmer climates as well.

    3. Re:As someone who works in tech support... by Anonymous Coward · · Score: 2

      IQs

      IQ != intelligence. The very idea that you can measure someone's intelligent with a simple number and simplistic, specific, one-size-fits-all tests is pseudoscience at best.

    4. Re:As someone who works in tech support... by nospam007 · · Score: 3, Funny

      " them dying off/merging may simply have been a matter of a warming earth. They were more barrel chested and not able to withstand the warmer climates as well."

      Or they were 80% more tasty.

    5. Re:As someone who works in tech support... by tie_guy_matt · · Score: 2

      Remember their brains were the same size, if not a little bigger, than ours. And we know they also had the genes that give us the ability to communicate complex information verbally. So no, I do not think we can say for sure that they were dumber -- not unless we were able to say clone a pure neanderthal and then talk to them to see how smart or dumb they really were.

    6. Re:As someone who works in tech support... by buswolley · · Score: 2

      trolling now, are we? With all we know about the limitations of that measure of cognition? Please.

      --

      A Good Troll is better than a Bad Human.

    7. Re:As someone who works in tech support... by tie_guy_matt · · Score: 4, Interesting

      Despite the fact that the I in IQ stands for intelligence, the standard IQ test is, by design, a measure of how well a person is likely to do in a tradition western school setting. It isn't, and was never meant to be, a measure of a person's worth as a human being or even ones true intelligence. Changes in environment and upbringing can change a person's chances of doing well in school and thus will also change their measurable IQ. So it is likely that certain ethnic groups score differently on their IQ tests, not because of genes or whatever, but because of their environment. Your genes might say that you should be the smartest person in the world; however if you do not get proper nutrition growing up, have parents that are too busy getting what little food is around on the table to read to you, and your early eduction system sucks, then your IQ is going to suffer and you are not going to seem as smart as you could be. Of course this won't stop racists from pointing to tests scores they don't understand in order to peddle their BS.

    8. Re:As someone who works in tech support... by Obfuscant · · Score: 2

      They didn't leave cave paintings or anything that indicates capacity for symbolic reasoning.

      "Billy, stop that drawing! Your father and I don't provide a warm comfortable cave for you to live in just so you can scribble all over the walls like a proto-hominid or one of those low-class Egyptian pyramid dwellers. Now clean that off before your father gets home, and go wash your hands for dinner. The brontosaurus steaks are almost ready... I mean 'uggh, food hot, eat now'."

    9. Re:As someone who works in tech support... by anagama · · Score: 3, Interesting

      Cold Winter Theory? That seems ridiculously simplistic. How about a dry summer theory? If cold winters make people evolve because they need to figure out how to survive the winter, then the exact same argument would apply to people living in the middle of a massive desert. The harsh summers would push them to technology or whatever. Or what about peoples who live near the Arctic Circle -- they should be time travelers by now considering the harshness of their winters.

      I think you are confusing technological knowledge with intelligence, and I'm willing to bet that the first appearance of a technology is due much more to some wild confluence of necessity, chance, state of the technology available prior, and resources to put it into practice. Once discovered, it spreads the easy way, via communication. But for people to pat themselves on the back and call themselves "more evolved" because they live in a place where some clever person was born, saw a need, a solution, and had the resources to make it work -- well, that could happen almost anywhere. You just won the tech lottery -- that doesn't make you evolved, it makes you lucky.

      --
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    10. Re:As someone who works in tech support... by HiThere · · Score: 2

      From one study of quite awhile back, one reason for Neanderthals dying out was that the heads of Cro-Magnon babies were shaped differently, meaning that Neanderthal mothers with Cro-Magnon fathers tended to die in childbirth, while the reverse wasn't true. There have also been some studies that suggested that their shoulders weren't as well adapted to throwing, so they needed to get close-in with spears, which was more dangerous.

      I can't recall any studies that found that they were stupider than Cro-Magnons which didn't start out by assuming the conclusion. (There have been a few that concluded that their range of vocalizations was smaller, but that's not intelligence, per se.)

      --

      I think we've pushed this "anyone can grow up to be president" thing too far.
    11. Re:As someone who works in tech support... by hey! · · Score: 2

      Let us assume for the moment that intelligence is a single thing that can be precisely described by a single number.

      Now imagine nobody has invented a way of measuring that number yet, so you set out to create an IQ test. You put together a number of tests and tasks, and assign various weights to each question and score. You administer the test to a bunch of people and the results seem reasonable.

      Here's the question: how do you know you are actually measuring intelligence, and not something else that approximately correlates with it?

      Alfred Binet, when faced with this problem, validated his test by correlating it with school achievement. This, at least, ensured that the test was at least somewhat useful in predicting school achievement. But it should be obvious that different kinds of people thrive in different kinds of schools, so at best tests calibrated this way are imprecise. We've all known underachievers and overachievers in school.

      At their very best, IQ tests tell us what we expect to hear. That's actually more useful than it sounds, as long as we remember that we've calibrated the test to do just that. Test results must be *contrived* to correlate with things we're interested in. That mightinclude stuff like algebra and geometry, and arguing as in a legal brief, which are all valuable mental tasks. But it might not correlate to stuff like finding food in a forest during an unseasonable drought, or negotiating with a neighboring group, or evaluating the motives of strangers, all of which are tasks requiring mental acuity, and at which people differ in talent.

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    12. Re:As someone who works in tech support... by InsectOverlord · · Score: 3, Interesting

      They didn't leave cave paintings or anything that indicates capacity for symbolic reasoning.

      We aren't so sure about that.

    13. Re:As someone who works in tech support... by maxwell+demon · · Score: 2

      Well, at the end of the ice age, it was getting warmer. But the Neanderthals simply denied that it got warmer, and therefore claimed that expensive adapting would not be necessary. After all, as long as they could think they had hunted mammoths, so why should they now invest time to find other sources of food? All those warnings about global warming were clearly nonsense. And anyway, last winter was pretty cold, so doesn't that disprove global warming?

      When they could not deny any longer that it was getting warmer, it was too late.

      --
      The Tao of math: The numbers you can count are not the real numbers.
    14. Re:As someone who works in tech support... by qubezz · · Score: 2

      We have homo sapiens that design firmware for avionics systems, and we have homo sapiens who throw spears at metal birds. Same species, the only difference is culture.

      Do not be so fast to judge the capabilities of neanderthal DNA based on the trinkets they left behind. The accomplishments of humans is due to language and learning, specifically learning of invention from the brightest 0.001%; we are still the same species as we were thousands of years ago.

  3. Trying to offset... by bob_super · · Score: 2

    I may be 20% neanderthal, but I'm statistically 0.5% Genghis Khan...

  4. Not found in "humans" in general by Eravnrekaree · · Score: 4, Informative

    These genes do not exist in humanity in general, only specific racial groups. They are completely absent from African populations. Similar to milk digestion. Being able to digest milk in adulthood is a feature found almost only in European race populations, because it is allowed by a genetic mutation that occured in these populations 10,000 years ago. Most other racial groups are lactose intolerant after early childhood. Milk digestion in adulthood is certainly a huge advantage and became much favored with cattle domestication in Europe.

    The insertion of neanderthal genes happened around 30,000 years ago immediately after early humans left africa, after that there were 30,000 years of divergent evolution and branching that gave us the geographically distinct racial groups.

    1. Re:Not found in "humans" in general by Anonymous Coward · · Score: 2, Informative

      This map distribution show African milk tolerant populations:
      http://www.popsci.com/science/article/2013-08/infographic-day-where-people-can-digest-milk

    2. Re:Not found in "humans" in general by smellsofbikes · · Score: 5, Informative

      Lactose intolerance is complex. The Tuareg of Saharan Africa have lower lactose intolerance rates than Finnish people, for instance. It mostly has to do with whether a group has spent a long time as nomadic herders or not, and adult persistence of lactase activity appears to be caused by several different mutations, that arose spontaneously. http://s1.zetaboards.com/anthr... has a nice list of adult lactase activity in different ethnic groups.

      --
      Nostalgia's not what it used to be.
  5. Why so low a commonality? by trims · · Score: 4, Interesting

    Neanderthals are barely a separate species.

    They're homo neanderthalensis, while modern man is homo sapiens sapiens. The immediate predecessor to modern humans is homo sapiens idaltu, which is minutely different than us. While a simple majority of paleontologists classify Neanderthals as a separate species, there's a significant minority that advocate them as merely another subspecies (home sapiens neanderthalensis) being more correct.

    Given that the ENTIRE Neanderthal genome differs from ours by 0.15% or less (we're about 2% different than our closest modern primate relative), I'm very surprised that the Homo-specific genome part is only 20% in common between Neanderthal and Modern Human. Particularly since it's now commonly accepted that they interbred with modern humans.

    I think the 20% commonality (if it bears out) probably reinforces the "separate species" theory more than the "distinct subspecies" theory of the Homo genus family tree.

    -Erik

    --
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    1. Re:Why so low a commonality? by Karellen · · Score: 2

      Yup, given that I've read elsewhere that we share about 90% of our genome with fricking cows - all that data for building animal cells, and vertebras, and hearts, and livers, and kidneys, and mammary glands, and hair, and eyes, and nerves, and skin, etc..., having only 20% of the Neanderthal genome in common with us is setting off my bullshit alarm big time.

      --
      Why doesn't the gene pool have a life guard?
  6. Black and white by Charliemopps · · Score: 2

    What I find interesting is the only group that doesn't have Neanderthal genes are Africans. It almost sounds like Caucasians got their light skin and ability to handle the cold from Neanderthals and are hybrids while Africans are the only pure humans. Ironic.

    1. Re:Black and white by tie_guy_matt · · Score: 4, Interesting

      Evidence shows that homo erectus left Africa and then evolved into homo neanderthal. Later early modern humans followed the path of their ancestors and once again migrated out of Africa. It seems that when they met what had evolved from homo erectus -- well let's just say that when the cave is a rockin you shouldn't go a knockin. So it isn't surprising that modern Africans do not have many Neanderthal genes because it doesn't look like they ever migrated back into Africa.

      Of course one definition of two groups being in the same species is if they can mate and have fertile offspring. Since we know early modern humans and neanderthals mated and had fertile offspring you could make a good argument that us, early modern humans, homo neanderthal, and homo erectus were/are all the same species.

  7. Time to repost (someone else's) old comment by Anonymous Coward · · Score: 2, Funny

    From God's Roadmap:

    Beta
    Release version: Homo neanderthalensis
    Build name: Adam
    Release date: 4,569,770,000 years after cooling
    Deprecated: 4,569,971,000 years after cooling

    Stable
    Release version: Homo sapiens
    Build name: Eve
    Release date: 4,569,800,000 years after cooling
    Deprecated:
    [Sigh] Still deciding. I mean, the codebase is starting to look a bit creaky in a few places, and they're starting to tinker with it themselves (they think it's open source - hah!). Inquisitive little so-and-so's can't leave well enough alone... They've noticed the legacy code from the previous build too - ick, some cruft in there. Very tempting to trash the lot and start again using AOP. Mind you I mightn't have to lift a finger if they don't stop blowing each other to smithereens.
    [sigh] TODO: Take oort cloud inventory - look for something nice and big...

  8. Re:"fertility skin pigment"? by shaitand · · Score: 4, Interesting

    There's no such thing as more primitive in a genetic sense which makes it ridiculous in both cases. Anything alive today is the result of all the evolution that has taken place since the first bits of life and is therefore equally evolved.

  9. Re:"fertility skin pigment"? by buswolley · · Score: 2
    Thank you.

    Also, 20% is a lot, so we might as well call it human DNA. We own it now, its shapes us.

    ...and whatever homosapiens mingled lines with the Neanderthals cannot really claim to be *more human* than we are now...they were something else. If we call them homo-sapiens, then we are not homo sapiens, but the hybrid.

    --

    A Good Troll is better than a Bad Human.

  10. Hoo boy, scientific racism again. by Valdrax · · Score: 5, Interesting

    For instance an average European has an average IQ of 105 compared to 70 in Africa. Though, the higher IQ is likely due to divergent racial evolution that occured well after the insertion of neanderthal genes...

    Or it could be a matter of education, relative stress in childhood, and diet. Or it could be a matter of a cultural upbringing that doesn't value and train people in the types of reasoning favored by IQ tests. I'd like to see a test cataloging our relative abilities to navigate vast terrain, to remember and recite oral histories, to perform pattern recognition based on ability to identify wild plants, or just a simple ability to navigate complex social situations, for example. Or it could be a function of languages, since we already know that languages can affect things like the ability to recognize and categorize colors.

    Have you ever read letters from American Civil War soldiers to their families back home? We're not talking a college education demographic by a long shot, but the eloquence and care of language in these letters is often breathtaking. Are we "dumber" than them as a populace for not being able to write like an average farm boy could 150 years ago? Or are we just trained for different uses of our brains.

    IQ is a crappy measure of genetic superiority, because it fails to account for environment & upbringing, and it's heavily biased towards one particular culture's most valued intelligence traits.

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    1. Re:Hoo boy, scientific racism again. by 140Mandak262Jamuna · · Score: 3, Interesting

      But IQ tests are the best measure of predicting how well one would do in IQ tests.

      --
      sed -e 's/Chuck Norris/Rajnikant/g' joke > fact
  11. Re:"fertility skin pigment"? by shaitand · · Score: 4, Informative

    Not that I disagree but it's worth pointing out that the summary is a bit misleading. Europeans share these genes but africans do not and it's 20% of the .15% of the neaderthal genome that is distinct, obviously humans share a lot more than 20% of their DNA with neaderthals, we share a lot more than that with primates!

  12. Re:"fertility skin pigment"? by Immerman · · Score: 4, Interesting

    Not entirely. Evolution is most meaningfully measured in generations, not years. Those species that have averaged a more rapid average reproductive cycle since their ancestors parted ways with ours will have undergone more evolutionary iterations than us. Mice are in the lead pack among mammals. And bacteria leave even mice in the dust, even before you factor in the fact that for them sex is more like performing limited genetic engineering on themselves, allowing useful mutations to spread through the population without any reproduction occurring. Granted they also lack the chaotic genetic roulette of sexual reproduction that the "higher" organisms benefit from, so their average evolution/generation is probably somewhat different than ours.

    --
    --- Most topics have many sides worth arguing, allow me to take one opposite you.
  13. Human-specific part is 20% common... by Anonymous Coward · · Score: 2, Insightful

    I think they're referring to the section of our DNA which is specific to the Homo genus.

    That is, DNA for the Homo genus is probably about 99.5% or more in common, across all species of Homo. You can tell where the Homo DNA starts by comparing it to other members of the subfamily Homininae, and looking for differences.

    So, in the Homo-specific portions of our DNA, TFA is claiming that 20% or so is common to modern humans and Neanderthals. That still seems low, given the interbreeding of Neanderthal and Modern Humans, and the fact we both share a direct common ancestor.

  14. Party "Animal" by Tablizer · · Score: 4, Interesting

    For a good long time, anatomically modern humans didn't make cave paintings and jewelry either, at least not often enough to be detected. Nobody knows what triggered the use of art in humans.

    The best theory I've heard is it's not that humans became smarter, but rather more social. Neanderthal brains were big if not bigger than ours, so they were potentially pretty smart. However, they may have been relatively anti-social.

    The most successful humans were probably those who used trade to get the resources their area lacked. For example, your area may have good arrow-head rocks, but not a lot of prey during the dry season. If you encounter another tribe whose area has a lot of prey but poor rocks, you can trade rocks for meat, and both groups benefit and give birth to more traders instead of making war with neighbors.

    Normally mammals battle neighboring groups because they compete with resources, so trade requires a different mentality: socializing with strangers. It may have taken several thousands of years to evolve this tendency. (Slashdotters are still working on it :-)

    Neanderthals may just have been slower to take advantage of trade. This is possibly because the human population was greater, magnifying the benefits of trade.

    Cave paintings and jewelry may have been an early form of advertising of your goods and services, and serving as social gestures of good will.

    1. Re:Party "Animal" by ebno-10db · · Score: 2

      Neanderthal brains were big if not bigger ... so they were potentially pretty smart. However, they may have been relatively anti-social.

      Now I know who programmers and engineers descended from.

    2. Re:Party "Animal" by morkk · · Score: 2

      Cave paintings [...] may have been an early form of advertising of your goods and services

      Hardly - the caves that were decorated are all deep, deep underground and very hard to get to. I think the art was a plea to the gods to send more animals because, between them, the Neanderthals and Cro-Magnons had wiped them out, especially the mega-fauna.

    3. Re:Party "Animal" by Tablizer · · Score: 4, Insightful

      Hardly - the caves that were decorated are all deep, deep underground and very hard to get to

      We perhaps are only seeing the art that is in hard-to-get-to caves precisely because it is hard to get to. Most surface art would be wiped out by weather or vandals. Thus, we are probably not seeing an accurate representation of original locations.

  15. At least 20% by russotto · · Score: 3, Funny

    In fact, 20% survive in Arnold Schwarzenegger alone. Add the National Football League, WWE Wrestling, and the Texas State Board of Education, and you've probably got well above 90%.

  16. military origins... by schlachter · · Score: 2

    actually i think it was designed to predict how well someone would do in the military, as the army were the originators of these tests and they used them when recruiting and tasking soldiers.

    --
    My God can beat up your God. Just kidding...don't take offense. I know there's no God.
  17. Re:"fertility skin pigment"? by GbrDead · · Score: 2

    We share 40% of our DNA with grass.

  18. Re:"fertility skin pigment"? by cusco · · Score: 2

    Aside from Neanderthals and Denisovians, which we know about, at least one more group of genes in Central Asian peoples comes from an "unknown" hominid for which we have no genetic samples. I'll skip the obvious joke about Homo Erectus.

    --
    "Think about how stupid the average person is. Now, realise that half of them are dumber than that." - George Carlin