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Controlling Fear By Modifying DNA

An anonymous reader writes "The fear of flying or of skittering spiders can mean more than just a momentary increase in heart rate and a pair of sweaty palms. A hard-core phobia can lead to crippling anxiety. Now an international team of researchers says it believes it has found a way to silence the gene that feeds phobic fear via a novel mechanism of gene regulation associated with fear extinction. The notion appears to be that phobias arise from experiences that have left an outsized imprint on gene expression, and that undoing this can undo the anxiety itself. The study was published this month (abstract) in the Proceedings of the National Academy of Sciences."

54 of 105 comments (clear)

  1. I thought fear was a choice by guytoronto · · Score: 5, Funny

    At least, that's what Will Smith told me.

    1. Re:I thought fear was a choice by Jmc23 · · Score: 1

      Apparently, that's what the study says as well.

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      Don't complain about syntax, grammar, or spelling. There is no.hell like input on android.
    2. Re:I thought fear was a choice by Muad'Dave · · Score: 1

      I thought fear was a choice

      No, Fear is the mind-killer. Fear is the little-death that brings total obliteration.

      Who says that? Muad'Dave says that!

      --
      Tiller's Rule: Never use a word in written form that you've only heard and never read. You will end up looking foolish.
  2. What could go wrong? by brainstem · · Score: 3, Insightful

    Um yea, I don't see ANY potential problems by altering someone's genetics to remove fear. This reads like a bad sci-fi movie plot.

    1. Re:What could go wrong? by Anonymous Coward · · Score: 5, Interesting

      Lack of fear as a child has been correlated with development of criminal behavior later in life: http://www.medscape.com/viewarticle/712468

      While reducing the fear response could be useful as a treatment for a crippling phobia, it would almost certainly contribute to risky behavior as well.

    2. Re:What could go wrong? by Jmc23 · · Score: 1
      Good thing this has nothing to do with that right?

      btw, if you actually read it, it reads nothing like a bad sci-fi movie.

      --
      Don't complain about syntax, grammar, or spelling. There is no.hell like input on android.
    3. Re:What could go wrong? by Kjella · · Score: 2

      Probably, but even if you take aware natural fears like claustrophobia or fear of snakes, spiders or the dark you'll still have intellectual fears. Nobody naturally fears going to prison - okay maybe the claustrophobia or the prison rapes but not the deprivation of liberty as such, that's an intellectual thing because you've learned about the law where your rational mind tells you that if you do crime you might get caught and might go to prison. If there's a correlation I think it's because you become more of a thrill seeker where higher propensity of criminal activity is a secondary effect. Which sounds just right when I look back at those I grew up with, the thrill seekers were also trouble makers many of which later ended up in trouble with the law.

      Besides, if you're having a crippling fear it might still make sense. I have someone I know who was suffering from horrible epilepsy attacks, in his 30s but still living with his parents who couldn't leave him alone, no job, no education, no drivers license because the seizures disrupted everything and if they weren't treated he could die. What he got is from what I can tell pretty much a modern lobotomy, they found the part of his brain that was causing it and cut most or all the links into that section. Let's just say it wasn't for everyone but he at least got semi-functioning, got a driver's license, finished a trade and overall got a life afterwards. If they're so horrible afraid they just can't cope with normal everyday life then really drastic measures might be called for.

      --
      Live today, because you never know what tomorrow brings
    4. Re:What could go wrong? by funwithBSD · · Score: 1

      The Bene Gesserit found out what can go wrong when you breed fear out.

      --
      Never answer an anonymous letter. - Yogi Berra
    5. Re:What could go wrong? by Obfuscant · · Score: 1

      Um yea, I don't see ANY potential problems by altering someone's genetics to remove fear. This reads like a bad sci-fi movie plot.

      Your fear of having your DNA modified can be dealt with by a simple DNA modification...

    6. Re:What could go wrong? by Darinbob · · Score: 1

      A phobia is a lot different from a regular fear, and different in more than just a degree of fear. This treatment, if the research pans out, is not about removing fear but about fixing specific phobias.

      I've got a phobia, and it is not like your general anxiety or misgivings about a situation. You can walk into a situation and think everything is fine and then suddenly freeze up. Sort of like going to the humane shelter to pick out a puppy and when you get there the sound of barking causes your palms to sweat and your heart to race. It is often totally illogical and unrelated to risky actions or situations. In my case it's actually getting worse as I get older, which doesn't make a lot of sense to me. It's not crippling but I am definitely altering behavior and plans to avoid it.

  3. Seems dauntless by BisuDagger · · Score: 2

    The Divergent series is all about gene manipulation including the fear gene. If only it was a more logical take on a society using gene manipulation. Anyone who read the Divergent series all the way through must be wishing they had this fear controlling gene modified so they wouldn't have had to suffer through the last two books.

  4. Easier than that. by Lumpy · · Score: 3, Informative

    Simple feed the children LEAD. IT will suppress the fear triggers and make them far more hostile.

    If you want to build the perfect warrior, then just do what the romans and the vikings did. Lead dosing.

    --
    Do not look at laser with remaining good eye.
  5. Western medicine at it again. by Jmc23 · · Score: 3, Informative
    Since nobody reads, or seems to understand, they are not manipulating any genes here.

    They found that learning to extinguish fear causes expression of a gene.

    In common western medicine fashion, the important thing here is not that behavioural methods are effective in changing gene expression, but we can now remove the stimulus for gene expression (a persons conscious control) and package it up into a pill to sell for profit!

    --
    Don't complain about syntax, grammar, or spelling. There is no.hell like input on android.
  6. Of all the thigns to do with DNA by gurps_npc · · Score: 2, Interesting

    they want to screw with our minds? Worse - with fear? You can't like start with getting rid of diabetic tendencies? Or even give us the power to choose our own skin color? One sure way to end racism in the US at least (of course we would probably have to change hair type as well).

    --
    excitingthingstodo.blogspot.com
    1. Re:Of all the thigns to do with DNA by Anonymous Coward · · Score: 1

      Stop posting on slashdot. You could have spent this time programming.

      (just because you don't think reducing fear excitation is a valuable use of these researchers' time doesn't mean it isn't valuable, or that they should be doing other things)

    2. Re:Of all the thigns to do with DNA by JimSadler · · Score: 1

      Medication to change skin color would result in a lot of strife. For example it is simply easier to be a white person that a darker person in America. I think that given the option most black folks would want to be white or at least have their kids be white. That would almost cause an extermination in appearance of black folks. It might also mean that black folks who are very dark would want to appear a bit less black at the very least. One can only imagine the shock of change and the response of both the black and white community.

    3. Re:Of all the thigns to do with DNA by gurps_npc · · Score: 1

      You appear to believe me when I said there would be a large market for it, but prefaced your agreement with me with an unsupported comment that it would cause strife. How? Why? People upset that others used their color? That sounds like complaining, not strife. Note I assume that the process would be cheap enough for middle class people to purchase.

      --
      excitingthingstodo.blogspot.com
  7. Fear suppression by gene manipulation by paiute · · Score: 2

    I am confident that none of this work was secretly funded by the armed forces.

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    If Slashdot were chemistry it would look like this:Cadaverine
  8. Re:Democrats want you to fear Republicans! by paiute · · Score: 1

    what is so bad about individual liberty, natural rights and limited government

    Those are great. You have a political party around which believes in these things?

    --
    If Slashdot were chemistry it would look like this:Cadaverine
  9. Re:Democrats want you to fear Republicans! by jeffmflanagan · · Score: 4, Informative

    >Do any of you realize you are biased against conservatives because you have been *trained* to be?

    Does it occur to you that we're biased against conservatives because people who self-identify as conservative keep saying deeply stupid things in public. See just about any Republican politician, or check out the insane conservatives that use tags like #TGDN, #TCOT, and #REDNATIONRISING on Twitter. They just keep feeding each other fake quotes, and reinforcing a hatred of anyone who isn't as delusional as they are. They think that intelligent liberal people are their enemy, when really the enemy is the "conservative" media that filled their heads with nonsense.

    Conservative didn't always mean crazy/stupid, but it sure does now.


    >what is so bad about individual liberty, natural rights and limited government huh?

    Nothing, it's the superstition, authoritarianism, racism, homophobia, and opposition to women's rights that's wrong with the ignorant conservatives.

  10. Why not just be less fearful by jeffmflanagan · · Score: 1

    There's no need to modify DNA to ease phobias, you just have to get over whatever personal issue is holding you back.

    I used to have an irrational fear of spiders, then I moved to a house with lots of spiders. Phobia cured.

    1. Re:Why not just be less fearful by Darinbob · · Score: 1

      My phobia is getting worse as I get older. I didn't even have it in my 20s.

      One of the problem is that I do think to myself that it's just a stupid thing and that I should act like an adult and not let it bother me. But then it does bother me enough that I feel the panic rising. When it's over I'm beating myself up for being stupid and not acting like an adult, with all of that fueled by the leftover surge of adrenaline.

      Mine's not that bad, but imagine someone who felt they had to walk down the street to use the gas station restroom because there was a spider sitting on their toilet.

  11. Re:Democrats want you to fear Republicans! by krashnburn200 · · Score: 1

    No one thinks it might be a good idea to unplug that cable from the back of your heads for a few minutes and let reason take over for a bit, and to see what comes from that?

    Please; You have no room to talk. If you had actually dared to face reality rationally you would not be so worked up about such meaningless things. You are participating in inherently irrational behavior and crying foul because others are a teensy bit more irrational than you.

  12. Do you want Reavers? by Anonymous Coward · · Score: 1

    Do you want Reavers? Because that's how you get Reavers.

  13. Re:Democrats want you to fear Republicans! by NatasRevol · · Score: 2, Informative

    I don't even have to have all that experience.

    'Democrats' - tax & spend
    'Republicans' - just spend (~80% of the federal deficit is from Reagan & 2 Bushes)

    Which one actually sounds fiscally more conservative?

    Neither are really responsible, but at least one tries to have the cash to spend.

    --
    There are two types of people in the world: Those who crave closure
  14. STUPIDITY by zoomshorts · · Score: 2, Funny

    They need to get to work on STUPIDITY. Fear has it's uses.

    1. Re:STUPIDITY by Immerman · · Score: 1

      So does stupidity. How else are you going to get someone to go put their life on the line fighting to prop up abusive regimes in far off nations so that we can secure exploitative mineral export deals?

      --
      --- Most topics have many sides worth arguing, allow me to take one opposite you.
  15. good and bad by CheshireDragon · · Score: 2

    I could be both good and bad.

    The good thing is that religion would end because no one would fear that Hell place that is crammed into ones head as a child, but the bad thing could be that we may die out sooner because we would not fear the bear coming to eat us.
    The deeper side though thinks that this might be a GREAT idea because I am afraid of heights and flying. In order for me to get on a plane I have to pretty much take enough sedatives to kill a horse. There isn't anything out there strong enough to where I have no clue of my surroundings. I also have anthropophobia which causes me to work from home and conduct business over the phone, text, email or online. It is very difficult for me to be around crowds of more than 5-6 people at a time.

    --
    "That's right...I said it."
    1. Re:good and bad by nospam007 · · Score: 1

      "The good thing is that religion would end because no one would fear that Hell place that is crammed into ones head as a child, but the bad thing could be that we may die out sooner because we would not fear the bear coming to eat us."

      IOW it's great for New Yorkers but they already don't believe in God and also not in bears.

      The military will want it to make soldiers not to fear bullets or death, after all only 25% of the soldiers are able to fire their weapons because of fear.

  16. Re:Disabled Geniuses by rogoshen1 · · Score: 2

    fear is probably one of our oldest (evolutionary speaking) emotions. how many other systems within body/mind could possibly rely upon it?

    With something as fantastically complex and interconnected as the brain, altering it to handle a superficial manifestation of something as primitive as 'fear' couldn't possibly have wide ranging side effects could it?

  17. Re:Democrats want you to fear Republicans! by JimSadler · · Score: 1

    I think we have reached the point at which being a conservative must be regarded as evil. One issue is the constant sheltering and support of race hate groups. The second issue is wanting to control the actions of others with belief systems that want to regulate abortion or pornography. If one dislikes abortions then simply don't have one. If one dislikes porn then don't consume porn. The notion that one's personal moral beliefs must be stamped upon everyone else is just wrong. Then there is a continuous display of lack of concern for others. Failure to support education or the teaching of science as well as the failure to support those in distress and dire need can not be tolerated. For example Palm Beach,Fl. has laws that make it a crime to feed the poor. And yes, good people do fear conservatives. And maybe we need to fear them even more than we do today. But more to the point if phobias are an expression of genetic damage then we have a proof that many people thought to have been mentally ill have nothing more than a damaged gene. Not only will that go a long way towards saving lives and eliminating suffering it will also mean that insurance companies would be forced to treat this form of "mental illness" as a physical illness and that in itself would open up care for some disabled people. Phobias can be so severe that people are totally non functional.

  18. It's not a flaw by slashmydots · · Score: 1

    I stand by the fact that people who aren't afraid of heights have brains that don't work correctly. Your brain is trying to keep your dumb ass alive by making you not go near ledges and stuff. We're afraid of bugs and spiders because they're often poisonous. Same with snakes. I'm not afraid of snakes at all so guess who's more likely to get bit, me or someone who's afraid of snakes? So why correct something that is a benefit? You know what my solution to spider phobia is? Kill the spider.

    1. Re:It's not a flaw by sjames · · Score: 1

      I don't fear snakes either. That doesn't mean I don't give them a wide margin until I positively identify them as non-poisonous. At least I don't run for cover when I see a snake only to discover that my hiding place has spiders.

    2. Re:It's not a flaw by Darinbob · · Score: 2

      There are other phobias that have little to do with normal situations. Such as not afraid of heights but afraid of bridges. Afraid of the number thirteen. And so on.

      So you think you just get rid of spider phobia by killing it. How do you kill it if you can't even be in the same room? If you try to kill it with a broom and then your brain starts screaming that it's going to run up the broom and get to you, and that maybe if you stay still it won't notice you're there. It's really funny if it's someone else but it's completely rotten if it happens to you.

  19. Re:Democrats want you to fear Republicans! by Vermonter · · Score: 1

    The problem with your statement is you start with the presupposition that your worldview is correct. Those who are against abortion feel that way because they perceive an unborn child as a human being who has a right to life. Yet liberals always frame the argument as "conservatives are against women's rights" (even though it's only a single "right" in question). Then again, phrasing it that way changes the frame of the discussion from women's rights to "when does life begin?", which is much harder to argue in favor of abortion, since by scientific definition life begins at conception, and by genetic definition the fetus is a human being. It's much easier to re-frame the issue as women's rights, and paint opponents as sexist bigots. Also, the law in Florida you mentioned came to light because it was used to stop a church from feeding the poor. The same church that is filled with conservatives (who are also painted as "idiots who believe in a magical sky fairy", because again, it's easier to paint your opponent as stupid than it is to actually debate their ideas).

  20. Re:Democrats want you to fear Republicans! by ab0mb88 · · Score: 1

    "Which was the party that pushed for and passed civil rights legislation over the objection of which other party? Which party was Robert Byrd from? Then there's that whole civil way thing that Lincoln used to free the slaves (simplification I know), which party was he from again, was that Democrat?"

    You are making a common modern mistake. You are using the Progressive/Conservative categories and Democratic/Republican parties interchangeably. The time frame you are talking about the Democrats were the conservatives (http://en.wikipedia.org/wiki/Timeline_of_modern_American_conservatism). You can and should be proud of the historical accomplishments of your political party but please be aware of which party would be implementing those changes to society today.

  21. Re:Democrats want you to fear Republicans! by ab0mb88 · · Score: 1

    And now you have shown why there is no longer any civil conversations in modern politics. You have repeatedly requested a citation for contentious claims. I provided a URL that backed up my statement and you instantly jump to insults and insinuations.

  22. Re:Democrats want you to fear Republicans! by sjames · · Score: 1

    It has everything to do with the public face of the so called conservative party in America.

    If you don't like it, you should either disavow the GOP or clean house. They are representing you as a homophobic elitist hypocritical ignorant martinet.

  23. Re:Democrats want you to fear Republicans! by sjames · · Score: 1

    Which was the party that pushed for and passed civil rights legislation over the objection of which other party?

    Let's face it, neither of those parties exists in a recognizable form today.

  24. Re:Democrats want you to fear Republicans! by ab0mb88 · · Score: 1

    "With the decline of the conservative wing of the Democratic Party after 1960, the movement is most closely associated with the Republican Party (GOP)"

    Literally the second sentence of the article... Thanks for playing.

  25. Re:More interested in the opposite by sjames · · Score: 1

    I can see it now, being the office joke where every time the receptionist reads her horoscope aloud you have to change your pants.

  26. Re:Democrats want you to fear Republicans! by Payden+K.+Pringle · · Score: 1

    Please do not use homophobia when describing such people.

    TFA is talking about phobias as genetic. i.e. they aren't something you choose. They are what you are born with.

    Homophobia, as you are talking about (AFAIK) is the kind of hatred that is a choice. It isn't fear. It's downright hatred. Fear can lead to hatred, but I think phobias aren't directly tied to that.

    In other words, there is a thing that is homophobia, a literal fear of gays that is akin to fear of heights and spiders. But that is a genetic thing apparently and not the same thing as the "homophobia" taught by many conservatives.

    They just accept their brainwashing to hate homosexuals, or fail to see it, or something similar. I say this as someone who identifies as a conservative. And as someone who sincerely believes he has homophobia in the sense of what that word really means. I get the flight or fight response when near someone I know that is openly homosexual unless I'm trained to do otherwise. I know this by way of an old friend I grew up with in high school who came out as soon as he graduated. It still bothers me to be around him, but I can be. Others like him cause a sort of panic response in me.

    I'm just saying. Please stop making homophobia an insult to the morality of a person when the actual word means something different. It's what happened to retarded (mental retardation was a completely legit medical term once), and I don't see how those who make this word an insult are any different from those who made gay an insult personally.

  27. Re:Democrats want you to fear Republicans! by sjames · · Score: 1

    Here.

    OH! Here's a heap of examples!

    Then there's the whole Rush Limbaugh tough on drug abusers except when blowhard radio personalities take so much non-prescribed oxycontin their ears quit working. Why hasn't he had himself locked up? (just Google, there's far too many references to link)

    Then there's these.. Here too. Even some (former) Republicans agree.

  28. Re:Democrats want you to fear Republicans! by sjames · · Score: 1

    What crazy crack are you smoking?

  29. Why stop there? by mariox19 · · Score: 1

    Next on the agenda, we clone Jem'Hadar and become galactic overlords.

    --

    quiquid id est, timeo puellas et oscula dantes.

  30. Re:Democrats want you to fear Republicans! by krashnburn200 · · Score: 1
    I am sorry you entirely missed my point AC.

    I responded specifically and directly to the only point raised about which I cared; the one I quoted.
    You reply with more political nonsense.
    Congratulations, you broke the rust of the old cogitator and fired it up to let 'logic' happen with regards to one very tiny piece of your life and then you rushed to shut it off again just as fast as you could... Congratulations again! Seriously you are now more rational then the majority of people on the planet.

    You still look ridiculous when you deride others for being 1% more irrational than you.

  31. Re:Democrats want you to fear Republicans! by sjames · · Score: 1

    So who is it that opposes gay marriage, abortion (even in the case of rape for a fair percentage), birth control, etc.

    I hear stuff from Democrats I disagree with all the time, but it tends to be the GOP saying things that are outrageously stupid or blatant lies, batshit crazy, or just sociopathic.

  32. Re:Democrats want you to fear Republicans! by sjames · · Score: 1

    I don't think so considering that I'm disappointed in the Democrats for shifting to the right. The rest f the world has noticed that the U.S. has no significant left, just right, righter, and wingnut.

  33. Tyrell Corporation by Frosty+Piss · · Score: 1

    Simple feed the children LEAD ... If you want to build the perfect warrior...

    An interesting idea, but modifying "fear DNA" is a great step towards bio-engineering "warrior drones". Think Tyrell Corporation...

    --
    If you want news from today, you have to come back tomorrow.
  34. It is the start of the Daleks! by adndgamer · · Score: 1

    All hail the Daleks! Destroy the humans! EXTERMINATE! EXTERMINATE!

  35. Re:Democrats want you to fear Republicans! by NatasRevol · · Score: 1

    So,

    Reagan took the debt from $1T to $3T
    Bush Sr took it from $3T to $6T
    Clinton took it from $6T to $5T
    Bush Jr took it from $5T to $12T
    Obama from $12T to $17T.

    Add it up, Republicans overspent $12T out of $17T debt. So it's only 70%.

    And Obama had to deal with the mess of the Bush tax cuts (again, spend only republicans) and an actual recession (when the government actually should be spending). But, yeah, all $17T is his fault. If you're a fucking idiot.

    --
    There are two types of people in the world: Those who crave closure
  36. Re:Democrats want you to fear Republicans! by DNS-and-BIND · · Score: 1
    It's more like liberalism has set itself up as the One True Truth[tm], and anyone who disagrees with it is branded as outcast, evil, insane. Progressives have labels for people who disagree with them, and being labeled like this is grounds to lose your job or have a SWAT team called on you in the middle of the night. They simply don't understand how anyone can hold a contrary opinion. They also can't understand how they could be racist as well, even though they think that people can't think for themselves and accept moral agency for their actions, depending on what race they are.

    Thanks for admitting your bias, though. It always gets denied and it's nice to see it admitted up front for once. It's like the time the New York Times came right out and admitted it was a liberal newspaper and not objective at all.

    --
    Shutting down free speech with violence isn't fighting fascism. It IS fascism!
  37. Re:Democrats want you to fear Republicans! by Kielistic · · Score: 1

    Religious people would be the answer to your question. Why they tend to lean conservative is a different question.

  38. Re:Democrats want you to fear Republicans! by jwdb · · Score: 1

    since by scientific definition life begins at conception, and by genetic definition the fetus is a human being.

    By scientific definition life began somewhere 3.5 billion years ago, just once, and we are all just a continuation of that one single starting point. Life replicates by splitting a living part of itself off into a separate entity, not by jump-starting new life in a separate piece of inert matter.

    The question is when the mother and child become separate beings, rather than just the one being a growth in the other. That line tends to get drawn at the point of viability, when you could remove the child from the mother's body and still have it survive. That's not at conception, however.