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Experimental Drug Compound Found To Reverse Effects of Alzheimer's In Mice
Zothecula (1870348) writes "While there has been progress made in the fight against Alzheimer's, our understanding of the dispiriting disease remains somewhat limited, with a definitive cure yet to be found. The latest development comes at the hands of researchers from Yale's School of Medicine, who have discovered a new drug compound shown to reverse the effects of Alzheimer's in mice."
... so yet another fraud from the animal torturers...
What a joke it is - endless fraud from psychopaths who enjoy torturing animals all day.
Do mice get Alzheimer's disease in the wild? This is blatantly fraudulent 'research'.
All we need now is a drug to turn humans into mice.
If I read that correctly (yeah, I RTFA) what that stuff does is facilitate the transfer of short term into long term memory.
Forget Alzheimer (please, no lame puns here), every student on this planet will want that stuff. I sure know I would've killed to get that shit to stuff all that nonsensical crap into my brain that I had to learn for a few tests that were about as interesting as watching the carpet warp during hot Summers.
We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
This will allow him to take the reigns of the Presidency instead, and serve the American people once more.
Oh sure, we'll have to get him a shiny new Robot body, but it's ok, there's bound to be one made of titanium.
It's only old people who get Alzheimer's. No loss there...
American politicians seem to have done a pretty good job on the American people without needing drugs.
Like Pavlov's dogs, only a few unique sounds (in this case keywords such as terrorist) turned out to be necessary.
Lets start with Figure S2c. Why does the 3 mg/kg S8 treatment band for phosphorylated pyk2 look exactly the same as the unphosphorylated band?
life imitates art?
Them sheeple gonna bark.
With so many advancements and near miraculous treatments being discovered almost daily it's never been a better time to be a mouse!
I browse on +1 so AC's need not respond, I won't see it.
Alzheimer's causes death of brain cells, and concomitantly the information stored in the neural networks they were part of.
That information is irrevocably destroyed, and that neural processing capability is lost. There will never be a treatment that can recreate the dead neurons with the synaptic network configuration they had—that would be like developing a "treatment" to reverse cremation.
Will we someday have a treatment that halts Alzheimer's? Perhaps. Will we someday have a treatment that augments lost cortical processing capability via unlocking new neural pathways/cortical plasticity? It's plausible.
Will we ever reverse the brain damage and (equally importantly) its state? No. Therefore, Alzheimer's can never be truly "reversed".
Albeit they're often difficult to differentiate from the morons and trolls.
That said: There's plenty of reasons somebody with the background to make sense of the data, interpret it, and raise concerns might not want their name associated with said statements. Given the IP laws, non-compete agreements, etc in place nowadays the last thing you want to be doing is running off your mouth in an identifiable fashion.
That said: Who really trusts research papers as solid evidence anymore? Short of a half dozen recreations of the subject matter, or a commercial process proving it legitimate too many current research papers have been called into question under knowledgable and motivated scrutiny to warrant trusting the publishing entity's proper vetting of the publication or of the scientists integrity being high enough to 'take their word for it.'
Every student on the planet already has what it takes to convert short term memories to long term memories. The drug isn't professed to improve the conversion rate, it's professed to restore the conversion rate in people with Alzheimer's disease. People with Alzheimer's disease get to live with the unfortunate prospect of watching that conversion rate go from normal to something approaching zero.
A mouse looked so stupid walking around and around in circles looking for the car keys.
An older mouse was screaming at the cheese "Do I know you?" in a mousey voice...
It was totally embarrassing.
You can always tell an article is based on junk science when it contains the words "Alzheimer's," "cancer," or "AIDS." I'd bet my last cent at least two of the researchers involved in this are implicated in fakery by next week.
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Alzheimer, cancer, HIV, thats where the gvt money is. Scientists apply for that money and in order to get it they need to invent a story why the stuff they research has something to do with one of those three. Of course its not that extreme, but sure there is some bias applied in abstracts to get funds.
If I understood the article. They suppose that all neurons are sort of like NAND memory cells, and not only do they acquire [New] memories from Short-Term to Long Term, but they also transfer [Old] Memories from long term storage to long term storage when [Old] neurons burn out, via the Short-Term memory pipeline.
So Alzheimers would be a disease of this natural "refresh" and "repair" mechanism.
Without renewal, [Old] Memories quite literally "die" when the neurons that support them die.
So "technically" this isn't a cure for Azheimers it's "boosting" the recycle process that takes old memories and puts them into [New] neurons, or neurons that are not "dead" yet. It helps [Salvage] what memories you have left. Our "mindful" use of partial memory fragments gets "re-coalesced" from potential "gibberish" into something co-herent and useful by processing through the "Short-Term" process.. "dreams" or "day dreaming" when we try to make sense of things. And then it has to get put back into [Long-Term] storage. If STEP gets in the way, then the memories eventually [Fade] from Short-Term memory, and are lost. Or die with the neurons that originally backed them.
This doesn't prevent Neuronal death.. but provides an enhanced "Coping" mechanism.. it would certainly help students learn things.. but their might be long term down sides.. like burning out the Short-Term memory cells capacity sooner than they would normally fail. Like accelerated aging of the Short-Term memory component of the brain. If I were a young person.. I would think very long and hard before trading Life-Span for Short-Term financial gains. As for older people.. its a Faustian deal at best.. and not question at all if your already at the doorstep of Alzheimers.
Are you thinking what I'm thinking?
Alternatively, is the mouse named Caesar?
Let's hope that this treatment works well, and is approved for human use quickly. Terry Pratchett's abilities to tie fascinating details of human experience, knowledge, and even science into an entertaining and educational story is an incredible loss to the world. Even if you only recovers enough to enjoy the well-earned adulation of his fans, the chance to thank him personally for his work is worth significant medical research.
I understand he particularly likes banana daiquiris.
We have successfully cured mice of every disease known to man. The unfortunate part is that things that cure mice don't always cure people. Is the correlation even 20%? It depends on the organ or organs similarity between humans and mice. Its nice to think that there is something that can slow the spread of Altzheimers by 95% or better, but we (sadly) won't be holding our breath till its shown to work in people.
All this drug does it improve the conversion of short-term memory to long-term memory. This is a problem in patients suffering from Alzheimer's but no way can it regain memory stored in neurons already lost to Alzheimer's. I hope this treatment works, but it's not even clear it will stop the progression of the disease to it's ultimate conclusion.
Finally elderly mice will not have to fear this terrible disease.
-- 29A the number of the Beast
If every time I read a story starting with "_______ reversed in mice!" it ended up being an actual advancement in medicine, by now we would be immortal and immune to almost every disease.
Instead of living long in a lab, I wonder if it is being stuck in a cage, being poked and prodded all their lives is part of why they go mad.
A recent study has found low vitamin D levels associated with Alzheimer's disease, as well as a bunch of other ailments. It seems like modest daily supplementation with vitamin D3 might be a good idea if Alzheimer's runs in your family.
https://www.yahoo.com/health/clear-link-found-between-vitamin-d-deficiency-and-94074543072.html
All kidding aside, I hope some headway is made in this field.
I think we all hope in this, regardless of our age. And, unless we destroy ourselves in some nice world war, or unless science will be oficially banned on religious grounds, the cure will be found. Alzheimer's is no magic, there is some underlying cause, and when we find it, we will find a way to block it, although it can be technically challenging.
I personally think (but this is just a guess) that we will have to learn pretty much details of neuronal functions at the lowest biochemical level, and also about glial-neuronal interactions, because so far I tend to think that there might be some subtle glitch in metabolism, something not being cleaned up properly, which leads to disastrous buildup of unusable stuff much, much later. But I repeat, that's just a guess, there might as well be a profound, brutal defect we just did not find yet.
I have no problem remembering technical things that I learn and once I learn them once, it is very rare for me to forget. But I am finding myself, at 30, confusing the chronological order of events, repeating conversations, and thinking that I may or may not 'have already done this before'. It kind of feels like a mild cross of aphasia and alzheimer's.
In 30? Probably loss of concentration. Alzheimer's is very rare at your age, and it usually manifests in a different way. A cause for concern would be if you were losing memories or how-tos of usual, routine things, experiencing strange mood swings with bouts of confusion, not recognizing people you regularly meet, or suddenly getting lost in a town you live in for 20 years. And even then, I would suspect epilepsy. (But beware, I am not a MD...)
And every ten years Alzheimer's organisations say that they'll have a cure in ten years time. I see some correlation with that tactic and the general lifespan of Alzheimer's patients.
"Everyone knows that vi vi vi is the number of the beast" -- Richard Stallman
God damn beta and god damn tablet software keyboards
"Everyone knows that vi vi vi is the number of the beast" -- Richard Stallman