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Anti-Ebola Drug ZMapp Makes Clean Sweep: 18 of 18 Monkeys Survive Infection
Scientific American reports, based on a study published today in Nature, that ZMapp, the drug that has been used to treat seven patients during the current Ebola epidemic in West Africa, can completely protect monkeys against the virus, research has found. ... The drug — a cocktail of three purified immune proteins, or monoclonal antibodies, that target the Ebola virus — has been given to seven people: two US and three African health-care workers, a British nurse and a Spanish priest. The priest and a Liberian health-care worker who got the drug have since died. There is no way to tell whether ZMapp has been effective in the patients who survived, because they received the drug at different times during the course of their disease and received various levels of medical care.
NPR also has an interview with study lead Gary Kobinger, who says that (very cautious) human trials are in the works, and emphasizes the difficulites of producing the drug in quantity.
with Ebola control is health care infra-structure in affected countries. A far cry from what would be necessary to contain further spread. There was one report on a radio station that there are like 10 doctors in a whole country (Africa, forgot the name).
Even if you have the best drug available defeating the virus in a day, it won't help at all under those circumstances - spread by body fluids from infected individuals.
The outcome can only be guessed...
I think it should be infected people.
brandelf -t FreeBSD
By law in the U.S. (and most other countries), as well as health care and research codes of ethics, study participants must voluntarily provide informed consent to receive experimental treatments. It's extremely difficult to prove the voluntary part for at-risk populations including people who are elderly, poor, or undereducated. Studies of these populations require additional oversight and safeguards.
Source: I'm qualified to perform research with participants who have linguistic or cognitive impairments and did so during my M.S. program and in my first job after graduation.
Looks like The Onion got this one wrong.
Experts: Ebola Vaccine At Least 50 White People Away
I suppose it's a commentary on the state of the world that The Onion is so often inadvertently right with their headlines.
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"Bad ones"
That isn't how evolution works. What you meant was genetically less fit to resist predation by lions and tigers before having a chance to breed if and only if lions and tigers are a significant cause of that species not being able to breed in comparison to other factors.
I, for one, don't give a shit about genetic fitness against Ebola. Thinking that somehow these people (or animals) "deserve" to be weeded out because they are "bad" in the sense there is something wrong with them is completely unfounded, and is nothing more than blaming the victim.
Or trolling.
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i read the fatality rate in this epidemic has been more around 40%.
The lowered lethality is actually a bad thing. It means people aren't getting as sick, are staying ambulatory longer, and are spreading the disease to more additional people. With a lethality rate of 90% a disease will likely burn out fast. At 40%, it has more time to spread, and can kill far more people in total. Despite the lower lethality, this outbreak has killed more than any other. If the virus continues to adapt to human hosts, and the lethality falls to 10 or 20%, we are in big trouble.
That's easy to say when the sample of drugs you have is those that have passed approval. If the requirements are relaxed, it's very hard to say what would happen without having access to information only the FDA has.
Perhaps nothing would happen. That'd be great, but it's also a gamble. It's possible that the relaxed requirements mean a side-effect slips through unnoticed, causing as great or greater harm later in the future. It's unlikely, but it's possible, and it only takes one for everyone to panic. Probably the best example we have of what could happen is Thalidomide.
Doctors Without Borders/Médecins Sans Frontiéres (MSF)
http://www.doctorswithoutborde...