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Why Scientists Think Completely Unclassifiable and Undiscovered Life Forms Exist

An anonymous reader writes: In a new paper published in Science, researchers at the Department of Energy's Joint Genome Institute note that "there are reasons to believe that current approaches [to discovering life] may indeed miss taxa, particularly if they are very different from those that have so far been characterized." They believe life forms exist that don't fall into the established eukaryota, archaea, or bacteria kingdoms. They argue that there may be life out there that doesn't use the four DNA and RNA bases that we're used to; there may be life out there that has evolved completely separately from everything that we have ever known to exist; there may be life that lives in places we haven't even looked.

33 of 221 comments (clear)

  1. Have we discovered all there is to discover? by QuietLagoon · · Score: 5, Insightful
    Of course not.

    .
    To think that we have discovered all there is to know regarding life forms would mean that we already know all there is to know in this field.

    So maybe we need to use different methods than the ones we have been using. Makes sense to me.

    1. Re:Have we discovered all there is to discover? by penguinoid · · Score: 3, Insightful

      Indeed. We have enough trouble finding certain DNA-based life forms. Plenty of life forms we only know about because we leaned how to copy DNA, and started grinding up samples and amplifying the DNA. Many of those refuse to grow in petri dishes and don't cause diseases, and would no doubt be unknown to this day if they didn't contain DNA.

      I think there's a fairly low chance that Earth has life that doesn't use DNA/RNA but if there is and it minds its own business, it could be decades or more before we discover them.

      --
      Don't waste your vote! Vote for whoever you want, unless you live in a swing state it won't matter anyways
    2. Re:Have we discovered all there is to discover? by Anonymous Coward · · Score: 5, Insightful

      And just to pick a nit a bit:
      "Unclassifiable" is pure nonsense. Unfamiliar, sure. Foundationally different than all terran life, sure. Unclassifiable, no. Even if it just starts a conversation that leads to a decision to add a larger category than 'kingdom,' once recognized, it can be classified.

    3. Re:Have we discovered all there is to discover? by Applehu+Akbar · · Score: 5, Informative

      What they mean by the term is "not fitting existing classifications" of course.

    4. Re:Have we discovered all there is to discover? by smellsofbikes · · Score: 5, Interesting

      Indeed. We have enough trouble finding certain DNA-based life forms. Plenty of life forms we only know about because we leaned how to copy DNA, and started grinding up samples and amplifying the DNA. Many of those refuse to grow in petri dishes and don't cause diseases, and would no doubt be unknown to this day if they didn't contain DNA.

      I think there's a fairly low chance that Earth has life that doesn't use DNA/RNA but if there is and it minds its own business, it could be decades or more before we discover them.

      Consider things that grow much, much more slowly. They're already finding chemolithoautotrophs living in rock 4 km beneath the surface of the earth, that reproduce over the course of years, rather than in twenty minutes like the bacteria we're used to working with. If there were organisms that didn't have DNA, but did have some sort of body that could maintain chemical gradients, allowing it some sort of metabolism, and reproduced on the scale of centuries, we'd have trouble ever noticing it was there because we haven't made the tools to find it, for lack of knowing what we're looking for.

      --
      Nostalgia's not what it used to be.
    5. Re:Have we discovered all there is to discover? by HiThere · · Score: 4, Insightful

      Are Prions a form of life? If not, why not?

      They don't use DNA, they use proteins.

      OTOH all known Prions are either symbiotes or parasites.

      Whether we recognize any particular non-DNA using entity as a form of life is going to depend strongly on what definition we use for life.

      --

      I think we've pushed this "anyone can grow up to be president" thing too far.
    6. Re:Have we discovered all there is to discover? by lgw · · Score: 2, Interesting

      The best phrase I've heard for this is "don't eat the menu". Indeed.

      --
      Socialism: a lie told by totalitarians and believed by fools.
    7. Re:Have we discovered all there is to discover? by Livius · · Score: 2

      It should have been phrased better, but I think they mean something not fitting into current classification systems. The response to which will be to improve the classification.

    8. Re:Have we discovered all there is to discover? by jc42 · · Score: 3, Informative

      Not quite. They're suggesting that there's a good chance that there's an entirely different domain (or more) of life other than eukaryotes, bacteria, and archaea. That's a pretty radical proposition, ...

      Um, not really. A bit of quick googling verified within a minute my memory that the "discovery" of the archaea only dates back to the 1970s. Before that, the few that were known were (mis)classified as bacteria. Then a few researchers looked into their details, and showed that they weren't bacteria at all. Biologists basically watched the discussions, and eventually recognized that those researchers were right, and since then we've had 3 "kingdoms" of Earthly life forms.

      It's the idea that those 3 root classifications are all there is that's really radical. The default conjecture should really be that, if we discovered such a major root clade so recently, there are probably more waiting to be discovered. Assuming otherwise mostly just shows a lack of knowledge of the recent history of biological discovery.

      In particular, someone else has already mentioned the fact that the various deep-drilling projects have found living things kilometers deep in the rocks, no matter where they've drilled. The folks working with this data have estimated that there's more biomass below the surface water+soil layer than there is above it. It's likely that the critters living their slow, warm lives down there are radically different from anything up here on the planet's thin skin. Learning about them is going to take time. (And we can hope that the rapid expansion of "fracking" won't cause a mass extinction due to the massive habitat destruction down there before we have a chance to study them. ;-)

      --
      Those who do study history are doomed to stand helplessly by while everyone else repeats it.
    9. Re:Have we discovered all there is to discover? by Chalnoth · · Score: 2

      A couple of points here.

      First, we've now sequenced the DNA of so many microorganisms that it would be very, very hard for a new domain of life that uses the same sort of DNA structures to exist. The only likely way for a new form of life to exist is for it to be of a kind that isn't picked up in our DNA tests. That's what is proposed in this article.

      Given that, and given that all life (and viruses) found so far speak the same basic DNA language, it's really not unreasonable at all that the domains we've already discovered are the only ones.

      There's an outside possibility of new discoveries shaking up the current tree of life, splitting one of our domains in two (as happened with bacteria/archaea). But that's not what is being discussed in this article.

    10. Re:Have we discovered all there is to discover? by serviscope_minor · · Score: 2

      Even if it just starts a conversation that leads to a decision to add a larger category than 'kingdom,'

      We already have that. The current popular top level is the domain, with the domains being bacteria, archaea and eukariotes.

      --
      SJW n. One who posts facts.
  2. GOD? by Chexsum · · Score: 2

    its life jim but not as we know it

    --
    Pixels keep you awake!
  3. is this news? by Triklyn · · Score: 5, Insightful

    I was under the impression that news was about you know, new things. This is just an article highlighting that money has up until now been targetted toward things we are pretty sure exist. you know, novel creatures not using radically different genetic bases. This is just some dudes going, "yup, there might be more out there than we thought" which is you know, the basic premise of all the sciences.

    Come back to me when they actually find something that uses a sixth nucleotide.

    Incidentally, where might this new life have hidden, that we haven't searched already. We've got extremophiles in the middle of godforsaken rocks already... there aren't that many new places that i imagine we

    A. haven't looked already
    B. aren't already colonized by the cousins we know.

    Generally speaking, the new life would need to be able to outcompete, in certain circumstances, the stuff we know or it wouldn't survive too well the 2 billion years that bacteria have dominated the planet.

    i'd think the only viable thing would be viruses, maybe, and us not fully understanding them. but then i'd imagine if an different nucleotide were somehow incorporated into a virus we'd already found, it'd also be present enough to show up as an unknown nucleotide. Might not know what it was, but we'd most likely have an idea that it were there.

  4. Spock was probably right by idontgno · · Score: 3

    "It is not life as we know or understand it. Yet it is obviously alive, it exists"

    --Spock, "Operation -- Annihilate!"

    --
    Welcome to the Panopticon. Used to be a prison, now it's your home.
  5. Probably. by Anonymous Coward · · Score: 4, Insightful

    I'd hardly be surprised if there were many forms of life that co-existed in the RNA world days, and eventually they just lost out to RNA and then DNA because maybe it is more efficient at replication.

    There are thousands of stable molecules, some we have even made, that can support a similar system of structure like DNA and can be made fairly easily with low energies.
    We know even DNA can replace a phosphor base with a more energetic arsenic and still function, more or less.
    Most likely there were more energetic forms of life that could survive back in the hotter early days that died off as Earth cooled.
    Maybe we will find that some planets that are really hot do in fact have some form of life, give at least some liquid is present that can be used for transfer and energy. (like water)
    Hell, we may even find them as we dig deeper in to Earth and find caverns even deeper than the ones we have found so far with ancient life in them.
    Let's just hope we don't find no temples.

    What there likely isn't, though, is nuclear creatures living on the surface of stars.

  6. Re:Discover life? by wierd_w · · Score: 5, Informative

    Historically, "Life" has been defined as being any phenomenon that possesses all 5 life processes:

    #1 Food intake/ nutrition
    #2 Respiration
    #3 Excretion
    #4 Growth & Repair
    #5 Reproduction

    However, this seems to have been expanded to 7:

    #1 Movement
    #2 Respiration
    #3 Sensitivity
    #4 Growth
    #5 Excretion
    #6 Reproduction
    #7 Nutrition

    This is for "Life" in the generalized sense, fully abstracted away from any specific mechanisms by which those processes may be achieved. It is perfectly sensible for an artificial lifeform to be constructed, as long as it is able to fully carry out those processes. It needn't have any organic components whatsoever.

    Nowhere in the historical definition of "life" used by life science is there a requirement for specific mechanisms-- just processes.

  7. Re:Discover life? by i+kan+reed · · Score: 2, Insightful

    I've never seen that list without "adaptation". Evolution and life are essentially inseparable.

  8. Re:Discover life? by wierd_w · · Score: 2

    That would be "Sensitivity"/Responds to stimulus.

    Evolution is the phenomenon that occurs as a result of living organisms responding to changing stimuli in their environment, coupled with the need to consume energy to procreate and survive.

    If the phenomenon consumes energy, reproduces, and responds to stimuli, it will experience evolution.

  9. Re:Discover life? by i+kan+reed · · Score: 2

    No, not at all. Response and evolution are distinct.

    Survival of the fittest has nothing to do with individual response to individual stimuli.

    A self-reproducing system that does so perfectly, with no errors won't ever change, and isn't really alive.

  10. "Generalized Life" by radtea · · Score: 5, Insightful

    Massive generalization has been good to the sciences.

    In physics, we have used invariance principles to expand our definitions to the most general possible. This was the argument behind General Relativity, for example: Einstein wanted equations of motion that would be invariant under any smooth second-order transformation whatsoever, and when he put that constraint, and only that constraint on, he found the most general form of the equations of motion were uniquely determined (up to a constant of integration, which is the Cosmological Constant).

    Biologists have generally shied away from this kind of approach to their field, but there is an argument to be made that there is an equally general definition of "life" as "anything that participates in a process of evolution by imperfectly heritable traits that result in differential reproductive success". It need not be tied to any particular concrete mechanisms like DNA and RNA.

    This idea may turn out to be silly (which is why I wrote a novel about it rather than a scientific paper: http://www.amazon.com/Darwins-...) but well into the 1800's there was no general view of "energy" that unified all the disparate forms, to the extent that the fact that light had energy that was in any way related to mechanical energy was not really appreciated. The kind of unified view of energy we have today would have seemed bizarrely speculative at that time, in the same way that the notion of a unified, generalized view of life is purely speculative today, but it turned out to be amazingly useful, so it's worth considering the possibility in biology today (anti-science people will likely attack it as a waste of money, using computer technology that would not exist without a similar "waste" on ridiculous fantasies like quantum theory and "obviously useless" research into the basic physics of semi-conductors in the past.)

    --
    Blasphemy is a human right. Blasphemophobia kills.
    1. Re:"Generalized Life" by Pfhorrest · · Score: 2

      Yes, this! The way I like to phrase it is that "life is self-productive machinery", where "productivity" is defined as a property of mechanical work such that that work decreases the entropy of the system it acts upon. Life is then any physical system that transforms some kind of energy flow through it (i.e. is a machine, does work) in a way that causes its internal entropy to decrease (necessarily at the expense of increasing the entropy of the environment). The operating conditions of such a machine are the conditions in which such life can live.

      By this definition, all traditional (DNA-based) living things are alive, but viruses are not (despite reproducing), fire is not (despite consuming energy and reproducing), crystals are not (despite reproducing and reducing their internal entropy — because they are not doing the work that reduces their entropy, they don't consume energy to do that, they have to have energy removed from them and then that just happens spontaneously), and perhaps most interestingly, computers are: the processing and storing of information is a reduction of their internal entropy, and they are machines that consume energy to accomplish this. A computer that built other computers that built other computers (etc) would undeniably be artificial life... but then if we add "reproduces" to the requirements, as you say, mules are out, and we definitely want them in, more so I think than we want non-reproducing computers out.

      --
      -Forrest Cameranesi, Geek of all Trades
      "I am Sam. Sam I am. I do not like trolls, flames, or spam."
  11. Why Hasn't Anyone Thought Of This Before by lys1123 · · Score: 2

    This is revolutionary. An amazingly original idea, perhaps some life form that is silicon based instead of carbon based, with no DNA, hiding at the bottom of a mine shaft or something. A Devil in the dark if you will.

    I just wonder why no one has ever though of this before now.

  12. Re:Discover life? by itzly · · Score: 4, Interesting

    A self-reproducing system that does so perfectly, with no errors won't ever change, and isn't really alive.

    If it is successful at surviving, why would it need to adapt to be alive ? Maybe it's already perfectly adapted to its environment.

  13. Re:Discover life? by fustakrakich · · Score: 2

    Survival of the fittest has nothing to do with individual response to individual stimuli.

    Well, indirectly it does. Those who respond a certain way might be more likely to survive and prevail, passing on all their goodies to the next generation.

    --
    “He’s not deformed, he’s just drunk!”
  14. Re:Discover life? by Khashishi · · Score: 2

    So, is fire alive? A key qualification has to be heredity, otherwise you can't rule out simple chemical reactions like fire.

  15. If there ever was a nebulous article... by pesho · · Score: 3, Informative

    The original article is pure speculation. Can life exist that is so different from the stuff we know, so that we can't detect it with current molecular biology techniques?

    Sure why not. What the article fails to mention is that we can find life in other ways. Even if we can't sequence the DNA in many cases we can culture microorganisms from environmental samples. We can also use microscopy to directly examine environmental samples. In fact both the microbial cultures and microscope have been done on large scale over many years. Not once have we seen an organism that does not conform to our current understanding of life on earth. Life can also be identified by the changes in the environment it create. Again nothing we have seen so far has suggested that there is a life form so unusual that we can't detect it with our current techniques.

    Where authors of the original article fail most miserably is their solution: high throughput sequencing techniques. Huh? How would those techniques lead to the discovery of life that is fundamentally different if they are dependent on the standard properties of DNA and DNA replicating enzymes??

  16. Re:Discover life? by ZombieBraintrust · · Score: 2

    Your going about your definition backwards. Your defining life by adding requirments till the list only matches terrestrial life. You could just as easly add DNA as a requirment. That would also rule out chemical reactions like fire.

  17. Re:Discover life? by itzly · · Score: 2
    No, there's no need for creatively redefine these terms. Plants do have respiration and excretion. Example: http://www.ncbi.nlm.nih.gov/pu... :

    During prolonged darkness, plants with low carbohydrate reserves exhibited a lower whole-plant respiration rate, which decreased rapidly to almost zero after 24 h, and carbohydrate pools were almost exhausted in leaves, roots and flowers

  18. Re:Discover life? by wierd_w · · Score: 2

    http://www.biology-online.org/...

    Already covered for some time.

    And plants DO engage in carbon dioxide release type respiration. They do it at night, when they are not photosynthesizing, and are metabolizing stored sugars.

    They also excrete through structures called stomata, found on the undersides of leaves, and in the grooves of stems.

  19. Re:Discover life? by wierd_w · · Score: 2

    Sunflowers.

    Named, because they move their flowers to track the sun.

    Then there is the dodder vine..

    Plants move all the damn time.

  20. Re:Discover life? by wierd_w · · Score: 2

    No, ALL plants move. Some move more perceptibly than others. The two examples I gave were "Very noticeable movement", but even grass moves.

    There are several mechanisms by which a plant may be able to move. The most common is "Phototropism", but there are other forms of plant movement, including those responding to tactile stimulous, and many others

    Your argument is what needs work.

  21. Re:Discover life? by david_thornley · · Score: 2

    We can, in principle, find out exactly how a sufficiently simple life-form is put together. There's no obvious reason why we couldn't construct one out of simpler, definitely not living, chemicals. It would be a very large project, but it appears doable. Given two identical single-cell organisms, one from nature and one from the lab, does it make sense to call one life and one a gooey robot?

    --
    "When you have eliminated the unacceptable, whatever is left, however improbable, must be the truthiness" - Holmes
  22. Re:Discover life? by wierd_w · · Score: 2

    fully synthetic biology is closer than you realize.

    This is from 2 years ago-- Researchers succeed in creating fully artificial cell membranes

    This from about 4 years ago-- First fully reproducing bacterium with fully synthetic genome

    This is from last year-- Creating synthetic ribisomes

    For real, being able to fully engineer a cell from the ground, all the way up, is fast leaving the exclusive realm of science fiction, and entering the realm of science fact.