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Study: Body Weight Heavily Influenced By Heritable Gut Microbes

FirephoxRising writes Our genetic makeup influences whether we are fat or thin by shaping which types of microbes thrive in our body, according to a new study. Scientists identified a specific, little known bacterial family that is highly heritable and more common in individuals with low body weight. So we are what we eat, and what we got from out parents. From the article: "The study, funded by National Institutes of Health (NIH), researchers sequenced the genes of microbes found in more than 1,000 fecal samples from 416 pairs of twins. The abundances of specific types of microbes were found to be more similar in identical twins, who share 100 per cent of their genes, than in non-identical twins, who share on average only half of the genes that vary between people. These findings demonstrate that genes influence the composition of gut microbes."

49 of 297 comments (clear)

  1. Oh no by AmiMoJo · · Score: 5, Insightful

    Here we go, endless posts about how it's all down to pure willpower and entirely the fault of the individual. Maybe we could try looking for more practical solutions and simply berating people this time?

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    1. Re:Oh no by Anonymous Coward · · Score: 2, Informative

      Here we go, endless posts about how it's all down to pure willpower and entirely the fault of the individual. Maybe we could try looking for more practical solutions and simply berating people this time?

      We could look at the first law of thermodynamics.

    2. Re:Oh no by orasio · · Score: 4, Interesting

      That's what is being done nowadays, counting calories.

      The problem is that calorie consumption is not constant. It's more like household economy.

      If you earn (eat) a lot every day, you will probably end up with a lot of savings (belly fat).

      One way of getting rid of those savings (belly fat) is taking a lower paying job (dieting). The problem is that your savings don't magically dissappear, and you can make changes that allow you to keep your savings (fat), even with a lower income (daily calorie intake).

      Another way you can get rid of your savings is just spending more daily (like exercise). The problem is that, if you have a good enough income (daily intake), and sizable savings, you will only lose capital (weight) in the long run, no sizable short term effect.

      So, a fat person body works, in what respects to calories, like a financially savvy household. Going skinny would be like going broke. Some of us could benefit from a way to teach our bodies to do a bit worse in the calorie finance department. Could be a lot easier than just dieting, exercising or both.

    3. Re:Oh no by Luckyo · · Score: 3, Informative

      Reducing intake will reduce weight regardless of state of your gut. Microbes don't generate energy out of nothing.

      This is a story about the fact that microbiome of the gut is being widely recognised as essentially another organ of the body, and differences in microbiome can affect things like how well your gut absorbs energy and so on. However reducing intake will cause weight loss regardless of it. The only question is, "how much of a weight loss per reduced intake".

    4. Re:Oh no by AmiMoJo · · Score: 3, Insightful

      In the 1950s food was less processed, tended to have less added calories. Women were much less likely to work, so were preparing food from scratch at home. Modern life has created a situation where many people find it hard to eat well due to time pressure and sedentary jobs. Even the fit ones have to make a special trip to the gym or go out running to get enough exercise.

      --
      const int one = 65536; (Silvermoon, Texture.cs)
      SJW, n: "Someone I don't like, and by the way I'm a fuckwit" - AC
    5. Re:Oh no by CastrTroy · · Score: 3, Insightful

      This is why I think exercising is so essential to maintaining a healthy weight. Because living without calories sucks. Nobody wants to live on 1000-1500 calories a day because you will feel exhausted and will probably have trouble getting all the needed nutrients while eating so little food. If, on the other hand, you exercise enough such that (on average) your body takes 2500-3000 calories a day maintain, you can eat a lot more food, have a lot more energy available for the body to do things, and still be at a point where you're losing weight, simply because you are using so much energy.

      --

      Anthropic principle: We see the universe the way it is because if it were different we would not be here to see it.
    6. Re:Oh no by Charliemopps · · Score: 2

      If you change your diet you can change these microbs as well.

      This is based on genes. Your genetic makeup makes your body a more hospitable environment for some microbes.

      My random made-up example: I have a genetic disposition for heartburn and increased acid production. These "Skinny microbes" cannot live in the higher acid environment so I don't get them.

      I do not know that acid is the problem, but it's likely something like that.

    7. Re:Oh no by Anonymous Coward · · Score: 3, Insightful

      Reducing intake will reduce weight regardless of state of your gut. Microbes don't generate energy out of nothing.

      This is a story about the fact that microbiome of the gut is being widely recognised as essentially another organ of the body, and differences in microbiome can affect things like how well your gut absorbs energy and so on. However reducing intake will cause weight loss regardless of it. The only question is, "how much of a weight loss per reduced intake".

      What it shows is another reason why the same diet doesn't work for everyone. Some people can cut back a small amount and lose weight easily, others have to go to such extremes that either their willpower inevitably breaks down or their body panics and goes even further into hording-mode. People who seem to be able to eat as much as they want without gaining much may be "lucky" to have inefficient microbes so they're not absorbing as much of the calories.

    8. Re:Oh no by daremonai · · Score: 4, Informative

      There's actually been serious study of this, and it really is tied to potential for weight gain/loss. Here's one recent summary: Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans.

    9. Re:Oh no by Roodvlees · · Score: 3, Informative

      But some people stay thin much longer, their microbes cause the food to be turned into fat much less.
      Also it's not so simple as "just eat less", the body has a concept of what your 'normal' weight is. If you lose some the chemical processes will change to make more fat and compensate for the weight loss. It probably takes about 6 months of holding an amount of weight before this concept changes.

      Eventually being fat is a combination of many factors, several of which you do have control over.

      --
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    10. Re:Oh no by BradleyUffner · · Score: 4, Informative

      At the calorie level they are EXACTLY identical. Those foods are only different in the WAY they are turned in to calories. A Calorie is just a measure of energy.

    11. Re:Oh no by ILongForDarkness · · Score: 2

      There is a whole psychological component you hinted at too. What if one guy feels happy/energetic etc at 2000 cal and another needs 2500? I think there are both biological reasons why it could be harder to burn, lower metabolism etc, but also other biological factors that just doesn't make you feel full, happy, etc without a certain calorie intake. Both may happen but in the one case at least if the cause is found I suspect you'd be forgive in the other case you'd be asked to suck it up and show some discipline.

      Personally, I like to eat both good and bad things for me. But I also don't mind spending 5 hours a week at the gym so it all works out. Not everyone has the free time I have though or the money to afford access to a gym (yeah I know jogging is relatively free but who wants to look like Richard Simmons?).

    12. Re:Oh no by transporter_ii · · Score: 4, Insightful

      You can turn genes on and off with diet and lifestyle. Check out the field of epigenetics. Genes are influencers, but your fate is not written in stone because of them.

      See: http://www.livescience.com/418...

      The types of bacteria in your gut today may be different tomorrow, depending on what kinds of food you eat, a new study suggests.

      --
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    13. Re:Oh no by Anonymous Coward · · Score: 2, Interesting

      Yeah. And first we must assume the human body is a frictionless sphere with uniform density in a vacuum.

      How many studies have to come out showing that caloric intake is only one small factor of many in weight management, and by itself means hardly anything? You people are as bad as the climate change deniers and anti-vaxxers.

      I know this is anecdotal, but to stave off any ad hominems: I eat enough calories to feed a small village every day and would be described as "thin" to "average". I know many other people like me, and I know many other people who hardly eat anything and still have weight problems.

      Trying a "first law of thermodynamics" diet is just going to leave you malnourished. You may lose some weight, while starving your body of nutrients it actually needs, and possibly "reprogramming" it to get even fatter in the future any time you actually do feed yourself.

    14. Re:Oh no by NatasRevol · · Score: 3, Interesting

      I always ask my wife (a dietitian) how many calories I release as waste.

      All {calorie in minus calorie out} calculations completely ignore calories in your waste.

      --
      There are two types of people in the world: Those who crave closure
    15. Re: Oh no by bill_mcgonigle · · Score: 2

      Careful ... as soon as you imply that the income tax is a contributing factor to childhood obesity, a singularity forms and obligate statists lose coherence.

      --
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    16. Re:Oh no by NatasRevol · · Score: 2

      You do realize that the calories out part of calorie counting depends massively on your metabolism+exercise, right?

      --
      There are two types of people in the world: Those who crave closure
    17. Re:Oh no by beelsebob · · Score: 2

      What does that have to do with the situation? That only applies in a closed system. These microbes (and many other factors) are making this not closed, and causing varying amounts of chemical potential energy to be leaked from the system depending on the genetic make up of the individual.

    18. Re:Oh no by delcielo · · Score: 2

      That's not what anybody is saying, and it's disingenuous to say that it is.

      This study shouldn't be any great shock to anybody; that life is more complicated than a single cause for something. Some people are fat because they live a fat lifestyle. Some are fat because of their genetic makeup. Some are fat for a combination of them. Some people will have to put more effort into staying thin than others. This study suggests that these microbes are one factor.

      The OP is making a statement that you completely confirmed: people are easily willing to bash and shame others. The second sentence of your post is the perfect example of using the worst possible scenario to describe everybody who exhibits a particular "fault". So tell me, what is the line of demarcation? Where is the fat line? What weight is 1lb more than the normal reasonable person and defines the lazy slovenly glutton you describe?

      What about smokers? Do they suck as people too? Drinkers? What about people who curse? Are religious fanatics ok (that could go either way with you, I'd guess)? Sex addicts? How about people who are thin but can't run very fast? Are they lazy, too? Tell us, how are all of these people failures, too? And what about people with more or less intelligence: are the more intellectual people simply harder workers and the less intelligent just lazy?

      Hmm, how about beautiful people vs the rest of us?

      Are you perfect? And if not, is it because you're lazy?

      --
      Hot Damn! It's the Soggy Bottom Boys!
    19. Re:Oh no by Dixie_Flatline · · Score: 2, Informative

      To a certain extent, that's meaningless. Those calories are bound up in a way that you can't use them--which is why they're waste). It may be that there are some usable calories in there if you went back and ingested them again, but obviously there are significantly diminishing returns.

      There are a certain number of calories per gram of food. Your body is capable of removing and using somewhere between 0-100% of those calories. Your gut flora pushes you in one direction or another--at the highest end, you can capture nearly 100% of the available food energy from your meals. No matter what, you cannot gain more than 1g of weight from 1g of food. Physics and chemistry being what it is, you probably won't, though.

      In the end, there are two things that people need to know if they want to control their weight: how much they're eating, and how much they're burning. Those are the only things you can meaningfully control (there is some evidence that changing your diet significantly can affect the microbiome--it seems pretty imprecise right now). If your gut microbiome is super efficient, you'll need to find ways to eat that don't leave you hungry but also don't give you too many calories.

    20. Re:Oh no by rockmuelle · · Score: 3, Informative

      The first few weeks of any training program typically suck. That's where willpower (or encouragement if you're in a group) plays such an important role.

      Once I'm passed the initial hump, I always feel the "addictive" need to get more exercise and chase the high. In my specific case, the "high" comes after sustained exertion in the med/high effort range. I rarely see it biking (I'm a bike commuter and never really push myself). But running, climbing, mountaineering, and snowboarding all bring it out. For running, on long runs at a moderate pace it kicks in around mile 5 or 6. For short, faster runs, it kicks in about 30 minutes after the run and lasts for a few hours. Other sports have similar patterns. In my experience, the feeling is most similar to hydrocodone (which, unfortunately, I also know about from running).

      Wikipedia's description of the "runner's high" covers some of the suspected mechanisms for it.

      -Chris

    21. Re:Oh no by beelsebob · · Score: 5, Insightful

      To a certain extent, that's meaningless. Those calories are bound up in a way that you can't use them--which is why they're waste). It may be that there are some usable calories in there if you went back and ingested them again, but obviously there are significantly diminishing returns.

      Of course it's not meaningless. Those calories are energy. If I ingest 1800 calories, and burn 1400, but poop out 400, I will maintain my weight, despite not burning as many calories as I ingested. If I have gut bacteria that break down certain long chain sugars so that that I can now ingest them, I will instead only poop out 200, and start gaining weight, despite eating the same thing, and doing the same amount of exercise.

      The point here is not really that the solution to my weight gain in that situation is either eat 200 calories less, or do 200 calories more work (or some combination of the above), it absolutely is.

      Instead, it's that there's a large part of the world out there that will eat the exact same food, and do the exact same exercise, and maintain or loose weight, because their gut bacteria is not the same. These people (as the person at the root of this thread said) are very likely to sit there screaming that all these "fatties" are just gobbling up donuts, and that's why they're fat. Instead, some of them are actually doing more, and eating less already, but will still gain weight by doing that.

      Basically, these studies don't change the correct approach to maintaining weight - but what they do do is highlight that people should be a bit more sensitive to each other, and stop assuming that anyone who gains weight is eating a lot, or exercising a little. There are more factors than those alone.

    22. Re:Oh no by orasio · · Score: 2

      They are identical on paper, but not for a person.

      It's a lot easier to get energy from doughnuts than from broccoli.

      It's 5 medium doughnuts versus 5 broccoli bunches. I'm pretty sure I can have 5 doughnuts in a sitting, but not 5 broccoli bunches.

      There's a lot of fiber in broccoli, so even if you manage to have all that broccoli, you will have a hard time extracting many calories from it. In any case, it will be slow, so at least it keeps you full for a longer time than doughnuts.

    23. Re:Oh no by doug141 · · Score: 4, Interesting

      Food calorie content is commonly measured in a bomb calorimeter, using a energy-release process totally different from the human body, and in some cases giving very different values. For example, Olestra releases calories in a bomb calorimeter, but not in the body. Same with sawdust, or "microcrystalline cellulose" as the fast-food places call it.

    24. Re:Oh no by txoutback · · Score: 2

      Don't eat too much, make sure what you eat isn't junk, and be more active.

      Quoted for Truth. And it should be noted that it takes a while to make a lasting difference...long enough for this behavior to become an everyday way of being, and not an exception.

    25. Re:Oh no by Anonymous Coward · · Score: 2, Informative

      Nope.

      Food calories are measured by burning the food with O2 in a calorimeter.

      Anyone who things that metabolism works the same way is an idiot. You have to take into account the efficiency of the various metabolic proceses, how much energy it takes to digest the food in the first place, what portion remains undigested, etc, etc.

    26. Re:Oh no by Anonymous Coward · · Score: 2, Funny

      In other news.. I am tall and skinny and have been all my life..

      So the question you have to ask yourselves is , who wants to buy a log of my poo?

    27. Re:Oh no by Shakrai · · Score: 2

      I believe the "runners high" to be a placebo thing for the same reason, I've never felt a "rush" or "buzz" after exercise. Then again perhaps they are only felt by people who've never had an actual buzz.

      It's not a buzz or a rush; for me it works in a few different ways:

      1) A small amount of euphoria about 20-25 minutes into a run; this primarily manifests itself as an increased pain threshold, meaning that if I had some minor nagging injury (say muscle aches) I can tune the pain out for the duration of the workout and a non-zero amount of time afterwards.
      2) A vastly improved mood after the exercise is complete. I'm usually smiling for no obvious reason after a run, no matter how bad my mood was prior to the run; this doesn't sound like a lot but my personality is such that I rarely smile or experience 'happiness' as others define it.
      3) Related to #2, a sense of accomplishment; Yes, I'm tired, but it's a good tired.

      #3 is the only one of the above that I can get from strength training, the rest require a relatively intense cardio workout to achieve, which for me usually means >20 minutes of running. I have experienced them after cardio workouts at the gym but not to the same degree or in as short of a time.

      There are other effects that I could point to too: sounder sleep and higher sex drive being the two that first come to mind.

      --
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      We are the United States Government! We don't do that sort of thing.
    28. Re:Oh no by Shakrai · · Score: 2

      Nobody wants to live on 1000-1500 calories a day because you will feel exhausted and will probably have trouble getting all the needed nutrients while eating so little food

      Why would anyone try to live on 1000-1500 calories? Even if you need to lose a massive amount of weight that's not sustainable. Weight loss is all about long term lifestyle adjustments not short term extremes. I've tried in vein to explain this to my fat friends who engage in yo-yo dieting; at one point I did some digging and discovered that the average ration at Alschwitz was in the 1,300 to 1,700 calorie range. Guess what? Most of those people were near death after three months. Even that analogy isn't enough to dissuade the idiots that think it's healthy to engage in starvation diets.

      I limited my caloric deficit to a 250-300 calories a day when I needed to lose weight. Guess what? I kept my weight off, without too many yo-yos (the biggest yo-yo for me is winter, living in the Northeast and all....), and I was never so hungry that I hated life or thought about quitting.

      --
      I want peace on earth and goodwill toward man.
      We are the United States Government! We don't do that sort of thing.
    29. Re:Oh no by NatasRevol · · Score: 2

      Not in the calculations used in current weight mgmt.

      Which is my exact point.

      --
      There are two types of people in the world: Those who crave closure
    30. Re:Oh no by AK+Marc · · Score: 2

      Skinny people poop lots of "usable" calories. They just have a less efficient digestive system. This has been known for a while. People used to deliberately ingest tapeworms to get/keep thin. It isn't what you eat, it's what you absorb.

      And the vast differences between people make most of the "just eat less" crowd wrong. Eating less (than someone else) will *never* guarantee weight loss. Bob could eat 1/2 the calories of Carol and still gain weight while Carol is losing weight, for the same activity levels for both. All the fat-haters ignore metabolism and digestive efficiency.

    31. Re:Oh no by AK+Marc · · Score: 4, Interesting

      I knew a guy that ate so few calories that he was malnutritioned. He also didn't lose weight. The less he ate, the more efficient his digestion and metabolism got. His energy levels dropped, reducing activity levels, and he maintained weight. "Eat less" is not always the answer. In fact, it's not even usually the answer. Anyone who says it is, is just proving they don't understand the question.

    32. Re:Oh no by AK+Marc · · Score: 2, Insightful

      I'm not surprised. I'm just pointing out all the people who say "eat less means you must lose weight" are idiots. What part of that confuses you so?

  2. Diet causes change in those microbes by trout007 · · Score: 5, Informative

    The microbs thrive in different environments. I went from a standard american diet to something more high fat low simple carbs diet with lots of fermented foods. Not only did I lose a bunch of weight but most digestive, allergy, and skin problems went away as well. I think there was something about the microbial environment that a high sugar diet caused that was giving me trouble.

    --
    I love Jesus, except for his foreign policy.
    1. Re:Diet causes change in those microbes by Derec01 · · Score: 5, Informative

      Diet doesn't really change the microbes.

      That is not what recent science indicates at all.

      "Diet rapidly and reproducibly alters the human gut microbiome", Nature 505, 559–563 (23 January 2014) doi:10.1038/nature12820
      http://www.nature.com/nature/j...

      "Here we show that the short-term consumption of diets composed entirely of animal or plant products alters microbial community structure and overwhelms inter-individual differences in microbial gene expression. "

  3. I'm not fat by WormholeFiend · · Score: 3, Funny

    I'm just big genetic'd

  4. How are microbes heritable? by Dcnjoe60 · · Score: 2

    If the fetus is in a sterile sack, how do these heritable "gut" microbes get in there? For instance, e.coli isn't in there, but comes from the environment. Wouldn't these microbes follow the same path, in which case they aren't actually heritable, but instead environmental?

    1. Re:How are microbes heritable? by oDDmON+oUT · · Score: 2

      In normal birth (vs. C-section), there's a fair amount of mess involved, much of it from Mom. So in that sense she's inadvertently passing on heritable and beneficial microbiota.

      We, in our wisdom, tend to try and tidy things up too much and so may have set our progeny up for later failure.

      The same attitude was prevalent about breastfeeding in the last century (don't do it, just buy our formula and keep those ta-ta's perky).

      --
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    2. Re:How are microbes heritable? by retroworks · · Score: 2

      Well, Yes, I understand, but that methodology (comparing identical twins to fraternal twins) was already used in 1992 to study alcoholism, and among the reasons it was not definitive is that taste buds are genetically inherited (for example), and dopamine receptors are genetically inherited. They could not say that alcoholism was genetic because correlations /= causation, and it was possible that diet and other causes, e.g. habits affected by taste, were being measured. http://pubs.niaaa.nih.gov/publ...

      ... It seemed to me that if the 1992 study could not determine whether alcoholism was genetic, or environmental, that the original poster had made a valid observation. If alcohol consumption could be caused by diet preference (e.g. people who love the taste of beer start drinking earlier in life, when the brain is developing, leading to stronger habits / dependencies), gut flora could also be affected by diet preference, habit, or tastes. I guess you could argue that is a genetic trait, but not nearly in as assertive a way as the Summary suggests.

      --
      Gently reply
  5. Re:Remember, I'm not a real scientist by mwvdlee · · Score: 4, Funny

    I think "-1: Post disagrees with my already-settled worldview" is entirely valid in this case.

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  6. Re:Bad study - findings do not illustrate that at by Anonymous Coward · · Score: 2, Informative

    Both identical and non-identical twins (typically) grow up sharing a household. The most obvious relevant thing different about them is their genome. Yes, it's possible there's some other effect, but both types of twins grow up in the same households exposed to the same foods. So the fact that significant differences are observed between identical and non-identical twins suggest that genetics is at play.

  7. NO!!!!!! by JimSadler · · Score: 3, Insightful

    We are what we eat is a lie. We are that we intake but do not poop.

  8. Re:Bad study - findings do not illustrate that at by dfghjk · · Score: 2

    "If two people grow up in the same house, are raised by the same parents, and exposed to the same food, it would naturally follow that they would develop the same gut microbes, regardless of their DNA."

    That's why they compared identical twins to non-identical twins.

    "If they actually wanted to study if gut microbes were influenced by DNA, they should have ALSO done the same study on the same number of adopted siblings, and compared them to the twins."

    And that would improve the data over non-identical twins in what way?

  9. Re:Bull Shite by drinkypoo · · Score: 2, Informative

    You're fat because you eat more calories than you burn plain and simple.

    That's a stupid thing to say right on the face of it, mostly because it just isn't true. Hmm, actually, completely because it isn't true. At all. First, the "caloric content" of foods is based on the amount of energy you get back when you set them on fire. Your body does not contain tiny furnaces into which magical goblins heave small pieces of the food you've eaten. The process for getting energy out of food may sound like that when mitochondria is described, but there's a number of steps between mastication and elimination which affect the amount of nutrition you derive from what you take in.

    What this research demonstrates, in fact, is that two people eating the same food will have different results in the area of nutritive uptake due to their intestinal environment. It proves, in fact, the exact opposite of what you're saying. But since you were saying something we already knew to be false, it did not bear saying at all.

    --
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  10. Re:Colonoscopy by wooferhound · · Score: 2

    How can you tell difference between a Male microbe and a Female microbe ?
    Pull down it's jeans .. .. ..

    --
    We are Dead Stars looking back Up at the Sky
  11. Runners high is quite real by sjbe · · Score: 2

    I believe the "runners high" to be a placebo thing for the same reason, I've never felt a "rush" or "buzz" after exercise.

    It exists. I've experienced it and I can introduce you to plenty of others who've experienced it during their athletic careers. You have to be quite fit for it to happen in most cases. (much more fit than I am presently) Last time I had a runners high was back when I was competing in college. (wasn't during running but the effect was the same) You just feel like you are floating and everything you do seems almost effortless. It happens rarely - I've only experienced it four times in my life but the sensation is very real.

    Then again perhaps they are only felt by people who've never had an actual buzz.

    Nope. I've never had a drop of alcohol or other drugs that could elicit a high in my life. The smell of alcohol makes me nauseous and I feel no need to get high. I've no problem with others getting a buzz (safely) but I've never had a chemically induced buzz.

  12. Re:Yes, let's do look, shall we? by onkelonkel · · Score: 2

    How do you know that us morally superior thin people aren't Person B types who are hungry all the time but don't use it as an excuse to eat when we don't need to?

    --
    None of them can see the clouds; The polished wings don't care.
  13. 1g food isn't 1g weight gain by dutchwhizzman · · Score: 2

    If you eat certain food, you could theoretically gain more than 1 gram of weight for every gram of food you eat. The human body is mostly made out of water and you can't go on a "drink less fluids" diet. That means that if you add 1 gram of solids from your food, you could very well add more than one gram of water to your body weight, even if that water holds no calories at all.

    --
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  14. Re:Energy in and energy out by nealric · · Score: 2

    I find a lot of people who claim to have "tried" diet an exercise haven't effectively done either. "Exercise" does not mean sitting on a recumbant bike for 30 minutes while reading a magazine a few times a week. Sure, it's better than nothing, but it's not going to burn significant calories or increase your basal metabolic rate much. Likewise, "diet" does not mean switching to the "low fat" or "diet" versions of the foods you usually eat.

    Effective exercise involves BOTH cardio and strength training. Cardio 5x a week, strength 3x. Unless you have a diagnosed health condition other than weight, it should not be moderate- It should be vigorous. Cardio can be pretty much anything, but it should involve periods above 80% max heart rate. Endurance exercise (1hr+ exertion) at a lower heart rate should be mixed in as well. Proper strength training involves doing sets of major exercises (deadlifts, squats, bench press, rows) until or near failure. Things like dumbell curls and kettlebell swings are fine supplements, but you won't see much in the way of gains from doing endless reps of curls on a 5lb dumbell.

    Effective diet involves eating whole unprocessed foods with a lot of micronutrients. Don't drink your calories (most caloric drinks get that way through sugar). While the exact components of an ideal diet are a matter of debate, it's pretty clear than anything that comes in a box or can or sealed bag is a lot less likely to be healthy.

    If you do the above, you will burn significant calories from the cardio and significantly increase your basal metabolic rate by adding muscle. Your total calories will likely decrease without any conscious reduction efforts because fresh fruits and veggies will fill you up a lot faster than a bag of Doritos. None of this is rocket science, but sadly is ignored by most people looking to loose weight. Mostly because it involves a lot of hard work (it will take a year of consistent training for your strength efforts to be visible), and because there is no gimmicky product to sell. All you need is the produce aisle, a good barbell set/bench/power rack, and a pair of running shoes.