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Woman Suffers Significant Weight Gain After Fecal Transplant

Beeftopia (1846720) writes In a case reported in the journal Open Forum Infectious Diseases, a woman suffering from a drug-resistant intestinal infection gained 36 pounds after receiving a fecal transplant from her overweight daughter. Previous mouse studies have shown thin mice gain weight after ingesting fecal bacteria from obese mice. The woman previously was not overweight. After the procedure, despite a medically supervised liquid protein diet and exercise regimen, the woman remained obese. Her doctor said, "She came back about a year later and complained of tremendous weight gain... She felt like a switch flipped in her body, to this day she continues to have problems... as a result I'm very careful with all our donors don't use obese people."

13 of 378 comments (clear)

  1. Re:Okay, so... by Megane · · Score: 4, Informative

    Fecal transplants from thin people to fat people causing weight loss is actually a thing. What I hadn't heard of before is the reverse, but I am certainly not surprised.

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    #naabhaprzrag, #sverubfr-000, #agi-fcbafberq, negvpyr[pynff*=' negvpyr-ary-'] { qvfcynl: abar !vzcbegnag; }
  2. Re:Have I lost my mind? by Shados · · Score: 5, Informative

    When something happens and your guts flora goes out of wack, because of a previous illness, some surgery, whatever, your digestive system suffers quite a bit, and has no way to recover (those bacterias don't come out of nowhere...if 100% of them are gone, they're not coming back...).

    So the only way to get them back is to transplant bacterias from someone else, to "bootstrap" your system anew. And the easiest way to get a bunch of those bacterias is in, well...yanno...

    So they either take a piece and stick it in you, or they make a pill out of a little bit of it. Gross as hell, but less gross than dealing with a fucked up guts flora.

  3. Re:Have I lost my mind? by ColdWetDog · · Score: 5, Informative

    It doesn't have to be all that bad. You freeze dry the feces (that can't be fun). The smelly parts go up the evaporator, mostly. Some protocols spin out the debris (yesterdays burrito bits) leaving you with some flotsam that should be mostly bacteria. You put that in an enteric coated pill (so the stomach acid doesn't clobber everything) or you shove it up the butt using one of a number of techniques (insert, so to speak, favorite joke here).

    Wait a bit and see what happens.

    This is a very trendy field since 1) it clearly works for a defined illness (Clostridium difficele infections) 2) has an interesting and biologically plausible mechanism(s) 3) is easy to make (see above, do not try this at home, professional driver on closed course and all that) and has virtually limitless advertising possibilities. Even aside from the Holy Grail of weight loss and 4) should be able to keep Jon Stewart, 4chan and the rest of the planet in bad jokes for quite some time.

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    Faster! Faster! Faster would be better!
  4. Re:what about skinny people? by stephanruby · · Score: 4, Informative

    If a fat person eats skinny people shit will they lose weight??

    I don't know about that one, but having worms in your intestine can make you lose weight for sure.

    See picture. It's just like a big bowl of yummy pasta!

  5. actual study by phantomfive · · Score: 4, Informative

    Here's a link to the actual study.

    In brief:
    Woman weighed 136 pounds, daughter weight 140 pounds. After transplant from daughter to woman, she didn't return for 16 months (according to my reading of the article). The woman had gained up to 177 pounds, while the daughter gained up to 170 pounds.

    So this is more a case report than an study. Journals are used for communication between professionals. This doctor is saying, "hey, something weird happened.....it might be a coincidence (there is a lot wrong with this woman), but keep an eye out for anything similar."

    --
    "First they came for the slanderers and i said nothing."
  6. Re:Okay, so... by ShanghaiBill · · Score: 3, Informative

    Here's what I ate on my way to losing 70 pounds in 9 months:

    Losing 70 lbs in 9 months is not hard. The important question is: How much did you weigh five years later?

  7. Re:Doubtful by sonicmerlin · · Score: 4, Informative

    Did you even bother to read the article? The woman's eating habits and calorie intake were carefully measured and she gained weight despite not changing anything. I've lost 35 lbs with exercise, but despite spending almost 100 minutes and 1100 calories a day, I still can't get rid of the last 5-10 lbs of flab. It doesn't matter how little I eat.

  8. Or our calorie measurement methods need updating by Anonymous Coward · · Score: 5, Informative

    You may find this article informative.

    Calorie measurements of food are just estimates, the particulars vary. The gut bacteria of fat people absorb more of the available energy than that of skinny people, but our measurements of the calories in food aren't necessarily the max amount that could be absorbed.

    To put it simply, fat people get more calories from the same food than skinny people, regardless of how many calories the label says the food has.

  9. Re:Okay, so... by wiredlogic · · Score: 3, Informative

    Bacteroides likes to eat complex polysaccharides, like those found in many plants, so it's speculated (but not known) that a diet high in plant polysaccharides would promote the presence of Bacteroides, and correspondingly reduce the number of Firmicutes

    What would be more interesting is if these bacteria actually influenced their host's behavior to drive more consumption of sugars. I'm skinny and have never had a strong desire to consume sweets. The majority of the overweight population who can't naturally control their consumption of high-energy foods seem alien and puzzling to me.

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    I am becoming gerund, destroyer of verbs.
  10. Re:Doubtful by Cinnamon+Beige · · Score: 4, Informative

    That only applies when you're dealing with basically an ISO Standard nutrient processing system on a lab-made nutrient slurry--basically, lab mice on lab block.

    Basically, gut bacteria are actually a pretty essential part of processing nutrients, and in some cases the actual source of much of them. Certain types of problems basically will leave you incapable of properly processing parts--for example, with my aunt certain kinds of foods are now pretty much processed directly into fats, and the body is quite capable of taking part of those 3000 Calories' worth of warm-blooded flesh and using that to sustain it when the 2000 Calories of the food intake is being mostly stored. (And yes, the capitalization matters: nutrition uses the kilocalorie, actually, and in a confusing fit of non-standard metric renders it Calorie instead. Either way, the amount of error due to rounding introduced into the values is left as an exercise for the reader.)

    This can, however, be caused by things like a food intolerance or a metabolic dysfunction, and one of the basic tests to see if the person's obesity is a symptom is to, well, cut the caloric intake while maintaining the same levels of activity and see if weight loss happens. The wide range of things it's a symptom of--from things as amazingly cheap & easy to treat such as thyroid disease to those essential to catch early like cancer--are such that failing to check the cause is like...well...failing to check to see if the computer's problem is that it's not turned on.

  11. Re:Doubtful by angel'o'sphere · · Score: 2, Informative

    Actually that has nothing to do with the laws of thermodynamics. (Hint: read them. You figure they are easy to understand and focus around heat engines, notable about the relation between volume, temperature and pressure of gases)

    Secondly, if you had read the article, which you did mot have obviously, you had noticed that the 'victim' here has the 'wrong' gut bacterias. What is 2000kcal on paper, according to nutrition tables, is 3000 - 3200kcal for her (that is not in the paper, that is my estimate) Read my other post a few pages up, which explains it in more details.

    --
    Cost free eBook I read (by iBook/Kobo/Amazon/ObookO/Gutenberg etc.): "The Green Odyssey" by Philip Jose Farmer.
  12. Re:Okay, so... by TheNarrator · · Score: 3, Informative

    Good find! Here's an interesting study on how over-activation of Toll-Like Receptor 5 by certain bacteria was highly correlated with obesity:

    http://www.ncbi.nlm.nih.gov/pu...