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Two New Male Birth Control Chemicals In Advanced Stages

BarbaraHudson writes Researchers at the University of Kansas and Harvard are working to give men more choices for avoiding unwanted pregnancies. From the article: "H2-gamendazole keeps sperm from maturing. The unfinished sperm fragments are then reabsorbed into the testis, never ending up in the semen. 'If there's no sperm, the egg's not going to get fertilized,' says Joseph Tash, a reproductive biologist at the University of Kansas Medical Center. Almost two years ago, the FDA reviewed the compound, and now the agency wants Tash to investigate if the compound remains in the semen and whether that would harm a woman if it ends up in the vagina. Jay Bradner, working with other anti-cancer researchers at Harvard, discovered that the JQ1 molecule blocked a bromodomain in cancer cells, causing them to forget how to be cancer. One side effect is that JQ1 also obstructed a testicle-specific bromodomain called BRDT, making the sex cells that would otherwise produce sperm non-functional — mice treated with JQ1 can hump with abandon yet generate zero mouselings. Researchers are looking for a version of the molecule that works on the testicle protein only, to avoid any weird side effects."

45 of 369 comments (clear)

  1. Time for men's liberation by AmiMoJo · · Score: 5, Interesting

    It would be awesome if this could be part of a men's liberation movement, like how women were liberated in the 60s when the pill became available. Not just contraception, a change in the way men look at themselves.

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    1. Re:Time for men's liberation by Anonymous Coward · · Score: 5, Insightful

      As moving targets and potential victims of the "women and children" state that will punish a Man to the ends of the Earth for having the audacity to father a child.

    2. Re:Time for men's liberation by Tyr07 · · Score: 5, Interesting

      Well, this will take away that excuse for behaving irresponsibly.

      Right, because men make the choice if the child was given up for adoption, day after pill or abortions. Or the fact that men don't have to carry a growing life inside of them with potential medical risks and bringing into the world, you know, because, that's clearly not possibly in the range of responsibility for a woman.

      I'm responsible myself, but seriously, if I would get a tiny life form growing inside of me, I would assume it's MY responsibility to decide if *I* want that to happen to me. Pro choice pro your body pro your responsiblity? Yeah no one likes that last part. Lot of special interest groups are pro everything I want except the responsibility that comes with that freedom of choice.

      This alternative will be a true freedom for men however, especially for couples when birth control doesn't work well for some women out there.

      However, this will also protect men from some other issues, like forced responsibility for the irresponsibility of women. If a women makes the mistake of not ensuring she will not get pregnant when both parties claim not to want children, there is no forced responsibility for a child to grow up in a broken home and finances garnished. You'll lose that "Well You're A MAN and you're responsible too!" Because a lot of us will be, a lot more than you would expect, and it will shift things in our favor.

      In addition, this will be so new that for women who do cheat (No no, not accusing all women, men do it to, yatta yatta, get your narrow minded self interests out), it will create a different scenario where more women won't be on birth control, but men will be. So when she suddenly gets knocked up, this is going to be interesting on a social / society level.

    3. Re:Time for men's liberation by brambus · · Score: 2

      If anything, this might actually give them a plausible response to "why didn't you bring a condom?". Oh the sad irony if this actually ends up hurting women.

    4. Re:Time for men's liberation by BarbaraHudson · · Score: 2

      Both of them should be taking precautions, rather than blindly trusting the other party. I get the whole "in the heat of the moment", but still ...

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    5. Re:Time for men's liberation by Defenestrar · · Score: 2

      You've got a lot of good points about the limitations of a male pill - especially about the danger associated with unprovable accusations. Where I think this may really help is that men can be responsible for taking risks again. I don't mean with the risk of pregnancy or any of the other unwanted consequences of sex - but the risk associated with birth control.

      There's plenty of down sides to the pill - emotional effects, cancer risks, permanently altered sex drive, etc... But with a male version, the man can risk the associated side effects (perhaps they'll even be more mild than the pill). This could be a boon to committed couples who want to have a couple of years between children. The permanent solution will still be a vasectomy*, but for the settling into the marriage phase, or the wait between kids phase, this could be great for people.

      *Based on the relative risks, it's a cowards choice to let the woman go through her version of that surgery unless the doctors are already in there for something (I'll allow rare medical conditions to be excepted from the cowardice charge - just because I'm not aware of any doesn't mean they don't exist).

    6. Re:Time for men's liberation by penguinoid · · Score: 3, Interesting

      Time for men's liberation

      Not yet! They accidentally found a cure for cancer, so they have to get rid of the cure for cancer before they'll sell this to you.

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    7. Re:Time for men's liberation by flink · · Score: 4, Insightful

      It would be awesome if this could be part of a men's liberation movement, like how women were liberated in the 60s when the pill became available.

      Was it the pill that led to women's liberation? Or was it penicillin? The pill allows women to have sex without getting pregnant. Penicillin allowed people to have sex without getting diseases. AIDS has somewhat rolled that back.

      Before HIV, there was still always Herpes, Hepatitis, HPV.... e.g. anything viral. People were just more ignorant of STDs 50 years ago, but that doesn't meant they still weren't getting them. You're still going to want a condom on the first date no matter how many new types of contraception get invented.

    8. Re:Time for men's liberation by brambus · · Score: 2

      If you can't trust the other party, why are you having sex in the first place? Sex is all about trust. If trust is not assured and sex is desired nonetheless, condoms are a must, or you might be exchanging a lot more than a few gamete cells.

    9. Re:Time for men's liberation by serviscope_minor · · Score: 5, Insightful

      Sex is all about trust.

      No it ain't, it's about shagging.

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    10. Re:Time for men's liberation by epyT-R · · Score: 2

      Well, as long as it's solely "her body, her right, her choice", it should also be solely "her responsibility." At least by default. If she gets him to sign a contract for support (ie marriage), and it is indeed his kid, that's different.

    11. Re:Time for men's liberation by Anonymous Coward · · Score: 3, Insightful

      Sex between equals involves trust, yes, but saying that it's "all about trust" is like saying that going to the movies is all about eating popcorn.

    12. Re:Time for men's liberation by ShanghaiBill · · Score: 2

      Sex is all about trust.

      If that was true, the human species would have died out millennia ago.

    13. Re:Time for men's liberation by epyT-R · · Score: 2

      This doesn't address the situation I was talking about. If you're happy with her choice, more power to you. That doesn't mean all men are (or should be forced into it on her whims). If it's ok for women to show up at a club, hook up drunk, and then decide what to do about the consequences, then men should have the same right to do so. Neither party should take advantage of the other.

    14. Re: Time for men's liberation by Magnus+Pym · · Score: 2

      Any reason why you think that the divorce & child support pillage is limited to white men? I know quite a few Indian and Asian men who are paying through the nose to keep their exes in the styles to which they have become accustomed.

    15. Re:Time for men's liberation by ShanghaiBill · · Score: 2

      Yes, well, her denying you a child is not the same as forcibly taking your money to fund her 'choice.'

      Sure, but she could do that too. If she wanted the kid, and I didn't, she could just tell me that it was "safe" when it wasn't. Once she was pregnant, I would have no choice. Marriage doesn't change who has the power over reproduction. The sad part is that she makes more money than me too. Well, anyway, I have to go, because she just told me to go wash the dishes ...

    16. Re:Time for men's liberation by Kielistic · · Score: 2

      You have an interesting definition of "carefree".

    17. Re:Time for men's liberation by Bob+the+Super+Hamste · · Score: 2

      While it is possible to have a vasectomy reversed it may not work. Having had it done a couple of years back you get the full run down on it and they state that even if it is reversed you may still be sterile if your body developed antibodies against sperm. There are other things that can happen as well that may leave you sterile so it isn't entirely reversible but is much easier than it is for a woman.

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  2. Think of the children. by Anonymous Coward · · Score: 5, Funny

    This is a murder of potentially trillions of human beings and as such an obvious affront to god!

    1. Re:Think of the children. by ColdWetDog · · Score: 3, Funny

      "Every sperm is sacred .... "

      --
      Faster! Faster! Faster would be better!
    2. Re:Think of the children. by Amtrak · · Score: 2
      Doubtful. The Catholic church bans all contraceptive methods based on an edict from the Pope Paul VI.

      In 1968, Pope Paul VI issued his landmark encyclical letter Humanae Vitae (Latin, "Human Life"), which reemphasized the Church’s constant teaching that it is always intrinsically wrong to use contraception to prevent new human beings from coming into existence. Contraception is "any action which, either in anticipation of the conjugal act [sexual intercourse], or in its accomplishment, or in the development of its natural consequences, proposes, whether as an end or as a means, to render procreation impossible" (Humanae Vitae 14). This includes sterilization, condoms and other barrier methods, spermicides, coitus interruptus (withdrawal method), the Pill, and all other such methods.

      You can read more here if you are interested.

  3. Curing cancer by Anonymous Coward · · Score: 4, Insightful

    TFA: [...] discovered that the JQ1 molecule blocked a bromodomain in cancer cells, causing them to forget how to be cancer. [...] Researchers are looking for a version of the molecule that works on the testicle protein only, to avoid any weird side effects

    Since when slowing down cancer is a "weird side effect"? :D

    1. Re:Curing cancer by ColdWetDog · · Score: 3, Insightful

      The pharma industry doesn't like to make medicines that solve more than one problem at a time. It's difficult to monetize that efficiently.

      Your trolling, but you're wrong. If all you need to do is another Phase III study for a different indication, you're golden. There are a number of drugs on the market that have different trade names for different uses but are the same molecule. It's not quite the Holy Grail for big Pharma, but it is at least a big lottery win.

      --
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  4. This type of preventative would be awesome by burtosis · · Score: 5, Insightful

    This could really help men everywhere, there are a ton of options for women but very few for men. I can only hope when the day comes that it's viewed as a positive direction from all rights groups. Doubtful, but one can dream.

    1. Re: This type of preventative would be awesome by Fwipp · · Score: 2

      Yeah, it's weird how the dudes here are complaining about having more options. Like...? This is obviously a good development.

  5. Universal Zero Tolerance of Side Effects by EmagGeek · · Score: 4, Funny

    "anti-cancer researchers at Harvard, discovered that the JQ1 molecule blocked a bromodomain in cancer cells, causing them to forget how to be cancer."

    "Researchers are looking for a version of the molecule that works on the testicle protein only, to avoid any weird side effects."

    Umm... can I please have the side-effects, if the side effects are, you know, NOT GETTING CANCER?

    1. Re:Universal Zero Tolerance of Side Effects by AuralityKev · · Score: 5, Funny

      Makes you wonder what the *ahem* delivery system would be... "Cmon, we don't need a condom, I'll cure your cancer!"

  6. Re:Not a fucking chance. by BarbaraHudson · · Score: 5, Insightful

    Birth control is a womens issue.

    You won't get a judge to agree with you if you accidentally father a child.

    I won't be putting any unknown chemicals into my body for HER sake.

    And yet you want her to put chemicals into her body for YOUR fun and enjoyment. Nice troll :-(

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  7. Re:Not a fucking chance. by XxtraLarGe · · Score: 5, Insightful

    Birth control is a womens issue.

    You won't get a judge to agree with you if you accidentally father a child.

    I like how this issue is always 1-sided. It's a woman's choice if she wants to have an abortion, but the guy doesn't have a choice to not support the child if the woman wants to have it but he doesn't.

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  8. Sad For My Gender by Jason+Levine · · Score: 5, Insightful

    The number of responses here along the lines of "women always trick men into marriage by getting pregnant" or "birth control is a woman's responsibility" make me sad for my gender. I can't be the only man on Slashdot who 1) respects women (my wife and I both manage our portions of birth control together - I would never suggest that's HER job and not for me to be bothered with), 2) sees fatherhood as a positive outcome - not something that is only entered into via trickery, and 3) would like to see new birth control methods available on the market (whether or not this one would work for my wife and I aside, the more options the better). Can I?

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    1. Re:Sad For My Gender by Tyr07 · · Score: 5, Insightful

      You should be sad for humanity, because men or women, both do some pretty shitty things.

      That aside, women, rightfully in my opinion, call out that it's their body, they have the right to make choices that affect their body.
      Yet for everyone pointing a finger a men, what happened to this right to choose what happens to your body, what, you get the right to chose but don't have
      the responsibility?

      Male birth control is the right step forward for equality for men. You see, although all the more extreme fem groups are all looking at the CEO's and measuring their own personal wealth against it, deciding it's the old boys club, there are other areas that have inequity for men, such as decreased pleasure sexually to prevent pregnancy, the way the courts favor women for parenting, that family courts are HEAVILY populated by women, almost always a female judge with female representatives, and that men are on the hook for children women decide to keep or come to term.

      Well, this is one way we can make our own choices about what responsibilities we're going to accept and it will be out of a woman's hand, so I'm all for it.

    2. Re:Sad For My Gender by eepok · · Score: 5, Insightful

      People comment based on experiences or the stories of others.

      Women have, historically, had the socially-supported option of getting pregnant instead of being old and single or instead of entering the workforce. In fact, entering the workforce is still a relatively new concept for women and still not universal throughout the world. Men still have the socially-enforced expectation of tying one's finances to the mother of his children regardless of the involvement of those men in the lives of the children or the mother. This is a genuine hobbling of the uninvolved man's life post impregnation and thus fear of a coerced pregnancy is a significant fear amongst men. As a result, SOME men are suspicious of women when it comes to birth control.

      Thus, you shouldn't be surprised by pessimistic online comments reading as "Women trick men into marriage by getting pregnant".

      But it does not define the entirety of the population. It MAY describe a part of an aging population of experiences (the younger generation doesn't seem too keen on popping babies out), but by no means defines an entire community.

      You can see such patterns of experiences -> comments by taking a look at your own. Your experience with your wife (cooperative birth control expectations, a happy outlook on parenthood, etc.) will bias you towards believing that women have not/do not use pregnancy as a investment-- but it would also suggest that you're fairly far-removed from the lives your male peers if you cannot understand their fears.

    3. Re:Sad For My Gender by rock_climbing_guy · · Score: 2
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  9. Re:Not a fucking chance. by Anonymous Coward · · Score: 3, Interesting

    You should have something to say when you have to deal with 18 years of financial responsibility wile having no/little interaction with an actual child.

  10. Re:Not a fucking chance. by Raseri · · Score: 4, Insightful

    I didn't realize straw men could father children. Thank you for enlightening us.

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  11. Re:Not a fucking chance. by Anonymous Coward · · Score: 2, Interesting

    Why? It takes two to tango.

    Because the only satisfactorily effective means of birth control are all in the hands of women, from the pill through the morning after pill to abortion. Additionally, as women would have us believe, pregnancy doesn't affect men nearly as much as it affects women. It seems only natural that women should take responsibility for that then. It's a shame that the responsibility seems to end when someone has to pay for the result.

    Male contraceptives will cause a lot of women to be childless, women who would now find a sucker and "forget" the pill. You see, birth control isn't just a burden, it's also a form of control that isn't implied by its name, one that men don't currently have.

  12. Boon to rapists? by MouseTheLuckyDog · · Score: 4, Interesting

    If the sperm is destroyed, is there anything left that contains DNA in the semen?

    If not that this could be a big boon to rapists who no longer have to worry about leaving their DNA behind.

  13. Re:I happen to be a Vampire... by BarbaraHudson · · Score: 2

    I guess you'll just have to suck it up then. ;-(

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  14. Re:Not a fucking chance. by BarbaraHudson · · Score: 2
    Used properly by themselves, they're effective at preventing pregnancy AND preventing the transmission of STDs. Throw in a spermicide and you've got nothing to worry about.

    Relying on what the other party says isn't nearly as effective when talking about disease transmission, and kind of silly when it comes to preventing pregnancies.

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  15. Re:Not a fucking chance. by XxtraLarGe · · Score: 4, Insightful

    Well guess what? Maybe you should have taken a little bit of responsibility by using a condom?

    That does not address the original issue. Would you find it acceptable for someone to say "Maybe you should have taken a little responsibility and not spread your legs" to a woman? If not, why is it o.k. to say that to the guy?

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  16. Re:You try it first by afidel · · Score: 2

    Vasectomies have potentially serious side effects, both in the short term, and in the long term (hormone issues), plus as others have pointed out they're more or less permanent (reversals are expensive and nowhere near 100% successful) .

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  17. Re:Not a fucking chance. by d34thm0nk3y · · Score: 4, Insightful

    Because the only satisfactorily effective means of birth control are all in the hands of women, from the pill through the morning after pill to abortion

    Women are also in control of the global condom supply, apparently.

    How does something so completely wrong get modded so highly?

  18. Re:STDs? by neminem · · Score: 2

    That's retarded. People have unprotected sex because it's better. Way better. Even, I would say *especially* people in long-term, monogamous, trusting relationships, who still happen to not want kids at the moment.

  19. Comment removed by account_deleted · · Score: 2

    Comment removed based on user account deletion

  20. calm yourself, White Knight by Uberbah · · Score: 2

    The number of responses here along the lines of "women always trick men into marriage by getting pregnant"

    "Always"? Which comments would those be? In any case, some men are tricked into being fathers, or think they are fathers. The chances of that happening are small, but the consequences (the next 20 years of your life) are large.

    I can't be the only man on Slashdot who 1) respects women

    /rollseyes

    How about respecting people?

    "birth control is a woman's responsibility"

    Women have a plethora of BC options open to them - various IUD's, the pill, diaphragms. None of which (well, occasionally diaphragms) interfere with her pleasure during sex. Condoms do interfere for men, and most American men are already missing half their nerves to begin with, when their genitals were cut without their consent as infants.