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Surgeon: First Human Head Transplant May Be Just Two Years Away

HughPickens.com (3830033) writes "Michelle Star writes at C/net that Surgeon Sergio Canavero, director of the Turin Advanced Neuromodulation Group in Italy, believes he has developed a technique to remove the head from a non-functioning body and transplant it onto the healthy body. According to Canavero's paper published in Surgical Neurology International, first, both the transplant head and the donor body need to be cooled in order to slow cell death. Then, the neck of both would be cut and the major blood vessels linked with tubes. Finally, the spinal cords would be severed, with as clean a cut as possible. Joining the spinal cords, with the tightly packed nerves inside, is key. The plan involves flushing the area with polyethylene glycol, followed by several hours of injections of the same, a chemical that encourages the fat in cell membranes to mesh. The blood vessels, muscles and skin would then be sutured and the patient would be induced into a coma for several weeks to keep them from moving around; meanwhile, electrodes would stimulate the spine with electricity in an attempt to strengthen the new nerve connections.

Head transplants has been tried before. In 1970, Robert White led a team at Case Western Reserve University in Cleveland, US, that tried to transplant the head of one monkey on to the body of another. The surgeons stopped short of a full spinal cord transfer, so the monkey could not move its body. Despite Canavero's enthusiasm, many surgeons and neuroscientists believe massive technical hurdles push full body transplants into the distant future. The starkest problem is that no one knows how to reconnect spinal nerves and make them work again. "This is such an overwhelming project, the possibility of it happening is very unlikely," says Harry Goldsmith."

36 of 210 comments (clear)

  1. Just y'know... reconnect them spinal nerves by popo · · Score: 4, Insightful

    Just reconnect the spinal nerves? This is like saying interstellar spaceships are just two years away. Just connect the warp drive to the antimatter, and there you go.

    Perhaps we should start by inventing a warp drive first? Or in this case, connecting severed spinal columns?

    --
    ------ The best brain training is now totally free : )
    1. Re:Just y'know... reconnect them spinal nerves by gbjbaanb · · Score: 4, Insightful

      I do think they could practice on paralysed people first - after all, if they can't reconnect severed spinal cord nerves in someone whose spinal cord is roughly still in place, what hope do they have for merging 2 different spinal cords?

    2. Re:Just y'know... reconnect them spinal nerves by rmdingler · · Score: 2

      Agreed, the spinal nerves get where they are during fetal development, and slicing through them pretty thoroughly kills off the distal parts of the axons (Wallerian degeneration). If this could be done now, then there wouldn't be any paraplegic or quadriplegic people. And then what are they going to do about tissue rejection, when the tissue being rejected is the entire head?

      Pretty much this, although I suspect cloning a body made from your own cell(s) will be plausible at or before spinal nerves are fused successfully.

      I'd be more pleased if they'd move forward on this body part cloning research before I need a heart, lung, or liver.

      --
      Happiness in intelligent people is the rarest thing I know.

      Ernest Hemingway

    3. Re:Just y'know... reconnect them spinal nerves by ideonexus · · Score: 5, Interesting

      The problem, even with a spinal cord cut intentionally and carefully, is that the surgeon has no way to know what connections in the head go to what connections in the body. Our nervous system-brain interface isn't a blueprinted thing at birth, our brains are actually born with no knowledge of the nerves running through our bodies. Our brains and bodies learn to interface with one another via "neural pruning." The brain is born with a bazillion* neurons, far more than it needs, but this is to account for all the possible nerve connections. Then, as the body grows, the nerves send signals to the brain, and those neurons that don't receive signals die off, leaving the neurons that are properly wired into the body. In other words, our brains grow by natural selection.

      So how is a surgeon supposed to wire up a body to a brain that hasn't grown into that body? How is a brain pruned in childhood to interface with a body of certain dimensions and nerve-wirings supposed to interface with a body of completely different dimensions? It's not just a problem of lining up the nerves in the donor body with the right connections in the patient's head (a seemingly impossible task in and of itself), its the fact that the nerves in one person's body are going to be a very different set of wires than those in the the head. Many of the major nerves will match, but the signals from those nerves will be very different.

      I wish this researcher the best of luck, and I imagine we will benefit tremendously from the new information we get from this research, but I suspect the final result will simply discover what the next challenge is to performing a successful head transplant.

      *Technical term. :)

      --
      i ~ Celebrating Science, Cyberspace, Speculation
    4. Re:Just y'know... reconnect them spinal nerves by Anonymous Coward · · Score: 2, Funny

      " with a clean cut, rather than trauma, severing the code."

      That's going to be an interesting SVN commit.

    5. Re:Just y'know... reconnect them spinal nerves by gstoddart · · Score: 5, Interesting

      So, here's the problem with that ... in addition to motor skills, your spinal column handles all of the autonomic stuff ... you know, heart beat, digestion, breathing, all that stuff which is controlled by the brain.

      If you don't have those things connected properly, you will die. Plain and simple. This is leaps and bounds beyond physiotherapy. This is the entire function of your body which is controlled by the brain, which, last I checked, is pretty much all of it.

      This isn't something where you can jam the two ends together and wait a few years until your brain remaps everything. Not unless you plan on keeping someone on extensive life support until the brain re-learns how to tell all of those other parts how to operate the body.

      I just don't see this being viable, not unless you plan on spending zillions of dollars to keep someone alive until possibly the brain remaps some connections.

      In which case this is a "treatment" which is only ever going to be viable for billionaires, because the resources to keep them alive in the mean time would be utterly staggering.

      If all you're doing is designing a treatment for billionaires ... well, experiment on the billionaires then.

      --
      Lost at C:>. Found at C.
    6. Re: Just y'know... reconnect them spinal nerves by Miamicanes · · Score: 4, Informative

      Not exactly. Some organ systems have controls that are a bit more local. That's why a quadriplegic can still digest food and have a beating heart, but needs a ventilator unless he had enough nerve connectivity remaining post-injury to breathe on his own. It's also why someone who's paralyzed can still have sex & enjoy it (even though he can't feel the orgasm).

    7. Re:Just y'know... reconnect them spinal nerves by ColdWetDog · · Score: 2

      If this guy had the technology to repair severed spinal cords, he'd already be a Nobel candidate. It is one of the Holy Grails of neurology / neurosurgery. Think of all the paraplegics and quadriplegics you could rescue using those techniques.

      Millions of rats have died trying to get us that information.

      --
      Faster! Faster! Faster would be better!
  2. How about healing spinal cord injuries first? by Ihlosi · · Score: 5, Insightful
    Right now, we can't even repair spinal cord injuries where head and body belong to the same person. Once that becomes a routine medical procedure, we might think about head transplants and how to solve the problems associated with them.

    Seriously, are the people who cleam this serious? I don't think so.

    1. Re:How about healing spinal cord injuries first? by bruce_the_loon · · Score: 2

      We are able to at least partially repair them now. http://www.medicalnewstoday.com/articles/284152.php. That's a lot further along than a couple of years ago.

      --
      Trying to become famous by taking photos. Visit my homepage please.
    2. Re:How about healing spinal cord injuries first? by barc0001 · · Score: 2

      To be fair, the guy outlines a process to cleanly sever and then prepare the nerves for reattachment under a very controlled environment, which is an entirely different thing from a spinal cord being damaged in an accident out in the world.

      That said, the whole idea is terrifying and if his end goal is literally making head swaps a somewhat common procedure nothing good will come of this. In order to make this possible you need bodies after all, and if this can extend the life of the transplant-ee by a significant margin we're going to see a huge amount of pressure brought to bear to create a supply of those bodies. Maybe something along the lines of Larry Niven's short story "The Jigsaw Man" where capital offense criminals were harvested to fill demand, and as demand grew over time the bar for a capital offense keeps dropping to keep up.

  3. Re:I know that novel by nospam007 · · Score: 3, Funny

    "That's Frankenstein. "

    First, that's _Doctor_ Frankenstein.

    Victor, for my friends.

      An it's pronounced Frank-on-steen!

  4. Mark my words by NotInHere · · Score: 4, Interesting

    One day there will be trillions of humans on this planet, brains only, connected to a huge computer, and all dreaming of a body of their own.

  5. ob.Heinlein by Alrescha · · Score: 2

    Please read "I Will Fear No Evil" to see how all this turns out.

    https://en.wikipedia.org/wiki/...

    A.

    --
    ...bringing you cynical quips since 1998
  6. It's a body transplant, not a head transplant... by patniemeyer · · Score: 5, Informative

    The first thing they need to do is start calling it a body transplant, not a head transplant. The living person got a new body, the dead person did not get a new head.

    Pat

  7. Re:Too much. by Dcnjoe60 · · Score: 4, Insightful

    Sitting in front of an electrical box that sends out signals to billions of people everyday is also against the "laws of nature."

    Please live up to your own lame excuse for why this shouldn't be and stop sitting in front of that box.

    Actually, computers and the internet, etc. do follow the laws of nature, quite well. Technically speaking, everything we do follows the law of nature, otherwise it would be miraculous. That said, it still doesn't address the morality of the issue.

  8. Re: Wrong title by Anonymous Coward · · Score: 2, Insightful

    And where do you (legitimately) find a "healthy body" without a head?

  9. Re:Congress by Marginal+Coward · · Score: 5, Funny

    Any word on removing non-functioning human heads and planting them on perfectly good bodies?

    Coincidentally, Sports Illustrated devotes a whole issue to that every year.

  10. OR-gan-leg-gers OR-gan-leg-gers... by jeffb+(2.718) · · Score: 2

    Well, heck. Now that we've mastered that pesky matter of grafting severed spinal cords, surely the optic nerve and other lesser bundles should be a piece of cake. So why not just do a brain transplant?

    Anubis? Is that you?

    1. Re:OR-gan-leg-gers OR-gan-leg-gers... by Theovon · · Score: 2

      What if you don't like your head? Ugly people could have their brains transplanted into pretty people. Think of the potential for sex changes too! Then just as there's a market for stealing kidneys, there will arise a market for stealing whole bodies. You don't have to steal a rich person's digital identity. You can steal their WHOLE LIFE. Mind you, you'd have to study up really hard on every detail of their life and even learn to imitate their accent and speach patterns exactly, so their friends don't catch on. And then, with everyone knowing about the potential for this kind of identity theft, imagine someone undergoes a personality change due to illness -- everyone will assume their brain was replaced by an imposter, because most people are fucking clueless about mental illness.

  11. Re:Too much. by B33rNinj4 · · Score: 2

    Mary Shelley tried to warn us of this a long time ago.

    No, she did not. Also, Nostradamus didn't predict Hitler or the September 11th attacks. As for the ethics of the issue, that's a tough one. I agree with you that there "may" be a black market for this, eventually. This isn't like getting a gunshot wound treated at a back-alley clinic. With proper regulations, it can be controlled in a safe, ethical manner.

  12. Re:Congress by disposable60 · · Score: 2, Funny

    Those heads are perfectly functional ... for the only functions anyone is really interested in employing them in.

    Fit for use, as it were.

    --
    You're looking for quotes? See my journal.
  13. Leg, Arm? by wisnoskij · · Score: 2

    What I don't understand is why do people without legs and arms get leg/arm transplants (how about bone transplants)? It seems that we would need to master that before we start attaching heads.

    --
    Troll is not a replacement for I disagree.
  14. Re:It's a body transplant, not a head transplant.. by Convector · · Score: 2

    NIXON'S BACK!

  15. Proof this guy is crazy by MobyDisk · · Score: 5, Interesting

    TLDR: Skip to the last paragraph for the best part. I didn't find it until I wrote all this up.

    Since this is the 2nd Slashdot summary talking about this seemingly wacky procedure, I I decided to look into him a bit. Unfortunately the hard transplant stuff is 99.99% of what the search results return. He even gave a TED talk on the topic of human consciousness. It is possible this guy is just trolling to sell his recent philosophy book since he left his job as a neurosurgeon.

    Dr Canavero believes that the brain does not generate consciousness, but only filters it. His goal is to open the filter and see what lies beyond.

    Perhaps the fields of neurosurgery and chiropractic draw people who have a fascination with human consciousness, like how some chiropractors think that they can cure any disease by cracking your back?

    He claims to be part of the "Turin Advanced Neuromodulation Group" which is "a Think Tank for the advancement of neuromodulation." It looks like that group is just him, and perhaps one colleage named "Vincenzo Bonicalzi MD" who co-authored a book with him in 2007. Together they wrote "Central Pain Syndrome: Pathophysiology, Diagnosis and Management" But in 2014 Dr Canavero self published "Immortal: Why CONSCIOUSNESS is NOT in the BRAIN". If you read the summary, it looks like your metaphysical philosophy.

    The best part: Doctor Canavero and his "group" believe that through a combination of electrical stimulation and head transplants that he can create a society of perfect immortal beings.

  16. The Head of Vecna by Translation+Error · · Score: 2

    Well, I can't think of a better opportunity to revisit the classic roleplaying tale of The Head of Vecna.

    --
    When someone says, "Any fool can see ..." they're usually exactly right.
  17. Need nanobots first by Theovon · · Score: 2

    Your comment is probably the most insightful here.

    Even with extreme optimism about neurplasticity and nerve cells sliced in the middle (not separated at the synapses but chopped like a stalk of celery) deciding to attach to other sliced neurons, the idea of taking one spinal cord and gluing it to another spinal cord and having ANYTHING line up right seems absurd to me. Talk about a registration problem! I suspect the only way to do it would be to be to perform microscopic surgery where tiny machines connect neurons one-by-one. Of course, even if we had that technology, there's a whole other problem of knowing which ones to connect to which, which probably doesn't have a real solution as you pointed out.

  18. Re:Congress by Hartree · · Score: 3, Funny

    Even worse:

    Nancy Pelosi and John Boehner in swimsuits, making out.

    Now imagine their secret love child.

  19. Whats the value proposition here? by DarkOx · · Score: 2

    I know brain injuries for events like near downing occasional leave bodies that can recover to health but the brain so damaged they will never escape a vegetative state. Certainly other brain injuries due to head knocks etc can have similar results.

    How many of these bodies are really available? Hollywood would have us believe quite a lot but I am not sure that is the case.

    That said how many of these potential donators are really out there ethically speaking? The body deteriorates when we are talking about a persistent vegetative state requiring feeding tubes and ventilators and such. Can we, will we in the foreseeable future be able to better identify when the patients brain won't recover. Right now there is already a financial incentive to pull the plug. What will happen to these patients who can't speak for themselves when those making decisions for them are under pressure to give their body to someone else? Will these lead to prematurely giving up on some folks?

    Seems like there should be some lower hanging fruit to go after in terms of modern medicine than head swaps. In fact just focusing reconnecting the sever spinal cord in the same monkey without adding the additional trauma and unknowns associated with the rest of the head swap would probably do more to help the disabled, which I am sure far out number the persistently comatose.

    --
    Repeal the 17th Amendment TODAY! Also Please Read http://www.gnu.org/philosophy/right-to-read.html
  20. Re:Too much. by 50000BTU_barbecue · · Score: 2

    Yes but I have to warn you, it seems resistant to sex.

    --
    Mostly random stuff.
  21. Re:Too much. by TapeCutter · · Score: 2

    I think he just wants someone to allow him to swap heads around on Monkey's to see what happens, I hope nobody encourages him.

    --
    And did you exchange a walk on part in the war for a lead role in a cage? - Pink Floyd.
  22. Re:Too much. by Wootery · · Score: 4, Insightful

    It goes against all the laws of nature

    If you mean to say I personally don't like the idea then just come out and say it. Don't waste our time with the 'laws of nature' garbage.

  23. Re:Congress by TheRealHocusLocus · · Score: 4, Insightful

    From the perspective of the head it's a body transplant.
    The body typically has no perspective of its own
    so the idea of a head transplant is ludicrously funny.
    We laugh to drown out the screaming inside.

    Those heads are perfectly functional

    Welcome back my friends to the show that never ends
    We're so glad you could attend, come inside, come inside
    Come inside, the show's about to start
    Guaranteed to blow your head apart
    Rest assured you'll get your money's worth
    Greatest show in Heaven, Hell or Earth
    You've got to see the show, it's a dynamo
    There behind a glass stands a real blade of grass
    Be careful as you pass, move along, move along.
    [...]
    Left behind the bars, rows of Bishops' heads in jars

    --
    <blink>down the rabbit hole</blink>
  24. Re: Wrong title by OrangeTide · · Score: 2

    And where do you (legitimately) find a "healthy body" without a head?

    Motorcycle riders.

    That's right, folks, when you get your Class M1 license, be sure to check the organ donor box.

    --
    “Common sense is not so common.” — Voltaire
  25. Hawking by phorm · · Score: 3, Insightful

    I recently read an article that was essentially "how could Steven Hawking have kids", and somebody with a similar condition basically stated that while you lose motor functions elsewhere, that particular part of the anatomy tends to work as it's part of the Parasympathetic nervous system

  26. Mod parent "misinformation" by Anonymous Coward · · Score: 3, Informative

    Or, you know, you could be talking out of your ass.

    The reason the parasympathetic system control of the heart and digestion continues to function in a case of a transected spinal cord is that CN X doesn't run in the spinal column. Instead, it comes out and runs down the neck roughly along the path of the jugular vein.

    Far from being "local control", the root of CN X is in the medulla. The brainstem.

    Here, educate yourself rather than spreading misinformation: Vagus Nerve.