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Mice Brainpower Boosted With Alteration of a Single Gene

Zothecula writes: By altering a single gene to inhibit the activity of an enzyme called phosphodiesterase (PDE4B), researchers have given mice the opportunity to see what an increase in intelligence is like. "They tended to learn faster, remember events longer and solve complex exercises better than ordinary mice. For example, the “brainy mice” showed a better ability than ordinary mice to recognize another mouse that they had been introduced to the day before (abstract). They were also quicker at learning the location of a hidden escape platform in a test called the Morris water maze. However, the PDE4B-inhibited mice also showed less recall of a fearful event after several days than ordinary mice." While many people would welcome such a treatment, the scientists say their research could lead to new treatments for those with cognitive disorders and age-related cognitive decline.

20 of 105 comments (clear)

  1. Zoink by future+assassin · · Score: 3, Funny

    n/t

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  2. I would laugh so hard... by EmperorOfCanada · · Score: 4, Funny

    I would laugh so hard if they develop a drug based on this and the only skills that people gain are the ability to recognize mice better and to be less scared of open spaces and cats. Oh and to find hidden escape ways.

    But really I do look forward to what will happen someday if these cognitive enhancement drugs turn out to be safe and make people smarter. I am not talking a limitless sort of thing but what happens if a university course ends up be retuned to be just too difficult for most people unless they are taking these sorts of things? If that hasn't already happened with things like Modafinil.

    1. Re:I would laugh so hard... by Sowelu · · Score: 2

      I dunno--in modern society, things that seem viscerally scary are often important or necessary (nuclear power, say) and things that seem reasonable at first glance can be dangerous. Losing instinctive fear and replacing it with cold rationality seems like an improvement for species survival, depending on what you think the nastiest Great Filter is.

    2. Re:I would laugh so hard... by viperidaenz · · Score: 2

      cold rationality is only going to work if you really understand what you're experiencing. When it comes to predators, you need to be able to think from their point of view. So far it's only known that humans can do that (and possibly our ancestors), and it's what gave us the advantage over everything else a few hundred thousand to a few million years ago. Being able to realise your smell, the sounds you make and your tracks are what your opponent are using to track you and using that knowledge to deliberately mislead them is not a simple task.

      I doubt the cognitive abilities of a mouse are really that advanced.

  3. Damn.... by mark-t · · Score: 4, Funny

    Now the theme to Pinky and the Brain is stuck in my head. Even less conducive to getting work done than reading Slashdot.

    And just now my coworker next to me just asked why I whispered "Narf".

  4. Flowers FROM Algernon? by grasshoppa · · Score: 3, Interesting

    How smart are we talking here?

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    1. Re:Flowers FROM Algernon? by thatseattleguy · · Score: 2

      My thought exactly; you beat me to it. http://en.wikipedia.org/wiki/F...

    2. Re:Flowers FROM Algernon? by Spy+Handler · · Score: 4, Funny

      The mouse was the Slashdot submitter.

  5. Super-Race of Humans Next by Tablizer · · Score: 2

    To be competitive, I'm pretty sure certain nations would allow and/or require adjusting human brain genetics to breed a "super race" with superior intelligence, memory, and/or discipline.

    I don't know how long a nation that forbids such could compete. If the super-brain nations become a threat, the hold-outs will be forced to tinker also.

  6. Re:I, for one, welcome by Megane · · Score: 2

    Of course they're our overlords, they built this planet to solve the Ultimate Question, or at least to solve it with a better answer than "forty-two".

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  7. Loss of memory, or just loss of fear? by Obfuscant · · Score: 3, Interesting

    However, the PDE4B-inhibited mice also showed less recall of a fearful event after several days than ordinary mice.

    Perhaps being smarter enabled them to process the "fearful event", determine the cause of the fear, the amount of actual hazard and any risk mitigation actions they could take, and thus not be as "afeard" the next time that event happened?

    That's what humans do. They get scared by something, realize that the fright was temporary and not based on an actual threat, and desensitize.

    And my fist thought was "Flowers For Algernon", too.

  8. Narf! by Rob+Riggs · · Score: 2

    n/t

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    the growth in cynicism and rebellion has not been without cause
  9. Package in a retrovirus by Etherwalk · · Score: 2

    Package it in a retrovirus and pass it around. And maybe we can use it to make an STD that will make people smarter. Stop being so damn conservative that you only use it on people with cognitive problems if society as a whole could benefit from fewer stupid people.

    1. Re:Package in a retrovirus by SuricouRaven · · Score: 4

      'Stupid' is not just a matter of low intelligence. It's also a subject of cognitive biases and undisciplined thinking.

      For a good example, look at Ben Carson, one of the Republican candidates. He has spouted a steam of policy positions that most people would regard as stupid: He suggested abolishing all taxes in favor of a fixed 10% income 'tithe' because that is what the bible specifies, he said that homosexuality must be a choice because people turn gay in prison, and he has claimed that the affordable care act enslaves people to the government. But is he stupid? Certainly not: Before going into politics he was a neurosurgeon, and a very good one too, one actively involved in research and responsible for developing new procedures. He is literally a brain surgeon.

      What Carson shows is that it's quite possible for a person to be of brilliant intelligence, but still come to hold positions that are quite obviously ridiculous. Humans are not logical creatures by nature: Their minds are the product of a process that optimized for reproductive success. A cobbled-together tangle of heuristics.

    2. Re:Package in a retrovirus by Ol+Olsoc · · Score: 2

      Just look at what SuricouRaven implies:

      .

      You are proving his point. You make fucking ridiculous long debunked claims, that normal people would howl at, but are smart enough to post as Anonymous Coward so we do't have a name to laugh at.

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    3. Re:Package in a retrovirus by blue9steel · · Score: 2

      I can tell that you never played D&D or you'd know the difference between wisdom and intelligence.

  10. Already done in humans for COPD. by sims+2 · · Score: 3, Interesting

    http://lungdiseasenews.com/201...

    "Roflumilast works by inhibiting the activity of an enzyme called phosphodiesterase 4B (PDE4B)"

    Maybe someone who's using it can tell us the side effects in humans.

    Its also known by its commercial name Daliresp.

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    1. Re:Already done in humans for COPD. by reboot246 · · Score: 3, Informative

      A better known and safer alternative is resveratrol. You can try taking supplements which may or may not work, or just drink the red wine.

      Resveratrol is an exceptional PDE-4 inhibitor. One supplement that has been thoroughly tested and found effective is Longevinex.

  11. Re:short term versus long term by Jumunquo · · Score: 3, Funny

    So it works better than alcohol!

  12. Re:Democrats by hackwrench · · Score: 2

    It's not just the Democrats, all of the rich and powerful keep all the real decision making away from those who are not, and we keep letting them. The window dressing is just different, that's all.