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Scientists May Have Found Molecular Gatekeeper Of Long-Term Memory (arstechnica.com)

hackingbear writes: While the general steps of forming a long-term memory are clear, the details, such as how exactly the molecular signals get shuttled to the command center, which generally has tight security, are unclear. A new study, led by neuroscientist Yi Zhong of Tsinghua University in Beijing, may finally have that answer. In the tiny minds of fruit flies, a protein called importin-7 acts to shuttle the memory-triggering signal into the nucleus with its top-level clearance to the restricted area, researchers report in the Proceedings of the National Academy of Sciences. With genetic tweaking, the researchers dialed up and down the amount of importin-7 in the flies and then put them through the memory training and test. They found that cranking up levels of the shuttle protein strengthened the long-term memories of the flies, while turning it off weakened their memory. "The current work confirms that [importin-7] is indeed critical at the behavioral level in mediating [long-term memory] consolidation," the authors concluded.

31 comments

  1. well, they did by turkeydance · · Score: 2

    but where did they put it?

    1. Re:well, they did by Anonymous Coward · · Score: 0

      Did they forget their findings?

      Scientists May Have Found ...

      Beat me to it ;)

    2. Re:well, they did by p0p0 · · Score: 1

      I forgot.

  2. From the article by 110010001000 · · Score: 5, Funny

    "We also acknowledge the contributions of Dr. Whats His Face and his assistant. The one with the big boobs. Jane something or other."

    1. Re:From the article by Anonymous Coward · · Score: 0

      I know a lot of women scientists are probably outraged at the "The one with the big boobs." statement. But just look at it the other way. Nobody EVER thinks of a guy as: "mr. big boobs". (well, usually). Hell, I'd love to be: "that dude with the nice rack who came up with General Relativity". **sigh**

    2. Re:From the article by Anonymous Coward · · Score: 0

      I'd love to be: "that dude with the nice rack who came up with General Relativity".

      You'd like to be dead?

  3. Fantastic malfunctions by invictusvoyd · · Score: 1

    Any one of these brains could teach us more about ours .
    http://www.neatorama.com/2008/...

    1. Re: Fantastic malfunctions by Anonymous Coward · · Score: 0

      You're assuming people here have a brain, which is a very poor assumption

  4. Hopeful, but too high to read the article by PopeRatzo · · Score: 4, Funny

    Scientists May Have Found Molecular Gatekeeper Of Long-Term Memory

    Please God, let it be weed.

    --
    You are welcome on my lawn.
    1. Re:Hopeful, but too high to read the article by Anonymous Coward · · Score: 0

      Well there is the guy who taught honeybees to love the resin of cannabis plants.

    2. Re:Hopeful, but too high to read the article by Anonymous Coward · · Score: 0

      I think weed just removes all the gatekeepers indiscriminately... you take enough and suddenly everything is exposed, introspection happens and you start thinking about your thoughts O_o if it does ease long term memory transition, the other effects are probably too great to notice...

      ...This is how over analytical I get if I'm not high.

    3. Re:Hopeful, but too high to read the article by PopeRatzo · · Score: 1

      That's deep. Say, you got any snacks around here?

      --
      You are welcome on my lawn.
  5. Well, that's actually easy to remember... by Anonymous Coward · · Score: 0

    ... because it's IMPORTIN7.

  6. memory blockers by Gravis+Zero · · Score: 1

    I've been assisting with the second phase of this project which is to medications to prevent the creation of long term memories . We are testing a few different compounds but so far no luck.

    --
    Anons need not reply. Questions end with a question mark.
    1. Re:memory blockers by Gravis+Zero · · Score: 1

      Hey! Who hacked my account and how do they know about my involvement?!

      --
      Anons need not reply. Questions end with a question mark.
    2. Re:memory blockers by Anonymous Coward · · Score: 0

      As one of the human test subjects, I have to say... shit ...what was I going to say?

      Oh yes. Riding your coattails is fun.

  7. Any practical applications? by mark-t · · Score: 1

    Because since it apparently requires making changes to genes, this method of memory enhancement kind of limits what would otherwise have been the most obvious applications for anybody who has already exited a womb.

    Or am I misunderstanding what "genetic tweaking" means?

    1. Re:Any practical applications? by Bite+The+Pillow · · Score: 1

      Since this is DashSlot, "genetic tweaking" could have been "generic twerking" or "general hospital" but it could mean epigenetic changes, methylation, or any of the things discovered in the last 15 plus years. I could read the article to you, but its much more fun to tell you to eat your butt.

    2. Re:Any practical applications? by Anonymous Coward · · Score: 0

      That is complicated, but gene therapy can be performed on developed organisms. Although thinking about think is a bit cart-before-the-horse since this is in a fruit fly. The practical application is better understanding how fruit fly memory works.

  8. Nonsense words, ignorant reader base? by vonvogel · · Score: 2

    I question the article ars article. Quoting: "a protein called importin-7 acts to shuttle the memory-triggering signal into the nucleus with its top-level clearance to the restricted area". "Top-level clearance" is just ridiculous in describing this biological process. Was the ars Technica article adapted to a computer knowing, but otherwise ignorant reader base?

    1. Re: Nonsense words, ignorant reader base? by Anonymous Coward · · Score: 0

      Thank you. Shows you how fucking stupid and vapid "tech" is

  9. Ok... by bytesex · · Score: 2

    "such as how exactly the molecular signals get shuttled to the command center, which generally has tight security, are unclear."

    This write-up simply *has* to have its own honorary place in the top-so-many of bad write-ups.

    --
    Religion is what happens when nature strikes and groupthink goes wrong.
    1. Re:Ok... by Anonymous Coward · · Score: 0

      "such as how exactly the molecular signals get shuttled to the command center, which generally has tight security, are unclear."

      Hackers using a default, hard-coded password on the command center's Cisco router.

    2. Re:Ok... by Anonymous Coward · · Score: 0

      It's a shocking summary, a copy paste of a second paragraph analogy from an over-simplified fluff piece. To be fair though, the submitter's comments suggest that Chinese, not English, is their primary language.

      Hackingbear submits a lot. The saddest part, their better - more technical - submissions are all skipped over, only this lowest quality hack-job bubbling up past the editor's filter.

  10. In the long-long-term? by symes · · Score: 1

    I'd be interested in the long term consequences of dialing up importin-7 - sure, recall of most recent events might be improved, but are they more likely to forget distant items as new information is stored? Brains are pretty darn sophisticated but still, without clever mnemonic tricks, memory is limited.

    1. Re:In the long-long-term? by Anonymous Coward · · Score: 0

      Sadly it doesn't even come close to starting to work like that.

      Importins are proteins that carry molecules between the cytoplasm and nucleus of cells.

      IMP7 does a lot than just memory. Reducing it, for example, in-vitro it has been shown to reduce HIV infection of cells.

      The long term effect of just "dialing it up" (or down) would be maybe smelling colours, maybe the loss of movement, maybe organ failure, maybe cancer, maybe death.

  11. More laughable 'research'. by Anonymous Coward · · Score: 0

    Outright fraud. Because human brains are nothing like fruit flies' brains, this is just more 'research for the sake of research', and will never amount to anything.

  12. importin-7 by Anonymous Coward · · Score: 0

    importin-7 Math;
    importin-7 Wife.Events.Special;
    importin-7 Common.Sense

  13. Obvious question: by avandesande · · Score: 1

    Coffee?

    --
    love is just extroverted narcissism
  14. Why fruit flies? by Anonymous Coward · · Score: 0

    Are they out of mice in China?

    1. Re:Why fruit flies? by Anonymous Coward · · Score: 0

      Here's how a cynical career researcher does things:
      1) Propose doing stuff on caenorhabditis elegans, get funding, do it
      2) Propose doing similar stuff on fruit flies, get funding, do it
      3) Propose doing similar stuff on zebrafish, get funding, do it
      4) Propose doing similar stuff on mice, get funding, do it
      5a) If you have tenure now, do what you like
      5b) If you don't have tenure but you are feeling old/rich enough, retire
      5c) figure out something else to do and repeat the same thing.