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American Scientists Working On Creating Chimeras: Half-Human, Half-Animal Embryos (ibtimes.com.au)

Researchers at the University of California, Davis are working on creating half-human, half-animal hybrid embryos dubbed chimeras to better understand diseases and its progression. But not everybody is thrilled about it. IBTimes reports: One of the aims of the experiment using chimeras is to create farm animals with human organs. The body parts could then be harvested and transplanted into very sick people. However, a number of bioethicists and scientists frown on the creation of interspecies embryos which they believe crosses the line. New York Medical College Professor of Cell Biology and Anatomy Stuart Newman calls the use of chimeras as entering unsettling ground which damages "our sense of humanity." They are not alone in voicing their opinion against the idea. Huffington Post adds: The project is so controversial that the National Institutes of Health has refused to fund it. The researchers are relying on private donors. Critics of these experiments say they are too risky because there is no way of knowing where the human stem cells will go. Will they just become a pancreas? Or could they become a brain? And if they become a brain, will the pigs who house them have human consciousness?

28 of 242 comments (clear)

  1. A Pig With Human Consciousness? by JayPee · · Score: 5, Funny

    A pig with human consciousness? They've already succeeded! Ladies and gentlemen, I give you Donald Trump.

    Thank you, thank you. I'll be here all night.

    1. Re:A Pig With Human Consciousness? by U2xhc2hkb3QgU3Vja3M · · Score: 2, Funny

      I think you just insulted pigs everywhere.

    2. Re:A Pig With Human Consciousness? by Hognoxious · · Score: 4, Funny

      Leave me out of it, monkey-boy.

      --
      Confucius say, "Find worm in apple - bad. Find half a worm - worse."
    3. Re:A Pig With Human Consciousness? by Roger+W+Moore · · Score: 2

      A pig with human consciousness? They've already succeeded! Ladies and gentlemen, I give you Donald Trump.

      I thought his problem is that he lacked a human conscience?

    4. Re:A Pig With Human Consciousness? by cellocgw · · Score: 2

      Then there is the pig without a conscious...Hillary

      Says the pig who can't tell the difference between "conscious" and "conscience."

      --
      https://app.box.com/WitthoftResume Code: https://github.com/cellocgw
  2. Prophetic Super Bowl by Ukab+the+Great · · Score: 4, Funny

    I guess PuppyMonkeyBaby was ahead of its time.

  3. It depends by Anonymous Coward · · Score: 4, Funny

    I'm absolutely against it for organ harvesting!

    On the other hand, I'm totally for it because that means we'll finally get catgirls, foxgirls, bunnygirls, etc!

    1. Re:It depends by NotDrWho · · Score: 2

      I shudder to think what the Furry community will do with this technology.

      --
      SJW's don't eliminate discrimination. They just expropriate it for themselves.
    2. Re:It depends by Archangel+Michael · · Score: 2

      Oh Great, a whole new Bathroom controversy as the Fury clans all want their own "non-human" bathrooms. Thanks Obama!

      --
      Agent K: A *person* is smart. People are dumb, stupid, panicky animals, and you know it.
    3. Re:It depends by slew · · Score: 2

      Oh Great, a whole new Bathroom controversy as the Fury clans all want their own "non-human" bathrooms. Thanks Obama!

      Nice try, they will of course be able to use the bathroom where they feel most comfortable...
      In the case of furries, perhaps they won't be comfortable in any bathroom and instead will be allowed to mark their own territory?

    4. Re:It depends by Applehu+Akbar · · Score: 4, Insightful

      "I'm absolutely against it for organ harvesting!"

      As with use of CRISPR tech, this is our first nibbling at the edges of a technology that will involve a host of delicate ethical choices as applications emerge. But the easiest of these ethical questions to resolve in favor of "go for it" is surely having farm animals grow human organs for transplantation. Even vegetarians would be mostly in favor of such a lifesaving application - or to put it another way, those who oppose it would quickly select themselves out of the population.

      A pig could be engineered to grow, not just a human kidney, but your kidney, cloned from your body. No more having to spend the rest of your life on anti-rejection drugs, risking death with every sniffle and paper cut.

    5. Re:It depends by meerling · · Score: 3, Funny

      For some reason that reminds me of a (fictional) quote in one of the Shadowrun books where the reporter is talking to a well known geneticist.

      "So what got you into genetics in the first place?"
      >"I had a dream."
      "A dream? Of what? Ending hunger and disease, creating world peace?"
      >"A redhead with legs up to here."

    6. Re:It depends by meerling · · Score: 4, Interesting

      We already use pigs for certain organ harvesting already.
      Where do you think most of those heart valve replacement 'donors' come from?
      All this would really do is increase the human viability of more tissues and organs.
      As to the brain, the porcine skull can't hold anything close to a human brain, and 'brain tissue' anywhere else would not be viable as a human brain either due to structural limitations, size, and vulnerability to damage from everyday actions. The human brain is on average 1320g, while a pig brain is only 180g. So the human brain is over 7 times the mass & volume. (I'm making a guess that their densities are relatively similar.)
      Sounds like more people afraid of more proof that humans are just a different kind of animal with specialization in generalized intelligence.

    7. Re:It depends by meerling · · Score: 2

      Getting tissues from non-human sources does run the risk of aiding a cross species jump for an infector, that's true.
      On the other hand, we do already transplant some pig parts into humans already.
      Of course, the flu seems to like crossing species boundries, and does it every couple of years. Here's an idea, don't use infected 'donors'. It's not perfect, but it will help. Of course, if you're choice was to wait for a compatible kidney that there's only a 4% chance of occurring before you are too far gone to receive, or maybe have already died, would you continue waiting for that 4%, or would you go for a non-human source of human compatible tissue?
      I suspect most people would choose the significantly higher probability of living over the other option. Also, what about all the people that are denied being on the list for one reason or another, such as being older, or having had a previous rejection? If there was a much more readily available source of organs, they too could have a shot at living.
      If you're worried about the pigs, well we eat them all the time, both for nourishment and just for plain enjoyment of the taste. What's so bad about including SAVING HUMAN LIVES in that equation?

  4. Ethics? by squiggleslash · · Score: 5, Funny

    If the problem is ethics, surely the solution would be to obtain military funding for this. A source of genetically engineered animal-human hybrids, combining the best features of both, would be invaluable to a modern military that needs new ways to fight a radically different type of enemy to that it was set up to do. The military could have at its disposal superhumans with animal senses, and at the same time push forward medical technology to benefit everyone.

    What could possibly go wrong?

    --
    You are not alone. This is not normal. None of this is normal.
  5. We were warned... by kwiecmmm · · Score: 4, Funny

    Al Gore tried to warn us about ManBearPig, but no one would listen to him.

    ManBearPig

  6. "our sense of humanity." put in perspective by Dorianny · · Score: 5, Insightful

    163.562 people died in 2014 due to wounds inflicted by other humans in armed conflicts around the world. 1.5 million children died in 2008 of vaccine-preventable disease and an estimated 3.5 million due to malnutrition. Considering the vast death and carnage that happens around the clock every single day, the idea that mixing genes in a test-tube is somehow dehumanizing to "our sense of humanity" is completely ludicrous

    1. Re:"our sense of humanity." put in perspective by 140Mandak262Jamuna · · Score: 4, Interesting
      And collectively human beings have never killed other human beings in such low levels ever in history. Get this human beings inherently violent, xenophobic and have gut level antipathy for everyone outside their extended family or clan. It is a great testament to the control of mind over instinct, they overcame this genetically wired violence and have peaceful, for the most part, by and large

      Focusing on the existing violence alone, and not putting it in proper context with historical trend lines is what called "making the perfect the enemy of the not-bad-and-its-getting-better".

      --
      sed -e 's/Chuck Norris/Rajnikant/g' joke > fact
  7. Caig Venter is upset by mugnyte · · Score: 2

    He couldn't get nearly this amount of press, and he's been customizing genes for a while now.

  8. Holy crap i want a half cat half dog by Anonymous Coward · · Score: 4, Funny

    Screw half human half animal, i want half cat half dog. Loyalty of a dog yet only shits on other people's lawns!

  9. Re:"the NIH has refused to fund it." by DamnOregonian · · Score: 4, Insightful

    Are you really trying to form an equivalency between genetic construction of a Chimera, and research on harvested fetal stem cells?

    And really with the political shit? left-wing?
    I'm a lefty (I think... hard to say these days), and I'm all for GMO chow, nuclear power, catdogs, bunnygirls, and not wasting the stem cells from terminated pregnancies. I don't feel like it's... political at all for me. Just logical.

    You need to get over yourself and your politics. Try to look at issues by their merit instead of whatever your coach tells you your team is all about.

  10. Manbearpig by HumanWiki · · Score: 2

    Sh*t... Al Gore was right!

  11. Sounds like a great idea... by Pollux · · Score: 3, Funny

    We'll create this "human organ farm" deep underground and convince all the organisms that they're the world's last hope for survival. We'll explain that a nuclear war made the vast majority of the world too contaminated for life, but a lone island presents hope for survival. We'll convince them that we'll use a lottery to "randomly select" who to send to this "island". All the while, we'll keep them ignorant and secluded, distracting them with organizational tasks like mixing particular organic molecules together to help feed growing organism embryos, and entertaining them with VR live-action versions of X-Box video games. Then, as long as we keep them secluded in this "distraction-dystopia", we don't need to worry about their consciousness, right?

    1. Re:Sounds like a great idea... by HumanWiki · · Score: 2

      We'll create this "human organ farm" deep underground and convince all the organisms that they're the world's last hope for survival. We'll explain that a nuclear war made the vast majority of the world too contaminated for life, but a lone island presents hope for survival. We'll convince them that we'll use a lottery to "randomly select" who to send to this "island". All the while, we'll keep them ignorant and secluded, distracting them with organizational tasks like mixing particular organic molecules together to help feed growing organism embryos, and entertaining them with VR live-action versions of X-Box video games. Then, as long as we keep them secluded in this "distraction-dystopia", we don't need to worry about their consciousness, right?

      Jordan Two Delta was hot.

  12. Diseases first, not Ethics by Roger+W+Moore · · Score: 4, Insightful

    Actually my first concern would be about diseases. Does having animals with human-like organs inside them make it easier for diseases which affect that animal to mutate into a version which will infect humans? Since we are talking pigs the example that comes to mind immediately is something like swine flu.

  13. What is our "sense of humanity"? by suupaabaka · · Score: 2

    I really want him to provide a definition of what a "sense of humanity" is, and apply it equally to a pool of well known individuals (Dalai Lama, Joseph Stalin, Charles Manson, Nelson Mandela) and try to avoid miring that definition in some sort of wishy-washy, mythical or biblical masturbation.

  14. Consciousness is not understood by axewolf · · Score: 2

    The sensations that come from our organs (other than the brain) profoundly influence our consciousness. Our mood, our thoughts, everything.
    What if our consciousness is not just centered in the brain but spread throughout the whole body?
    Do organs have their own consciousness that is a direct constituent of the highest-level consciousness of thought? Are there thoughts that you have that are a direct reflection of the sensation of a specific organ other than the ears, eyes, nose, and tongue?

    People are trained like dogs to eschew these kinds of questions, for precisely the reason that they interfere with commerce. But they must be answered eventually or humanity's greed will catch up with it: we will develop arts too powerful and create something we don't understand that consumes us. Possible candidates so far are the media, nuclear energy, and artificial intelligence. What next?

    The simple truth is this: some people are taking advantage of the relative standstill in the last ~2000 years of human moral development and education to do something horribly wrong, in every sense of the word, that they do not understand the implications of.
    Indeed, this is the story of modern civilization in general.

  15. Pointy Hats by JimSadler · · Score: 2

    The morality wizards are at it again. " Our sense of humanity" is so abstract that it can not be damaged. I doubt that there is much agreement at all on what our sense of humanity is. What moral wizards actually do is get attention, power, and positions for themselves. Yes, a pig could acquire a sense of self. But that pig need not know fear or know about death at all. Put the pig to sleep covertly and harvest what is needed from the pig. That pig could have a very happy life. Meanwhile you just might save millions of human lives with the parts and processes derived from these chimeras. So what kind of balance scale does one need to weigh a human life against "our sense of humanity"? Well "our sense of humanity"has zero weight on a balance beam. Hopefully even one human being has real weight.