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UW, Microsoft Successfully Encoded 200MB of Data Onto Synthetic DNA Molecules (seattletimes.com)

An anonymous reader writes from a report via The Seattle Times: Researchers from Microsoft and the University of Washington said Thursday that they had successfully encoded about 200 megabytes of data onto synthetic DNA molecules. The information included more than 100 books, translations of the Universal Declaration of Human Rights, and a high-definition music video from the band OK Go. Previously, the record was 22 megabytes encoded and decoded on DNA, said the researchers. Microsoft's lead researcher on the project, Karin Strauss, said DNA storage of the type demonstrated in the UW lab could, theoretically, store an exabyte (one billion gigabytes) of data in about one cubic inch of DNA material. "Our goal is really to build systems to show that it is possible," she said. DNA is also very durable. If stored in the right conditions, data encoded on DNA could be readable for thousands of years, compared to typical hard disks or flash drives that can fail in a few years.

46 comments

  1. Was it kb3035538? by Anonymous Coward · · Score: 1

    ...

  2. Déjà vu by Yvan256 · · Score: 3, Funny
    1. Re:Déjà vu by stooo · · Score: 1

      Now inject this MS software into a sheep's DNA....
      Hmm, in fact that's not new, MS is already making software for sheep since 30 years.

      --
      aaaaaaa
    2. Re:Déjà vu by Anonymous Coward · · Score: 0

      No. That's Apple you're thinking of.

  3. Thousands of blahblahblah by ilsaloving · · Score: 3, Insightful

    Why do people always feel the need to give such ridiculous longevity estimates? Especially when you factor in the real world, that sort of longevity simply doesn't happen unless you're etching into a plate of metal (gold?) that doesn't corrode readily.

    1. Re:Thousands of blahblahblah by avandesande · · Score: 1

      Yeah it doesn't really make any sense. PCR works because you have millions of copies of DNA, and if it is 10% decomposed it is in different areas so on average you get the information. Is the thing in the article making more than one copy?

      --
      love is just extroverted narcissism
    2. Re:Thousands of blahblahblah by Anonymous Coward · · Score: 0

      The Long Now Foundation uses Nickle-alloy disks because they are more durable than gold, and probably a lot less desirable to melt down into coins or jewelry

      The estimates for duration of DNA are probably in a cooled (low entropy) environment where there is no mechanism for replication (avoids mutation) and loss is due to molecular entropy. Similar estimates have been applied to the potential for recovering DNA from Mastadons as opposed to Dinosaurs (tens of thousands of years vs millions of years)

    3. Re:Thousands of blahblahblah by MagnumChaos · · Score: 1

      Actually, the best way we could store data would be optically, and use the benefit of storing data into diamonds and other hard materials (such as topaz and corundum).

    4. Re:Thousands of blahblahblah by rmdingler · · Score: 2

      The Long Now Foundation uses Nickle-alloy disks because they are more durable than gold, and probably a lot less desirable to melt down into coins or jewelry

      A modern day Socratic Conundrum...

      Well, the wedding is on there and most of the early photographs of the kids are on there, but shite, we need the money for groceries. Damn the luck.

      --
      Happiness in intelligent people is the rarest thing I know.

      Ernest Hemingway

    5. Re:Thousands of blahblahblah by WillAffleckUW · · Score: 1

      Actually, the best way we could store data would be optically, and use the benefit of storing data into diamonds and other hard materials (such as topaz and corundum).

      My eyes already have Property of Cybertron encoded on them

      --
      -- Tigger warning: This post may contain tiggers! --
    6. Re:Thousands of blahblahblah by Anonymous Coward · · Score: 0

      Don't know about the PCR bit. You usually do PCR when you *don't* have millions of copies of DNA. You do it when you have a few copies and you need more for whatever you're doing.

      If you were to buy the necessary bits of DNA to do this job from the company I work for you would get a little tube filled with multiple copies of each sequence you requested. I imagine they make more than one copy of their data pieces at a time.

      From the papers I've read, they aren't encoding this all into one strand. You make a vial full of "addressable" strands. And of course, there's error correction schemes in place.

    7. Re:Thousands of blahblahblah by Blaskowicz · · Score: 1

      The best is when you're in a prison cell guarded by deadly visible lasers, and your girlfriend smuggles in a storage diamond. You route deadly laser into the diamond and you get a 3D hologram showing you the escape route displayed in the air, right from the diamond.
      It must have been a very special kind of diamond too, as it didn't catch fire.

  4. Hmm... by EmeraldBot · · Score: 1

    So then what does that make us? Nothing but merely exobytes of data in a sack of liquid, filled with billions of much smaller exobytes of data in sacks of fluid? If we really find a way to manipulate DNA, we've unlocked life itself. Haven't we?

    --
    "Set a man a fire, he'll be warm for the rest of the night. Set a man afire, he'll be warm for the rest of his life."
    1. Re:Hmm... by Anonymous Coward · · Score: 0

      You are information. Nothing survives but information.

      Must be very annoying for materialists.

    2. Re:Hmm... by ClickOnThis · · Score: 1

      The human genome has about 3.2 billion base-pairs, each of which can be in one of four configurations. So, that's 6.4 billion bits, or about 800 megabytes. And that doesn't even consider the fact that the vast majority of "values" those bases can take on do not make a viable organism.

      You might be able to encode information in the inert portions of the human genome, but exabyes worth? Not a chance.

      --
      If it weren't for deadlines, nothing would be late.
    3. Re:Hmm... by slew · · Score: 1

      So then what does that make us? Nothing but merely exobytes of data in a sack of liquid, filled with billions of much smaller exobytes of data in sacks of fluid? If we really find a way to manipulate DNA, we've unlocked life itself. Haven't we?

      FWIW, we *already* have a ways to manipulate DNA (e.g., CRISPR/Cas9). However, we don't fully understand the code yet...

    4. Re:Hmm... by subanark · · Score: 1

      Sure you can, you just need to encode a different "genome" in each cell. However, I'd imagine that to have an effective multi-cell encoding technique you would store the data in RNA instead of DNA.

    5. Re:Hmm... by someone1234 · · Score: 1

      Nope, it isn't annoying. It is great, It is what makes stargates work.

      --
      Patents Drive Free Software as Hurricanes Drive Construction Industry
    6. Re:Hmm... by ThluksatorStrauch · · Score: 1

      You seem to be a bit behind. We have already found a way to manipulate DNA. Look up CRISPR.

    7. Re:Hmm... by bluefoxlucid · · Score: 1

      Does the human genome even fit in 1 cubic inch of DNA?

    8. Re:Hmm... by jellomizer · · Score: 1

      We have been for Generations that we have been on the cusp of understanding it all. The further we go the more details we find, causing more questions.

      --
      If something is so important that you feel the need to post it on the internet... It probably isn't that important.
  5. Metal backbone by Anonymous Coward · · Score: 0

    If you were to combine this DNA storage with that artificial DNA strand with a metallic backbone, it could last a long ass time indeed.

    Maybe one day in the future when we crack DNA, we could even encode actual junk DNA in our genes after we stabilize our DNA from our relatively quick evolution.
    Human history encoded in every human.

    Of course, at that rate, you may as well create true genetic memory and be done with it.
    No more education needed, it will all come to you as you age.
    I think we might need a new chromosome. Let's go logically to the next letter, Z. (funny that there is a "Z" already)

    1. Re: Metal backbone by Anonymous Coward · · Score: 0

      From reading your comments there, I'd say that you already have an extra chromosome.

  6. Needs better source by cdogg4ya · · Score: 1

    The article misses important information like which OK Go video this was. (Hopefully "This Too Shall Pass") given how Rube Goldberg this is...
    https://www.youtube.com/watch?...

  7. Gene Rodenberry, eat your heart out by subk · · Score: 1

    This sounds just like the Bio-neural Gel Packs from Star Trek

    --
    Now, if you'll excuse me, I have backups to corrupt.
    1. Re:Gene Rodenberry, eat your heart out by slew · · Score: 1

      Or maybe the chase... http://memory-alpha.wikia.com/...

  8. Junk DNA by bluegutang · · Score: 3, Interesting

    If you put your data into an organism's "junk DNA", then the data will last forever... (barring mutations)

    1. Re:Junk DNA by Yvan256 · · Score: 1

      What do you think we are?

    2. Re:Junk DNA by kshort · · Score: 2

      If you put your data into an organism's "junk DNA", then the data will last forever... (barring mutations)

      Very little "Junk DNA" is junk. miRNAs, gene regulatory regions, histone folding and regulation systems, chromatin folding hotspots. Anyway, if there is true Junk DNA, it will be under less selective pressure and very quickly become riddled with mutations and errors. Moreso than protein encoding regions. The best way to do it would to be to place an index somewhere in the genome containing references to locations within the existing coded/exome areas -- which already contain a pre-existing massive dictionary of 4-5-n base sequences. Mapping the data would be a bitch, but if you're that desperate to encode data long term, it might be worth it. Providing your mouse/rabbit/fly/c.elegans colony doesn't die in flood/heat/poisoning/infection etc.

  9. Multi-pass by CaptnCrud · · Score: 1

    Say what you want about that movie (and I've met a few people that genuinely didn't like it at all, from a plot standpoint I can't say I blame them...)...there are so many things that movie got right that seemed way outlandish even to me at the time.

    Leeloo is 3d printed for crying out loud, I think most people can see at the very least replacement body parts and organs 3d printed in the next 10-15 years. Pretty exciting time to be alive really...i'm willing to bet people will be living an extra 100++ years easily very soon...assuming we can get other things like alzheimer's and other degenerative brain diseases under control too.

    Haha, I can see it now, there will be people against synthetic or hybrid cybernetic parts but consider the organic ones ok, or something akin to people preferring a more "natural" or homeopathic solution like they do today.

    1. Re:Multi-pass by Peristaltic · · Score: 1

      Haha, I can see it now, there will be people against synthetic or hybrid cybernetic parts but consider the organic ones ok, or something akin to people preferring a more "natural" or homeopathic solution like they do today.

      Sure they're going to be against the hybrid parts- Don't forget who's working on this stuff.

      Do you really want "Upgrade now to Microsoft Cornea 15" popping into your field of vision when you're trying to control your flying car?

      God help us if they bring Clippy back: "I see you're trying to perform intercourse with a defective pecker- would you like to upgrade?"

    2. Re:Multi-pass by Plus1Entropy · · Score: 1

      people will be living an extra 100++ years

      So... 101 years?

      --
      Only crack the nuts that crack. You don't put the ones that don't crack in the sack.
    3. Re:Multi-pass by jellomizer · · Score: 1

      Replacing body parts is still a risky procedure. Being able to grow body parts will more likely help get people off of donors lists. And having to make decisions on if someone is worthy of a treatment or not. So it may help out a bit. But in terms of immortality. We don't see someone living long times by taking parts that fared better off their identical twin who had experienced an "Accident". Because there is other ways of getting useful body parts without printing them.

      --
      If something is so important that you feel the need to post it on the internet... It probably isn't that important.
  10. Sounds like copyright infringement by swm · · Score: 3, Funny

    The information included [...] a high-definition music video from the band OK Go.

    Sounds like copyright infringement.
    Maybe the BSA should get on the case.

    1. Re:Sounds like copyright infringement by flyingfsck · · Score: 1

      Well, not much copyright infringement if anything - 200 MB, is only about one empty MS Word document.

      --
      Excuse me, but please get off my Pennisetum Clandestinum, eh!
  11. New nucleotides and engineered polymerases by kshort · · Score: 1

    I think I could do better than 200 meg. It doesn't sound like a significant enough jump and nor is it a huge improvement over the previous proof of concept. Plenty of companies (particularly asian ones) to long/large scale custom synthesis. The reading of the code isn't difficult these days. Assembly of the sequences into meaningful files is probably the trick. I think a true advance would be making synthetic or highly modified polymerases which can incorporate synthetic pyrimidines/uridines into a "hyper DNA" which could improve on the 4 base nucleotide array available. Imagine a 5, 10, 26 base code. If the "DNA" doesn't have to be duplicated by an organism, it can be anything. Imagine the packing density then.

  12. Clippy to the rescue by Anonymous Coward · · Score: 0

    It looks like you're creating homicidal nocturnal mutants

    Would you like help?

  13. data mining with PCR? by slew · · Score: 1

    Maybe I should hurry up and file a patent... ;^)

  14. Spy could hide data in a mole on their arm by Anonymous Coward · · Score: 1

    Could you imagine spy's using this technology to encode data into moles on their skin. Would be pretty hard to detect.

  15. Microsoft is pushing for the technology ... by Anonymous Coward · · Score: 0

    .. so that by the time Windows 20 comes out, there will be enough storage to actually run it.

  16. Virus by manu0601 · · Score: 4, Funny

    Now, we are going to see DNA-based computer virus!

    1. Re:Virus by jfdavis668 · · Score: 1

      or maybe your computer will just catch a cold.

    2. Re:Virus by Anonymous Coward · · Score: 0

      Now, we are going to see DNA-based computer virus!

      Better. DNA based DRM.

  17. HYPE METER AT 11 by Anonymous Coward · · Score: 2, Informative

    Cost of writing information: 200 MB data = 20 Mbp DNA = $200,000 USD @ $0.01 /bp. The cost was $0.30/bp for the past decade, and it's recently dropped to $0.07/bp for short fragments with the latest scale-down improvements. Some serious scale-down innovations need to occur before they drop further -- DNA synthesis costs do NOT follow a Moore-like law because DNA oligos are still produced via chemical reactions on solid supports and scale-downs have led to poor kinetics and poor yields. Cost reductions are possible, but they need to drop by a factor of 100X to even remotely compete with silicon or magnetic tape.

    Cost of reading information: 200 MB data = 20 Mbp DNA = 1 MiSeq next-gen sequencing run = 150 nt read length x 10 million reads = 75X coverage = about $1100. So your reads are not cheap, and are only performed once -- ie, DNA storage could only be used as long-term write-once, read-rare storage.

    Information Lifetime: "Under the right conditions, Ceze said, data encoded on DNA could be readable for thousands of years." This is a laughable statement. Under the right conditions, *any* storage medium is readable for thousands of years. So let's be serious about this. There are many real-world conditions where DNA molecules will have a lifetime of days, or even hours.

    For example, if your spit or sweat accidentally mix with the DNA, some enzymes (called DNAses) could contaminate your DNA. Guess what happens? Chop chop chop chop chop. That's your information going bye bye! It doesn't have to be human spit/sweat, *any* biological contamination (bacteria, protozoa, etc) will see your DNA storage as a tasty treat to eat. Yum yum yum yum! Bye bye information! What about DNA storage in space? Well, that will certainly need some heavy duty radiation shielding because *surprise* just about every form of high energy radiation will break or mutate DNA -- UV, X-rays, gamma, etc. So even sending DNA into space for storage doesn't guarantee unlimited longevity.

    It's also quite amusing that DNA (as a polymer) is not that dissimilar to another highly stable, recalcitrant polymer called cellulose, otherwise known as PAPER. Under the right conditions, PAPER *is also* readable for thousands of years. Now, paper isn't perfect, but I would choose paper over DNA for long-term storage in every way. Vacuum seal it. Firepoof it. Done. Cost to read? $0.

     

  18. It's alive!!! by Anonymous Coward · · Score: 0

    Up next: self-replicating virus infects thousands, spreading through organic mainframes