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Alzheimer's Gene Already Shrinking Brain By Age of Three (telegraph.co.uk)

schwit1 quotes a report from The Telegraph: The Alzheimer's gene, which dramatically raises the risk of developing dementia, is already affecting carriers by the age of three, shrinking their brains and lowering cognition, a new study suggests. Children who carry the APOEe4 gene mutation, which raises the chance of dementia by 15 fold, were found to do less well in memory, attention and function tests. Areas of the brain affected by Alzheimer's disease, such as the hippocampus and parietal gyri, were also found to be up to 22 percent smaller in volume. [Around 14 percent of people carry the APOEe4 mutation. The research is the first to show that genetic changes which can lead to Alzheimerâ(TM)s are already affecting the brain extremely early in life. Scientists from the University of Hawaii, Yale and Harvard say screening for the gene could help doctors identify which children could benefit from early interventions, such as educational help, preventative treatments, health monitoring and increased exercise. The study involved 1,187 youngsters between the age of three and 20 who took part in genetic tests and brain scans as well as undertaking a series of tests to measure their thinking and memory skills.] According to research from Oregon Health and Science University (OHSU), infrequent use of a computer in later life could be an early sign of reduced cognitive ability.

62 comments

  1. Anyone... by Anonymous Coward · · Score: 0

    Anyone else annoyed by the add-on things below the Slashdot summaries?
    Like in this one:

    According to research from Oregon Health and Science University (OHSU), infrequent use of a computer in later life could be an early sign of reduced cognitive ability.

    1. Re:Anyone... by EzInKy · · Score: 1

      I ignore such tripe. Or, at least I will as long as I can recognize spam as spam.

      --
      Time is what keeps everything from happening all at once.
    2. Re: Anyone... by Anonymous Coward · · Score: 0

      Adding on unrelated news to stories is also an early warning sign of reduced cognitive ability.

    3. Re: Anyone... by Anonymous Coward · · Score: 0

      Perhaps the /. editors should get the size of their brains checked, as it's likely shrinking.

  2. Re:Soda Cans by EzInKy · · Score: 0

    So aluminum is the culprit then? I've heard that but not convinced enough by the evidence to quit buying reynold's wrap.

    --
    Time is what keeps everything from happening all at once.
  3. We shall see. by Anonymous Coward · · Score: 3, Interesting

    According to research from Oregon Health and Science University (OHSU), infrequent use of a computer in later life could be an early sign of reduced cognitive ability.

    That study only showed an association between computer use and cognitive decline. And what I haven't seen is if folks who are suffering cognitive decline are reducing reading and other cognitive pursuits.

    Folks and the media extrapolate too much from individual studies - like that ONE study that showed that babies who heard Mozart in the womb became smarter and all those parents went out and bought Mozart CDs.

    And this study? Well we'll see.

    1. Re:We shall see. by Hognoxious · · Score: 1, Funny

      Mozart is overrated. He just chucks large numbers of notes about.

      --
      Confucius say, "Find worm in apple - bad. Find half a worm - worse."
    2. Re:We shall see. by GLMDesigns · · Score: 1

      I think the quote is "There are simply too many notes" "Just cut a few and it'll be perfect."

      --
      If you're scared of your govt then you need to further restrict its powers
      Vote 3rd Party in 2016 and beyond
    3. Re:We shall see. by Anonymous Coward · · Score: 0

      Disney soundtracks ought to be enough for anybody.

  4. Re: Soda Cans by Anonymous Coward · · Score: 1

    Try latex condoms. I did. They worked so well I swore off aluminium years ago.

  5. bollocks by l3v1 · · Score: 3, Funny

    "infrequent use of a computer in later life could be an early sign of reduced cognitive ability"

    However, infrequent reading of idiotic articles might just be an early sign of higher intelligence.

    --
    I am putting myself to the fullest possible use, which is all I can think that any conscious entity can ever hope to do.
  6. "Alzheimerâ(TM)s" by Anonymous Coward · · Score: 0

    Did someone just copyright Alzheimer's disease?

    1. Re:"Alzheimerâ(TM)s" by Anonymous Coward · · Score: 0

      No, just lazy editors not filtering out junk characters that don't render. They are trying to incite a riot for unicode, which real people DO NOT WANT! We don't want their politically correct smileys around here. Unfortunately management has decided to change the place from a tech forum into another facebook sociomedia platform. So unicode, like ISIS, is about to make its grand arrival very soon, by the truckload...

    2. Re: "Alzheimerâ(TM)s" by Anonymous Coward · · Score: 0

      No, they trademarked it.

    3. Re:"Alzheimerâ(TM)s" by Anonymous Coward · · Score: 0

      Hey now. You can't expect BeauHD to use the preview button to read the text and make sure that it's rendering correctly. He's too busy searching for marginally related slashdot stories to link below the actual summary in order to drive up page views!

  7. Re: Soda Cans by EzInKy · · Score: 1

    Totally agree! My girlfriends all are totally turned off by aluminum raincoats.

    --
    Time is what keeps everything from happening all at once.
  8. Re: Soda Cans by Anonymous Coward · · Score: 0

    This came from a study of bauxite miners that had a high diagnosis rate for Alz. No other correlation, and the sample size was way too small. Nothing to see here.

  9. Re:Soda Cans by Anonymous Coward · · Score: 0

    The aluminum can give you Alzheimer.

    I don't drink from it.

    I only wear it as a hat.

  10. Starts all brain damage at a young age? by Anonymous Coward · · Score: 1

    The constant preaching of hatred towards the western civilization and the indoctrination that any failure is the cause of this western civilization starts to form irreversible neurological links in the brain at the age of three. This can manifest at a later age by either cheering for every death after any terrorist attack, or by always asking more and more privileges, or by asking to get more and more positive discrimination, or by simply driving a truck through a crowded avenue where people are celebretating the liberation of the people from the ancient regime, Liberty, egality and fraternity.

    The disease is unknown, although some people suggest that it maybe has to do with the indoctrination of an ideology of hate that is disguised as a religion of peace at a very young age. But an UN law that was introduced by the president of the United States bans these kind of ideas from being part of free speech.

    The desease is no longer a desease. Talking about the desease has become not only the most awful desease, but even an act of pure evilness.

    But I can't help myself when I look at indoctrinated people, who often were indoctrinated at a very young age, and think they suffer from brain damage. It doesn't matter if they are Catholic, Calvanist, Lutherian, Meuniete, Old Christian, or that ideology that may not be named anymore, ... It's followers have a lack of common sense, and healing only works when the fight hard every single day, helped by people they work and live with everyday.

  11. Re:Soda Cans by jellomizer · · Score: 4, Funny

    You are well aware that Aluminum foil only amplifies your brain waves to be spied on by the government.
    Made by NASA National Aluminum Security Administration as a way to transmit brain waves. Then starting the rumor that it suppose to stop it. So the people who are guilty and with something to hide will begin wearing it as hats. However they found that small doses are effective as well. So they started putting in food prep selling it as a corrosion resistant substance, and subsidizing it to make it a cheap container. for Soda, and cooking ware. So everyone has aluminium in their bodies. What we call Alzheimers is actually just a long term sucking of our brainwaves from the government, meaning after 70 or so years of exposure are mental capabilities are ran dry.

    --
    If something is so important that you feel the need to post it on the internet... It probably isn't that important.
  12. Funny thing about being born... by Anonymous Coward · · Score: 0

    It's just a (hopefully) long march to death afterwards.

    1. Re:Funny thing about being born... by gweihir · · Score: 1

      Definitely one thing where being goal-oriented is not an advantage ^^

      --
      Most ACs are not even worth the keystrokes to insult them. Be generically insulted by this and ignored otherwise.
    2. Re: Funny thing about being born... by Anonymous Coward · · Score: 0

      Hey, you don't know what happens after death. Could be fun.

  13. So my brain is shrinking... by Anonymous Coward · · Score: 0

    What's your excuse?!

  14. gene by Anonymous Coward · · Score: 0, Funny

    The Trump gene, which dramatically raises the risk of developing dementia, is already affecting carriers by the age of three, shrinking their brains and lowering cognition, a new study suggests. Children who carry the TPOEe4 gene mutation, which raises the chance of dementia by 15 fold, were found to do less well in memory, attention and function tests. Areas of the brain affected by Trump's disease, such as the hippocamtrump and parietrump gyri, were also found to be up to 22 percent smaller in volume. [Around 14 percent of people carry the TPOEe4 mutation. The research is the first to show that genetic changes which can lead to Trumpâ(TM)s are already affecting the brain extremely early in life. Scientists from the University of Hawaii, Yale and Harvard say screening for the gene could help doctors identify which children could benefit from early interventions, such as educational help, preventative treatments, health monitoring and increased exercise. The study involved 1,187 youngsters between the age of three and 20 who took part in genetic tests and brain scans as well as undertaking a series of tests to measure their thinking and memory skills.]

  15. Trademark by Anonymous Coward · · Score: 0

    Is "Alzheimerâ(TM)s" trademarked?

    Doctor: Congrats, you dont have alzheimers, you have a something thats excactly like it.

  16. IRL by Anonymous Coward · · Score: 0

    >Scientists from the University of Hawaii, Yale and Harvard say screening for the gene could help doctors identify which children could benefit from early interventions, such as educational help, preventative treatments, health monitoring and increased exercise.

    IRL, society does not give a shit about helping others. No heath care but for the richer.

    1. Re:IRL by GLMDesigns · · Score: 2

      Which is why society is spending itself to oblivion in social programs? Or maybe you're full of sh!t

      --
      If you're scared of your govt then you need to further restrict its powers
      Vote 3rd Party in 2016 and beyond
  17. News: Donald Trump Farted by Anonymous Coward · · Score: 0

    In other news, 84 people were murdered, but since it didn't happen in the USA we're not going to bother discussing it.

  18. Shrinking from the age of 3?? by Viol8 · · Score: 2

    If the brain starting shrinking again at the age of 3 - an age at which it isn't even close to its adult size - the sufferers would never mentally progress beyond that age. Clearly they do so this article is rubbish from the 1st sentence.

    1. Re:Shrinking from the age of 3?? by Anonymous Coward · · Score: 0

      If the brain starting shrinking again at the age of 3 - an age at which it isn't even close to its adult size - the sufferers would never mentally progress beyond that age. Clearly they do so this article is rubbish from the 1st sentence.

      One assumes this is in comparison to some age-normalized, as opposed to an absolute, sizing standard.
      Have you considered genetic testing?

    2. Re:Shrinking from the age of 3?? by budgenator · · Score: 1

      It the Telegraph, I'm sure most of their editors and writers are APOEe4 carriers; one wouldn't expect them to know the difference between not growing to the expected size and shrinking.

      --
      Apocalypse Cancelled, Sorry, No Ticket Refunds
  19. Re:Soda Cans by Anonymous Coward · · Score: 0

    You are well aware that Aluminum foil only amplifies your brain waves to be spied on by the government.
    Made by NASA National Aluminum Security Administration as a way to transmit brain waves. Then starting the rumor that it suppose to stop it. So the people who are guilty and with something to hide will begin wearing it as hats. However they found that small doses are effective as well. So they started putting in food prep selling it as a corrosion resistant substance, and subsidizing it to make it a cheap container. for Soda, and cooking ware. So everyone has aluminium in their bodies. What we call Alzheimers is actually just a long term sucking of our brainwaves from the government, meaning after 70 or so years of exposure are mental capabilities are ran dry.

    That's why you are supposed to be running electricity through it. Plug the hat into the nearest AC socket.

  20. Re:Soda Cans by Stewie241 · · Score: 1

    >> You are well aware that Aluminum foil only amplifies your brain waves to be spied on by the government.

    That is a lie spread by the government to get us to stop wearing our hats.

  21. infrequent use of a computer by Anonymous Coward · · Score: 0

    "infrequent use of a computer in later life could be an early sign of reduced cognitive ability."

    -- Ok, I am not in immediate danger, can carry on

  22. Prions by Anonymous Coward · · Score: 0

    Is there a prion gene? A kuru, or a CJD gene? A chronic wasting gene? A madcow gene? Maybe a scrapie gene? Or might Alzheimer's be a variant of one of those, and not genetic. ? . ? .

  23. Re:Soda Cans by Anonymous Coward · · Score: 0

    Good thing I stopped using that nasty aluminum years ago. Today I only drink from right proper aluminium cans - none of that nasty business the yanks put out.

  24. Re:Soda Cans by Ol+Olsoc · · Score: 1

    So aluminum is the culprit then? I've heard that but not convinced enough by the evidence to quit buying reynold's wrap.

    Yeah, that AL= Alumina plaque thing was kind of like a folk merdicine cause,

    --
    The shepherds did so well protecting the flock that the sheep no longer believed that wolves existed.
  25. Re: Soda Cans by Ol+Olsoc · · Score: 1

    Totally agree! My girlfriends all are totally turned off by aluminum raincoats.

    Replace the batteries?

    --
    The shepherds did so well protecting the flock that the sheep no longer believed that wolves existed.
  26. Re:Soda Cans by budgenator · · Score: 1

    Aluminium compounds tend to be very low in solubility so it is unlikely to have any effect on us, not to mention it's common metal compound in the Earth's crust anyway.

    --
    Apocalypse Cancelled, Sorry, No Ticket Refunds
  27. Re:Soda Cans by budgenator · · Score: 2

    You have to use Tin, Real tin is what works, Aluminium is for shit.

    --
    Apocalypse Cancelled, Sorry, No Ticket Refunds
  28. Original Article by sackvillian · · Score: 1

    Took some digging, but here is the original study (paywalled).

    Contrary to the click-baity Telegraph article linked, the brains were not shrinking -- there was a correlation between the most strongly linked genes to Alzheimer's and relatively smaller/thinner areas of the brain associated with things like memory and executive function. There was also a correlation between these thin areas and reduced ability of the tested children.

    If reproducible, this result would be absolutely shocking. Our current understanding is that the genes in questions (APOE 4) are not even associated with early-onset Alzheimer's, only late-onset, and even then the association is so weak that screening is unjustifiable.

    --
    Hey mate, spare a sig?
  29. NOT being computer-addicted is a danger sign? by gweihir · · Score: 1

    This one is funny. Apparently, the universe has a sense of humor...

    --
    Most ACs are not even worth the keystrokes to insult them. Be generically insulted by this and ignored otherwise.
    1. Re:NOT being computer-addicted is a danger sign? by alvinrod · · Score: 1

      It doesn't have anything to do with computer addiction, rather a decrease in activities that are cognitively challenging. It's similar to how a person who does less reading as they age may be doing so due to cataract build-up which makes it more difficult for them to see and by extension read.

    2. Re:NOT being computer-addicted is a danger sign? by gweihir · · Score: 1

      And why do you think this explanation is necessary? Have you missed the satiric character of the posting entirely?

      --
      Most ACs are not even worth the keystrokes to insult them. Be generically insulted by this and ignored otherwise.
  30. Indeed Hillary by Anonymous Coward · · Score: 0

    You carry the LeftCorrupt5 gene.

  31. NOT by Anonymous Coward · · Score: 0

    Hillary's friends showed their true colors.

    It's all one big Darwin Test. If you believe the Marxist nonsense, your genes will be removed from pool and be replaced by those who paid of the Marxists.

  32. Re:Soda Cans by Anonymous Coward · · Score: 0

    >> You are well aware that Aluminum foil only amplifies your brain waves to be spied on by the government.

    > That is a lie spread by the government to get us to stop wearing our hats.

    No, that's what the government wants you to think.

  33. Since there is no cure.. by Anonymous Coward · · Score: 1

    Why dont they detect the gene in utero early in the pregnancy so the parents can abort if they so choose?

  34. Re: Soda Cans by Xamindar · · Score: 1

    Thanks for posting this. Why does this stuff not receive more coverage? Is there some flaw to this way of thinking?

  35. No danger of Alzheihmer's here! by Steve1952 · · Score: 1

    If computer use correlates inversely with risk of Alzheimer's, then I suspect that Slashdot readers are going to be completely immune from the disease.

  36. That explains it by tgrigsby · · Score: 0

    Around 14 percent of people carry the APOEe4 mutation... shrinking brain by age of three...

    Finally! An explanation for those crazy-ass Trump supporters that started off as Sanders supporters...

    --
    *** *** You're just jealous 'cause the voices talk to me... ***
  37. It's not computer use, so much as following events by Anonymous Coward · · Score: 0

    It's not computer use per-say but anything that requires you to follow a story or line of thought. As my grandmothers alzheimers progressed, a life long reader and TV watcher slowly just stopped unable to remember/follow events.

    Terrible way to die/live... If It comes my way, I hope theres a good moment of clarity where I can turn on the helium.

    I've given thoughts to some devices that could be built that required an action/puzzle code entered every X days; and if not(correct) it would kill you.. Once your mind deteriorates to that point....problem solved. hmmm I suppose it could be of use in the public school system for attention and lesson retention.. ;p

  38. Genetic may be an illusion. by Anonymous Coward · · Score: 0

    A friend of me said to me that genetic as we understand it is not real. It is an illusion. Chromosomes do not exists. They are ghosts images in the microscopes. How could I check this ? I was showed pictures and photographies and explanations of chromosoms, as a child in school. Now some people say to me : that was illusions. Some bouddhists monks pretend all the reality is in fact illusions, and that the only reality should be love and care and help and beauty.

    Is the bread an illusion too ? Is the water an illusion ?

  39. Re:Soda Cans by sysrammer · · Score: 1

    Case in point: "after 70 or so years of exposure are mental capabilities are ran dry".

    --
    His ignorance covered the whole earth like a blanket, and there was hardly a hole in it anywhere. - Mark Twain
  40. Re:Soda Cans by sysrammer · · Score: 1

    That's why you are supposed to be running electricity through it. Plug the hat into the nearest AC socket.

    No, you're buying into Edison's game. Tesla had the answer: plug your hat into a rectifier.

    --
    His ignorance covered the whole earth like a blanket, and there was hardly a hole in it anywhere. - Mark Twain
  41. Re:Soda Cans by Anonymous Coward · · Score: 0

    >> You are well aware that Aluminum foil only amplifies your brain waves to be spied on by the government.

    > That is a lie spread by the government to get us to stop wearing our hats.

    No, that's what the government wants you to think.

    Don't listen to him/her/hit, he/she/shit is an agent, hence the AC posting.

  42. Go Bows! by Anonymous Coward · · Score: 0

    "Scientists from the University of Hawaii, Yale and Harvard"

    How often does UH get mentioned with Yale and Harvard? Anyone want to play the "which one is not like the other" game?

  43. two edged sword by superwiz · · Score: 1

    poor memory is not necessarily a downside. understanding is not just repurposing of knowledge to new contexts. it's also culling of unimport information. and forgetting is a culling mechanism. so this may be useful in long-term study of complicated ideas (the ones which require deep perception).

    --
    Any guest worker system is indistinguishable from indentured servitude.
  44. Re: Soda Cans by Anonymous Coward · · Score: 0

    I don't know anything about Chris other than that video, but I like how he doesn't pretend to know everything and is really just trying to get everyone to ask questions.