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Video Shows How Bacteria Invade Antibiotics And Transform Into Superbugs (npr.org)

guises writes: By making a giant petri dish out of bands of increasingly antibiotic-laced agar, a couple of microbiologists have created a means to watch bacterial evolution as it happens: colonies introduced to the dish expand to fill the areas in which they can survive and then mutate and spread into the areas in which they can not. It takes only eleven days for the bacteria to evolve sufficient resistance to survive in an area with a thousand times the concentration of antibiotics that would have killed the original colonies. And it makes a pretty neat video.

19 of 87 comments (clear)

  1. Re:What a waste! by Anonymous Coward · · Score: 3, Funny

    Yeah, but how many of them survived the incinerator? Or just pour some bleach into the dish.

    It wasn't wasted. They just created a new condiment for Chipotle restaurants.

  2. Re:Misleading headline by Immerman · · Score: 4, Insightful

    Which is exactly what you want when you're investigating / demonstrating a single process.

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    --- Most topics have many sides worth arguing, allow me to take one opposite you.
  3. DNA analysis? by ceo2 · · Score: 4, Interesting

    has anyone compared the DNA of the final generations to determine if they are genetically identical or radically different?

    1. Re:DNA analysis? by meerling · · Score: 4, Informative

      That has been done before and they are different. Also, there's not just one mutation that can occur to create antibiotic resistance, they've cataloged a large number of them that can each result in resistance.

    2. Re:DNA analysis? by RockDoctor · · Score: 2

      has anyone compared the DNA of the final generations

      Yes they did. It's in the Science paper at http://science.sciencemag.org/... (Sci-hub at http://science.sciencemag.org....) They sequenced several hundred of the mutant strains, plus, of course, multiple isolates of the wild-type strains (as wild types drift, even without deliberately applied evolutionary pressures).

      to determine if they are genetically identical or radically different?

      To no-one's surprise, when they sequenced up to a dozen isolates in a lineage which negotiated their "antibiotic landscape," they found small differences between individual isolates.

      The paper is worth reading because your next three questions are probably answered before you formulate them.

      --
      Birds are not dinosaur descendants;birds are dinosaurs, for all useful meanings of "birds", "are" and "dinosaurs"
  4. Re:Title is incorrect by rtb61 · · Score: 3, Insightful

    Bacteria do not evade antibiotics, they die and quite simply those that are not affected by the particular anti-biotic survive and reproduce. As the bacteria are relatively simple and they DNA is also relatively simply, they can only be resistant to a limited number of potential antibiotics, so new anti-biotics mixes can simply be many older ones mixed together, don't kill the bacteria with one, kill it with the other, they could also add in immune system supplements to power up the immune system in conjunction with the anti-biotic mix. As the anti-biotic mix could be quite a large dose, it would be better that side affects do not compound but impact the body in different ways, so many smaller side affects rather than compounding side affects.

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    Chaos - everything, everywhere, everywhen
  5. Re:What a waste! by meerling · · Score: 4, Interesting

    Among other things, to analyse the resultant resistant strains and how they developed their resistance. Doing such things they have found that there's no one method to develop resistance. That kind of data and testing has also been used to develop new methods to help fight the resistant strains, though of course, they eventually adapt to those as well since none of our methods are 100% effective at wiping them out, thus there is always the possibility to develop resistance.

  6. Re:Heathens! Pagans! This is the devil's work! by meerling · · Score: 2

    So was your post a sarcastic joke, or are you actually one of those anti-science fools?
    I can't tell as you write the exact same things they do.

  7. Re:Title is incorrect by meerling · · Score: 2

    The didn't invade or evade the antibiotic, they just became resistant to it. But yes, I agree, the article has a poorly written title.

  8. Re:Title is incorrect by meerling · · Score: 2

    It wasn't just slashdot, that's the title of the article slashdot linked to.

  9. Now this is cool! by McLae · · Score: 4, Informative
    A very graphic way of showing selection in action.

    Now you know why your doctor says take all the pills in the prescription. You want to be at 1000, not 1.

    1. Re:Now this is cool! by secretsquirel · · Score: 2

      Would also be curious to see a video where the first stripe was 10 or 1000. If they're not allowed to develop resistance gradually how long does it take?

  10. Title is Correct by georgehh6 · · Score: 2

    Just read the article and watched the video. The video has areas that have no antibiotics that's where the bacteria start. Further in areas have higher concentrations of antibiotics. The bacteria colonizes into the antibacteria areas they are literally invading the antibiotic material / area.

    1. Re:Title is Correct by guises · · Score: 4, Informative

      It's not the title I submitted: "Scientists create invincible super bacteria in order to make a cool video"

      Oh well, it bothers me more that they changed "couldn't" to "can not." Let it be known: I got the tense right.

  11. Re:Heathens! Pagans! This is the devil's work! by kanweg · · Score: 2

    We remember these people for what they contributed to mankind, not for their superstitions.

    Newton was into alchemy (and religion). I'd say he has wasted the rest of his life with it. But hey, it was his life so he got to spend it like he wanted it. I didn't have any right that he'd spend it the way I would have liked it anyway. But still, what a waste.

    Bert

  12. Re:What a waste! by sexconker · · Score: 2, Funny

    That depends on how slowly they were fed into the incinerator or how slowly the concentration of bleach was raised.

  13. Re:Heathens! Pagans! This is the devil's work! by Plus1Entropy · · Score: 2

    Poe's Law in all it's glory.

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    Only crack the nuts that crack. You don't put the ones that don't crack in the sack.
  14. Re:Heathens! Pagans! This is the devil's work! by Plus1Entropy · · Score: 3, Interesting

    Too bad a bunch of other avowed Christians were likely responsible for cutting Turing's life in half. Also, I'll give you Babbage, but Boole was leaning hard towards deist.

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    Only crack the nuts that crack. You don't put the ones that don't crack in the sack.
  15. on a positive note by cas2000 · · Score: 4, Funny

    it's a good thing that nobody's dumb enough to routinely dose cattle and chicken and other livestock with anti-biotics. that would enable resistant bugs to evolve and spread everywhere.