Alcohol Switches the Brain Into Starvation Mode In Mice, Increasing Hunger and Appetite, Study Finds (bbc.com)
An anonymous reader quotes a report from BBC: In tests on mice, alcohol activated the brain signals that tell the body to eat more food. The UK researchers, who report their findings in the journal Nature Communications, believe the same is probably true in humans. The mice were given generous doses of alcohol for three days -- a dose being equivalent to around 18 units or a bottle-and-a-half of wine for a person. The alcohol caused increased activity in neurons called AGRP. These are the neurons that are fired when the body experiences starvation. The mice ate more than normal too. When the researchers repeated the experiment but blocked the neurons with a drug, the mice did not eat as much which, the researchers say, suggests that AGRP neurons are responsible for the alcohol-induced eating. The study authors, Denis Burdakov and colleagues, say understanding how alcohol changes the body and our behavior could help with managing obesity. Around two-thirds of adults in the UK are overweight or obese.
when the researchers repeated the experiment but blocked the neurons with a drug, the mice did not eat as much ...
You reaise that this drug could put a lot of late night kebab shops out of business
Explains why you see a line of cars at taco bell, white castles, McDonald's around 1-3am most nights, especially Friday/Saturday.
Alcohol gives you the munchies??
All the best research on addiction, consumption and rehabilitation of all drugs is done in Europe.
Here in the States, it's treated as a character flaw and research pales in comparison. And rehab is mostly ineffectual 12-Programs that were created 80 years-ago by a drunken religious kook. But when one fails a 12-step program, it's all on them and not the fact that 12-programs are quackery and thinly disguised religion.
If this study were done in America you wouldn't even need mice. Just go into any Waffle House at 2am.
The only thing necessary for evil to triumph is for it to be pitted against a slightly greater evil
Exactly. Colleges and universities, and especially frat houses, are full of morbidly obese fat kids. This is explained by their exceptionally high consumption of alcohol.
Or by the fact that most colleges have meal plans that are essentially all you can eat which leads to overeating since the food is "free" for the student (free as in not out of pocket since loans,parents, scholarships or whatever are paying for the meal plan as part of tuition/room/board)
The only thing necessary for evil to triumph is for it to be pitted against a slightly greater evil
I see you don't speak clickbaitese.
The mice were given generous doses of alcohol for three days ... equivalent to around ... a bottle-and-a-half of wine for a person. ... The mice ate more than normal too.
See, being a lab mouse is not all bad. All that free booze and food!
Free, as in your money being freed from the confines of your account.
Look at most heavy drinkers. They're usually overweight, more so than can be accounted for by the extra calories in alcohol alone.
On the other hand, these rodent heavy drinkers went at it for only 3 days...
Free, as in your money being freed from the confines of your account.
... but after three days, they sobered up again. (I guess all those giants in white lab coats messing with your neurons does that.)
Free, as in your money being freed from the confines of your account.
These findings are not surprising because alcohol causes dehydration and dehydration is often confused with hunger. A lot of people who are chronically dehydrated aren't even aware of it and confuse it with hunger and thus try to resolve by eating when what they really need is a glass of water.
We'll make great pets
more so than can be accounted for by the extra calories in alcohol alone.
Damn, they wasted all their time doing this study when they really should have just asked you.
I do not want your cheap brainburning drugs. They are useless for work. And I am a working man today.
Exactly. Colleges and universities, and especially frat houses, are full of morbidly obese fat kids. This is explained by their exceptionally high consumption of alcohol.
Mhmm. Your certainty is completely misplaced. You don't know if it's drink, or if it's food, or a sedentary lifestyle, or all of the above. I know you think you know, because most people on slashdot think they know everything, but you actually don't.
I do not want your cheap brainburning drugs. They are useless for work. And I am a working man today.
Boy, the quality of the food must have increased markedly since I was in school in the 90s. The only edible thing was the Lucky Charms.
W..w..W - Willy Waterloo washes Warren Wiggins who is washing Waldo Woo.
I'd say it's probably a nuanced technical term. But hey you're not personally familiar with it, so it must be bullshit right?
I do not want your cheap brainburning drugs. They are useless for work. And I am a working man today.
Boy, the quality of the food must have increased markedly since I was in school in the 90s. The only edible thing was the Lucky Charms.
I went to school out in the country. The biscuits and gravy seemed to be popular (I found the gravy somewhat bland though), as was the pizza and stir fry. Really good chicken and dumplings and fried chicken, too.
The only thing necessary for evil to triumph is for it to be pitted against a slightly greater evil
Yeah, a bottle-and-a-half of wine is definitely into "serious drinking problem" territory. Marginally increased appetite is the least of your worries in that situation.
Eat the rich.
Alcohol is poison with a relatively high LD50, and a rather pleasant buzz at moderate doses.
Eat the rich.
Explains why you see a line of cars at taco bell, white castles, McDonald's around 1-3am most nights, especially Friday/Saturday.
If high school was any indication, I believe you have your drugs mixed up. That line in front of Taco Bell at 2AM would be the weed talking, not the alcohol. Weed also explains half the crazy shit they come up with to put on a menu.
That said, it's no surprise that alcohol also induces food consumption, and often overindulgence, as if that's been some unsolved mystery through the ages. Those "mice" we affectionately label drunk humans validated that theory hundreds of years ago. We needed a fucking study for this? Seriously?
Uhhh... Yes.
If you actually read, you'll see that the study isn't about the fact that alcohol triggers you to eat more, it's about how it does it, which parts of your brain are affected, and why. That's important information if you say.... wanted to make drugs that suppressed your starvation response to help you lose weight.
Hey just because the last fresh meal was made Friday morning and they just reheated the same shit over and over again until Monday morning doesn't mean it was awful. I never asked for a plate with a heaping pile of sausage patties that were closer to charcoal just so I could dump them in the trash on Sunday morning. I also never told the person who was cooking burgers that if they cooked them half as long they would be twice as good since they would cook every drop of moisture out of them.
Time to offend someone
Or as other researchers have already proven sugar is alcohol in disguise, same metabolithic pathway, just no receptors to feel the buzz. YouTube sugar: the bitter truth
Hm. I would have guessed that, if someone's up unusually late on a weekend, they'd just be hungry due to elapsed time. If you have supper around 6, then by 3 a.m. it's been 9 hours since you've eaten. That would make it time for another meal, right?
The Quirkz Handbook of Self-Improvement for People Who Are Already Pretty Okay
Apparently we do - since YOU clearly have no idea wtf you're talking about.
Maybe you're just doing that stupid thing where people that don't understand shit project their weird ideas onto the scene and make a stupid joke about weed - but clearly the 2am taco bell line is both drunks and stoners.
Then you weirdly contradict yourself to be correct in paragraph 2.
My statement was not meant to be a contradiction, it was meant to clarify other influences lining up humans at 2AM, along with the influences creating the weird shit we like to label "food" today. Alcohol isn't exclusive in this influence, and my point regarding wasting time studying mice stands, especially when humans have been capitalizing on the known behavior of drunks for literally hundreds of years.
Check out the typical local "Skid Row". A bunch of skinny old dudes with full heads of hair. (Heavy Alcohol consumption suppresses the production of Testosterone.) Alkies don't much like eating. Some of those skinny old dudes are under forty. Skinny old young dudes with bloated faces and full heads of hair...
Fat Alcoholics tend to have other addictions. It's all about Feeding, stuffing the face. Skinny Alcoholics are quite the opposite; they embrace starvation. If they were impressionable teenaged Girls, they would be Purging and cutting themselves to embrace the pain.
Let's try this Bukowski style:
Check out the typical local "Skid Row".
A bunch of skinny old dudes
with full heads of hair.
(Heavy Alcohol consumption suppresses the production of Testosterone.)
Alkies don't much like eating.
Some of those skinny old dudes are under forty.
Skinny old
young dudes
with bloated faces and full heads of hair.
Fat Alcoholics
tend to have other addictions.
It's all about Feeding, stuffing the face.
Skinny Alcoholics are quite the opposite;
they embrace starvation.
If they were impressionable teenaged Girls,
they would be Purging
and cutting themselves
to embrace the pain.
Drink until you puke.
I went to school in Philadelphia, and even the cheesesteaks were nasty in the cafeteria. That's sacrilegious in those parts.
W..w..W - Willy Waterloo washes Warren Wiggins who is washing Waldo Woo.
A bottle and a half of wine has over 1000 kilocalories. I wouldn't exactly call that 'starvation mode'.
HOWEVER, the next day, if hungover, my food choices become dismal I will admit.
If I'm hungover, I often don't feel like getting up and cooking a healthy meal with lots of veggies, etc. THOSE are the times I reach for the phone for a pizza....or if I can manage to get up and out just for a quick run...fast food like Taco Bell.
But that's more alcohol withdrawal related than alcohol consumption.
Light travels faster than sound. This is why some people appear bright until you hear them speak.........
Alcoholics I know replace eating with drinking and lose wait as a result.
So, if alcohol hacks your brain into thinking it is hungry, if you do NOT then eat--you purposefully resist the urge--does those same "starvation mode" signals then trigger different metabolic responses from the body as well and lead to weight LOSS?
Of the functioning alcoholics that I know, a not-insignificant number of them are rail skinny; while, yes, others are obese (mostly beer-gut "fat"). But I have empirically noticed that the skinny ones tend not to eat; they "drink" their dinners. In a few instances, those folks are also ones who "can eat what I want and not get fat"... but perhaps mostly because they likely rarely eat regularly. It would be an interesting next step to follow through on the research and see what the mice do if kept hydrated but underfed, or perhaps fed just a moderate calorie diet, versus a high calorie diet typical of many people. Comparing to recent research on fasting, alcohol might could turn out to be yet another "hack" that allows for metabolic disruption and significant weight-loss. (Though I'm not sure doctors/scientists would approve, given alcohol's other deleterious health effects, but if you're already a drinker I'd think obesity would be significantly more harmful on top of it.)
Scott
"Hokey religions and ancient weapons are no match for a good blaster at your side, kid."
"This study is flawed an false."
I rather like the way that you went to such great effort to spell "Empirically" properly, that you put it in all-caps.
After that though- Fail.
Fat, drunk, and stupid is no way to go through life, son.
Drunks don't waste their money on food,
This is why the meal voucher program for the homeless failed so miserably in my city. Hand a beggar a coupon for food and they just scream at you.
Have gnu, will travel.
mmmm gravy
Fully licensed blockchain psychiatrist
I wanna party with these rats!
I thought a hangover was not so much an alcohol withdrawal symptom as the body healing from alcohol damage and dehydration. I stopped drinking because of the hangovers, man I really hated the hangovers.
As I recall from a movie I saw a long time ago (probably sensationalist, incorrect, and overdramatized), alcohol withdrawal is more characterized by DTs (Delirium Tremens).
Only I can judge you.
We offered a homeless lady a slice of freshly made, hot pepperoni pizza, she was very happy to have it. Didn't scream at me (or my kids) at all.
Only I can judge you.
This must be very school dependent. I graduated in 1994 and the food was fantastic.
Breakfast: The usual cereals from dispensers, a line if you wanted a fresh made omelette (from real eggs) with whatever ingredients you wanted: bacon, sausage, assorted veggies, cheeses...
Lunch: Burgers, sandwiches, could have grabbed a to-go PBJ at breakfast.
Dinner: Typical dinner fare, it all seemed fresh made.
Only I can judge you.
*whoosh*
Only I can judge you.
Look at most heavy drinkers. They're usually overweight
You're a genius, a true scientist. Someone fetch this man a nobel prize.
Maybe it's city school vs country school or something? I went to a city school and so there were dozens of lunch options, including lunch trucks, fast food, bars, and the like. As a result, not a single faculty member used the cafeteria. For that matter, no one not required to buy the meal plan ate there. I suspect in a self-enclosed campus with fewer options, the faculty and students would demand better food.
W..w..W - Willy Waterloo washes Warren Wiggins who is washing Waldo Woo.
researchers find that the sky is blue .. seriously though, these researches need to get out more if they've never experienced the munchies themselves..
for an organism new to alcohol, that is a lot imo
Or the same for the reverse: increase apatite in those who may require it.
Maybe so. Or maybe the school already knew the competition was fierce, what with being in the middle of Westwood. That said, I doubt anyone was going to go from the dorms out to town just for breakfast, it was hard enough to roll out in time to make breakfast hours downstairs. Even the student athletes ate in the caf (basketball players are easy to spot). I knew a couple of people who didn't live in the dorms but bought the meal plans. Yeah! Good times!
Only I can judge you.
I think it is fascinating that alcohol stimulates chemical receptors linked with the starvation response. Nobody knew this before the study. I'm not sure why you hate science so much you dismiss the "fucking study" with so much hostility. You even have geek in your handle, which would imply respect for science.
Man, you really need that seminar!
Sugar creates hunger. Alcohol is a sugar.
This study doesn't add anything to our knowledge of diet.
Learn to love Alaska
I think it is fascinating that alcohol stimulates chemical receptors linked with the starvation response. Nobody knew this before the study....
You mean other than the tens of thousands of alcohol proprietors across hundreds of years of history who have found that pairing drunk people with food results in a quite a profitable business? (FYI, capitalism is also the reason that there will not be some form of AGRP-blocking chemical added to alcohol in order to try and make drinking "healthier", regardless of the study.)
People who have a drinking problem are also likely to be obese due to over-consumption of food. Alcohol is also a poison to the human body, creating other ailments and diseases, especially targeting the liver. Given these facts come directly from the No-Shit-Sherlock department, yes, I'd say a study that will ultimately change the opinions and attitudes of exactly zero obese drinkers tends to showcase the entire value of it. Doubly so if this study was funded by taxpayers.
Don't get me wrong. I'm all for the science, when it exceeds the water-is-wet threshold.
Sbisa dining hall was one of the top rated food locations on the planet. Multiple patents on serving mass food came from there (or the tours were lies). The idea to stabilize warmed food by putting heat under a water bin, with food above that was invented there, then adopted world-wide.
Pizza and hamburgers made to order. A mix of fast food, short-order, and cafeteria, all in one dining hall.
But, if one wanted, one could stick to the vegetables and eat quite well, while healthfully. I dropped weight and gained muscle mass in college.
Learn to love Alaska
Lesson: go to a massive agricultural school with an active food science department :)
W..w..W - Willy Waterloo washes Warren Wiggins who is washing Waldo Woo.
As freshmen, we had the somewhat torturous ritual of walking past a number of restaurants and food trucks on our way to the university-required foodplan cafeteria :) We hated it, but it was already paid for! I definitely did not step foot in there ever again after freshman year...
I wonder if the other center city Philly schools were as terrible. Aramark food service was native to Philly, and I think that was part of the problem. They switched to Marriott a little later and apparently that improved things, but I wouldn't know firsthand :)
W..w..W - Willy Waterloo washes Warren Wiggins who is washing Waldo Woo.
Obesity causes are linked mostly to sugar consumption and junk food. Alcohol accounts for a very small percentage of that.
That depends on what you're drinking.
The latest trend in beer making leans towards putting 300+ calories in a 10% beer, along with an ingredient list that would make a Starbucks hipster jealous. This is all done to make beer taste good for the I-hate-beer crowd (not unlike what Starbucks has done to coffee).
I'd say there's more than enough in that bottle to warrant a growing waistline.
for an organism new to alcohol, that is a lot imo
I think a bottle and a half of wine is a hell of a lot to drink for a mouse regardless.
To have a right to do a thing is not at all the same as to be right in doing it
I've observed benzos having a similar appetite-increasing effect. Curious whether this is a property of GABAergic compounds in general...
I see my shadow changing, stretching up and over me...