Why An LSD High Lasts For So Long (pbs.org)

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Why An LSD High Lasts For So Long (pbs.org)

Posted by BeauHD on Tuesday January 31, 2017 @01:00AM from the revolutionary-idea-making dept.

Lysergic acid diethylamide (LSD) has been credited, in part, for the creation of the iPhone, the polymerase chain reaction, as well as some pretty abstract artwork. Since the drug is classified as a Schedule 1 substance in the U.S., it's been more difficult for scientists to legally study the drug and learn about how it affects the brain. Therefore, when a study (or two) is published it makes the findings all the more fascinating. Two studies were published last week (one in Current Biology, the other in Cell) that examine how LSD produces such diverse effects and why the drug takes so long to wear off. The Scientist reports the findings from for the first study: For the Current Biology study, 21 volunteers were given a placebo, a small dose of LSD alone, or the same dose of LSD but with kentaserin, a serotonin 2A antagonist. Study participants who took the kentaserin reported virtually the same experiences as those who took the placebo, and fMRI brain scans confirmed similar brain activities across participants in both groups. The serotonin 2A antagonist "blocked all the effects of LSD, so it was like if people didn't take any drugs," coauthor Katrin Preller, neuroscientist at the Zurich University Hospital in Switzerland told The Verge. "All the typical symptoms -- hallucinations, everything -- were gone." As for why an LSD high lasts for so long, Angus Chen has written an in-depth report on PBS Newshour about the findings from the study published in Cell: LSD and other psychoactive drugs work by binding to specialized proteins called receptors on the surfaces of neural cells. On the receptor protein is a sculpted "pocket," into which molecules with the right shape can fit and thus stick to the cell, where they initiate changes in the brain. But different substances can often fit into the same receptor. Many receptors that bind LSD and DMT, for example, also fit the natural chemical messenger serotonin -- which is produced in the body and helps regulate mood. Figuring out how each drug interacts with the same receptor in a different way is key to understanding why an LSD trip lasts all day whereas an experience with extracted DMT is often over in 15 minutes or less. By freezing an LSD molecule bound to a single brain cell receptor as a crystal in a lab, researchers were able to get a 3-D x-ray image of the drug and the protein locked together. The image showed Bryan Rother, a pharmacologist at the University of North Carolina at Chapel Hill and senior author on the paper, and his co-authors something strange about the way LSD fit inside this receptor. Drugs typically come and go from receptor proteins like ships pulling in and out of a port. But when an LSD molecule lands on the receptor, the molecule snags onto a portion of the protein and folds it over itself as the molecule binds to the receptor. LSD seems to stimulate the receptor for the entire time it is trapped underneath the protein "lid," Roth says. Proteins are in constant motion, so he thinks the lid eventually flops open, allowing the drug to fly out and the effects to wear off. But the team ran computer models that suggest it could take hours for that to happen. Until then, the trip goes on.

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Hey man by Anonymous Coward · 2017-01-31 01:05 · Score: 0

Why is every story today about Cowboy Neal?
1. Re:Hey man by MrL0G1C · 2017-01-31 01:30 · Score: 1
  
  They're not, you're just hallucinating.
  
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and you retards believe in it! by Anonymous Coward · 2017-01-31 01:06 · Score: -1

omg! creativity is based on anything but drugs! while you get high, another scientist discovers something useful! by the way, is way easier to steal your inventions while you are high.
1. Re:and you retards believe in it! by Oswald+McWeany · 2017-01-31 02:06 · Score: 4, Informative
  
  Creativity comes from many sources, absolutely it appears some highs may stimulate creativity and conversely some seem to suppress creativity. Interestingly, lack of sleep is supposed to stimulate creativity too.
  
  --
  "That's the way to do it" - Punch
2. Re:and you retards believe in it! by Anonymous Coward · 2017-01-31 03:24 · Score: 1
  
  Don't do drugs, drugs are bad. Well only *those* drugs. You poor naif. I feel bad for people who are so limited in their thinking. And also for those who are willfully ignorant of the role mind-altering substances play every day of much life as it has evolved over the last few billion years.
3. Re:and you retards believe in it! by Anonymous Coward · 2017-01-31 03:38 · Score: 1
  
  Religions are some of the most creative works of fantasy art in history and they most likely come from either full-on schizophrenics or ingesting drugs, knowingly or not.
4. Re:and you retards believe in it! by Anonymous Coward · 2017-01-31 06:36 · Score: 0
  
  I once went without sleep for 5 days, and while the 5th day was wasted, the 3rd and 4th were amazing for getting work done, particularly writing. I wrote a semester's worth of work on landscape architecture during that 5 day stretch, and having re-read a lot of it (15 years later) recently, it's a) not bad, and b) not something I could do now on a good day.
5. Re:and you retards believe in it! by ShanghaiBill · 2017-01-31 06:40 · Score: 1
  
  I have met several people that said dropping acid was a positive life changing experience. It changed the way they look at the world. Steve Jobs made this claim, and credited LSD as one reason for his success.
  The main reason given to NOT use LSD is the claim that it causes genetic damage and birth defects, but that has been totally debunked. It is not addictive, and side effects like anxiety and paranoia, only occur with repeated use.
6. Re:and you retards believe in it! by Anonymous Coward · 2017-01-31 09:59 · Score: 0
  
  Anonymous, due to cowardice.
  It is my opinion that the drug LSD does most certainly have the capacity to change lives for the better. It's next to impossible to get addicted to it, and even people try do find that they quickly develop a high tolerance for it. The hallucinations in particular do not appear.
  I've only personally taken it a handful of times in my life, always in the context of either live or recorded music, and the experience has been overwhelmingly positive every time. Maybe I acted a bit crazy on the dance floor, but that's hardly a crime. It's just straight-up good for you. Everyone should try it at least once in their lives. And, of course, along with all recreational drugs, it should be 100% legal.
7. Re:and you retards believe in it! by TrekkieGod · 2017-01-31 10:35 · Score: 1
  
  I once went without sleep for 5 days, and while the 5th day was wasted, the 3rd and 4th were amazing for getting work done, particularly writing. I wrote a semester's worth of work on landscape architecture during that 5 day stretch, and having re-read a lot of it (15 years later) recently, it's a) not bad, and b) not something I could do now on a good day.
  Uh...I once went 76 hours without sleep while finishing up my senior project in college. Toward the end of that period, I was in the computer lab writing, I looked at the clock, I wrote a sentence, I looked at the clock again and 20 minutes had passed. That's when I decided I wouldn't be productive anymore without going to sleep, so I walked to my dorm to take a few hours.
  I later found out my roommate had seen me in the computer lab during that period, went in to say hello, but I was completely unresponsive, with my hands on the keyboard and staring at the screen. He figured I was too busy and annoyed to respond back, thought I was being weird for not at least saying that I was too busy to talk, but left anyway. I have no recollection of that, I assume he showed up during that missing 20 minutes. Turns out you start micro-sleeping when you're that sleep deprived. So you're telling me you were amazingly productive on the 3rd and 4th day? I mean, there's a point in sleep deprivation where you move past being tired and get an euphoria going that actually focuses you, but that's within the first 24 hours. After that, it just seemed to get progressively worse with me, until eventually there wasn't any productivity to be wrung out.
  
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  Warning: Opinions known to be heavily biased.
8. Re: and you retards believe in it! by Anonymous Coward · 2017-01-31 22:39 · Score: 0
  
  This can happen also when one is driving long distances.
  Your eyes don't necessarily need to be closed for your brain to be in a sleep state.
9. Re:and you retards believe in it! by GuB-42 · 2017-02-04 01:00 · Score: 1
  
  The main reason not to take LSD is that it can drive you insane. It is unlikely but the risk is non-zero, especially if you have predispositions to schizophrenia.
  It is a substance that can change your life for the better or for the worse, or just give you an enjoyable trip. From what I've seen, the outcome is more likely to be positive, especially if you do what you can to minimize the risks. However the risks are real, and LSD is mostly unpredictable.
  And while LSD is not toxic and not addictive, you really need to make sure that what you are taking really is LSD. Due to its potency, adulterants shouldn't be a problem. However, common substitutes like 25I-MBOMe have been linked to several deaths.
  That being said, if you minimize the risks and take a moderate dose the most likely scenario by far is a mostly inconsequential good trip.
They mention DMTs short effects by AvitarX · 2017-01-31 01:11 · Score: 1

But taken orally there are no effects without an MAOI, and with one it too lasts hours (though not as long as LSD).

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Depends by Anonymous Coward · 2017-01-31 01:14 · Score: 0

if you know you ARE hallucinating; could be you think it's real, like now.
Or, Depends as an adult diaper.
Take your pick while you still have a say!
1. Re:Depends by GuB-42 · 2017-01-31 02:59 · Score: 5, Informative
  
  There are different kinds of hallucinogens. They usually fall into 3 broad categories : dissociatives, delirants and psychedelics.
  - Dissociatives disconnect your mind from your body, causing things like out of body experiences, makes you feel light, etc... Ketamine and PCP are dissociatives.
  - Delirants cause hallucinations that are indistinguishable from reality, no matter how strange they are. Making you talk to imaginary people, see monsters, etc... Datura as well as many plants associated with whichcraft are delirants. These effects are rarely enjoyable so these substances are not considered drugs of abuse.
  - Psychedelics cause you to "see things differently". While the hallucinations are convincing, you are usually fully aware that things aren't as they normally are. Technically, they are pseudohallucinations. Common effects include light tracers, distorting shapes, divine revelations, etc... LSD, DMT and psylocibin mushrooms are psychedelics.
  tl;dr : people under LSD know they are hallucinating.
2. Re:Depends by Anonymous Coward · 2017-01-31 05:21 · Score: 5, Funny
  
  associated with whichcraft
  
  That craft. That one right there.
what a buzz... by Anonymous Coward · 2017-01-31 01:18 · Score: 3, Funny

LSD is all fun and games right up to the point you are standing in your best friends kitchen on Xmas night talking to his mum. She has a wasps head and you can't work out if you're whispering to her or shouting at her.
1. Re: what a buzz... by Anonymous Coward · 2017-01-31 01:20 · Score: 1
  
  And you're trying to explain why you've dropped out of university.
2. Re: what a buzz... by budgenator · 2017-01-31 02:01 · Score: 1
  
  And you're trying to explain why you've dropped out of university.
  They don't drop out,they just transfer to the Dept. of Barista Studies and minor in Burger-flipping
  
  --
  Apocalypse Cancelled, Sorry, No Ticket Refunds
3. Re: what a buzz... by Anonymous Coward · 2017-01-31 04:16 · Score: 1
  
  And you're trying to explain why you've dropped out of university.
  They don't drop out,they just transfer to the Dept. of Barista Studies and minor in Burger-flipping
  Or start Apple...
4. Re: what a buzz... by Anonymous Coward · 2017-01-31 12:38 · Score: 0
  
  Yes, everyone who takes drugs is a failure at life, and everyone who doesn't is successful. It's just that black n white! :)
Never liked acid by Anonymous Coward · 2017-01-31 01:20 · Score: 2, Interesting

Never liked acid. While other drugs tend to amplify or enhance mind states that you normally experience to a lesser degree without drugs, acid always made me feel like my brain was doing shit it fundamentally shouldn't be doing at all, not really related to any normal mind state. If I had to do psychedelics again, I'd stick to mushrooms, I always found they had more euphoric effects to go with the trippy shit, generally a much more fun experience. And yeah, acid did tend to go on a bit too long.
1. Re: Never liked acid by Anonymous Coward · 2017-01-31 02:00 · Score: 0
  
  shooms are more body high and mellow hallo.. its all natural though and lets not even get into discusion of payote and mescalin in intensity.
2. Re: Never liked acid by Anonymous Coward · 2017-01-31 04:54 · Score: 0
  
  That's a ridiculous statement. You can absolutely have a breakthrough psychedelic experience with mushrooms. It's all about dosage. It certainly is not just simply "more body high" and definitely can be far from "mellow". You are not experienced.
3. Re:Never liked acid by kelemvor4 · 2017-01-31 05:23 · Score: 4, Funny
  
  Never liked acid. While other drugs tend to amplify or enhance mind states that you normally experience to a lesser degree without drugs, acid always made me feel like my brain was doing shit it fundamentally shouldn't be doing at all, not really related to any normal mind state. If I had to do psychedelics again, I'd stick to mushrooms, I always found they had more euphoric effects to go with the trippy shit, generally a much more fun experience. And yeah, acid did tend to go on a bit too long.
  Forget that, last time I did mushrooms they grew eyes and started walking towards me. Later, I discovered that if I jumped up and smashed my head into bricks that sometimes a "good" mushroom would come out and give me the power to destroy they eyeballed mushrooms. From that point on, only falling into a bottomless pit or walking into the bad mushroom's eyes would be harmful to me. Eventually I climbed a flagpole and moved on.
4. Re: Never liked acid by Anonymous Coward · 2017-01-31 20:45 · Score: 0
  
  Ive done several different varieties of shooms, from teachers, penis envy, and fluffcaps. I've never had a "mellow" high... The best experience ever was the penis envys wile watching a fireworks show...
5. Re:Never liked acid by Anonymous Coward · 2017-02-01 09:35 · Score: 0
  
  Wait till you get a load of the "Star Power" dust I got. Oh, and then there's the Flower Power herb....
Placebo? by Dins · 2017-01-31 01:20 · Score: 2

I know scientific method and all that, but I think it would be relatively easy to determine whether you were given the placebo or the actual LSD...
1. Re:Placebo? by GabeGhearing · 2017-01-31 01:30 · Score: 2
  
  There were three groups; placebo , LSD, LSD+2A_antagonist. The interesting thing was that the placebo group AND the LSD+2A_antagonist group had the same outcomes. Seems serotonin antagonists are very effective at blocking the same receptors used for LSD. I'm guessing their will be more studies to see if you could give a serotonin 2A antagonist to someone to make them come down from LSD.
2. Re:Placebo? by Opportunist · 2017-01-31 01:39 · Score: 5, Interesting
  
  5HT-2A antagonists aren't really something you should hand out like candy. Those receptors are all over your body, not just your brain, and they deal with a LOT of body functions. Particularly blood clotting.
  Using it as a "safety switch" to cancel horror trips is something I would not recommend!
  
  --
  We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
3. Re: Placebo? by Anonymous Coward · 2017-01-31 02:03 · Score: 0
  
  probably they never expeirenced it and so did not know what to expect and thus imagined(literaly) some effect.
4. Re:Placebo? by budgenator · 2017-01-31 02:19 · Score: 5, Insightful
  
  The article says the effect lasts so long because the receptor lock on to the LSD molecule. I doubt an antagonist would work because they generally block the receptor without activating them but in this case the sites are activated already and the LSD is locked on. The antagonist can't replace the LSD molecule. At best they can keep the LSD from activating additional receptors.
  It looks like with LSD, once you're high, you just have too ride it out.
  
  --
  Apocalypse Cancelled, Sorry, No Ticket Refunds
5. Re:Placebo? by GuB-42 · 2017-01-31 03:35 · Score: 1
  
  It depends on the dosage.
  With very small doses the effects are not that strong. It is more about slightly altered perception than full-blown hallucinations. Colors may become more vivid, you notice small things that you haven't noticed before, etc... You can get the same effects with a placebo. Even experienced trippers can be fooled, at least to some extent.
  And the summary explicitly mentioned small doses.
  Of course, at high doses, there is no way you are going to say you had a placebo if you were given the real deal, though the opposite may be possible if you are naive.
6. Re:Placebo? by bodog · 2017-01-31 07:02 · Score: 1
  
  try it before you make an unfounded proposition :)
7. Re:Placebo? by Johann+Public · 2017-01-31 08:05 · Score: 1
  
  Quetiapine is reasonably safe, & quite effective for the purposes of aborting a bad trip.
8. Re:Placebo? by Anonymous Coward · 2017-01-31 09:05 · Score: 0
  
  You dont need to either, any Opioid will do.
9. Re:Placebo? by Anonymous Coward · 2017-01-31 10:02 · Score: 0
  
  There's no need to cancel a bad trip, to the extent that such a thing even exists. Just wait it out, in a quiet space, preferably with some pleasant rhythmic sounds to calm down your mind. It'll finish in the end, and then you can sleep.
10. Re:Placebo? by Anonymous Coward · 2017-01-31 10:54 · Score: 0
  
  There's no need to cancel a bad trip, to the extent that such a thing even exists. Just wait it out, in a quiet space, preferably with some pleasant rhythmic sounds to calm down your mind. It'll finish in the end, and then you can sleep.
  The problem with that is that someone on a bad trip just might not be able to "wait it out" without feeling too much anxiety to sit still or stay in one place, or even reliably remember that they took acid and will be fine in a while. Been there, and without some to remind me what was going on (you should always have a sober/non-tripping person around, or at least someone you can contact who is aware of what's going on) I would have gone outside for a second time, and likely gone for another drive. It can't be overstated how important set and setting are, and having someone to make sure you don't forget you're tripping and do something silly.
11. Re:Placebo? by Opportunist · 2017-01-31 19:40 · Score: 1
  
  That will knock the tripper out, but not end his trip.
  
  --
  We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
12. Re:Placebo? by Anonymous Coward · 2017-01-31 20:11 · Score: 0
  
  If part of the model is that once an LSD molecule is dislodged, it will not attach to another receptor (because it is damaged, or maybe the body is destroying it, for example), then an antagonist would not speed up a recovery. Or if a receptor 'kicks out' and LSD molecule somehow alters to block any other LSD molecules from binding it, then an antagonist would not speed up a recover.
  But if during a 'trip' there is a continuous turnover of LSD molecules binding and unbinding from receptors, an antagonist via competition may over reduce the rate of new LSD-receptor pairing while the LSD is being cleared out of the system, resulting is a faster recovery.
  Testing for a faster recovery should be easy to test. Understanding the biochemistry of whether it works or not may take a little longer : ).
13. Re:Placebo? by Lehk228 · 2017-02-01 03:45 · Score: 1
  
  possibly useful for when you take some acid, then half an hour take a bunch more because "it's not working man i think it wa s a dud" then "woah oh shit there it goes"
  
  --
  Snowden and Manning are heroes.
14. Re:Placebo? by Anonymous Coward · 2017-02-01 07:16 · Score: 0
  
  Placebos have always worked for me...
15. Re:Placebo? by budgenator · 2017-02-01 08:25 · Score: 1
  
  Well they could try, but I still suspect that when you're at the "woah oh shit there it goes" stage, you better be planning on being there for a few hours. There is stuff that gets you tripping for a half hour or so but acid isn't one of them.
  
  --
  Apocalypse Cancelled, Sorry, No Ticket Refunds
Why a summary lasts for so long by amanaplanacanalpanam · 2017-01-31 01:21 · Score: 1

Nt
1. Re:Why a summary lasts for so long by DickBreath · 2017-01-31 02:17 · Score: 1
  
  Simple. Because you didn't get the placebo or the 2A antagonist before reading the summary.
  
  You know it's a bad trip when the summary uses the term DMT, twicefully, but does not explanify what it means. Not that I am one of those people who would read beyond the subject line. Please don't think less of me or judge me. I'm the same person I was before this secret became generally known. There may be some kind of cure or electroshock therapy for those of us who read more than the subject title.
  
  --
  
  I'll see your senator, and I'll raise you two judges.
2. Re:Why a summary lasts for so long by Anonymous Coward · 2017-01-31 04:46 · Score: 0
  
  You know it's a bad trip when the summary uses the term DMT, twicefully, but does not explanify what it means.
  +2 for new words
Too long was always my gripe by swb · 2017-01-31 01:23 · Score: 1

The first 4 hours were fun, but after that it just got kind of tedious.
There were always rumors it was jacked up with speed or strychnine, but I never thought you could fit enough of either in blotter for that to be true.
1. Re:Too long was always my gripe by Dins · 2017-01-31 01:28 · Score: 1
  
  DMT is nice and quick (15-30 minutes I hear). I've never done it, but wouldn't mind trying it.
2. Re: Too long was always my gripe by tylersoze · 2017-01-31 01:57 · Score: 4, Insightful
  
  Yeah mushrooms are preferable for just a nice time. LSD for profound mind altering experiences that you need to plan a whole block of time for, at least it was for me. I never understand these people that have bad trips or see things that aren't there (as opposed to just simple visual effects) It really is all about set and setting as they say (and making sure you know exactly what your ingesting). You can absolutely take these drugs responsibly, like everything else it's the dumbasses that ruin it for everybody.
3. Re: Too long was always my gripe by The-Ixian · 2017-01-31 02:17 · Score: 1
  
  I always assumed that the "bad trip" was really about loss of control. Some people can't seem to handle that.
  
  --
  My eyes reflect the stars and a smile lights up my face.
4. Re:Too long was always my gripe by DickBreath · 2017-01-31 02:20 · Score: 2
  
  > The first 4 hours were fun, but after that it just got kind of tedious.
  
  WRONG DRUG.
  
  If you experience an erection lasting more than four hours see your doctor immediately, or go to a party.
  
  --
  
  I'll see your senator, and I'll raise you two judges.
5. Re:Too long was always my gripe by Anonymous Coward · 2017-01-31 02:21 · Score: 3, Interesting
  
  I've heard the same. I know somebody in town who's invited me to come give it a try some time when his daughter isn't home but I've yet to take him up on it. The nice things about LSD over mushrooms are price, longer trip, and (more) predictable onset. I can't think of any others. Mushrooms cost more, but aren't too tricky to grow - Plus I think growing them yourself adds something to the experience. The trip with shrooms is only 2/3 as long (or so), but coming down after that duration is usually welcome and seems to be as gentle with either psychedelic. The onset with mushrooms can be a kicker - It can take as long as an hour after ingestion before the first signs of a trip come on. Hopefully that hour's not up before somebody decides, "These must be bunk - Let's eat some more."
  AC 'cuz, yeah.
6. Re: Too long was always my gripe by swb · 2017-01-31 03:00 · Score: 1
  
  Mushrooms are lower impact, but that works against them, too, with shorter and less intense peak effects, and though shorter, they had a similar "long tail" effect where you just felt kind of hyper but without the benefits of peak effect.
  They required dedicating less time, but I never found the difference completely compelling.
7. Re:Too long was always my gripe by Anonymous Coward · 2017-01-31 03:03 · Score: 0
  
  The first 4 hours were fun, but after that it just got kind of tedious.
  There were always rumors it was jacked up with speed or strychnine, but I never thought you could fit enough of either in blotter for that to be true.
  As someone who attempted to do LSD in the last few years, I ended up with a blotter of some sort of upper. You definitely could cut LSD with uppers (some so-called "research chemicals" are uppers which can give a trip, but not an LSD trip). I guarantee you I know people (millennial) who have never done acid, only research chemicals. In my experience, going out to buy LSD from a dealer, even one your trust, and actually getting LSD are two different things (at least in my lifetime).
8. Re: Too long was always my gripe by Ellis+D.+Tripp · 2017-01-31 03:04 · Score: 4, Insightful
  
  Pretty much. Some people are just too "tightly wrapped" for psychedelics. Rather than surrendering to the experience, they try to fight it and end up having a really bad time.
  Control freak personalities in particular are prone to this. I can only imagine the scene if somebody dosed the White House water cooler these days....
  
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9. Re: Too long was always my gripe by Anonymous Coward · 2017-01-31 03:22 · Score: 1
  
  I've done a fair bit of acid, up to 1mg a few times. My hands have turned into Julia fractals and all sorts of other crazy stuff - I love that kind of thing... Never had a bad trip though.
  
  I wont give my partner acid any more as he goes crazy, complete dissociation with only a couple of tabs. Had to hold him to the bed for 4 hours as he kept wanting to go outside and fight random made-up situations. Not really a bad trip though because he cant really remember what happened.
  
  Once I took AMT, and figured it wasn't doing anything so I decided to top it up with some 25c-NBOME. That was crazy - all the surfaces in my house turned into flowing waves of evil forest creatures. When I looked in the mirror, they started climbing out of the mirror and into the bathroom like it was a portal. I really enjoyed that.
10. Re:Too long was always my gripe by Anonymous Coward · 2017-01-31 04:03 · Score: 0
  
  Hmm.. Comedown welcome and gentle? Um no..
11. Re: Too long was always my gripe by Anonymous Coward · 2017-01-31 04:18 · Score: 1
  
  Really +5 for anyone who has a bad trip is a dumbass? You guys will learn the hard way if you think that's how it works.
12. Re:Too long was always my gripe by Anonymous Coward · 2017-01-31 04:20 · Score: 0
  
  Hmm.. Comedown welcome and gentle? Um no..
  It is for me...
13. Re:Too long was always my gripe by Anonymous Coward · 2017-01-31 05:05 · Score: 0
  
  I've experienced 5-10 minutes...feels like 45 mins to an hour though.
14. Re:Too long was always my gripe by Anonymous Coward · 2017-01-31 05:11 · Score: 0
  
  In my experience, going out to buy LSD from a dealer, even one your trust, and actually getting LSD are two different things (at least in my lifetime).
  His user ID is low enough that there's a pretty good chance he had the real stuff. Up until the early 00's it wasn't that hard to find. But these days it's not worth bothering to even look- almost anything sold as LSD is just a research chem that mimicks some of the effects. Stay away from that shit, it can get nasty.
  As for the strychnine thing, I've heard two primary rumors "on the street."
  First is that it helps the acid stick to the blotter so they cut a small amount in. Second is that the LSD can break down over time, especially if exposed to moisture, heat, or light, and that strychnine is one of the resulting compounds. Not sure if either of those are actually true at all or not.
15. Re: Too long was always my gripe by JonnyCalcutta · 2017-01-31 06:18 · Score: 1
  
  I dunno. With acid I always ended up sick of it towards the end - the last few hours being a drag when I just wished it was over. Mushrooms on the other hand, I always preferred the time when the visuals had pretty much gone but the world still felt sparkly and nice. More euphoric. That's when me and the wife would head off into town. Maybe that's just different occasions and expectations though.
16. Re: Too long was always my gripe by tylersoze · 2017-01-31 07:21 · Score: 1
  
  I meant dumbasses in the sense of not using these kinds of drugs in a responsible manner and then freaking out, dying or whatever giving more fuel to the anti drug crowd. I personally would never allow myself to be under the influence of anything in public or in an environment I was not comfortable in or I had to be responsible for anyone but myself.
17. Re: Too long was always my gripe by Anonymous Coward · 2017-01-31 10:05 · Score: 0
  
  only a couple of tabs
  Oh. Is that all.....Just give him a third of a tab, for god's sake. I'd be hiding at the bottom of the garden from the monsters on two tabs.
18. Re:Too long was always my gripe by Anonymous Coward · 2017-01-31 10:50 · Score: 0
  
  In my experience, going out to buy LSD from a dealer, even one your trust, and actually getting LSD are two different things (at least in my lifetime).
  His user ID is low enough that there's a pretty good chance he had the real stuff. Up until the early 00's it wasn't that hard to find. But these days it's not worth bothering to even look- almost anything sold as LSD is just a research chem that mimicks some of the effects. Stay away from that shit, it can get nasty.
  True, RCs are commonly passed off as LSD these days but one can reasonably confirm you have ACTUAL LSD by testing a sample dose with both an Ehrlich, and a Marquis reagent test. LSD supply has made quite a comeback. It's the most available, in the US at-least, now since the Pickard bust.
  
  As for the strychnine thing, I've heard two primary rumors "on the street."
  First is that it helps the acid stick to the blotter so they cut a small amount in. Second is that the LSD can break down over time, especially if exposed to moisture, heat, or light, and that strychnine is one of the resulting compounds. Not sure if either of those are actually true at all or not.
  Strychnine thing is a complete myth: https://erowid.org/chemicals/lsd/lsd_myth5.shtml
19. Re:Too long was always my gripe by uvajed_ekil · 2017-01-31 11:21 · Score: 1
  
  The first 4 hours were fun, but after that it just got kind of tedious.
  There were always rumors it was jacked up with speed or strychnine, but I never thought you could fit enough of either in blotter for that to be true.
  While the strychnine thing was a myth (which was understood by the time I was into psychedelics), there are at least a handful of other active substances that can fit on a square of blotter and produce qualitatively similar effects. Some other psychedelics are active at sub-miligram dosages and have been around for decades, and some of them are somewhat commonly available now. They may be sold surreptitiously as "acid" or more openly and correctly named. LSD experiences are notoriously variable and unpredictable, even for experienced psychonauts, but in some cases bad trips, unusual durations (either long or short) and unexpected effects can probably be attributed to mislabeled substitutes.
  
  --
  This is a hacked account, for which the owner can not be held responsible.
So, an LSD trip is like, bad TV reception? by davide+marney · 2017-01-31 01:23 · Score: 1

That molecule gets trapped in there, feeding crazy signals to the brain, until it just happens to fall out.

--
"We receive as friendly that which agrees with, we resist with dislike that which opposes us" - Faraday
1. Re:So, an LSD trip is like, bad TV reception? by DickBreath · 2017-01-31 02:22 · Score: 1
  
  Imagine if a small but statistically significant number of those molecules stay trapped in there for a very long time. And even if they come lose, they get trapped in another receptor and fold it over before being removed from the body.
  
  --
  
  I'll see your senator, and I'll raise you two judges.
2. Re:So, an LSD trip is like, bad TV reception? by budgenator · 2017-01-31 02:24 · Score: 1
  
  Or until the receptor sites are hopelessly fatigued and you crash into a two day hang-over.
  
  --
  Apocalypse Cancelled, Sorry, No Ticket Refunds
3. Re:So, an LSD trip is like, bad TV reception? by GuB-42 · 2017-01-31 04:04 · Score: 1
  
  I think we can model this as an exponential decay.
  As in : the molecule has a 50% of coming out loose and being eliminated every 6 hours.
  They sure, some molecules will stay in for much longer than the duration of the trip but after a few days, nothing significant will be left, and after maybe 2 weeks, there won't be a single molecule left in your brain.
  There are mentions about some kind of "afterglow" lasting a couple of days after a good trip and sometimes subsequent "flashbacks". However, I think they are more likely to be an effect or memorization rather than some of the substance staying in your body.
4. Re:So, an LSD trip is like, bad TV reception? by Anonymous Coward · 2017-01-31 10:14 · Score: 0
  
  I think they do. I love acid, but I've noticed that my responses to other drugs has changed permanently after I took it.
People who use elicit drugs... by Anonymous Coward · 2017-01-31 01:24 · Score: -1

disgust me.
1. Re:People who use elicit drugs... by hughbar · 2017-01-31 01:25 · Score: 3, Funny
  
  how about people who use illicit drugs?
  
  --
  On y va, qui mal y pense!
2. Re: People who use elicit drugs... by Anonymous Coward · 2017-01-31 01:29 · Score: 0
  
  Their body, their choice. Hey, women who have abortions and the "doctors" who perform them disgust me.
3. Re: People who use elicit drugs... by Anonymous Coward · 2017-01-31 01:34 · Score: 1
  
  no one gives a fuck what you think.
4. Re: People who use elicit drugs... by Anonymous Coward · 2017-01-31 01:49 · Score: 0
  
  Except that doing an abortion have very little effect on the surroundings but doing drugs can have huge consequences for other people (operating vehicles or heavy machinery while under the influence of drugs, etc).
  So comparing abortions to drugs is not only a really bad comparison, it is rather tasteless. The their body, their choice don't really work for drugs unless you are narrowminded and are unable to see consequences of actions.
  But if you want to know: people who are disgusted by women doing abortions, disgust me!
5. Re: People who use elicit drugs... by tylersoze · 2017-01-31 01:50 · Score: 2
  
  So if it were made legal it would be fine? I guess people that take pot in states where it's legal don't disgust you? And people that drank during prohibition disgust you?
6. Re: People who use elicit drugs... by tylersoze · 2017-01-31 02:06 · Score: 4, Insightful
  
  Well no shit dumbass, so can "licit" drugs like alcohol, the legality of the substance has no bearing on the issue. If I want to take mushrooms or LSD in the comfort of my own home in a controlled setting (look up set and setting) and have a great time that's my business. Heck I don't even drink and really drunk people are the ones that disgust me.
7. Re: People who use elicit drugs... by The-Ixian · 2017-01-31 02:22 · Score: 4, Insightful
  
  Dude, how about operating machinery while sick with the stomach flu? I mean really, distraction is distraction.
  Obviously the problem is not the drugs it is the choices that people make while on drugs. There's a difference. Just like you can't blame a gun for killing people. People kill people. Why don't we outlaw guns?
  Why does everybody feel it's ok to blame the drugs? oooo the drugs made me do it... how about no, the drugs enabled you to do it... they didn't make you anything.
  
  --
  My eyes reflect the stars and a smile lights up my face.
8. Re: People who use elicit drugs... by rmdingler · 2017-01-31 02:29 · Score: 3, Funny
  
  Except that doing an abortion have very little effect on the surroundings but doing drugs can have huge consequences for other people (operating vehicles or heavy machinery while under the influence of drugs, etc).
  While I am not specifically against a person's right to choose what happens to their own body, it's tough to claim that an operation preventing a person from existing is without consequence for other people.
  Aside: this is why I love me some Slashdot. In 20 comments or less, we're comparing tripping to abortions.
  
  --
  Happiness in intelligent people is the rarest thing I know.
  Ernest Hemingway
9. Re: People who use elicit drugs... by Anonymous Coward · 2017-01-31 04:03 · Score: 0
  
  You know who else loved LSD and abortions? Ayn Rand! Bet you thought I was gonna say, "Hitler!"
10. Re:People who use elicit drugs... by hughbar · 2017-01-31 08:09 · Score: 1
  
  Or even people who elicit the use of illicit drugs. But I've milked it to death now, haven't I? Not a drop left.
  
  --
  On y va, qui mal y pense!
11. Re: People who use elicit drugs... by Anonymous Coward · 2017-01-31 10:37 · Score: 0
  
  Except that doing an abortion have very little effect on the surroundings but doing drugs can have huge consequences for other people (operating vehicles or heavy machinery while under the influence of drugs, etc).
  So comparing abortions to drugs is not only a really bad comparison, ...
  
  I'm with you on abortion being a bad comparison, but equally as terrible is your arguments against drugs because operating vehicles or heavy machinery under the influence could have negative consequences.
  Taking drugs and operating a vehicle is just one of many many ways to make poor decisions that have negative consequences for someone other than the user. Are you going to outlaw all loud music from cars because a driver has the ability to exercise poor judgement and listen to loud music while driving and thus preventing him from hearing that minivan's horn warning of imminent collision killing twin babies?
  Ffs, you can make dumb decisions if you want to, but don't take away my rights to make smart informed decisions just because you're ignorant.
And anonymous cowards... by Anonymous Coward · 2017-01-31 01:34 · Score: 0

disgust me. Especially when they can't write.
Creative high by Is+Don+the+new+Ron · 2017-01-31 01:34 · Score: 1

Lysergic acid diethylamide (LSD) has been credited, in part, for the creation of the iPhone, the polymerase chain reaction, as well as some pretty abstract artwork.
Don't forget the Beatles song. Incidentally don't talk about flower power. The substance is a fungus.

--
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1. Re:Creative high by Anonymous Coward · 2017-01-31 01:40 · Score: 0
  
  Then the effects wore off and we got disco and "Silly Love Songs".
2. Re:Creative high by Opportunist · 2017-01-31 01:43 · Score: 1
  
  Yay, mushroom power!
  
  --
  We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
3. Re:Creative high by DickBreath · 2017-01-31 02:28 · Score: 1
  
  > Lysergic acid diethylamide (LSD) has been credited, in part, for the creation of the iPhone
  
  The effects wore off and we got Windows 10.
  
  --
  
  I'll see your senator, and I'll raise you two judges.
4. Re:Creative high by TheFakeTimCook · 2017-01-31 05:58 · Score: 1
  
  > Lysergic acid diethylamide (LSD) has been credited, in part, for the creation of the iPhone The effects wore off and we got Windows 10.
  LOL, Perfect!
AL-LAD by Anonymous Coward · 2017-01-31 01:36 · Score: 1

Alexander Shulgin synthesized a slight variation of LSD called AL-LAD.
https://erowid.org/library/boo...
It lasts about half as long as LSD.
At low doses, AL-LAD is less cerebral, more visual than LSD.
At high doses, the effects get more similar, nearly identical.
I can fully recommend it and haven't taken any apparent damage after 20+ AL-LAD trips. ... or if you're more naturally inclined, you could just eat magic mushrooms, which also act much shorter than LSD.
Personally I find mushrooms to be much more difficult to handle emotionally.
but people who elicit drugs... by MrKaos · 2017-01-31 01:39 · Score: 2

can be the life of the party.

--
My ism, it's full of beliefs.
1. Re:but people who elicit drugs... by Anonymous Coward · 2017-01-31 01:56 · Score: 2, Funny
  
  Alyssa listed illicit drugs; elicited listless shrugs from online readers.
2. Re: but people who elicit drugs... by Anonymous Coward · 2017-01-31 02:07 · Score: 0
  
  or a major drag. some people just can not handle.
psychedelic drugs and animals by MrKaos · 2017-01-31 01:43 · Score: 4, Interesting

Animals and insects eat psychedelic drugs in the wild - just to get wasted. Deers do it, so do some flies - and they repeat the experience, so it is not an accident.
It says a lot for how long the psychedelic experience has been around consciousness, that it is not unique to humans.

--
My ism, it's full of beliefs.
1. Re: psychedelic drugs and animals by Anonymous Coward · 2017-01-31 02:09 · Score: 0
  
  rrrrrrright........
2. Re:psychedelic drugs and animals by budgenator · 2017-01-31 02:29 · Score: 1
  
  Sounds like more fun than a troop of monkeys eating fermented fruit and getting falling down drunk.
  
  --
  Apocalypse Cancelled, Sorry, No Ticket Refunds
3. Re:psychedelic drugs and animals by Anonymous Coward · 2017-01-31 05:33 · Score: 0
  
  http://news.bbc.co.uk/1/hi/sci/tech/110565.stm
  Fruit flies have the "cheapdate" gene. I wonder how that got named...
4. Re:psychedelic drugs and animals by Anonymous Coward · 2017-01-31 05:43 · Score: 0
  
  Way back in prehistory before I went full techie I worked a dairy farm. The dry cow pasture had run-off from haylage and silage bags running through it. Super potent alcoholic run-off. You wouldn't drink that, no way, no how. But if we got a rain, it'd puddle up with the water and we'd have a bunch of drunken cattle on our hands.
  And some cows, just like some people, were MEAN drunks.
5. Re:psychedelic drugs and animals by syntotic · 2017-02-04 06:12 · Score: 1
  
  Evolutionary speaking it is our duty and prerrogative to experiment it. The keyword is receptors, if it was a destructive effect would be different, but the moment it binds, the result is controlled. Seemingly all people who try it, like it! That simple. Though we know that (for reasons), even something as delicious as pork was forbidden. If cows are sacred in India ad prefer to starve, what can we expect from something you like, even if the binding tells us our bodies are ready to use it?
Flying by amiga3D · 2017-01-31 01:54 · Score: 0

I can fly! I can fly! I can fly! Splatt!
You're all missing the important part by Anonymous Coward · 2017-01-31 01:59 · Score: 0

This report shows that scientists now know about a substance called "kentaserin", which can SWEET JESUS PLEASE MAKE IT STOP IT'S 7AM AND I NEED SOME SLEEP.
This is why LSD is the best! by Anonymous Coward · 2017-01-31 02:18 · Score: 0

It's the most cost-effective and non-addictive. Granted, some tiny portion of its users may experience drug-induced schizophrenia, but that's only because they're already schizophrenic, or soon will be. So, really, it's also a great way to identify schizophrenics... a bargain!
Haven't you ever... by Anonymous Coward · 2017-01-31 02:19 · Score: 0

watched Dragnet? Remember Blue Boy? I don't want any part of that hippie stuff.
1. Re:Haven't you ever... by DickBreath · 2017-01-31 02:26 · Score: 1
  
  I remember the episode where a young couple let their baby drown while filling the bathtub because they were using . . . OMG !!! . . . weed!
  
  --
  
  I'll see your senator, and I'll raise you two judges.
2. Re:Haven't you ever... by Anonymous Coward · 2017-01-31 02:57 · Score: 0
  
  A cautionary tale to this viewer at the time. We would have less of a drug problem in this country if kids watched Dragnet. Fewer hippies too.
"Cure" to LSD Trip? by cmseagle · 2017-01-31 02:19 · Score: 1

Maybe someone who knows more biochemistry can answer. Could you give kentaserin to someone having a bad trip to bring them back to reality? At that point, is it already too late because the LSD has already bound to the relevant receptors?
1. Re:"Cure" to LSD Trip? by PolygamousRanchKid+ · 2017-01-31 04:11 · Score: 1
  
  Could you give kentaserin to someone having a bad trip to bring them back to reality?
  There are those of us who perceive and experience reality as the bad trip.
  
  --
  Schroedinger's Brexit: The UK is both in and out of the EU at the same time!
2. Re:"Cure" to LSD Trip? by GuB-42 · 2017-01-31 04:18 · Score: 1
  
  I know that antipsychotics can be used to stop a bad trip. Some of them can act as serotonin antagonists.
  Though I don't know how effective they really are compared to a placebo, and if they are, by what mechanism.
3. Re:"Cure" to LSD Trip? by Anonymous Coward · 2017-01-31 06:10 · Score: 0
  
  Valium is the only one that will snap you back to reality in my experience. Pseudoephedrine is good for stopping it too, but more useful in a "bitch is having a really bad reaction to it, and we either physically knock them out, or put way more Pseudoephedrine than normally recomended". Valium you can stay awake (but won't really want to). Pseudophedrine you will likely pass the fuck out, and when you wake it'll be over.
4. Re:"Cure" to LSD Trip? by Johann+Public · 2017-01-31 08:03 · Score: 1
  
  "I had a bad trip once, I hope it ends soon."
5. Re:"Cure" to LSD Trip? by DMFNR · 2017-01-31 09:51 · Score: 1
  
  Really? I've heard of using benzos, but never the psuedoephedrine thing. I would have thought that a nasal decongestant and a shitty stimulant would have the opposite effect on a LSD trip, but what do I know? Interesting.
6. Re:"Cure" to LSD Trip? by Anonymous Coward · 2017-01-31 18:17 · Score: 0
  
  "I had a bad trip once, I hope it ends soon."
  I dropped two tabs and believed Donald Trump was elected president. Please help, I can't come down to reality and it seems like the world has gone crazy. I hope this trip ends soon, cause it keeps getting scarier by the day.
7. Re:"Cure" to LSD Trip? by uvajed_ekil · 2017-01-31 18:42 · Score: 1
  
  Pseudoephedrine, what!? Knocking you out? Valium can keep you awake, or just fail to make you sleepy? I don't see how using a mildly stimulating decongestant would help, and Valium is a proven and somewhat available means to calm a bad trip. Inf fact, benzodiazepines are commonly given for bad trips because they both mitigate the associated anxiety and often induce drowsiness. Something faster/shorter acting like alprazolam or lorazepam can be pretty effective, though the longer action of Valium isn't necessarily a problem. I have no firsthand experience but a couple of years ago a friend used 2 mg of etizolam to fall asleep and effectively abort a trip after about 4 hours. Said he woke up clear headed and feeling rested 8 hours later.
  
  --
  This is a hacked account, for which the owner can not be held responsible.
This story... by Anonymous Coward · 2017-01-31 02:30 · Score: 1

...is a trip.
Wrong by Anonymous Coward · 2017-01-31 02:44 · Score: 1

Steve Jobs used it as a young man, and what he said was that he thought everyone should have the experience. None of Apple's inventions have been credited directly to that, that's your own flawed conclusion. He was talking about himself and the kind of person he felt he could become (incidentally, you don't need substances to access that part of yourself). Don't pass it off as fact. Bear in mind too that LSD was a very different proposition back then, it was a very different substance, initially used in a very controlled fashion. How much of what troubles young people today is derived from the misunderstanding of something someone said? I know your parents won't nudge you in a direction or correct you, so consider me your nudger for the day. So ends my millennial rant for Tuesday.
1. Re:Wrong by Anonymous Coward · 2017-01-31 06:34 · Score: 0
  
  Fuck off dad, you moralising prick!
Terrence McKenna talked about the "Stoned Ape" by Ellis+D.+Tripp · 2017-01-31 02:47 · Score: 3, Interesting

hypothesis, in which proto-humans regularly ingested psychedelic plants or fungi, and it led to the rapid development of the higher mental functions found in humans.
http://www.lycaeum.org/~sputnik/McKenna/Evolution/

--
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1. Re:Terrence McKenna talked about the "Stoned Ape" by Anonymous Coward · 2017-01-31 18:15 · Score: 0
  
  hypothesis, in which proto-humans regularly ingested psychedelic plants or fungi, and it led to the rapid development of the higher mental functions found in humans.
  http://www.lycaeum.org/~sputnik/McKenna/Evolution/
  But of course he was a huge crackpot who ranted on and on about his visions and pseudoscience. Don't get me wrong, I love the idea of psychedelics enhancing creativity and providing lasting effects, including deep spiritual insight, but McKenna was a nut. An eloquent, willing, and prolific nut, but a nut nonetheless, no matter how much untapped potential LSD or DMT might hold.
2. Re:Terrence McKenna talked about the "Stoned Ape" by OneoFamillion · 2017-01-31 23:28 · Score: 1
  
  Cue Bill Hicks (RIP) and the 2001: A Space Odyssey theme...
Creation of Alcoholics Anonymous by Anonymous Coward · 2017-01-31 03:01 · Score: 1

LSD was also a strong influence on Bill Wilson in his search for a cure to alcoholism. The story goes that Bill Wilson eventually split with AA over AA becoming a completely anti-drug organization, and he still wanted to experiment with LSD and alcoholism.
ketanserin misspelled by Anonymous Coward · 2017-01-31 03:34 · Score: 0

Please fix summary. Now it reads 'kentaserin.'
DMT = N, N-dimethyltryptamine by Anonymous Coward · 2017-01-31 04:03 · Score: 0

For those who were wondering. Tryptamine is an indole ring (C4N) with an ethyl amine group attached to the 5 membered ring.
1. Re:DMT = N, N-dimethyltryptamine by Anonymous Coward · 2017-01-31 04:05 · Score: 0
  
  Sorry, Indole C6 ring (benzene) fused with C4N ring (pyrrole).
2. Re:DMT = N, N-dimethyltryptamine by OneSmartFellow · 2017-01-31 04:25 · Score: 1
  
  Thank god you cleared that up.
Tiger tripping by aepervius · 2017-01-31 04:22 · Score: 1

https://www.youtube.com/watch?...

Although it is an extract from a film (BBC?) I do not recall the original.

There are also films of apes tripping on fermented alcohol taken from tree pockets and some of them (10%) are repeat "alcoholic" offender. As you say tripping was not invented by human :)

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visit randi.org
data by Anonymous Coward · 2017-01-31 04:28 · Score: 0

Probably causes continued production of the neurotransmitters that cause the emotion of guilt. After a while guilt appears to be the only emotion; probably nature efficiently transforms it into the other emotions, saving a lot of brainspace.
oh, for the love of... by zephvark · 2017-01-31 04:34 · Score: 0

Does Slashdot need to repost everything on Reddit a few days later? Mother of God. This site is increasingly obsolescent. I love it, but I think that's just nostalgia talking.
"So long"? No, long was STP by whitroth · 2017-01-31 05:22 · Score: 1

https://en.wikipedia.org/wiki/...
And STP lasted for close to 24 hours. Yes. I can personally verify that it did. And yes, this is long, long beyond the statute of limitations.
Imagine being so dense by Johann+Public · 2017-01-31 05:40 · Score: 1

that you thought a long-duration psychedelic was a bad thing.

DOI & other 4-substituted psychedelic phenylisopropylamines are where it's at, (nod to the "STP" (DOM) poster) with 36+ hour durations. You can fall asleep & wake up still in that oh-so-desirable mindspace. DOI has been shown to have health-promoting effects (via TNF-alpha (beneficial to the cardiac system)) and is not illegal. Not for everyone, but that ought to go without saying. Educated, responsible use is vital.
1. Re:Imagine being so dense by uvajed_ekil · 2017-01-31 18:58 · Score: 1
  
  36 hours, jeez, that's a lot of time to set aside, or a long time to be so "altered." LSD seems plenty long enough, and has a well-established safety profile when used with care. DMT might be a bit too quick, like a drag race, but I'd think an Indy 500-type duration would be enough for most people, rather than going up to a whole 24 hour endurance race like LeMans.
  
  Something producing a full-on LSD-like experience in say, 2-4 hours would be a huge hit, both with psychonauts and scientists. I think 8+ hours of a psychedelic experience can be extremely exhausting, and long enough to forget a lot of the desirable details. To each his own of course, and a marathon can produce an extreme feeling of accomplishment for those willing to endure it. I just think something more manageable could be more useful, and become more accepted.
  
  --
  This is a hacked account, for which the owner can not be held responsible.
Great. Can they make me a dose that'll last by Anonymous Coward · 2017-01-31 06:59 · Score: 0

4 years?
1. Re:Great. Can they make me a dose that'll last by Anonymous Coward · 2017-01-31 19:13 · Score: 0
  
  Monday: east LSD, define your own future.
  Tuesday: smoke reefer all day like a Rastafarian, remember that things go in cycles.
  Wednesday: eat a bottle of Robotussin cough gels, listen to inspirational music that never sounded so good, realize that you are okay.
  Thursday: smoke crack (being sure to only have a day's worth of crack), and just forget the BS (no real benefit).
  Friday: eat some mushrooms (not portobellos or shiitakes, smartass), relax, order pizza.
  Saturday: copious amounts of alcohol, your choice of flavors, get angry at the status quo, and resolve to do better.
  Sunday: go to church, pray a lot, eat donuts, hang with family, console each other, pray some more for our future.
  
  Repeat weekly as necessary, likely until January 2021, or at least November 2020.
Operation Julie by Anonymous Coward · 2017-01-31 08:04 · Score: 0

Speaking as someone that is still coming down from the orange microdots of the mid 1970s (Sadly busted by operation Julie) this serotonin 2A antagonist sounds really boring :)
https://en.wikipedia.org/wiki/Operation_Julie
Of course operation Julie had unwanted side effects. With the removal of the wholesome LSD produced by David Solomon and Richard Kemp the market was flooded with all kind of toxic crap and the drug problem we have today follows.
Ah well.
Dock Ellis by way2slo · 2017-01-31 08:17 · Score: 1

"(LSD) has been credited, in part, for the creation of the iPhone, the polymerase chain reaction, as well as some pretty abstract artwork." ...and also a Baseball No-Hitter by Dock Ellis.
Must See Video Story: https://www.youtube.com/watch?...
Oan a permo by Anonymous Coward · 2017-01-31 10:09 · Score: 0

Ah cannae believe you cunts huvnie linked tae https://www.youtube.com/watch?v=Nr0eJIW4gPI awready. Limmy shagged yer maw.
Best chemical to abort trip by UnkyHerb · 2017-01-31 10:13 · Score: 1

Try L-Theanine, 200-2,000mg+ (you can mix the pure powder into tea like peppermint tea). It's a harmless amino acid found naturally in green tea in small amounts, and aborts trips via another way besides 5ht2a antagonism. I believe it just quiets the excitation (glutamate) of the brain. I've tested it personally and with other people who all agree it works, and is the least prone to side effects of any other medication administered for such purposes. I was actually trying to test out the combination on someone who uses psychedelic 5HT2-A agonists such as LSD or mushrooms for cluster headaches, to see if they could avoid having to do the "trip" part, I wonder if it'd still help with the cluster headaches. Be an interesting experiment.
You can buy it at Walmart in the health supplement section, or really cheap via bulk powder on the internet with a quick search. Just make sure if you use it for these purposes it doesn't contain anything besides the l-theanine (no green tea or caffeine).

--
Your Momma's so fat she makes emacs look like nano!
Science discoveries and LSD by Anonymous Coward · 2017-01-31 11:10 · Score: 0

Both Dr. Francis Crick (co-discoverer of the structure of DNA) and Dr. Kary Mullis (inventor of the polymerase chain reaction) credit their use of LSD assisting them with coming up with their respective discoveries.
Longer if... by Anonymous Coward · 2017-02-01 06:50 · Score: 0

Longer, if you are within two meters of a router...