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Studies Link Some Stomach Drugs To Alzheimer's Disease and Kidney Problems (scientificamerican.com)
While the recommended dosage for Nexium, Prevacid and Prilose is just two weeks, doctors often advise patients to continue taking them for years. But now Scientific American reports that "Chronic use of popular heartburn medicines may be riskier than was thought," citing two papers linking the drugs to an increase risk of dementia, including Alzheimer's disease, and a greater risk of kidney problems.
schwit1 quotes their report:
The papers did not prove that PPIs cause the problems. But some researchers have nonetheless suggested possible mechanisms by which long-term use of the drugs could trigger dementia or kidney problems. A reduction in vitamin B12, for example, might leave the brain more vulnerable to damage, says Britta Haenisch, an author of the JAMA Neurology study and a neuropharmacologist at the Bonn campus of the German Center for Neurodegenerative Diseases. Last spring clinicians at the Houston Methodist Research Institute reported another plausible explanation for how PPIs might lead to these unexpected health issues: they picked up signs that the drugs act not only in the stomach but elsewhere in the body, too.
The article ends on an ambiguous note. "Without conclusive data, physicians and patients have to balance the need to prevent the ill effects of excess stomach acid and reflux with the desire to avoid potentially serious -- if theoretical -- side effects from long-term use of PPIs."
The article ends on an ambiguous note. "Without conclusive data, physicians and patients have to balance the need to prevent the ill effects of excess stomach acid and reflux with the desire to avoid potentially serious -- if theoretical -- side effects from long-term use of PPIs."
The recommended dose is two weeks for the over the counter (OTC) versions of the medications. That's so you don't keep taking it by yourself when you have symptoms that need an evaluation by a doctor.
Taking drugs isn't healthy! Who knew.
Not Doctors. They'd fucking make you mainline heroin just to shut you up.
http://www.jesus-is-savior.com/False%20Religions/Jehovah%20Witnesses/jw_lie.htm
I am now going to EXPOSE and REFUTE the Jehovah's Witnesses' (JWs) publication, Knowledge That Leads to Everlasting Life (Publishers: Watchtower Bible and Tract Society of New York, inc and the International Bible Students Association, 1984 edition). In this little booklet, which is distributed by the JWs, many LIES are presented to the reader. Only God knows the total number of victims who have gone to Hell, because of the lies of the Jehovah's Witnesses. On page 173 of this JW booklet, we read the title, Steps That Lead to Life Eternal, and I quote ...
"Unlike Jesus, we are imperfect and can reach the milestone of baptism only after taking other vital steps. This begins by talking accurate knowledge of Jehovah God and Jesus Christ into our heart. Doing this causes us to exercise faith and to have profound love for God. (Matthew 22:37-40; Romans 10:17; Hebrews 11:6). Compliance with God's laws, principles, and standards should move us to repent, expressing godly sorrow over our past sins. This leads to conversion, that is, to a turning around and abandoning any wrong course we followed when we did not have the knowledge of God. (Acts 3:19) Naturally, if we are still secretly practicing some sin instead of doing what is righteous, we have not really turned around, nor have we fooled God. Jehovah detects all hypocrisy.--Luke 12:2,3. -(page 173, Knowledge That Leads to Everlasting Life).
These are lies of the Devil. Several things are wrong with the above statements.
First, baptism is NOT required by God for salvation (1st Corinthians 1:17). Out of all the hundreds of references to faith in the New Testament, baptism is usually NOT mentioned with faith. Please read, What is Baptism?
Secondly, there are no "vital steps" required for a person to be baptized. There is only ONE step (singular), and that is to become a born-again believer (John 3:3). A person becomes a born-again believer by trusting solely upon Jesus Christ as personal Savior, for the forgiveness of sin (Romans 4:5; 10:13). The requirement to be baptized is simply to ALREADY be a Christian believer. A policeman wears his badge because he's ALREADY a policeman. A woman wears a wedding ring because she's ALREADY married. And a believer gets baptized because he's ALREADY a believer. We get baptized because we ARE saved, not to get saved.
Thirdly, the above statement, "Compliance with God's laws, principles, and standards should move us to repent" is a lie of Satan. Repentance in a person's mind always comes first, before any change in their life. Biblical "repentance" is a change of mind. The change of life will follow. We read in 2nd Corinthians 7:10, "For godly sorrow worketh repentance ..." There's nothing in this Scripture which speaks of "complying" with anything. Jehovah's Witnesses teach people to join their visible organization, to learn about their cult, and then to be baptized once they've made those "vital steps" leading up to baptism. The Word of God NEVER teaches anything about preparation, or vital steps, before salvation. Jesus never told anyone to first get educated concerning religion, and then they could get saved.
No, Jesus simply said ...
"I am the bread of life: he that cometh to me shall never hunger; and he that believeth on me shall never thirst." -John 6:35
"I am the light of the world: he that followeth me shall not walk in darkness, but shall have the light of life." -John 8:12
" I am the door: by me if any man enter in, he shall be saved, and shall go in and out, and find pasture." -John 10:9
"I am the resurrection, and the life: he that believeth in me, though he were dead, yet shall he live." -John 11:25
"I am the way, the truth, a
Trump approves of all stomach bowl drugs in his latest alternative fact executive orders.
Build a digestive wall and make the parasites pay fer it! Make digestation grate again!
Maybe instead use an H2 blocker like ranitidine, aka Zantac? That way the effects of the drug are localized to the stomach and treat the root cause: over production of hydrochloric acid.
Thank you, fuck off.
its killing the messenger
instead
eat clean food
regulate your fluids
CHEW YOUR FOOD
keep your diet consistent
eat the same quantity and types of food on the same schedule
PPIs: Proton-pump inhibitor
Proton pump inhibitors are a group of drugs whose main action is a pronounced and long-lasting reduction of gastric acid production. Within the class of medications, there is no clear evidence that one agent works better than another. FROM: Wikipedia
Drugs in class: Omeprazole, Pantoprazole, Esomeprazole,
https://en.wikipedia.org/wiki/Proton-pump_inhibitor
"While the recommended dosage for Nexium, Prevacid and Prilose is just two weeks"
The dosage for most drugs is measured in mass (mg, often)/time, not time alone. How does one meter a dosage in the time domain with no regard to mass (homeopathic medicines excepted, of course)?
"National Security is the chief cause of national insecurity." - Celine's First Law
Proton pump inhibitor have been known to be troublesome for a long time
By reducing stomach acidity, it increases the amount of bacteria that pass alive in the intestine, increasing the odds of Small intestine bacterial overgrowth (SIBO). It also increase the odds of proliferation of some bacteria such as heliobacter pylori in the stomach itself.
All that pathogens overload the immune system, and degrade digestive functions.
These drugs are perfectly safe, and anyone who says otherwise is a child molesting homosexual. And probably a Hillary Clinton Supporter that wants California to secede from the USA because they want to have gay sex with children in San Francisco.
I mentioned this association to my doctor. She advised caution in interpreting these results because these PPIs are routinely prescribed to patients at risk for the linked diseases. Anyone know more on this?
Of course, the older H2 blockers can be effective for those who want to avoid PPIs. Better still, some people, including myself, get complete relief by finding a healthy diet that does not trigger acid reflux. (For me, that means cutting down on grains and starchy vegetables, YMMV).
Anyone can suggest an alternative that actually works for them long term ? I have heard of apple cider ? does that actually work ?
I have been taking PPIs for 8 years now. Though I have reduced the dosage as much as possible but stopping them altogether gets really difficult in 1-2 days.
If you're old enough to remember... nexium "the purple pill"'s introduction was in the same year as the introduction of the new M&M color. Both ad campaigns had much hype surrounding them. I laughed out loud when the M&M color was revealed, and never trusted a drug ad after that (OK, I've never trusted a drug ad before that either).
I would think that PPI use is also strongly associated in many case with certain lifestyle choices. Stuff like poor diet, lack of excercise, alcohol use. And also stress. PPI use and dementia could both be symptoms of the same underlying cause.
I don't know why, but I fear consuming cyanocobalamin
You know, the whole cyanide thing.
The article also doesn't mention that omeprazole has serious interactions with B12 supplements, so what is one supposed to do?
Clay works far better than those awful, worthless PPIs do.
Now that they cause 10 kinds of brain illness? Yeah, na. I'll keep eating my liquid clay.
Geophagy is used for a reason.
The papers did not prove that PPIs cause the problems.
So, click-bait, then ?
just solved 4 months of heartburn by realizing i needed to chew my food waaaay more. Shitty food is generally soft and easily swallowable. I can now eat anything including mcdonalds and not get heart burn. Chew your food in to a watery paste and be free of medication!
First:
It is unwise to immediately and completely change ones medications or prescription habits just based on one study. These large observational multivariate studies are always hindered by bias, though trying hard to compensate for them.
On the other hand, these kind of findings should not be ignored.
Proton pump inhibitors are already known for a long time to cause trouble. The article already mentions several, like the bacteria get a change of growing in the changed environment of the stomach, a defensive barrier is removed, certain vitamins and drugs need the acidity to get absorbed etc etc. Kidney issues are also not news. Other weird side effects, like I'll never forget a patient with an extreme hypomagnesia, like 0.10 mmol/l or so. She did not feel well.
But not forget the number of patients who have gained significant quality of life and the reduction of severe gastric bleeding. Remember the time where Bilroth gastrectomies were as common as cholecystectomies. The two week maximum advise for the over the counter drugs is because of the risk of patients masking a serious condition like malignancies.
But there is no denying that most people at some point start their PPI for some discomfort, and continue to swallow them for the rest of their lives. (Ideal drug for pharmaceutical companies.) The majority should just quit them, change their food habits and posture and get on with their lives.
The use of these drugs should be reserved for those who really need them. Right now it is prescribed more or less as a luxury drug
Why are other peoples sig's always more witty ???
It has been know for ages Omeprazol fucks up your brain. Now that could explain one thing or two about my ex. I already warned my parents to not abuse it...
Milk of Magnesia. As a bonus, your body actually LIKES the extra magnesium.
The sleazy money game that is the drug corporations and their focus on lucrative, often dangerous drugs for aging boomers in denial over aging, and the endless studies that reek of ambiguity and questionable data capture? Everybody has something to gain here (market share and more research grants).
I have tried these drugs twice, and each time never made it through the two weeks. They triggered severe, daily migraines, with extreme halo effects. It literally felt like they messed with my brain. I will never take them again.
See you space cowboy
I had to go all the way to Brazil to find a gastro-enterologist who actually had the time to explain the difference to me.
He told me omeprazole lowers your acidity (increases pH) very effectively. Even so effectively that with prolonged use polyps can develop due to the almost total lack of acid. Lansoprazole, as he told me, didn't reduce the acidity that much, and so prevented way better those polyps to form.
"Trump!!", the new Godwin.
If suffering heartburn symptoms and taking PPIs frequently consider getting tested for the H-Pylori bacteria. I was taking PPIs daily for 3 years before suffering a bleeding ulcer - testing revealed H-Pylori. After the bacteria was killed off in two weeks, I've not taken a PPI in four years and have not had any recurrence of the symptoms that had originally driven me to PPI use.
A related problem seems to be that some of these drugs suppress gastrin production. As soon as you try to quit (and I mean a VERY slow tapering off, even), gastrin levels immediately go back up, and the heartburn can be worse than ever. I have tried backing off in 1% increments, and found it not possible. (Yes, I opened up the capsules and counted the pellets inside.) Diet, posture, avoiding acidic foods and not eating near bedtime have been taken care of and ruled out as possible solutions.
So these drugs are addicting in the sense of creating an artificial need for something that you don't have a natural need for. (Not in the mentally-addicting sense in which the term is most often used, however.)
But, we make tradeoffs all the time in life. Here, we're solving the problem of near certain ulcers and perhaps cancer in favor of problems not yet conclusively proven to occur, so it makes more sense to keep taking them...
Been taking pantoprazole for 7 years now, but I've always been"scared" of the possible long-term consequences. For that reason I only taken one when I need it, which averages to about2 pills a week (20 mg). But at the same time I'm more concerned about the long-term consequences of frequent heartburn, thinking of Barret's esophagus, cancer,tissue proliferationetc.
It's a shitty situation being dependent on a drug to function, I honestly couldn't live without it, while having to fear possible nutritional deficiencies (iron, calcium, magnesium, B12, B6 etc)- will I end up with early osteoporosis? Do I have low iron storage andmore fatigued than I otherwise could be?
I previously would occasionally take a Tums here or there, but my wife mentioned I should try drinking a small amount of Raw Apple Cider Vinegar. It tastes horrible, and you have to rinse your teeth, but shockingly it works better than anything I've ever tried.
Am I lying when I tell you that im telling the truth? Or am I telling the truth when I say that Im lying?
First off. I am not a doctor but I'd like to relate my personal anecdotal experience.
I was told to go on nexum for life, but was uncomfortable with long term use of a product that didn't seem to be well tested long term.
SOO.... i looked into it. Something that , according to my doctor, and several other sources has been used in the past to help fix acid reflux
is the stimulate acid production so you food digest more quickly. One way to do this is to drink 2 tablesppons of apple cider with a cup of water before every meal.
I kept this up for something like 2 months. The acid reflux , which had been regular went away and has yet to return a year later. I think if it comes back I will try this way again first.
So, just my nickle. you can try it, your mileage might very, on the other hand , it's probably safest to run in past your doctor to make sure you understood all the inns and outs, assuming you trust their advice.
âoeTolerance applies only to persons, but never to truth. Intolerance applies only to truth, but never to persons.
Low carb and moderation will end acid reflux.
love is just extroverted narcissism
Most drugs, just treat the SYMPTOMS, not the cause. If you constantly have headaches, "aspirin" might get rid of the headache, but the headache comes back. You need to treat WHY you are getting the headache. Same with some of these stomach drugs. Yeah, they might get rid of your ache, but it keeps coming back. Is it masking an underlying problem?
Do they know the mechanisms and thus know that these are directly related cause and effect, or is this just more paper publishing by chimpanzees with keyboards doing statistics and noticing dubious correlations?
Correlation studies are interesting and possibly informative when properly used, but they also lead to classic correlation-causation fallacies.
Everybody who has eaten pickles is dead or will die, therefore eating pickles kills! (sadly, this too-often passes for "science" these days...)