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Aspirin May Prevent Cancer From Spreading, New Research Shows (scientificamerican.com)

An anonymous reader quotes a report from Scientific American: In recent years scientists have discovered another possible use for aspirin: stopping the spread of cancer cells in the body after an initial tumor has already formed. The research is still developing, but the findings hint that the drug could one day form the basis for a powerful addition to current cancer therapies. Not everyone responds equally well to the drug, however, and for some people it can be downright dangerous. Investigators are thus trying to develop genetic tests to determine who is most likely to benefit from long-term use of aspirin. The latest research into the drug's cancer-inhibiting activity is generating findings that could possibly guide those efforts. More recently, investigators have started to elucidate a third way that aspirin works -- one that interferes with the ability of cancer cells to spread, or metastasize, through the body. Intriguingly, in this case, the drug's anti-inflammatory properties do not appear to play the starring role. Researchers often inject tumor cells into the bloodstream of mice to approximate what happens during metastasis when cancer cells must navigate the bloodstream to find a new home in the body. When Elisabeth Battinelli, a hematologist at Brigham and Women's Hospital in Boston, and her team fed aspirin to certain strains of mice and then injected them with malignant cells, the investigators discovered that the platelets did not shield breakaway cancer cells from the immune system or produce the necessary growth factors that allow cancer cells to grow and divide in a new location. Thus, aspirin appears to fight cancer in two ways: its anti-inflammatory action prevents some tumors from forming, and its antiplatelet properties interfere with some cancer cells' ability to spread.

49 comments

  1. As in all reporting of science stories ... by Anonymous Coward · · Score: 0

    Keep in mind the word "may" means "there is still insufficient evidence to believe that" -- and chances are whatever is asserted will eventually be proven not to be the case. Oh yes ... and it won't be reported on again in that case because it doesn't make a good story.

    1. Re:As in all reporting of science stories ... by ShanghaiBill · · Score: 4, Interesting

      A big problem is that many "animal models" are wrong. For instance, we model Alzheimer's by using mice bred to reliably grow the beta amyloid plaques in brain tissue that are thought to cause the disease. We have developed dozens of drugs that prevent these plaques from forming in these mice. Yet, in human clinical trials NONE of these drugs has been effective. An obvious hypothesis is that the beta amyloids are just a symptom of Alzheimer's disease, and not the underlying cause. So the animal model may be completely wrong.

    2. Re:As in all reporting of science stories ... by rmdingler · · Score: 2
      The encouraging aspect of this, and other trials, is that animal models are occasionally accurate reflections of the effect of a drug on the human animal.

      I suspect this is why drug trials are still tested in this manner.

      --
      Happiness in intelligent people is the rarest thing I know.

      Ernest Hemingway

    3. Re:As in all reporting of science stories ... by Anonymous Coward · · Score: 0

      At the least, this serves as a reminder that researchers do research common substances for their effects on cancer, and not just patent-able exotic drugs. There are certainly biases in how research money gets spent, but some conspiracy theorists would like you to think that cancer researchers are all inhuman monsters that are hiding cheap OTC cures so they can make more money...

    4. Re:As in all reporting of science stories ... by Anonymous Coward · · Score: 0

      I really don't see any convincing evidence (I don't even talk about a proof) why the animal model may be wrong. Another possibility is that when the Alzheimer disease diagnosed in humans, it is already too late and the disease is already in an irreversible state. Their are a very well-known hypothesis about the crucial role of the deregulation of the Ca2+. Numerous models simulated an studied for stability analysis showed an irreversible character above a certain Ca2+ threshold. With ageing the Ca2+ level is naturally higher, but small stochastic variation may be responsible for stepping above the irreversible threshold.

      May be the work on animal is valid and but they receive the treatment before the threshold is reached and for humans, it is just too late. Just remember we have got no reliable test for the diagnosis of Alzheimer disease...

      PS: It is also well known that Alzheimer is more predominant when the sunlight on the skin is lacking (correlation with the localization on earth is established). Ca2+ is regulated by vitamin D, Vitamin D is produced when the skin is exposed to the sunlight...

    5. Re:As in all reporting of science stories ... by SNRatio · · Score: 1

      Yes. Plus the animal models do improve over time. The Alzheimers/amyloid mouse models are being updated to remove artifacts caused by overexpression of APP (think amyloid). Other models directly manipulate tau instead.

    6. Re:As in all reporting of science stories ... by TheNarrator · · Score: 1

      There are also treatments for Alzheimer's that have a lot of study evidence in humans, decades of safe use, and are already on the market that nobody uses because of the social stigma and they are too cheap to bother promoting. For example, pharmaceutical grade Methylene Blue.

    7. Re:As in all reporting of science stories ... by Anonymous+Cow+Ward · · Score: 1

      That's not at all what biologists do, but keep showing your ignorance, I'm sure that'll help your cause.

      --
      Examine even your most deeply held beliefs. Nobody is always right.
  2. Re: But Obama confirmed... by Anonymous Coward · · Score: 0

    Correct. We should support science instead of "feelings."

  3. Re: But Obama confirmed... by Anonymous Coward · · Score: 0

    That is what he said but racists stand against him.

  4. Re:But Obama confirmed... by Anonymous Coward · · Score: 0

    He said no serious person disagrees with them, and he hasn't confirmed that he doesn't stand against this study.

  5. Re:But Obama confirmed... by Anonymous Coward · · Score: 0

    His exact quote was ‘No Serious Person Would Suggest That You Could Even Rig America’s Elections’ but since then he keeps making-up claims that he even he admits he has no evidence to prove. He is expecting us to believe ridiculous garbage with no proof just because he hates the world. Hates the world.

  6. Re: But Obama confirmed... by Anonymous Coward · · Score: 0

    Obama has proven he hates science and loves nonfact liberal education.

  7. Re:But Obama confirmed... by Anonymous Coward · · Score: 0

    Obama is a Muslim from Kenya.

  8. Re: But Obama confirmed... by Anonymous Coward · · Score: 0

    And anyone that disagrees is a racist.

  9. Re:But Obama confirmed... by Anonymous Coward · · Score: 0

    As he said, "No Serious Person..."

  10. Re: But Obama confirmed... by Anonymous Coward · · Score: 0

    He is correct. Only racists disagree.

  11. Re: But Obama confirmed... by Anonymous Coward · · Score: 0

    This. He is smart so people that disagree are anti-science like flat earthers.

  12. Re:But Obama confirmed... by Anonymous Coward · · Score: 0

    This. People that disagree with Obama are racist by definition.

  13. Seems about right by Anonymous Coward · · Score: 1

    I take a few aspirins each month and no cancer here.

    I suspect the drug companies will try to isolate what part of aspirin is preventing cancer, isolate it, and remove it from over-the-counter aspirin. Then they'll sell it to us for thousands/month. I guess it's time to stock up on some aspirin.

    1. Re:Seems about right by ArmoredDragon · · Score: 1

      I suspect the drug companies will try to isolate what part of aspirin is preventing cancer, isolate it, and remove it from over-the-counter aspirin. Then they'll sell it to us for thousands/month. I guess it's time to stock up on some aspirin.

      Because this has totally happened before? What else, IPv6 is a plot by the NWO to take over the world?

      Anyways I could see them isolating it and then making a purified version, because taking aspirin in large amounts long-term is not good for you (it will probably result in loss of kidney function, among other things.)

  14. democrats bomb aspirin factories by Anonymous Coward · · Score: 0

    and put peple in prison

  15. Sooo by Anonymous Coward · · Score: 1

    If I eat a chocolate aspirin pot brownie every day I'll be immortal?

    1. Re:Sooo by Applehu+Akbar · · Score: 2

      If I eat a chocolate aspirin pot brownie every day I'll be immortal?

      Just to make sure, we should incorporate graphene somehow.

    2. Re:Sooo by Anonymous Coward · · Score: 0

      It needs to be in the shape of a head of broccoli to enhance the sympathetic magic field, and, ideally, consumed in an accurate model of the Great Pyramid, for the Feng Shui.

    3. Re:Sooo by Anonymous Coward · · Score: 0

      don't forget to 3D-print the brownie

  16. Re: But Obama confirmed... by Anonymous Coward · · Score: 0

    This. Only republicans believe this lie.

  17. Re: But Obama confirmed... by Anonymous Coward · · Score: 0

    This. The DNC typically supports feelings over facts.

  18. Re: But Obama confirmed... by Anonymous Coward · · Score: 0

    Smart but as he said he hates nonbreeders.

  19. Re: But Obama confirmed... by Anonymous Coward · · Score: 0

    Bit some not so serious people disagree.

  20. Re: But Obama confirmed... by Anonymous Coward · · Score: 0

    Obama lied.

  21. Old news by Anonymous Coward · · Score: 0

    When I was doing chemo for stage 4 cancer, I was encouraged to take aspirin to deal with some of the side effects. While looking around for other possible cures, I found research that suggested my specific cancer may be stopped by aspirin in some cases but not consistently. I looked at the effectiveness of my chemo and it looked about the same as just the aspirin.

    I came to the conclusion that the chemo just convinced me to take aspirin and that was what worked. Not really, but it looked like a possibility. Chemo success was under 6%, aspirin alone was about 4% in one study. Either way what I have is "incurable" as I was told, and something worked. I would find it funny if it was only the aspirin. I honestly believe the chemo fixed other problems I was having that were minor.

    This was all a little over 5 years ago. So this is old news.

  22. Re: But Obama confirmed... by Anonymous Coward · · Score: 0

    His denial of outside election interference proves that.

  23. Re: But Obama confirmed... by Anonymous Coward · · Score: 0

    No he said he denies science. Of course that also includes a stand against breeders.

  24. Aspirin by Anonymous Coward · · Score: 0

    contains chemicals known to the state of California to cause cancer.

  25. Re: But Obama confirmed... by Anonymous Coward · · Score: 0

    But he has two spawn which makes him a hypocrite.

  26. Re: But Obama confirmed... by Anonymous Coward · · Score: 0

    As they should in order to help the people. Help the people.

  27. Aspirin working against cancer has been known by Anonymous Coward · · Score: 0

    I first read about this in 2011, right after I had myself been diagnosed with colon cancer.
    My tumour had been detected only because it had slowly leaked blood into the colon, causing anemia and I had been lucky to have a pedantic doctor who wanted to find the root cause.
    I immediately started self-medicating on ibuprofen (another drug in the NSAID group, together with Aspirin) and after two weeks the bleeding had stopped.

    The theory back then on how Aspirin and other NSAIDs work is that a tumour causes the its surroundings to be inflamed in order to feed it with blood - and Aspirin is a potent anti-inflammatory drug.

  28. Ibuprofen by Anonymous Coward · · Score: 0

    Does Ibuprofen provide the same protection for this?

    1. Re:Ibuprofen by Anonymous Coward · · Score: 0

      Considering that it is another substance I would not rule it out but consider it as likely as alcohol or marijuana providing the same protection.
      "Further studies needs to be done."

    2. Re:Ibuprofen by Anonymous Coward · · Score: 0

      While you're at it, why don't you test any and every toxic thing.

      Toxic things will stop cancer from growing.

      Therefore, Aspirin is as toxic as chemo drugs.

  29. Acetylsalicylic Acid by GNious · · Score: 1

    Because I had to look it up: Aspirin is acetylsalicylic acid

    1. Re:Acetylsalicylic Acid by Psychotria · · Score: 1

      Because I had to look it up: Aspirin is acetylsalicylic acid

      Thanks dude. I'm sure heaps of us hear don't know what it is. When I first read about it in an Agatha Christie book from 1914 or something I was stunned that she'd mention such an uncommon drug without giving the proper name.

    2. Re:Acetylsalicylic Acid by GNious · · Score: 1

      Odd fact: Due to Bayer's trademark, there's a lot of countries where you cannot buy "Aspirin". Some of them even have access to Slashdot.

      heaps of us hear

      That's a new one...

    3. Re:Acetylsalicylic Acid by Anonymous Coward · · Score: 1

      Odd fact: Due to Bayer's trademark, there's a lot of countries where you cannot buy "Aspirin". Some of them even have access to Slashdot.

      heaps of us hear

      That's a new one...

      MD here, some formal training and interest in this topic. What you say is true in the specific sense that you can not buy the chemical with trademarked name "Aspirin". But you can freely buy the same chemical under it's generic name "acetylsalicylic acid."

  30. With news articles, Some People Assume its a Cure by BoRegardless · · Score: 1

    Just to be straight up: Aspirin kills over 10,000 people a year in the US and Ibuprofen & similar NSAIDs do the same. If you mix alcohol and either aspirin or ibuprofen together, you can get deadly gastrointestinal hemorrhages, which happen to be as deadly as heart attacks. Don't do continuous daily aspirin or ibuprofen without a doctor's advice..

    A healthy marathoner friend preparing for his next marathon was pushing hard and taking a lot of ibuprofen every day to limit pain. He noted to my neighbor he was having a little blood in the toilet. My neighbor asked him what he was doing the rest of the day. The marathoner said he was going wherever and my friend said "Cancel it!" What? was the reply. My friend said get to the Em. Dept. now, now one hour from now, now. The marathoner had massive internal GI lesions and was in the hospital for over a month. He was plain lucky he didn't die.

  31. Re:With news articles, Some People Assume its a Cu by Anonymous Coward · · Score: 0

    Just to be straight up: Aspirin kills over 10,000 people a year in the US and Ibuprofen & similar NSAIDs do the same. If you mix alcohol and either aspirin or ibuprofen together, you can get deadly gastrointestinal hemorrhages, which happen to be as deadly as heart attacks. Don't do continuous daily aspirin or ibuprofen without a doctor's advice..

    A healthy marathoner friend preparing for his next marathon was pushing hard and taking a lot of ibuprofen every day to limit pain. He noted to my neighbor he was having a little blood in the toilet. My neighbor asked him what he was doing the rest of the day. The marathoner said he was going wherever and my friend said "Cancel it!" What? was the reply. My friend said get to the Em. Dept. now, now one hour from now, now. The marathoner had massive internal GI lesions and was in the hospital for over a month. He was plain lucky he didn't die.

    Agree. I'm an MD in the field of radiology and I've seen people die from internal bleeds, with underlying cause attributed to injury or cancer while taking aspirin. So while I'm naturally interested in finding this "third mechanism" of aspirin, even if I had cancer today I wouldn't start taking aspirin just yet. Let's figure out if the sum of benefits outweigh the risks and go from there.