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Could Diabetes Spread Like Mad Cow Disease? (sciencemag.org)

sciencehabit quotes Science magazine: Prions are insidious proteins that spread like infectious agents and trigger fatal conditions such as mad cow disease. A protein implicated in diabetes, a new study suggests, shares some similarities with these villains. Researchers transmitted diabetes from one mouse to another just by injecting the animals with this protein. The results don't indicate that diabetes is contagious like a cold, but blood transfusions, or even food, may spread the disease.

The work is "very exciting" and "well-documented" for showing that the protein has some prionlike behavior, says prion biologist Witold Surewicz of Case Western Reserve University in Cleveland, Ohio, who wasn't connected to the research. However, he cautions against jumping to the conclusion that diabetes spreads from person to person. The study raises that possibility, he says, but "it remains to be determined."

18 of 128 comments (clear)

  1. It's known that diabetes can spread by cheesybagel · · Score: 4, Informative

    It's called the pancreatitis virus. Much like there is a hepatitis virus that can destroy the liver, there is a pancreatitis virus that can destroy the pancreas and lead to diabetes. The prionlike protein in the article though seems to be new and this is much welcome research.

    I've heard similar things with people with metabolic syndrome, e.g., twins one is fat and the other isn't fat, one has metabolic syndrome and the other doesn't. Take a bit of fat from the one with metabolic syndrome and inject it in the skinny one and they start getting more abnormal fat concentration in the place where it was injected. Perhaps it's a similar issue?

    1. Re:It's known that diabetes can spread by cheesybagel · · Score: 4, Informative

      Since when did I mention Type 1? I said diabetes. Diabetes just means that someone has elevated blood glucose due to impaired insulin production.

      Pancreatitis is listed as a possible cause of diabetes here:
      https://www.niddk.nih.gov/heal...

      I hope the NIH is good enough for you. But you seem to be all knowing so perhaps it isn't good enough for you.

      I'll give you a hint: doctors typically give names to disease symptoms not to disease causes.

    2. Re:It's known that diabetes can spread by redcliffe · · Score: 2

      There's a vaccine about to go to trial for a virus thought to trigger the auto-immune disease.

  2. Re:Or Sugar by hey! · · Score: 5, Informative

    One recent study found that 3/4 of the food purchased by American households contain added sugar, so it's not that easy for most people.

    That said, I prepare nearly all of my own meals from scratch; having grow up in a restaurant family it's second nature. The last 4 pound bag of sugar I bought was purchased maybe three years ago and it's still not empty. So I don't eat much sugar one way or the other, and I'm certainly waay below the average 100 pound/per capita/per year average for an American.

    Yet I still developed Type 2 diabetes, which two of my siblings also have and which killed my mother and grandmother.

    IT's not as simple as "people who eat sugar get diabetes." Some people do and do; some people do and don't. Others like me don't touch the stuff and still get it.

    --
    Post may contain irony: discontinue use if experiencing mood swings, nausea or elevated blood pressure.
  3. Not the best summary by LordNelsonthe2nd · · Score: 5, Informative

    In case others wonder about the same, the article is about TYPE 2 diabetes. Just writing "diabetes" is quite pointless since type 1 and 2 are completely different. (Got type 1 myself for 26 years)

    1. Re:Not the best summary by drinkypoo · · Score: 2

      As usual, the one, we already have a method of prevention for more than 90% of the cases: for chrism sake, don't get fat!

      Now if only we had a method of prevention for getting fat.

      For some people, just eating less is simple. For some people, just eating less is scarcely effective. For some people, just eating less is damned near impossible. You can feel any way you want about their self-control, but this is yet another area that needs more solutions.

      --
      "You're right," Fisheye says. "I should have set it on 'whip' or 'chop.'"
    2. Re:Not the best summary by Antique+Geekmeister · · Score: 2

      > It's not about eating less

      I'm afraid to say that it's about eating less. Getting to that state in a way one can live with can be difficult, and complex.

      > eat as much as I want until satisfied

      This is one of the keys. "Being satisfied" can be very awkward to achieve.

      > What finally worked for me was switching to a ketogenic diet (high-fat, low-carb)

      Please, also note: "ketogenic" means "producing ketones". It does not necessarily mean "high-fat, low carb". It can also mean "high protein, low carb", or simply "low carb, nothing else". I understand that it used to be very common among humans during winter, or outside the local growing seasons.

  4. which brings up a point about the paleo diet by drinkypoo · · Score: 2

    Cannibalism is an easy way for prion transfer to occur... and cannibalism was a whole lot more common in the paleolithic age. Is it really 'paleo' if you don't eat your neighbor? Or well... the people in the next town over, I guess.

    --
    "You're right," Fisheye says. "I should have set it on 'whip' or 'chop.'"
  5. Re:Not even possible by gurps_npc · · Score: 2

    By your logic, everybody should have AIDS, as it's transfer is similar.

    The study made it clear that it requires unsual circumstances to transfer, you are the only person that thinks it said it was transferable from eating any food.

    --
    excitingthingstodo.blogspot.com
  6. Re:Not even possible by drinkypoo · · Score: 4, Insightful

    AIDS is only transferred when you fuck someone in the ass or share needles. It is VERY difficult to catch unless you are a stupid drug addict or you like to sodomize other people and not use a condom.

    Are you trolling, or do you really believe this? If the latter, please tell us that you're not actually sexually active. If you are, by all means, please give this speech to any prospective partners.

    --
    "You're right," Fisheye says. "I should have set it on 'whip' or 'chop.'"
  7. Re:Not even possible by BarbaraHudson · · Score: 4, Insightful

    It's only when politicians discovered that they can get HIV from having penis/vagina sex with female prostitutes that government research funding took off.

    This isn't a public health issue? Check out the rates world-wide.

    --
    "Transparent" is a shit show that trades on every stereotype going. A man in drag is NOT a transsexual.
  8. Re: Or Sugar by longk · · Score: 2

    Sugar is just one of many sources of carbohydrates. You may want to try cutting them altogether. I won't claim it's the magic cure-all, but it certainly fixed a lot of issues for me. (I eat 15g carbs/day.)

  9. unlikely by doctorvo · · Score: 2

    Although there is an effect of vegetarian diets on diabetes (beyond BMI), I don't think it is strong enough to suggest that Type 2 diabetes is a zoonotic disease: https://www.ncbi.nlm.nih.gov/p...

  10. Re: Or Sugar by Applehu+Akbar · · Score: 4, Funny

    Yes, eating other carnivores is how you get prion-based diseases.

    Eat vegans instead, letting them do the work of eating vegetables for you. And besides, everyone around them will thank you.

  11. Re:Or Sugar by hey! · · Score: 2

    I agree on Type 1. On Type 2 -- it's complicated. Sugar is certainly associated with risk factors like central obesity, and there is now some evidence that there is a link, and more evidence pointing to sugar's effect on the liver. But the point is that even if there *is* a link, it's not as simple as "people who get type 2 diabetes because they eat too much sugar."

    I believe what drives that misperception is the need to believe that bad things only happen to bad or irresponsible people.

    --
    Post may contain irony: discontinue use if experiencing mood swings, nausea or elevated blood pressure.
  12. Re:Or Sugar by hey! · · Score: 3, Informative

    It's so common in my family I hardly need to do a genetic test. Autoimmune diseases also run in my family, and there is some evidence that Type 2 for some people at least has an autoimmune component.

    --
    Post may contain irony: discontinue use if experiencing mood swings, nausea or elevated blood pressure.
  13. Re:Or Sugar by jenningsthecat · · Score: 4, Interesting

    ... Autoimmune diseases also run in my family, and there is some evidence that Type 2 for some people at least has an autoimmune component.

    Interesting connection there, given that carbohydrates, (especially the simple ones), are implicated in inflammation. So maybe sugar causes inflammation that can eventually degrade to an autoimmune disorder, while in other people the autoimmune component is genetic, as in your case.

    Maybe in people whose Type 2 diabetes is eliminated when they change their diet, the inflammation response never developed into an autoimmune disorder. So perhaps there are 3 different varieties of Type 2 diabetes - lifestyle-triggered reversible, lifestyle-triggered irreversible, and genetic-therefore-irreversible. Just a thought ...

    --
    'The Economy' is a giant Ponzi scheme whose most pitiable suckers are the youngest among us and the yet-unborn.
  14. Re: Or Sugar by yithar7153 · · Score: 3, Informative

    Jesus christ dude, you're probably gonna be dead in no time from atherosclerosis.

    I'm assuming you're talking about the saturated fat content. It's a myth that saturated fat clogs arteries.
    From here:

    The epidemiology of saturated fats and atherosclerosis doesn't look good for the old theory that one is caused by the other. Mostly it's been confounded by the fact that intake of preserved meat (which is high in saturated fat) correlates with atherosclerosis. But it's a proxy because intake of fresh meat and dairy and tropical oils, all does NOT correlate with it.