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Human Mini-Brains Growing Inside Rat Bodies Are Starting To Integrate (inverse.com)

At the annual meeting of the Society for Neuroscience starting November 11 in Washington D.C., two teams of scientists plan to present previously unpublished research on the unexpected interaction between human mini-brains and their rat and mouse hosts. "In the new papers, according to STAT, scientists will report that the organoids survived for extended periods of time -- two months in one case -- and even connected to lab animals' circulatory and nervous systems, transferring blood and nerve signals between the host animal and the implanted human cells," reports Inverse. "This is an unprecedented advancement for mini-brain research." From the report: That mini-brains can even be grown in the lab is a huge advancement in the first place, as they have many of the same characteristics as living human brains that are in the early stages of development. Though they're not "alive" in the same sense that you and I are, they grow and are organized into different layers like our brains are. They even react in similar ways to stimuli like psychedelic drugs. Organoids are poised to revolutionize research on the human brain since scientists can perform tests on them that would be unethical to attempt on living humans. STAT also reports that a third lab, in addition to the two presenting at the Society for Neuroscience meeting, has successfully connected human brain organoids to blood vessels. This attempt veered into such challenging ethical territory, though, that the lab reportedly paused its efforts.

15 of 193 comments (clear)

  1. Ethics or morals? by Anonymous Coward · · Score: 5, Insightful

    Ethical is informing someone of the risks, not misrepresent anything for the purpose of obtaining consent.

    Moral is can't do it at all because of some taboo.

    Mini brains in mice are a clever workaround. As long as we can pretrnd its like growing vegetables, its ok.

    Scientists should be careful to ensure they can't communicate meaningfully with these minibrains, because the instant one of those things signals that it's hurting or wants the pain to stop, the ethics and morals will apply again and we will be having strange discussions about whether those mini brains come with souls or not.

  2. I know how this ends by PopeRatzo · · Score: 5, Funny
    --
    You are welcome on my lawn.
  3. another incarnation of Project B.R.A.I.N. by Idisagree · · Score: 3

    Pinky: Gee, Brain, what do you want to do tonight?

            Brain: The same thing we do every night, Pinky - try to take over the world!

  4. Science safety tip: by joe_frisch · · Score: 5, Funny

    If it sounds like the intro to a horror movie / game, maybe you should think twice about proceeding....

  5. Re: When Will This Work On Republicans? by gurps_npc · · Score: 3, Insightful

    That might have to do with who you hang out with and where you live.

    I have found that the smartest Republicans are at least as smart as the smartest Democrats. And I have found that both Democrats and Republicans lie about the same.

    But I have also found that the smarter the Republican is, the more likely he is to lie to the public and tell the truth to his allies, while the smarter the Democrat is, the more likely he is to lie to his allies and tell the truth to the public.

    Personally, I would rather have someone lie to their ally and tell the public the truth.

    --
    excitingthingstodo.blogspot.com
  6. Says Who? by sexconker · · Score: 4, Interesting

    Though they're not "alive" in the same sense that you and I are, they grow and are organized into different layers like our brains are. They even react in similar ways to stimuli like psychedelic drugs.

    Who's to say what they experience or feel? That they're not alive? Seems to me they're making them as close to a live brain as possible, so...

  7. Jesus H. Christ... by Nicolas+Cage · · Score: 3, Insightful

    This is horrifying. How could you go home and sleep at night after working on something like this?

    Growing extra organs in or on animals is already pretty grotesque, but at least that has obvious and practical applications. But this? This is some shit, man...

    1. Re:Jesus H. Christ... by Rujiel · · Score: 4, Insightful

      "Fine, all the humans who died of treatable nervous diseases because it took decades to get the medicines properly tested....their blood is on your hands."

      That''s assuming that anything comes of the research, which is just that, an assumption. You' re offering a false choice and tagging it with phony morality. You could make the same arguments to justify nazi experimentation too--" hundreds died to save thousands"--so spare me your "calm down".

  8. differentiation by slothman32 · · Score: 3, Funny

    Any brain can integrate; wake me up when they can find derivatives.

    --
    Why don't you guys have friends or journals?
  9. Re: When Will This Work On Republicans? by MrKaos · · Score: 5, Interesting
    We only need to remove the political rhetoric from your post for it to be closer to truth..

    The typical Political archetypes are psychopaths as the leaders with narcissists as the minions, willing to do anything for anyone for empty compliments about how great they are

    For what we can see politics has become so dis-functional with the identity game that it is precisely what attracts psychopaths and narcissists. The image of competence. Meanwhile, the competent are subject to all of the games psychopaths and narcissists play, manipulating people.

    Your example of Tesla and Edison is a good one, especially considering that when Einstein was asked, What's it like to be the smartest man in the world? he replied: "I don't know, you would have to ask Nicola Tesla." It's a good example of what this sickness costs our species.

    I'm only pointing it out because I think that sickness overshadows politics and we have to fix politics to prevent psychopaths spreading their corruption throughout our society.

    --
    My ism, it's full of beliefs.
  10. God help us all by hyades1 · · Score: 4, Funny

    "Human Mini-Brains Growing Inside Rat Bodies Are Starting To Integrate"

    Big deal. So they've invented vat-grown lawyers.

    --
    I've calculated my velocity with such exquisite precision that I have no idea where I am.
  11. Frankenstein by joao.cordeiro · · Score: 3, Interesting

    I do love how the author comes up with a lovely name like "mini brains" for something that can be compared to Frankenstein.

  12. Re:When Will This Work On Republicans? by Z80a · · Score: 5, Interesting

    When you have to choose between two people trying to ruin your life, and one of em is very smart and talented and the other is a complete dumbass, i don't think you would choose the more capable one.

  13. Ratios are relevant by DrYak · · Score: 4, Interesting

    If you grew a brain twice as large as a persons brain would it be twice as intelligent?

    Very serious answer :
    size plays some role, but only in relation of other metrics.

    - You need to compare the ratio between the size of the brain and the overall size of the body that said brain needs to control.
    The more body you need to control, the more primary motor and sensory zone you need inside the brain to control it.
    i.e.: the more you needs cells in the brain whose primary role is to be connected to part of the body.

    A human has a brain of around a kilogram. An elephant's is a bit under 5kg, a whale is a bit 8 kg.
    That doesn't mean that whales laugh at our "inability to come with a good theory of everything and struggle with string theory instead". It's just that whales have a lot more "whale" to move around and thus need the corresponding brain parts to control it.

    - You need to compare the amount of neurons (the actual brain cells doing the work) to the amount of other cells (the support cells that help the whole thing work out). (It's an approximation but you got the thing).
    Part of the reason why dolphins aren't winning Nobel prizes yet (apart from obvious specie-ism) is also because they have brain better adapted to their harsh environment (cold seas). Part of their brain size isn't due to neurons working to make them intelligent, but to all the other support cells making sure that the brain keeps working without any problem under circumstances where a human would have been frozen.

    - You need to have a look at the brain surface. The more intelligent species (great apes, cetaceans, etc.) have found way to cram more brain power in tighter volumes by wrinkling and crumbling the surface : we tend to have deeper sulci.

    --
    "Sufficiently advanced satire is indistinguishable from reality." - [Tips: 1DrYakQDKCQ6y52z6QbnkxHXAocMZJE61o ]
  14. Re: When Will This Work On Republicans? by Ol+Olsoc · · Score: 3, Funny

    Are you sure about your IQ? Because you might want to get refund on the test.

    You have to admit, he made the perfect example of the Dunning-Kruger effect

    --
    The shepherds did so well protecting the flock that the sheep no longer believed that wolves existed.